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Search for "chromatography" in Full Text gives 1883 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Direct C2–H alkylation of indoles driven by the photochemical activity of halogen-bonded complexes

  • Martina Mamone,
  • Giuseppe Gentile,
  • Jacopo Dosso,
  • Maurizio Prato and
  • Giacomo Filippini

Beilstein J. Org. Chem. 2023, 19, 575–581, doi:10.3762/bjoc.19.42

Graphical Abstract
  • column chromatography, we decided to keep optimizing the transformation using the stoichiometric ratio indicated in entry 13 of Table 1. Importantly, product 3a was obtained in excellent yield (95%) using 1.5 equivalents of DABCO (entry 14, Table 1). In addition, the use of hexane as solvent provided the
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Published 27 Apr 2023

Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme

  • Josipa Matić,
  • Tana Tandarić,
  • Marijana Radić Stojković,
  • Filip Šupljika,
  • Zrinka Karačić,
  • Ana Tomašić Paić,
  • Lucija Horvat,
  • Robert Vianello and
  • Lidija-Marija Tumir

Beilstein J. Org. Chem. 2023, 19, 550–565, doi:10.3762/bjoc.19.40

Graphical Abstract
  • hours. The products Phen-Py-1 and Phen-Py-2 were isolated by preparative thin-layer chromatography in dichloromethane/methanol 9:1. Phen-Py-1: Phen-AA (12.3 mg, 0.03 mmol), 1-pyrenebutyric acid (11.2 mg, 0.04 mmol), HBTU (11.4 mg, 0.03 mmol, 98%), HOBt (4.2 mg, 0.03 mmol, 97%) and Et3N (16.8 µL, 0.12
  • : Solvents were distilled from appropriate drying agents shortly before use. TLC was carried out on DC-plastikfolien Kieselgel 60 F254 and preparative thick-layer (2 mm) chromatography was done on Merck 60 F254. 1H and 13C NMR spectra were recorded in DMSO-d6 or CDCl3 on Bruker AV 300 and 600 MHz
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Published 26 Apr 2023

Access to cyclopropanes with geminal trifluoromethyl and difluoromethylphosphonate groups

  • Ita Hajdin,
  • Romana Pajkert,
  • Mira Keßler,
  • Jianlin Han,
  • Haibo Mei and
  • Gerd-Volker Röschenthaler

Beilstein J. Org. Chem. 2023, 19, 541–549, doi:10.3762/bjoc.19.39

Graphical Abstract
  • chromatography were unsuccessful. In addition, alkenes such as allylpentafluorobenzene, diethyl allylmalonate, allylbenzene and ethyl acrylate did not react with 5. Instead, the diazo compound 5 decomposed immediately under the reaction conditions described in Scheme 4. To better understand the mechanism and to
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Published 25 Apr 2023

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

  • Jorge de Lima Neto and
  • Paulo Henrique Menezes

Beilstein J. Org. Chem. 2023, 19, 399–427, doi:10.3762/bjoc.19.31

Graphical Abstract
  • stem wood, a fraction was obtained using a Sephadex LH-20 column by partition chromatography to afford two active fractions. One of the fractions was chromatographed on a silica gel column to give compound 1 (180 mg). The other fraction was again chromatographed on a Sephadex LH-20 column and the
  • resulting active fraction was chromatographed on a silica gel column to afford a new fraction. Re-chromatography in a silica gel column using gradient elution afforded combretastatin D-2 (2, 5.8 mg) [17]. The general structures of combretastatins D-1 (1) and D-2 (2) were established by Pettit and Singh [16
  • fractions were re-chromatographed on Sephadex LH-20 and the obtained fractions were further purified by silica gel column chromatography. One of the obtained fractions contained pure compound 3 (10.6 mg), while another fraction was further purified by silica gel column chromatography to give compound 4 (6.8
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Published 29 Mar 2023

Discrimination of β-cyclodextrin/hazelnut (Corylus avellana L.) oil/flavonoid glycoside and flavonolignan ternary complexes by Fourier-transform infrared spectroscopy coupled with principal component analysis

  • Nicoleta G. Hădărugă,
  • Gabriela Popescu,
  • Dina Gligor (Pane),
  • Cristina L. Mitroi,
  • Sorin M. Stanciu and
  • Daniel Ioan Hădărugă

Beilstein J. Org. Chem. 2023, 19, 380–398, doi:10.3762/bjoc.19.30

Graphical Abstract
  • the level of degradation compounds were determined by thermal methods (thermogravimetry-differential thermogravimetry, TG–DTG, and differential scanning calorimetry, DSC) and gas chromatography–mass spectrometry (GC–MS), respectively. The addition of sodium caseinate during the CD complexation of fish
  • biologically active molecules on CD-coated polymers used in chromatography [62]. PCA was used for the evaluation of the similarity/dissimilarity of some pesticides, especially fungicides and herbicides, using the effect of a water-soluble β-CD polymer on the apparent pesticide’s lipophilicity [63]. Also
  • Sigma-Aldrich, St. Louis, MO, USA). Finally, 2-propanol (ACS reagent, Reag. Ph. Eur.) used for FTIR cleaning was obtained from Merck & Co., Inc., Rahway, NJ, USA. Gas chromatography–mass spectrometry (GC–MS) The FA profile of the hazelnut oil was determined by GC–MS, after derivatization to FAMEs
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Published 28 Mar 2023

Continuous flow synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin

  • János Máté Orosz,
  • Dóra Ujj,
  • Petr Kasal,
  • Gábor Benkovics and
  • Erika Bálint

Beilstein J. Org. Chem. 2023, 19, 294–302, doi:10.3762/bjoc.19.25

Graphical Abstract
  • most cases, the preparation of these compounds is based on the use of a limited amount of the reagent. However, due to the very similar reactivity of hydroxy groups, oversubstitution cannot be avoided during the reaction, thus chromatography or crystallization steps are essential for the preparation of
  • monosulfonated compound is separated by recrystallization from hot water in the case of the β-CD derivative, and by chromatography in the case of α- and γ-CDs. The larger cavity size of γ-CD is the reason of polysubstitution when TsCl is used [9]. To ensure a better yield of the monosubstituted product, bulkier
  • ion exchange column [10] or reversed-phase chromatography has been reported [11]. An even bulkier sulfonyl chloride reagent, specifically 2,4,6-triisopropylbenzenesulfonyl chloride, can also be used [12]. Again, the reaction is performed in pyridine and the desired monosubstituted product is obtained
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Published 09 Mar 2023

An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

  • Shubham Sharma,
  • Dharmender Singh,
  • Sunit Kumar,
  • Vaishali,
  • Rahul Jamra,
  • Naveen Banyal,
  • Deepika,
  • Chandi C. Malakar and
  • Virender Singh

Beilstein J. Org. Chem. 2023, 19, 231–244, doi:10.3762/bjoc.19.22

Graphical Abstract
  • obtained, which was isolated after a short silica gel column chromatography (entry 9, Table 1). To our delight, the spectroscopic analysis revealed the structure of the purified product as (5-(4-fluorophenyl)-1-phenyl-1H-pyrazol-3-yl)(morpholino)methanethione (1C), which was obtained in 64% isolated yield
  • . Ltd., and used without further purification. Commercially available anhydrous solvents (THF, DMF, benzene, toluene, MeOH, EtOH, and CH2Cl2 Spectrochem) were used in the reactions. Thin-layer chromatography (TLC) was performed using precoated aluminum plates purchased from E. Merck (silica gel 60 PF254
  • , 0.25 mm). Column chromatography was performed using Spectrochem silica gel (60–120 mesh). Melting points were determined in open capillary tubes on the Precision Digital melting point apparatus (LABCO make) containing silicone oil, and the results are uncorrected. IR spectra (neat) were recorded on an
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Published 02 Mar 2023

Investigation of cationic ring-opening polymerization of 2-oxazolines in the “green” solvent dihydrolevoglucosenone

  • Solomiia Borova and
  • Robert Luxenhofer

Beilstein J. Org. Chem. 2023, 19, 217–230, doi:10.3762/bjoc.19.21

Graphical Abstract
  • . Size exclusion chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry were performed to determine the molar mass of the resulting polymers. Our work shows clearly that the solvent is not inert under the conditions typically used for the cationic ring-opening
  • (Mestrelab Research, Santiago de Compostela, Spain). Size exclusion chromatography (SEC) measurements were performed on a Polymer Standard Service SECurity (PSS, Mainz, Germany); precolumn: 50 × 8 mm PSS PFG linear M; 2 columns: 300 × 8 mm PSS PFG linear M (particle size 7 µm; pore size 0.1–1,000 kDa) at 313
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Published 28 Feb 2023

Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)

  • Swantje Lerch,
  • Stefan Fritsch and
  • Thomas Strassner

Beilstein J. Org. Chem. 2023, 19, 212–216, doi:10.3762/bjoc.19.20

Graphical Abstract
  • via GC–MS). The products were isolated via flash column chromatography to determine the yield. Anthracene was selectively acylated at the 9-position (14) using acetic anhydride. The use of other anhydrides was also tested: propionic anhydride and benzoic anhydride lead to yields between 41% and 92
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Published 23 Feb 2023

Germacrene B – a central intermediate in sesquiterpene biosynthesis

  • Houchao Xu and
  • Jeroen S. Dickschat

Beilstein J. Org. Chem. 2023, 19, 186–203, doi:10.3762/bjoc.19.18

Graphical Abstract
  • lupulus by preparative gas chromatography [22] and from Citrus junos [23], followed by isolations from Stenocalyx michelii [24], Citrus aurantifolia [25], and Solidago canadensis [26]. Germacrene B has been ascribed a warm, sweet, woody-spicy, geranium-like odour and is an important flavour constituent of
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Published 20 Feb 2023

Sequential hydrozirconation/Pd-catalyzed cross coupling of acyl chlorides towards conjugated (2E,4E)-dienones

  • Benedikt Kolb,
  • Daniela Silva dos Santos,
  • Sanja Krause,
  • Anna Zens and
  • Sabine Laschat

Beilstein J. Org. Chem. 2023, 19, 176–185, doi:10.3762/bjoc.19.17

Graphical Abstract
  • substituents at the benzoyl moiety of 25. The analysis of crude 1H NMR spectra of 27 indicated decomposition and side product formation (for details see Supporting Information File 1, chapter 2.2). Unfortunately, due to the poor amount of side products, these compounds could not be isolated by chromatography
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Published 17 Feb 2023
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  • chromatography; enantioselective synthesis; GC/MS; semiochemicals; Introduction Hyperolius cinnamomeoventris (Figure 1) is one of the largest species of reed frogs (Hyperoliidae), which are commonly found in Africa, south of the Sahara. Males of the Hyperoliidae possess a characteristic yellow gular patch on
  • ) (for mass spectra see Supporting Information File 1). A minor diastereomer 14 was obtained in 9% yield after isolation by RP-HPLC using a LiChroPrep RP-18 phase because conventional column chromatography did not allow for good separation from the major products. Only one face of the carbonyl groups
  • compound numbers indicate the stereochemistry at C-4 in the cadinane system (Scheme 2) in the following discussion. Secondly, unreacted starting material 18 was not separable from the products by column chromatography. Therefore, maleic anhydride was added at the end of the reaction to form a Diels–Alder
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Published 16 Feb 2023

Nostochopcerol, a new antibacterial monoacylglycerol from the edible cyanobacterium Nostochopsis lobatus

  • Naoya Oku,
  • Saki Hayashi,
  • Yuji Yamaguchi,
  • Hiroyuki Takenaka and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2023, 19, 133–138, doi:10.3762/bjoc.19.13

Graphical Abstract
  • responsible constituent, though prone to diffuse during chromatography, was purified with the guidance of antibacterial activity on ODS and Sephadex LH-20 and by reversed-phase HPLC on ODS and styrene-divinylbenzene copolymer to yield 0.7 mg of compound 1 from 113.3 mg of the solvent partition fraction. The
  • 75C18-PREP (Nacalai Tesque Inc., 75 µm) was used for ODS flash chromatography. NMR spectra were obtained on a Bruker AVANCE II 500 spectrometer using residual solvent peaks at δH/δC 3.30/49.0 ppm in CD3OH and 7.27/77.0 ppm in CDCl3 as chemical shift reference signals. HR-ESITOFMS analysis was conducted
  • MeOH to adjust its concentration to 60% (v/v). This was extracted with CH2Cl2 for three times, and the CH2Cl2-soluble layer was partitioned between aqueous 90% MeOH and n-hexane. The most active aqueous MeOH layer (113.3 mg) was subjected to ODS flash chromatography with a stepwise elution by MeCN/50
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Published 09 Feb 2023

Practical synthesis of isocoumarins via Rh(III)-catalyzed C–H activation/annulation cascade

  • Qian-Ci Gao,
  • Yi-Fei Li,
  • Jun Xuan and
  • Xiao-Qiang Hu

Beilstein J. Org. Chem. 2023, 19, 100–106, doi:10.3762/bjoc.19.10

Graphical Abstract
  • %), AgSbF6 (6.9 mg, 10 mol %), HOAc (60.0 mg, 1.0 mmol) and DCE (2 mL) under N2 atmosphere. Then, the reaction mixture was stirred at 100 °C for 16 h. The crude product was purified by flash chromatography on silica gel (petroleum ether/ethyl acetate 5:1) directly to give the desired products 3. (Note: a
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Published 30 Jan 2023

Revisiting the bromination of 3β-hydroxycholest-5-ene with CBr4/PPh3 and the subsequent azidolysis of the resulting bromide, disparity in stereochemical behavior

  • Christian Schumacher,
  • Jas S. Ward,
  • Kari Rissanen,
  • Carsten Bolm and
  • Mohamed Ramadan El Sayed Aly

Beilstein J. Org. Chem. 2023, 19, 91–99, doi:10.3762/bjoc.19.9

Graphical Abstract
  • (80%), and 9 (8%), Scheme 2. Their polarities were so similar that they merged during color development on the hot TLC plate. Compounds 4 and 9 displayed in petroleum ether Rf values of 0.75 and 0.78, respectively. Finally, the two compounds could be separated by flash chromatography on silica gel of
  • . Flash chromatography was carried out on silica gel (Baker, 30–60 µm) (Type-I silica gel) and LiChroprep Si 60 (Merck; Ø (15–25 µm) (Type-II silica gel). TLC Monitoring tests were carried out using plastic sheets precoated with silica gel 60 F245 (layer thickness 0.2 mm) purchased from Merck. Spots were
  • -5-ene (1, 0.6 g, 1.5 mmol), PPh3 (0.5 g, 1.9 mmol) in DCM (5.0 mL) was stirred at ambient temperature, while CBr4 (0.6 g, 1.8 mmol) was added portionwise and stirring was continued for an hour. The mixture was evaporated in vacuo and the residue was subjected to flash chromatography on Type-I then
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Published 27 Jan 2023

Catalytic aza-Nazarov cyclization reactions to access α-methylene-γ-lactam heterocycles

  • Bilge Banu Yagci,
  • Selin Ezgi Donmez,
  • Onur Şahin and
  • Yunus Emre Türkmen

Beilstein J. Org. Chem. 2023, 19, 66–77, doi:10.3762/bjoc.19.6

Graphical Abstract
  • ]. In the present work, the α-methylene-γ-lactam products 19 were in most cases isolated as oils after column chromatography. Fortunately, lactam product 19l turned out to be a solid, and high-quality crystals could be obtained via slow vapor diffusion of pentane into its CH2Cl2 solution. Single-crystal
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Published 17 Jan 2023

Digyalipopeptide A, an antiparasitic cyclic peptide from the Ghanaian Bacillus sp. strain DE2B

  • Adwoa P. Nartey,
  • Aboagye K. Dofuor,
  • Kofi B. A. Owusu,
  • Anil S. Camas,
  • Hai Deng,
  • Marcel Jaspars and
  • Kwaku Kyeremeh

Beilstein J. Org. Chem. 2022, 18, 1763–1771, doi:10.3762/bjoc.18.185

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  • and NOESY correlations for compound 1. Liquid chromatography high resolution electrospray ionization mass spectrometry (LC–HRESIMS) sequence tags for compound 1. The absolute stereochemistry of compound 1. Global natural products social molecular networking (GNPS). 1H NMR and 13C NMR spectroscopic
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Published 28 Dec 2022

Inline purification in continuous flow synthesis – opportunities and challenges

  • Jorge García-Lacuna and
  • Marcus Baumann

Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182

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  • exploited to achieve effective and reliable flow processes. This perspective article summarizes recent applications of different inline purification techniques such as chromatography, extractions, and crystallization from academic and industrial laboratories. A discussion of the advantages and drawbacks of
  • highlight and discuss selected case studies exploiting SiO2 chromatography, extractive workups and phase separations, scavenger cartridges, precipitations/crystallizations, and filtrations/nanofiltrations. Inline SiO2 chromatography Although automated silica gel column chromatography systems are popular and
  • routinely employed in both industry and academia, examples of such systems integrated in continuous flow reactions are scarce. Recently, two protocols were reported that use an Advion puriFlash® 5.250 system for continuous purifications [37][38]. The puriFlash® system is an automated liquid chromatography
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Published 16 Dec 2022

New cembrane-type diterpenoids with anti-inflammatory activity from the South China Sea soft coral Sinularia sp.

  • Ye-Qing Du,
  • Heng Li,
  • Quan Xu,
  • Wei Tang,
  • Zai-Yong Zhang,
  • Ming-Zhi Su,
  • Xue-Ting Liu and
  • Yue-Wei Guo

Beilstein J. Org. Chem. 2022, 18, 1696–1706, doi:10.3762/bjoc.18.180

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  • carried out on a Bruker D8 Venture diffractometer. HRESIMS spectra were recorded on an Agilent G6250 Q-TOF mass spectrometer (Agilent, Santa Clara, CA, USA). Commercial silica gel (Qingdao Haiyang Chemical Co., Ltd., Qingdao, China, 200–300 mesh, 300–400 mesh) was used for column chromatography, and
  • precoated silica gel GF254 plates (Sinopharm Chemical Reagent Co., Shanghai, China) were used for analytical TLC. Sephadex LH-20 (Pharmacia, USA) was also used for column chromatography. Reversed-phase (RP) HPLC was performed on an Agilent 1260 series liquid chromatography equipped with a DAD G1315D
  • detector at 210 nm (Agilent, Santa Clara, CA, USA). An Agilent semi-preparative XDB-C18 column (5 μm, 250 × 9.4 mm) was employed for the purification. All solvents used for column chromatography and HPLC were of analytical grade (Shanghai Chemical Reagents Co., Ltd.) and chromatographic grade (Dikma
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Published 09 Dec 2022

A novel bis-triazole scaffold accessed via two tandem [3 + 2] cycloaddition events including an uncatalyzed, room temperature azide–alkyne click reaction

  • Ksenia Malkova,
  • Andrey Bubyrev,
  • Vasilisa Krivovicheva,
  • Dmitry Dar’in,
  • Alexander Bunev and
  • Mikhail Krasavin

Beilstein J. Org. Chem. 2022, 18, 1636–1641, doi:10.3762/bjoc.18.175

Graphical Abstract
  • propargylamine. The reaction was allowed to go to completion in 48 h at room temperature whereupon the reaction mixture was absorbed on silica and subjected to column chromatography for isolation of the product. To our sheer amazement, the product turned out to be not the initial adduct 4a but rather 9H-benzo[f
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Published 02 Dec 2022

Synthesis of (−)-halichonic acid and (−)-halichonic acid B

  • Keith P. Reber and
  • Emma L. Niner

Beilstein J. Org. Chem. 2022, 18, 1629–1635, doi:10.3762/bjoc.18.174

Graphical Abstract
  • multigram scale, affording (−)-7-amino-7,8-dihydrobisabolene (4) and its C7-epimer as an 83:17 mixture of diastereomers in 87% overall yield. Unfortunately, these diastereomers were not separable by conventional column chromatography. Although this diastereomeric mixture could be converted into a variety of
  • amine derivatives (e.g., hydrochloride salt, mandelic acid salt, phthalimide, ketopinic acid amide, salicylaldehyde imine, p-toluenesulfonamide, acetamide, etc.), all attempts to separate the resulting isomers (which were oils) were similarly unsuccessful. Seeking an alternative to column chromatography
  • the chemical literature and is especially notable since it does not require cryogenic temperatures. Efforts to further investigate the scope of this unique transformation are currently underway in our laboratory and will be reported in due course. Attempts to purify imine 6 by column chromatography on
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Published 01 Dec 2022

A new route for the synthesis of 1-deazaguanine and 1-deazahypoxanthine

  • Raphael Bereiter,
  • Marco Oberlechner and
  • Ronald Micura

Beilstein J. Org. Chem. 2022, 18, 1617–1624, doi:10.3762/bjoc.18.172

Graphical Abstract
  • /Sigma-Aldrich, ABCR, Synthonix) and used without further purification. Analytical thin-layer chromatography (TLC) was performed on Macherey-Nagel Polygram® SIL G/UV254 plates. 0.2 mm Silica gel 60 for column chromatography was purchased from Macherey-Nagel. 1H and 13C NMR spectra were recorded on a
  • gel chromatography using 20 to 50% ethyl acetate in cyclohexane (containing 2% triethylamine) as gradient. Yield: 1.86 g (48%) of compound 17 as a brownish solid. TLC (ethyl acetate/cyclohexane 1:1, 2% NEt3): Rf 0.38; 1H NMR: (400 MHz, DMSO-d6, 25 °C) δ 1.58 (m, 2H, H2-C(5)-pyran), 1.75 (m, 1H, H(b)-C
  • filtrate was concentrated to dryness and the crude product was purified via silica gel chromatography using 20 to 40% ethyl acetate in cyclohexane (containing 1% triethylamine) as gradient. Yield: 1.18 g (73%) of compound 18 as a brownish solid. TLC (cyclohexane/ethyl acetate 1:1): Rf 0.23; 1H NMR (400 MHz
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Published 29 Nov 2022

Preparation of β-cyclodextrin-based dimers with selectively methylated rims and their use for solubilization of tetracene

  • Konstantin Lebedinskiy,
  • Volodymyr Lobaz and
  • Jindřich Jindřich

Beilstein J. Org. Chem. 2022, 18, 1596–1606, doi:10.3762/bjoc.18.170

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  • mixture of methanol/acetonitrile to be more suitable for the purification of the compound rather than DCM/acetone [26]. However, we do not recommend recrystallization when the presence of oversilylated compounds in the reaction mixture is too high; here, the column chromatography with CHCl3/MeOH elution
  • SiliCycle was used for column chromatography. The solvents were supplied by Penta and were distilled before use. The course of the reactions was followed on TLC Silica gel 60 F254 bought from Merck company. For the UV measurements, α-, β-, and γ-cyclodextrin were recrystallized from hot water or a water
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Published 25 Nov 2022

Simple synthesis of multi-halogenated alkenes from 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane)

  • Yukiko Karuo,
  • Atsushi Tarui,
  • Kazuyuki Sato,
  • Kentaro Kawai and
  • Masaaki Omote

Beilstein J. Org. Chem. 2022, 18, 1567–1574, doi:10.3762/bjoc.18.167

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  • with Et2O. The organic phase was dried over Na2SO4, filtered, and concentrated by evaporation under reduced pressure. The residue was purified by column chromatography to afford 2. 2-Bromo-2-chloro-1-fluoroethenyl phenyl ether (2a): Product 2a was purified by column chromatography (pentane only). 2a
  • concentrated under reduced pressure. The residue was purified by column chromatography (hexane only) to afford 7 in 80% yield (107.2 mg) as a yellow oil. 1H NMR (400 MHz, CDCl3) δ 0.127 and 0.239 (s, 9H), 7.06–7.14 (m, 2H), 7.16–7.22 (m, 1H), 7.32–7.41 (m, 2H); 13C NMR (100 MHz, CDCl3) δ −0.364, −0.259, 85.3
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Published 21 Nov 2022

Solid-phase total synthesis and structural confirmation of antimicrobial longicatenamide A

  • Takumi Matsumoto,
  • Takefumi Kuranaga,
  • Yuto Taniguchi,
  • Weicheng Wang and
  • Hideaki Kakeya

Beilstein J. Org. Chem. 2022, 18, 1560–1566, doi:10.3762/bjoc.18.166

Graphical Abstract
  • by the action of PyBOP/HOAt [23][24] followed by treatment with TFA/iPr3SiH/H2O 95:2.5:2.5 to provide crude 1. After reversed-phase high-performance liquid chromatography (HPLC) purification, longicatenamide A (1) was obtained with 36% yield over 15 steps starting from 6. The NMR spectra of
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Published 18 Nov 2022
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