Metal-free synthesis of biarenes via photoextrusion in di(tri)aryl phosphates

• Hisham Qrareya,
• Lorenzo Meazza,
• Stefano Protti and
• Maurizio Fagnoni

Beilstein J. Org. Chem. 2020, 16, 3008–3014, doi:10.3762/bjoc.16.250

• dichloromethane, acetonitrile, and acetone (Table 1, entries 1–3), whereas 4-chlorobiphenyl (2a) was observed in traces as the only product in neat methanol (30% of 1a consumption, Table 1, entry 4). Interestingly, the addition of water (a methanol/water 2:1 mixture) increased the overall yield of the product 2a

Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes

• Dmitrii A. Aksenov,
• Nikolai A. Arutiunov,
• Vladimir V. Maliuga,
• Alexander V. Aksenov and
• Michael Rubin

Beilstein J. Org. Chem. 2020, 16, 2903–2910, doi:10.3762/bjoc.16.239

• :1–80:30:1. The titled compound was obtained as colorless powder, overall yield 80% (1.89 g, 8.00 mmol). Overall yield 1.89 g (8.00 mmol, 80%). Mp 73–74 °C; Rf 0.50 (CH2Cl2/EtOH/NEt3 80:30:1, v/v/v); 1H NMR (400 MHz, CDCl3) δ 8.01 (d, J = 8.5 Hz, 1H, 9-H), 7.95 (d, J = 1.0 Hz, 1H, 4-H), 7.91 (d, J

Changed reactivity of secondary hydroxy groups in C8-modified adenosine – lessons learned from silylation

• Jennifer Frommer and
• Sabine Müller

Beilstein J. Org. Chem. 2020, 16, 2854–2861, doi:10.3762/bjoc.16.234

• Sonogashira coupling following a previously established protocol [13], resulting in nucleoside derivative 7 with 44 % yield over these two steps, corresponding to an overall yield of 17% over six reaction steps. Further functionalization of 7 for RNA synthesis required selective 2’-O-silylation to deliver

• , formation of the desired adenosine derivative 8 was achieved with an overall yield of 12.4% over seven reaction steps. A mentioned above, 3’-O-phosphitylation of 8 was carried out [40], and the resulting phosphoramidite building block 9 was used for the synthesis of an oligoribonucleotide (Table S1 in

• various Pd-catalyzed reactions. Comparing the two reaction paths, the overall yield of the desired adenosine derivative 8 was increased from 2% to 12% over 7 reaction steps by changing the protecting group strategy. Characterization and assignment of the TBDMS isomers via HSQC (red) and HMBC (blue) NMR

Design and synthesis of a bis-macrocyclic host and guests as building blocks for small molecular knots

• Elizabeth A. Margolis,
• Rebecca J. Keyes,
• Stephen D. Lockey IV and
• Edward E. Fenlon

Beilstein J. Org. Chem. 2020, 16, 2314–2321, doi:10.3762/bjoc.16.192

• % overall yield. Ammonium and pyridinium guests were synthesized in 4–5 steps. The TLC knot-forming sequence was carried out and produced a product with the expected molecular weight, but, unfortunately, further characterization did not produce conclusive results regarding the topology of the product

• % yield (Scheme 1). Alkylation of 5 with 1,2-dibromoethane provided key intermediate azido-bromide 6 in 60% yield. This two-step route to 6 is efficient, but the 16% overall yield was lower than desired. An alternate route began by converting diol 4 to bis(2-hydroxyethoxy)naphthalene 7 in 92% yield by

• DMSO to give azide-mesylate 9 in 35–46% yield, which is reasonable based on a maximum statistical yield of 50%. Displacement of the mesylate with bromide provided a 94% yield of 6. This route to 6 is twice as long as the alternative described above, but it is preferred because the 37% overall yield is

Syntheses of spliceostatins and thailanstatins: a review

• William A. Donaldson

Beilstein J. Org. Chem. 2020, 16, 1991–2006, doi:10.3762/bjoc.16.166

• removal of the dithiane protecting group and the cyclic-ketal formation gave 84. The oxidative hydrolysis of the PMB ether and the reaction with mCPBA afforded the epoxide 85. While relatively short (9 steps), the nonstereoselective formation of 81a/b led to a lower overall yield. Syntheses of the C-1–C-6

• cleavage afforded the methyl ketone 96. The cyclic hemiketal 97 was unstable at an elevated temperature (37 °C), with t1/2 = 48 h. Both the Jacobsen (10 steps, 24.4% yield) and the Koide syntheses (11 steps, 22.3% yield) are relatively efficient in terms of the length and overall yield. Syntheses of the C

• 100 was relatively inefficient (31%) and was the main factor in diminishing the overall yield. The transformation of the silyl-protected 1° alcohol group of 100 into an ester afforded 101. Finally, the C-3 spirocyclic oxirane was introduced stereoselectively by a VO(acac)2-directed epoxidation. While

Selective preparation of tetrasubstituted fluoroalkenes by fluorine-directed oxetane ring-opening reactions

• Clément Q. Fontenelle,
• Thibault Thierry,
• Romain Laporte,
• Emmanuel Pfund and
• Thierry Lequeux

Beilstein J. Org. Chem. 2020, 16, 1936–1946, doi:10.3762/bjoc.16.160

• corresponding chloride (not shown). An Arbuzov reaction was performed directly on the allylic bromide obtained by treatment of 27 with LiBr (5 equiv), to give the phosphonate 29 in 76% overall yield. Finally, azide 28 was obtained in 89% yield in two steps from the non-isolated intermediate mesylate 27. After

Et₃N/DMSO-supported one-pot synthesis of highly fluorescent β-carboline-linked benzothiophenones via sulfur insertion and estimation of the photophysical properties

• Dharmender Singh,
• Vipin Kumar and
• Virender Singh

Beilstein J. Org. Chem. 2020, 16, 1740–1753, doi:10.3762/bjoc.16.146

• increment in the overall yield of 2bA (from 67% to 74%) was also noted. Similarly, a remarkable improvement in the yields of 2aA (from 32% to 35%), 2dA (from 78% to 83%), and 2hA (from 69% to 78%) was also observed during the one-pot approach. The comparison of the product yields obtained through both

Nonenzymatic synthesis of anomerically pure, mannosyl-based molecular probes for scramblase identification studies

• Giovanni Picca,
• Markus Probst,
• Simon M. Langenegger,
• Oleg Khorev,
• Peter Bütikofer,
• Anant K. Menon and
• Robert Häner

Beilstein J. Org. Chem. 2020, 16, 1732–1739, doi:10.3762/bjoc.16.145

• (DCM), and ETT served as the activator. The subsequent oxidation of the unstable phosphite triester to the more stable phosphotriester was performed with t-BuOOH. The resulting intermediates were then treated overnight with a solution of ammonia in methanol to remove the protecting groups. An overall

• yield of about 45% was achieved when no further purification was carried out (for details see Supporting Information File 1). The major goal of this work was the synthesis of molecular probes with a configurationally defined mannosyl headgroup, i.e., a pure β-anomer. In order to verify the preferred

Synthesis of the tetrasaccharide repeating unit of the O-specific polysaccharide of Azospirillum doebereinerae type strain GSF71^T using linear and one-pot iterative glycosylations

• Arin Gucchait,
• Pradip Shit and
• Anup Kumar Misra

Beilstein J. Org. Chem. 2020, 16, 1700–1705, doi:10.3762/bjoc.16.141

• temperature of the reaction and coupling the in situ-generated trisaccharide derivative 6 with compound 4 to furnish the desired tetrasaccharide derivative 7 in 30% overall yield. The structure of compound 7 obtained by the three iterative glycosylation reactions in one pot fully matched with the product

• treatment with HClO4-SiO2 [34]; (c) selective acetylation of the primary hydroxy group, and (d) removal of the benzyl groups by catalytic transfer hydrogenation [35] using triethylsilane in the presence of Pearlman’s catalyst [36] to furnish the desired tetrasaccharide 1 in 50% overall yield with the two O

• successively washed with 5% Na2S2O3 (25 mL), satd. NaHCO3 (25 mL), and H2O (25 mL), dried (Na2SO4) and concentrated to give the crude product, which was purified on SiO2 using hexane/EtOAc 2:1 as eluent to give pure compound 7 (320 mg, overall yield 30%). Structure of the synthesized tetrasaccharide and its

Clickable azide-functionalized bromoarylaldehydes – synthesis and photophysical characterization

• Dominik Göbel,
• Marius Friedrich,
• Enno Lork and
• Boris J. Nachtsheim

Beilstein J. Org. Chem. 2020, 16, 1683–1692, doi:10.3762/bjoc.16.139

• 78% yield and an overall yield of 56% (starting from 4-bromobenzaldehyde). Azide-functionalized ortho-bromobenzaldehyde 4 was prepared by a similar route as aldehyde 3. Initially, oxazoline formation from 4-methylbenzaldehyde yielded 2-aryloxazoline 10 in almost quantitative yield. The introduction

• of benzyl bromide with sodium azide delivered the primary azide 13 in quantitative yield. Again, the final back-conversion of the oxazoline group to the corresponding aldehyde afforded azide-functionalized ortho-bromobenzaldehyde 4 in 85% yield and an overall yield of 41% (starting from 4

• previous deprotection reactions, fluorene 21 was converted by means of a three-step sequence to the desired azide-functionalized 7-bromofluorene-2-carbaldehyde 5 in 86% yield and an overall yield of 45% (starting from fluorene). The molecular structure of 5 could be verified by X-ray diffraction (XRD, see

Facile synthesis of 7-alkyl-1,2,3,4-tetrahydro-1,8-naphthyridines as arginine mimetics using a Horner–Wadsworth–Emmons-based approach

• Rhys A. Lippa,
• John A. Murphy and
• Tim N. Barrett

Beilstein J. Org. Chem. 2020, 16, 1617–1626, doi:10.3762/bjoc.16.134

• . This represents a 64% overall yield which was increased to 68% when no column chromatography was undertaken between transformations, with no loss of purity (Scheme 5). Olefin reduction and Cbz deprotection could not be performed simultaneously by palladium-catalysed hydrogenation as this resulted in

• defluorination, presumably via a Tsuji–Trost-like elimination of the allylic fluoride [18][19]. This sequence represents a marked improvement from the Wittig-including route, lowering the number of synthetic steps and increasing the overall yield [2]. Furthermore, no problematic byproducts are formed, and good

• desired compound in 64% overall yield. A Horner–Wadsworth–Emmons/reduction/deprotection procedure was used to synthesise amines in good yield requiring no chromatography, although racemisation was observed where chiral aldehydes possessed an α-proton. This methodology utilised the underused base-stable

Recent synthesis of thietanes

• Jiaxi Xu

Beilstein J. Org. Chem. 2020, 16, 1357–1410, doi:10.3762/bjoc.16.116

• second displacement was an intramolecular SN2 process performed under mild basic conditions, affording the desired thietane 116 in 92% yield. After deprotection, oxidative cleavage, and reduction, a thietanose 117 was obtained in 63% overall yield. The thietanose 117 was further applied to synthesize a

Fluorinated phenylalanines: synthesis and pharmaceutical applications

• Laila F. Awad and
• Mohammed Salah Ayoup

Beilstein J. Org. Chem. 2020, 16, 1022–1050, doi:10.3762/bjoc.16.91

• nitrile 48a with 30% HCl aq/acetic acid, gave the 4-fluorophenylalanine·HCl 49a in a good overall yield (67%) [47] (Scheme 11). 1.4. Hydrolysis of Erlenmeyer’s azalactone A multistep Erlenmeyer azalactone synthesis was reported as an important method for the synthesis of fluorinated α-amino acids 53a–h

Copper-catalysed alkylation of heterocyclic acceptors with organometallic reagents

• Yafei Guo and
• Syuzanna R. Harutyunyan

Beilstein J. Org. Chem. 2020, 16, 1006–1021, doi:10.3762/bjoc.16.90

• the total synthesis of the natural product (+)-myrtine with 14% overall yield (Scheme 1B) [17]. For this application, the highest yield (73%) and enantioselectivity (96% ee) were obtained using the chiral ligand L3 and a copper salt as the catalyst. Despite the fact that examples of high yield and

Recent applications of porphyrins as photocatalysts in organic synthesis: batch and continuous flow approaches

• Rodrigo Costa e Silva,
• Luely Oliveira da Silva,
• Aloisio de Andrade Bartolomeu,
• Timothy John Brocksom and
• Kleber Thiago de Oliveira

Beilstein J. Org. Chem. 2020, 16, 917–955, doi:10.3762/bjoc.16.83

• photoarylation of isopropenyl acetate. The corresponding α-aryl ketone was obtained in 28–53% overall yield depending on the scale. An 8 h experiment was conducted in a continuous steady-state mode, producing the same α-aryl ketone in 48% yield on a 3 gram-scale (Scheme 5B). Photoredox catalysis is not limited

• -methoxyphenyl)porphyrin (CoTMPP) in the dark, furnishing the alkoxycarbonyl intermediate in 92% yield. The combination of this intermediate with a thiophenol derivative and Hantzsch ester (HEH) afforded ethylbenzene in 94% yield (86% overall yield) under both blue and green LED irradiation. The thiophenol and

• rearrangement (Scheme 39) [89]. Further photochemical [2 + 2] cycloaddition and hydrolysis allowed them to obtain rhodonoid A in 30% overall yield. Other similar natural products (rhodonoid B, E and F) were also prepared by the same synthetic strategy. Singlet oxygen has also been efficiently used for

Synthesis of new asparagine-based glycopeptides for future scanning tunneling microscopy investigations

• Laura Sršan and
• Thomas Ziegler

Beilstein J. Org. Chem. 2020, 16, 888–894, doi:10.3762/bjoc.16.80

• is well known that Fmoc-protected tryptophane can lead to unwanted side products when the NH group in the indole ring remains unprotected, we decided to refrain from additional protection of the indole moiety because the removal of that protecting group would have reduced the overall yield in the end

Efficient synthesis of piperazinyl amides of 18β-glycyrrhetinic acid

• Dong Cai,
• ZhiHua Zhang,
• Yufan Meng,
• KaiLi Zhu,
• LiYi Chen,
• ChangXiang Yu,
• ChangWei Yu,
• ZiYi Fu,
• DianShen Yang and
• YiXia Gong

Beilstein J. Org. Chem. 2020, 16, 798–808, doi:10.3762/bjoc.16.73

• higher reaction temperature of the solvent mixture contributed to the synthesis of compound 8. To promote the yield of compound 8 and improve the overall yield of the reaction, an optimization of the reaction conditions was performed (Table 2). First, by using low boiling point solvents, only low or no

Towards the total synthesis of chondrochloren A: synthesis of the (Z)-enamide fragment

• Jan Geldsetzer and
• Markus Kalesse

Beilstein J. Org. Chem. 2020, 16, 670–673, doi:10.3762/bjoc.16.64

• provided alcohol 11 in an excellent yield which was subjected to aminolysis to provide amide 3 in seven steps and an overall yield of 16% [16][17][18][19][20]. Synthesis of (Z)-bromide 4 For the synthesis of (Z)-bromide 4 we chose a palladium-catalyzed, stereoselective dehalogenation as the key step

• double bonds into the corresponding (Z)-monohalogenated derivatives using palladium(II) acetate, triphenylphosphine and tributyltin hydride. Following this procedure, we were able to obtain (Z)-bromide 4 in four steps and an overall yield of 39% [21][22][23][24]. Cross coupling of fragments 3 and 4 The

• best results for the cross-coupling reaction. Conclusion In summary, we established a (Z)-selective Buchwald-type coupling reaction as a key step in the synthesis of an advanced fragment of chondrochloren A (1). The required amide 3 can be synthesized in seven steps with a 16% overall yield [16][17][18

Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibition

• Sivaraman Balasubramaniam,
• Sajith Vijayan,
• Liam V. Goldman,
• Xavier A. May,
• Kyra Dodson,
• Sweta Adhikari,
• Fatima Rivas,
• Davita L. Watkins and
• Shana V. Stoddard

Beilstein J. Org. Chem. 2020, 16, 628–637, doi:10.3762/bjoc.16.59

• literature procedure [39]. The intermediate 21 was then subjected to the Suzuki reaction using conditions already developed to provide the ester aldehyde 17 in overall yield of 16% for two steps. Having identified synthetically suitable conditions for compound 17, we scaled up the reaction to complete the

Synthesis of disparlure and monachalure enantiomers from 2,3-butanediacetals

• Adam Drop,
• Hubert Wojtasek and
• Bożena Frąckowiak-Wojtasek

Beilstein J. Org. Chem. 2020, 16, 616–620, doi:10.3762/bjoc.16.57

• –8 are obtained. We therefore decided to apply this compound for the synthesis of both enantiomers of disparlure and both enantiomers of monachalure. Results and Discussion Compound 14 was prepared and converted to 15 by Fukuyama reduction as described previously [37]. The overall yield for the

Exploring the scope of DBU-promoted amidations of 7-methoxycarbonylpterin

• Anna R. Bockman and
• Jeffrey M. Pruet

Beilstein J. Org. Chem. 2020, 16, 509–514, doi:10.3762/bjoc.16.46

• modifications to the pteridine core which disrupt the hydrogen-bond assembly, such as benzylation of the lactam oxygen or conversion of the exocyclic amine to the pivalic amide [12][13]. The installation and subsequent removal of these groups naturally affects the overall yield and time necessary to generate

Architecture and synthesis of P,N-heterocyclic phosphine ligands

• Wisdom A. Munzeiwa,
• Bernard Omondi and
• Vincent O. Nyamori

Beilstein J. Org. Chem. 2020, 16, 362–383, doi:10.3762/bjoc.16.35

• addition of chlorophosphine resulted in the desired ligand 58. However, the overall yield was lower than the yield obtained through the other method. Imidazole can be regioselectively deprotonated at the more acidic C2 position. The mono- and diphosphine imidazole ligands 62 and 63 were conveniently

Copper-catalyzed enantioselective conjugate addition of organometallic reagents to challenging Michael acceptors

• Delphine Pichon,
• Jennifer Morvan,
• Christophe Crévisy and
• Marc Mauduit

Beilstein J. Org. Chem. 2020, 16, 212–232, doi:10.3762/bjoc.16.24

• CuBr∙SMe2/(R,S)-Josiphos (L9). However, the catalytic system was poorly selective toward sterically hindered organomagnesium nucleophiles (15–25% ee). The synthetic versatility of the thioester function was illustrated in the synthesis of (−)-lardolure (26% overall yield over 12 steps) via a relevant

Combination of multicomponent KA² and Pauson–Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones

• Riccardo Innocenti,
• Elena Lenci,
• Gloria Menchi and
• Andrea Trabocchi

Beilstein J. Org. Chem. 2020, 16, 200–211, doi:10.3762/bjoc.16.23

• one-pot, resulting in the generation of the stereochemically dense epoxyalcohol 37 in 68% overall yield. The treatment of compound 5 with EtMgBr as a Grignard reagent in the presence of CeCl3 gave the corresponding tertiary alcohol 38 with similar stereochemical features as of 36 in the formation of

Convenient synthesis of the pentasaccharide repeating unit corresponding to the cell wall O-antigen of Escherichia albertii O4

• Tapasi Manna,
• Arin Gucchait and
• Anup Kumar Misra

Beilstein J. Org. Chem. 2020, 16, 106–110, doi:10.3762/bjoc.16.12

• ) hydrogenolysis of benzyl ethers and benzylidene acetals over Pearlman’s catalyst [36] to furnish the desired pentasaccharide 1 in 49% overall yield (Scheme 4). The structure of compound 1 was unambiguously characterized by its NMR spectral analysis [signals at δ 5.37 (d, J = 2.0 Hz, H-1A), 5.29 (d, J = 3.5 Hz, H