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Search for "N-heterocycles" in Full Text gives 83 result(s) in Beilstein Journal of Organic Chemistry.
Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes
Beilstein J. Org. Chem. 2012, 8, 1839–1843, doi:10.3762/bjoc.8.211
- aldehyde and aniline derivatives) with alkenes have become efficient strategies for the generation of N-heterocycles [9][10][11]. In these reactions the alkene must be electron-rich, which means that functional groups attached to the alkene should be able to donate electrons. Among the electron-rich
Asymmetric Brønsted acid-catalyzed aza-Diels–Alder reaction of cyclic C-acylimines with cyclopentadiene
Beilstein J. Org. Chem. 2012, 8, 1819–1824, doi:10.3762/bjoc.8.208
- construction of optically active, nitrogen-containing, six-membered rings, such as tetrahydroquinolines and piperidines. N-heterocycles are found in a wide range of natural products and many biologically active compounds [1][2][3][4]. To date, most aza-asymmetric Diels–Alder reactions have been catalyzed by
Copper-catalyzed CuAAC/intramolecular C–H arylation sequence: Synthesis of annulated 1,2,3-triazoles
Beilstein J. Org. Chem. 2012, 8, 1771–1777, doi:10.3762/bjoc.8.202
- - and step-economical access to annulated carbo- as well as O- and N-heterocycles. Finally, we found that the catalytic system also proved to be applicable to the one-pot copper-catalyzed direct arylation of various azoles 5 through N–H/C–H bond cleavages with aryl iodides 6 as the organic electrophiles
Carbohydrate-auxiliary assisted preparation of enantiopure 1,2-oxazine derivatives and aminopolyols
Beilstein J. Org. Chem. 2012, 8, 662–674, doi:10.3762/bjoc.8.74
- diastereoselectivity [9]. We previously reported on the unusually diverse synthetic potential of carbohydrate-derived 1,2-oxazines allowing the smooth and flexible preparation of various highly functionalised compounds, including de novo syntheses of carbohydrates and their mimetics, as well as N-heterocycles [10][11
- as well as additional spots seen on TLC of the crude reaction mixtures support this assumption, but none of these possible by-products could be isolated. With respect to the enormous importance of polyhydroxylated N-heterocycles as carbohydrate-mimicking glycosidase inhibitors [41][42][43][44][45
One-pot four-component synthesis of pyrimidyl and pyrazolyl substituted azulenes by glyoxylation–decarbonylative alkynylation–cyclocondensation sequences
Beilstein J. Org. Chem. 2011, 7, 1173–1181, doi:10.3762/bjoc.7.136
- glyoxylation of electron rich N-heterocycles, such as indoles and pyrroles, leads to the formation of glyoxylyl chlorides, which can be reacted without isolation by decarbonylative Sonogashira coupling to form the desired ynones. So far, only one example of the synthesis of azulenylynones has been described
Gold-catalyzed heterocyclizations in alkynyl- and allenyl-β-lactams
Beilstein J. Org. Chem. 2011, 7, 622–630, doi:10.3762/bjoc.7.73
- approach to other N-heterocycles [52]. Thus, the benzene ring was substituted by a cis-alkene, and a gold-catalyzed synthesis of 5,6-dihydro-8H-indolizin-7-ones 21 from N-(pent-2-en-4-ynyl)-β-lactams 20 was developed (Scheme 11). Pt(II) and Pt(IV) also catalyzed this reaction, albeit less efficiently. In
Rh-Catalyzed rearrangement of vinylcyclopropane to 1,3-diene units attached to N-heterocycles
Beilstein J. Org. Chem. 2011, 7, 298–303, doi:10.3762/bjoc.7.39
Palladium- and copper-mediated N-aryl bond formation reactions for the synthesis of biological active compounds
Beilstein J. Org. Chem. 2011, 7, 59–74, doi:10.3762/bjoc.7.10
- , carbamates, N-heterocycles, enamines and intramolecular N-arylation reactions [45]. We compare here the success of the different C–N-arylation reactions as applied to the synthesis of more complex structures and discuss selected examples of palladium- and copper-mediated reactions for the synthesis of
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