Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts

• Esther Vicente-García,
• Rosario Ramón,
• Sara Preciado and
• Rodolfo Lavilla

Beilstein J. Org. Chem. 2011, 7, 980–987, doi:10.3762/bjoc.7.110

• tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence. Several oxidizing agents were studied and manganese dioxide proved to be the reagent of choice, affording higher yields, cleaner

Palladium- and copper-mediated N-aryl bond formation reactions for the synthesis of biological active compounds

• Carolin Fischer and
• Burkhard Koenig

Beilstein J. Org. Chem. 2011, 7, 59–74, doi:10.3762/bjoc.7.10

• contributing to the synthesis of murrazoline. Synthesis of vitamin E amines. Improved synthesis of martinellic acid. New tariquidar-derived ABCB1 inhibitors. β-Carbolin-1-ones as inhibitors of tumour cell proliferation. Copper-catalysed synthesis of promazine drugs. Palladium-catalysed multicomponent reaction

One-pot three-component synthesis of quinoxaline and phenazine ring systems using Fischer carbene complexes

• Priyabrata Roy and
• Binay Krishna Ghorai

Beilstein J. Org. Chem. 2010, 6, No. 52, doi:10.3762/bjoc.6.52

• approach to these ring systems is the annulation of benzene rings onto pre-existing heterocyclic rings [22]. This manuscript focuses on the successful execution of the latter transformation through a multicomponent reaction process to access these ring systems (Scheme 1). The synthetic approach involves a

Zeolite catalyzed solvent- free one-pot synthesis of dihydropyrimidin- 2(1H)-ones – A practical synthesis of monastrol

• Mukund G. Kulkarni,
• Sanjay W. Chavhan,
• Mahadev P. Shinde,
• Dnyaneshwar D. Gaikwad,
• Ajit S. Borhade,
• Attrimuni P. Dhondge,
• Yunnus B. Shaikh,
• Vijay B. Ningdale,
• Mayur P. Desai and
• Deekshaputra R. Birhade

Beilstein J. Org. Chem. 2009, 5, No. 4, doi:10.3762/bjoc.5.4

• monastrol, a potent inhibitor of kinesin Eg5. Keywords: Biginelli reaction; DHPMs; neat; MCR; zeolite; Introduction The Biginelli reaction is a well-known multicomponent reaction involving a one-pot cyclocondensation of an aldehyde, β-ketoester and urea/thiourea [1][2][3]. Multicomponent reactions (MCRs