Beilstein J. Org. Chem.2009,5, No. 4, doi:10.3762/bjoc.5.4
monastrol, a potent inhibitor of kinesin Eg5.
Keywords: Biginelli reaction; DHPMs; neat; MCR; zeolite; Introduction
The Biginelli reaction is a well-known multicomponentreaction involving a one-pot cyclocondensation of an aldehyde, β-ketoester and urea/thiourea [1][2][3]. Multicomponent reactions (MCRs
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Graphical Abstract
Scheme 1:
General procedure for the synthesis of DHPMs.