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Search for "anti-inflammatory" in Full Text gives 289 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Isoxazole derivatives as new nitric oxide elicitors in plants

  • Anca Oancea,
  • Emilian Georgescu,
  • Florentina Georgescu,
  • Alina Nicolescu,
  • Elena Iulia Oprita,
  • Catalina Tudora,
  • Lucian Vladulescu,
  • Marius-Constantin Vladulescu,
  • Florin Oancea and
  • Calin Deleanu

Beilstein J. Org. Chem. 2017, 13, 659–664, doi:10.3762/bjoc.13.65

Graphical Abstract
  • ]. The thiophene is a core system of a large number of bioactive molecules such as antineoplastic agents [49], non-steroidal anti-inflammatory drugs [50] or compounds with antibacterial activities against several Gram-positive strains [51]. Thus, 3,5-disubstituted isoxazole derivatives were obtained by
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Published 06 Apr 2017

N-Propargylamines: versatile building blocks in the construction of thiazole cores

  • S. Arshadi,
  • E. Vessally,
  • L. Edjlali,
  • R. Hosseinzadeh-Khanmiri and
  • E. Ghorbani-Kalhor

Beilstein J. Org. Chem. 2017, 13, 625–638, doi:10.3762/bjoc.13.61

Graphical Abstract
  • derivatives) are also important structural motifs that are widely found in biologically active natural or synthetic products [44][45][46][47][48][49][50]. Compounds containing these rings have widespread biological applications as anticancer [51][52][53], anti-HIV [54][55], anti-inflammatory [56
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Published 30 Mar 2017

Synthesis of 1-indanones with a broad range of biological activity

  • Marika Turek,
  • Dorota Szczęsna,
  • Marek Koprowski and
  • Piotr Bałczewski

Beilstein J. Org. Chem. 2017, 13, 451–494, doi:10.3762/bjoc.13.48

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  • , have been performed. This review also covers the most important studies on the biological activity of 1-indanones and their derivatives which are potent antiviral, anti-inflammatory, analgesic, antimalarial, antibacterial and anticancer compounds. Moreover, they can be used in the treatment of
  • allowed the synthesis of 60 in yields ranged from 31 to 56%. 1-Indanones exhibit a broad spectrum of biological activity including anti-inflammatory [41], analgesic [42], antimicrobial [43], antiviral [5], anticancer [44] and antimalarial [45] activity. A combination of two or more biologically active
  • moieties may increase or decrease the biological activity. A series of isoxazole fused 1-indanones 64 with increased anti-inflammatory and antimicrobial activity has been synthesized by Giles et al. [46]. In this synthesis, diethyl phthalate (61) was reacted with ethyl acetate to obtain indane-1,3-dione
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Published 09 Mar 2017

Dynamics and interactions of ibuprofen in cyclodextrin nanosponges by solid-state NMR spectroscopy

  • Monica Ferro,
  • Franca Castiglione,
  • Nadia Pastori,
  • Carlo Punta,
  • Lucio Melone,
  • Walter Panzeri,
  • Barbara Rossi,
  • Francesco Trotta and
  • Andrea Mele

Beilstein J. Org. Chem. 2017, 13, 182–194, doi:10.3762/bjoc.13.21

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  • . Ibuprofen is the API of many nonsteroidal anti-inflammatory formulations widely used in the treatment of fever, rheumatoid arthritis and other inflammatory diseases [10]. From the chemical viewpoint, ibuprofen is the (RS)-2-(4-(2-methylpropyl)phenyl)propanoic acid. Its sodium salt is water-soluble and
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Published 27 Jan 2017

Synthesis and evaluation of anti-oxidant and cytotoxic activities of novel 10-undecenoic acid methyl ester based lipoconjugates of phenolic acids

  • Naganna Narra,
  • Shiva Shanker Kaki,
  • Rachapudi Badari Narayana Prasad,
  • Sunil Misra,
  • Koude Dhevendar,
  • Venkateshwarlu Kontham and
  • Padmaja V. Korlipara

Beilstein J. Org. Chem. 2017, 13, 26–32, doi:10.3762/bjoc.13.4

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  • are a class of natural compounds which are found ubiquitously in the plant kingdom. They are reported to possess a wide range of biological properties like anti-oxidant, antimicrobial, anti-inflammatory, anticarcinogenic and antiviral activities [1]. The phenolic acids are also reported to show in
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Published 04 Jan 2017

Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction

  • Manjunatha Narayanarao,
  • Lokesh Koodlur,
  • Vijayakumar G. Revanasiddappa,
  • Subramanya Gopal and
  • Susmita Kamila

Beilstein J. Org. Chem. 2016, 12, 2893–2897, doi:10.3762/bjoc.12.288

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  • [7][8][9][10]. Indole and indazolyl subunits are central to numerous alkaloids and are constituents of many classes of compounds that display a wide range of bioactivities such as antimycobacterial, anti-inflammatory, antihypertensive, anticancer, antidepressant, antidiabetic, antimalarial
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Published 29 Dec 2016

The digital code driven autonomous synthesis of ibuprofen automated in a 3D-printer-based robot

  • Philip J. Kitson,
  • Stefan Glatzel and
  • Leroy Cronin

Beilstein J. Org. Chem. 2016, 12, 2776–2783, doi:10.3762/bjoc.12.276

Graphical Abstract
  • was used to 3D print reaction vessels (reactionware) of differing internal volumes using polypropylene feedstock via a fused deposition modeling 3D printing approach and subsequently make use of these fabricated vessels to synthesize the nonsteroidal anti-inflammatory drug ibuprofen via a consecutive
  • platform is a three-step synthesis of the popular nonsteroidal anti-inflammatory drug ibuprofen ((R,S)-2-(4-(2-methylpropyl)phenyl)propanoic acid) starting from isobutylbenzene and propanoic acid (see Scheme 1). These starting materials undergo a Friedel–Crafts acylation using trifluoromethanesulfonic
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Published 19 Dec 2016

Interactions between cyclodextrins and cellular components: Towards greener medical applications?

  • Loïc Leclercq

Beilstein J. Org. Chem. 2016, 12, 2644–2662, doi:10.3762/bjoc.12.261

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  • triglyceride serum levels, this CD reduces cholesterol accumulation in atherosclerotic plaques by the modification of HDL-cholesterol levels. It is noteworthy that HDL and apolipoprotein A-I (ApoA-I) cause a dose-dependent reduction in the activation of CD11b (i.e., anti-inflammatory effect on monocytes
  • , the researchers suspect that the CD boosts the activity of macrophages, enabling them to attack excess cholesterol without causing inflammation. Indeed, CD increases liver X receptor (LXR) involved in the antiatherosclerotic and anti-inflammatory effects as well as in the RCT improvement. Moreover, α
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Published 07 Dec 2016

Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides

  • Ilya V. Efimov,
  • Marsel Z. Shafikov,
  • Nikolai A. Beliaev,
  • Natalia N. Volkova,
  • Tetyana V. Beryozkina,
  • Wim Dehaen,
  • Zhijin Fan,
  • Viktoria V. Grishko,
  • Gert Lubec,
  • Pavel A. Slepukhin and
  • Vasiliy A. Bakulev

Beilstein J. Org. Chem. 2016, 12, 2390–2401, doi:10.3762/bjoc.12.233

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  • chemistry over the years [1]. Isoxazoles have been found in natural products [1], and they exhibit anticancer [2], antiviral [1], anti-inflammatory [3], antidiabetic [4], anti-Alzheimer [5] and many other types of biological activity [6]. Isoxazolines and isoxazoles have been applied as chemosensors, liquid
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Published 15 Nov 2016

Rearrangements of organic peroxides and related processes

  • Ivan A. Yaremenko,
  • Vera A. Vil’,
  • Dmitry V. Demchuk and
  • Alexander O. Terent’ev

Beilstein J. Org. Chem. 2016, 12, 1647–1748, doi:10.3762/bjoc.12.162

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  • activities, including antibacterial, antiviral, antifungal, anti-allergic, anti-oxidant, and anti-inflammatory [348][349]. The treatment of endoperoxide 238 with Et3N gave 1,4-diketone 240 in quantitative yield instead of expected hydroxy ketone 239 (Scheme 73) [350][351][352]. The endoperoxide 238 is
  • rearrangement is one of the steps in the synthesis of the natural compound angelone from Nauclea, a plant species widely acclaimed for its anti-inflammatory and antibacterial utilities in traditional Chinese herbal medical formulations [370]. A Kornblum–DeLaMare enantiomeric resolution was also used to obtain
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Published 03 Aug 2016

One-pot synthesis of tetracyclic fused imidazo[1,2-a]pyridines via a three-component reaction

  • Bo Yang,
  • Chuanye Tao,
  • Taofeng Shao,
  • Jianxian Gong and
  • Chao Che

Beilstein J. Org. Chem. 2016, 12, 1487–1492, doi:10.3762/bjoc.12.145

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  • broad range of biological activities such as antibacterial [11][12][13], antiviral [14][15], anti-inflammatory [16][17], antitumor [18][19][20], and anti-HIV [21]. It is found as the core structure in several drugs such as Zolpidem, Alpidem and Zolimidine (approved for treatments of insomnia, anxiety
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Published 18 Jul 2016

Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

  • Mohammad Haji

Beilstein J. Org. Chem. 2016, 12, 1269–1301, doi:10.3762/bjoc.12.121

Graphical Abstract
  • , carbamate 138, hexahydrobenzothiophene 140 and benzothiophene 142 were converted to the corresponding bisphosphonates 139, 141 and 143, respectively (Scheme 30). The synthesized heterocyclic bisphosphonates showed anti-inflammatory properties. 3 Knoevenagel-induced domino reactions An efficient method into
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Published 21 Jun 2016

Conjugate addition–enantioselective protonation reactions

  • James P. Phelan and
  • Jonathan A. Ellman

Beilstein J. Org. Chem. 2016, 12, 1203–1228, doi:10.3762/bjoc.12.116

Graphical Abstract
  • :36.5 to 67.5:32.5 er). To demonstrate the utility of the transformation, the sulfur–carbon bond of 26a was reduced using Raney nickel to access (S)-naproxen (27), an anti-inflammatory drug (Scheme 6b). Inspired by the work of Pracejus, Tan and colleagues applied their C2-symmetric guanidine catalyst 30
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Published 15 Jun 2016

Biradical vs singlet oxygen photogeneration in suprofen–cholesterol systems

  • Fabrizio Palumbo,
  • Francisco Bosca,
  • Isabel M. Morera,
  • Inmaculada Andreu and
  • Miguel A. Miranda

Beilstein J. Org. Chem. 2016, 12, 1196–1202, doi:10.3762/bjoc.12.115

Graphical Abstract
  • nonsteroidal anti-inflammatory drug that contains the 2-benzoylthiophene (BZT) chromophore and has a π,π* lowest triplet excited state. In the present work, dyads (S)- and (R)-SP-α-Ch (1 and 2), as well as (S)-SP-β-Ch (3) have been prepared from β- or α-Ch and SP to investigate the possible competition between
  • light. The latter involves energy transfer from the photosensitizer triplet excited state to ground state molecular oxygen [5][6]. Ketoprofen (KP) is a nonsteroidal anti-inflammatory drug that contains the benzophenone (BZP, Figure 1) chromophore and displays a n,π triplet excited state [7][8][9
  • -Ch dyads are suitable to generate biradicals by intramolecular HA from the C7-allyl position of Ch [11][12], whereas the TPA-α-Ch analogs are unreactive via HA but they generate singlet oxygen efficiently [13]. Suprofen (SP) is another nonsteroidal anti-inflammatory drug, which contains a BZT
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Published 14 Jun 2016

Antibacterial structure–activity relationship studies of several tricyclic sulfur-containing flavonoids

  • Lucian G. Bahrin,
  • Henning Hopf,
  • Peter G. Jones,
  • Laura G. Sarbu,
  • Cornelia Babii,
  • Alina C. Mihai,
  • Marius Stefan and
  • Lucian M. Birsa

Beilstein J. Org. Chem. 2016, 12, 1065–1071, doi:10.3762/bjoc.12.100

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  • display antibacterial, antiviral, antifungal, anti-inflammatory and anticancer properties [4][5][6][7][8][9][10]. Their polyphenolic structure also gives them excellent anti-oxidant and cardioprotective properties [11][12]. Our research group has recently reported the antibacterial properties of a new
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Published 23 May 2016

The synthesis of functionalized bridged polycycles via C–H bond insertion

  • Jiun-Le Shih,
  • Po-An Chen and
  • Jeremy A. May

Beilstein J. Org. Chem. 2016, 12, 985–999, doi:10.3762/bjoc.12.97

Graphical Abstract
  • remote functionalizations on the piperidine ring. Many examples of the sequence with different piperidines were also reported. The resulting 3-amino-2,6-disubstituted piperidines like 52 are known to display anti-allergic and anti-inflammatory activities. Rao generated a bridged polycycle via a formal C
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Published 17 May 2016

Three new trixane glycosides obtained from the leaves of Jungia sellowii Less. using centrifugal partition chromatography

  • Luíse Azevedo,
  • Larissa Faqueti,
  • Marina Kritsanida,
  • Antonia Efstathiou,
  • Despina Smirlis,
  • Gilberto C. Franchi Jr,
  • Grégory Genta-Jouve,
  • Sylvie Michel,
  • Louis P. Sandjo,
  • Raphaël Grougnet and
  • Maique W. Biavatti

Beilstein J. Org. Chem. 2016, 12, 674–683, doi:10.3762/bjoc.12.68

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  • its leaves presents anti-inflammatory properties. Cyperane, guaiane, nortrixane, and trixane sesquiterpene types were reported as the main metabolites in Jungia species. This work aims to describe the isolation and identification of sesquiterpenes in the leaves of J. sellowii using liquid–liquid
  • -inflammatory and antioxidant effects of J. paniculata were associated to the presence of flavonoids and other polyphenols [4]. Recently, we reported the in vivo anti-inflammatory properties of an aqueous fraction of the leaves of J. sellowii, that is in agreement with its popular use in Brazil [5]. Apart from
  • herbs, widely distributed from Central to South America, including Southern Brazil. Species such as J. paniculata and J. polita are used in South America to disinfect and cure external wounds, to treat inflammation [1][2], and as a blood depurative [3]. Pharmacological studies demonstrated that the anti
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Published 12 Apr 2016

Biosynthesis of α-pyrones

  • Till F. Schäberle

Beilstein J. Org. Chem. 2016, 12, 571–588, doi:10.3762/bjoc.12.56

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  • ’-dichlorodihydrofluorescein (DCFH) to the fluorescent 2’,7’-dichlorofluorescein (DCF) [29]. This antioxidant activity was also linked to anti-inflammatory effects by testing the in vivo effects of 23 in a carrageenan-induced paw edema assay. Oral administration of 23 to mice prior to carrageenan injection resulted in a
  • interesting target of research, due to the fact that the progression of Alzheimer’s disease was slowed down by using anti-inflammatory drugs. Thus, selective COX-2 inhibitors, anti-inflammatory compounds themselves, might have beneficial effects in vivo. Several derivatives of 6-alkyl (alkoxy or alkylthio)-4
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Published 24 Mar 2016

Regiodefined synthesis of brominated hydroxyanthraquinones related to proisocrinins

  • Joyeeta Roy,
  • Tanushree Mal,
  • Supriti Jana and
  • Dipakranjan Mal

Beilstein J. Org. Chem. 2016, 12, 531–536, doi:10.3762/bjoc.12.52

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  • condensation; Hauser annulation; proisocrinins; Introduction Anthraquinones constitute the largest group of naturally occurring quinones [1][2][3][4][5]. Isolated mainly from fungal sources, they display a wide range of biological activities which include anti-inflammatory, antifungal, antiparasidal, and
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Published 16 Mar 2016

A selective and mild glycosylation method of natural phenolic alcohols

  • Mária Mastihubová and
  • Monika Poláková

Beilstein J. Org. Chem. 2016, 12, 524–530, doi:10.3762/bjoc.12.51

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  • -glucopyranoside (vanillyl β-D-glucoside, 1) isolated from the exocarp of Juglans mandshurica Maxim showed antibacterial activity [1]. A wide range of pharmacological effects, e.g., anti-oxidant, anti-inflammatory, anticancer, hepatoprotective, cardioprotective, neuroprotective, antidiabetic, and antiviral
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Published 15 Mar 2016

Physical properties and biological activities of hesperetin and naringenin in complex with methylated β-cyclodextrin

  • Waratchada Sangpheak,
  • Jintawee Kicuntod,
  • Roswitha Schuster,
  • Thanyada Rungrotmongkol,
  • Peter Wolschann,
  • Nawee Kungwan,
  • Helmut Viernstein,
  • Monika Mueller and
  • Piamsook Pongsawasdi

Beilstein J. Org. Chem. 2015, 11, 2763–2773, doi:10.3762/bjoc.11.297

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  • inclusion complexes. The data obtained by the dissolution method showed that complexation with RAMEB resulted in a better release of both flavanones to aqueous solution. The flavanones-β-CD/DM-β-CD complexes demonstrated a similar or a slight increase in anti-inflammatory activity and cytotoxicity towards
  • , grapefruit and orange. Several reports on biological effects of hesperetin and naringenin have been found [6], including blood lipid- and cholesterol-lowering effects [7][8][9], anti-inflammatory [10][11][12][13] and anticancer [14][15][16] activities, improved microcirculation, recovery of venous ulcers
  • dissolution study of flavanones were studied. The formed inclusion complexes were analyzed by DSC. The anti-inflammatory activity of inclusion complexes and the free flavanones were determined by investigating the secretion of certain cytokines in lipopolysaccharide (LPS)-stimulated macrophages. In addition
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Published 29 Dec 2015

A concise and efficient synthesis of benzimidazo[1,2-c]quinazolines through CuI-catalyzed intramolecular N-arylations

  • Xinlong Pang,
  • Chao Chen,
  • Ming Li and
  • Chanjuan Xi

Beilstein J. Org. Chem. 2015, 11, 2365–2369, doi:10.3762/bjoc.11.258

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  • ]quinazolines were intensively investigated and promising biological activities were observed, such as anticancer, antiviral, antimicrobial, anti-inflammatory and anticonvulsant [3][4][5]. Indeed, some of them are already used as antimicrobial agents and lipid peroxidation inhibitors [6]. Consequently, the
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Published 30 Nov 2015

Syntheses of 2-substituted 1-amino-4-bromoanthraquinones (bromaminic acid analogues) – precursors for dyes and drugs

  • Enas M. Malik,
  • Younis Baqi and
  • Christa E. Müller

Beilstein J. Org. Chem. 2015, 11, 2326–2333, doi:10.3762/bjoc.11.253

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  • ][18][19]. AQ derivatives can also exert a variety of pharmacological activities including laxative, anti-inflammatory [20][21], antitumor [22][23], antifungal [24], antiviral [25], and blood platelet inhibitory effects [26][27][28]. Reactive Blue 2 (RB-2), a chlorotriazinyl-containing AQ dye, defined
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Published 26 Nov 2015

A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines

  • Mingxing Liu,
  • Jiarong Li,
  • Hongxin Chai,
  • Kai Zhang,
  • Deli Yang,
  • Qi Zhang and
  • Daxin Shi

Beilstein J. Org. Chem. 2015, 11, 2125–2131, doi:10.3762/bjoc.11.229

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  • important because of their biological activity [1][2][3][4][5][6]. They have shown a wide range of pharmacological potential such as kinase inhibitors [1], antitumor [7][8], anti-inflammatory [9][10], antimicrobial [11][12][13], pesticides [14], radio protectant [15] and cardiovascular activity [16][17
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Published 06 Nov 2015

Fe(II)/Et3N-Relay-catalyzed domino reaction of isoxazoles with imidazolium salts in the synthesis of methyl 4-imidazolylpyrrole-2-carboxylates, its ylide and betaine derivatives

  • Ekaterina E. Galenko,
  • Olesya A. Tomashenko,
  • Alexander F. Khlebnikov,
  • Mikhail S. Novikov and
  • Taras L. Panikorovskii

Beilstein J. Org. Chem. 2015, 11, 1732–1740, doi:10.3762/bjoc.11.189

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  • -imidazole polyamides [1][2][3][4][5]. Derivatives of 4-imidazolylpyrrole-2-carboxylic acid are much less known, though some of these compounds showed various bioactivities [6][7][8][9] and were patented as inhibitors of c-Met protein kinase [8] and as anti-inflammatory agents [9]. Additionally, 5
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Published 24 Sep 2015
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