An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

• Marcus Baumann,
• Ian R. Baxendale,
• Steven V. Ley and
• Nikzad Nikbin

Beilstein J. Org. Chem. 2011, 7, 442–495, doi:10.3762/bjoc.7.57

Synthesis of 3-(quinolin-2-yl)- and 3,6-bis(quinolin-2-yl)-9H-carbazoles

• Yang Li and
• Wentao Gao

Beilstein J. Org. Chem. 2010, 6, 966–972, doi:10.3762/bjoc.6.108

• : acetylcarbazole; β-aminoaldehyde; β-aminoketone; Friedländer condensation; sodium ethoxide; Introduction Nitrogen-containing heterocycles are a very important group of organic compounds because of their wide application in medicine, agriculture, and technology. Among these, quinoline and carbazole derivatives

One-pot three-component synthesis of quinoxaline and phenazine ring systems using Fischer carbene complexes

• Priyabrata Roy and
• Binay Krishna Ghorai

Beilstein J. Org. Chem. 2010, 6, No. 52, doi:10.3762/bjoc.6.52

• . Keywords: azaisobenzofuran; Diels–Alder; Fischer carbene complex; phenazine; quinoxaline; Introduction Nitrogen-containing heterocycles are abundant in nature and exhibit diverse and important biological properties [1]. Quinoxaline and phenazine derivatives are important classes of nitrogen containing

• heterocycles which exhibit a wide range of biological activities. Many phenazine compounds are found in nature and are produced by bacteria such as Pseudomonas spp., Streptomyces spp. and Pantoea agglomerans. These phenazine natural products have been implicated in the virulence and competitive fitness of the

A review of new developments in the Friedel–Crafts alkylation – From green chemistry to asymmetric catalysis

• Magnus Rueping and
• Boris J. Nachtsheim

Beilstein J. Org. Chem. 2010, 6, No. 6, doi:10.3762/bjoc.6.6

• catalysts are required that stabilize the transient carbocations and are able to mediate enantioselective SN1 reactions. Moreover, Friedel–Crafts alkylations of arenes bearing free amines or nitrogen-containing heterocycles will be a great advance in this area. This increase in functional group tolerance

Analogues of amphibian alkaloids: total synthesis of (5R,8S,8aS)-(−)-8-methyl- 5-pentyloctahydroindolizine (8-epi-indolizidine 209B) and [(1S,4R,9aS)-(−)-4-pentyloctahydro- 2H-quinolizin- 1-yl]methanol

• Joseph P. Michael,
• Claudia Accone,
• Charles B. de Koning and
• Christiaan W. van der Westhuyzen

Beilstein J. Org. Chem. 2008, 4, No. 5, doi:10.1186/1860-5397-4-5

• development of enaminones as versatile intermediates for the synthesis of alkaloids and other nitrogen-containing heterocycles. In this paper we describe the enantioselective synthesis of indolizidine and quinolizidine analogues of bicyclic amphibian alkaloids via pyrrolidinylidene- and piperidinylidene

• -containing heterocycles [10], we previously reported total syntheses of (−)-indolizidine 167B 7 [11][12], the 5,8-disubstituted indolizidine (−)-209B 8 and its racemic diastereomer (±)-9 [13], and the 5,6,8-trisubstituted indolizidines (+)-10 and (+)-11 [14], among other similar compounds (Figure 2). While

• quinolizidine 207I, 217A and related compounds have been reported [4][5][6][7][8][9]. As part of a long-standing investigation into the utility of pyrrolidinylidene- and piperidinylidene-containing enaminones (vinylogous urethanes) 5 and 6 as key intermediates in the synthesis of alkaloids and other nitrogen

Contemporary organosilicon chemistry

• Steve Marsden

Beilstein J. Org. Chem. 2007, 3, No. 4, doi:10.1186/1860-5397-3-4

• Chemistry". We have contributions from some of the leading practitioners in the area, covering a wide range of topics including the stereoselective construction of oxygen and nitrogen-containing heterocycles, the use of tethered silicon reagents to deliver acyclic stereocontrol, chiral-at-silicon reagents

Cobalt(II) chloride catalyzed one-pot synthesis of α-aminonitriles

• Surya K. De

Beilstein J. Org. Chem. 2005, 1, No. 8, doi:10.1186/1860-5397-1-8

• α-aminonitriles, which are useful intermediates for the synthesis of amino acids and nitrogen-containing heterocycles such as thiadiazoles, imidazoles, etc [2][3]. They are usually prepared by the nucleophilic addition of cyanide anion to imines. Numerous methods describing the preparation of α