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Search for "industry" in Full Text gives 405 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

A simple and effective preparation of quercetin pentamethyl ether from quercetin

  • Jin Tatsuzaki,
  • Tomohiko Ohwada,
  • Yuko Otani,
  • Reiko Inagi and
  • Tsutomu Ishikawa

Beilstein J. Org. Chem. 2018, 14, 3112–3121, doi:10.3762/bjoc.14.291

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  • (HRMS). Quercetin (2) was purchased from Tokyo Chemical Industry Co. Ltd., Japan. Methylation of quercetin (2) with the Me2SO4/KOH/DMSO system (run 2 in Table 2): QPE [2-(3,4-Dimethoxyphenyl)-3,5,7-trimethoxy-4H-1-benzopyran-4-one] (1). To a suspension of powdered KOH (1.66 g, 29.7×10−3 mol) in DMSO (8
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Published 28 Dec 2018

Repurposing the anticancer drug cisplatin with the aim of developing novel Pseudomonas aeruginosa infection control agents

  • Mingjun Yuan,
  • Song Lin Chua,
  • Yang Liu,
  • Daniela I. Drautz-Moses,
  • Joey Kuok Hoong Yam,
  • Thet Tun Aung,
  • Roger W. Beuerman,
  • May Margarette Santillan Salido,
  • Stephan C. Schuster,
  • Choon-Hong Tan,
  • Michael Givskov,
  • Liang Yang and
  • Thomas E. Nielsen

Beilstein J. Org. Chem. 2018, 14, 3059–3069, doi:10.3762/bjoc.14.284

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  • compounds in both academia and the pharmaceutical industry. Here, we report how the widely used antitumor drug cisplatin may be repurposed as an effective antimicrobial against the nosocomial pathogen Pseudomonas aeruginosa. Cisplatin was found to effectively kill strains of P. aeruginosa. In such
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Published 14 Dec 2018

Organometallic vs organic photoredox catalysts for photocuring reactions in the visible region

  • Aude-Héloise Bonardi,
  • Frédéric Dumur,
  • Guillaume Noirbent,
  • Jacques Lalevée and
  • Didier Gigmes

Beilstein J. Org. Chem. 2018, 14, 3025–3046, doi:10.3762/bjoc.14.282

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  • networks. Keywords: photoinitiator; photopolymerization; photoredox catalysis; photoredox catalyst; Introduction Photopolymerization reactions are now widely used both in industry and in academic laboratories. These processes usually lead to the transformation of a liquid resin in a 3D solid polymer upon
  • used to produce the polymers. At present, most of the photoinitiating systems in use in the industry required high light intensity, the emission of these lamps being mainly centered in the UV range. To create safer photoinitiating systems, photoinitiators exhibiting a strong absorption in the near UV
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Published 12 Dec 2018

The activity of indenylidene derivatives in olefin metathesis catalysts

  • Maria Voccia,
  • Steven P. Nolan,
  • Luigi Cavallo and
  • Albert Poater

Beilstein J. Org. Chem. 2018, 14, 2956–2963, doi:10.3762/bjoc.14.275

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  • Olefin Process (SHOP) [3][4]. Additionally, the olefin metathesis reaction has provided a useful tool in polymerisation [5][6], as well as in the pharmaceutical industry in the formation of C=C bonds. Early catalyst examples were ill-defined entities and it is not until Grubbs [7] and Schrock [8
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Published 30 Nov 2018

Synthesis of indole–cycloalkyl[b]pyridine hybrids via a four-component six-step tandem process

  • Muthumani Muthu,
  • Rakkappan Vishnu Priya,
  • Abdulrahman I. Almansour,
  • Raju Suresh Kumar and
  • Raju Ranjith Kumar

Beilstein J. Org. Chem. 2018, 14, 2907–2915, doi:10.3762/bjoc.14.269

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  • ]pyridine has been reported as inhibitors of cytochrome P450 [33]. Furthermore, muscopyridine is being used in perfume industry [34]. Among the several methods available for the synthesis of pyridines or cycloalkyl-fused pyridines [23][24][25][26][27][35][36][37][38][39][40][41][42][43][44], the one-pot
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Published 22 Nov 2018

Olefin metathesis catalysts embedded in β-barrel proteins: creating artificial metalloproteins for olefin metathesis

  • Daniel F. Sauer,
  • Johannes Schiffels,
  • Takashi Hayashi,
  • Ulrich Schwaneberg and
  • Jun Okuda

Beilstein J. Org. Chem. 2018, 14, 2861–2871, doi:10.3762/bjoc.14.265

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  • catalyst or redox catalyst. Various metalloenzymes have been applied in laboratory-scale reactions and a few metalloenzymes such as nitrile hydratase (cobalt(III) in the active site) for the production of acrylamide have found application in industry [25]. Notably, however, the reaction scope of natural
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Published 19 Nov 2018

Enhanced single-isomer separation and pseudoenantiomer resolution of new primary rim heterobifunctionalized α-cyclodextrin derivatives

  • Iveta Tichá,
  • Gábor Benkovics,
  • Milo Malanga and
  • Jindřich Jindřich

Beilstein J. Org. Chem. 2018, 14, 2829–2837, doi:10.3762/bjoc.14.261

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  • ; heterobifunctionalized alpha-cyclodextrin; homobifunctionalized alpha-cyclodextrin; regioisomers; regioselectivity; Introduction Cyclodextrins, cyclic cone-shaped oligosaccharides [1], have long attracted interest for their properties in host–guest complexes both in research and in pharmaceutical and food industry
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Published 13 Nov 2018

Copolymerization of epoxides with cyclic anhydrides catalyzed by dinuclear cobalt complexes

  • Yo Hiranoi and
  • Koji Nakano

Beilstein J. Org. Chem. 2018, 14, 2779–2788, doi:10.3762/bjoc.14.255

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  • . LLC, Tokyo Chemical Industry Co., Ltd., and Kanto Chemical Co., Inc., and were used without further purification unless otherwise specified. Commercially available anhydrous solvents were used for air and/or moisture-sensitive reactions. Epoxides for the polymerizations were dried over CaH2 and
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Published 05 Nov 2018
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  • isolation of products, very short reaction times (only 10 s), and better yields. The use of glycerol as a starting material is another important advantage because it is the main byproduct in the biodiesel industry and the application of renewable feedstocks for the preparation of suitable chemicals and
  • reusable catalysts, due to their ability to catalyze different chemical processes in industry and laboratories. There are many reports on the carbon-based materials containing the sulfonic acid group, but the future advances of this field will depend on the better understanding of all aspects of their
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Published 01 Nov 2018

Synthesis of a tyrosinase inhibitor by consecutive ethenolysis and cross-metathesis of crude cashew nutshell liquid

  • Jacqueline Pollini,
  • Valentina Bragoni and
  • Lukas J. Gooßen

Beilstein J. Org. Chem. 2018, 14, 2737–2744, doi:10.3762/bjoc.14.252

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  • neurodegenerative diseases [30]. Therefore, the study and development of tyrosinase inhibitors from renewable resources is of particular interest for research and industry [31][32]. Fu et al. investigated naturally occurring ginkgolic acids which they selectively synthesized from 2,6-dihydroxybenzoic acid (4), and
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Published 31 Oct 2018

Pathoblockers or antivirulence drugs as a new option for the treatment of bacterial infections

  • Matthew B. Calvert,
  • Varsha R. Jumde and
  • Alexander Titz

Beilstein J. Org. Chem. 2018, 14, 2607–2617, doi:10.3762/bjoc.14.239

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  • excessive and inappropriate use of antibiotics in the commercial livestock breeding industry. Since numerous targets of classical antibiotics are conserved across a large number of bacterial species, it is obvious that resistance against antibiotics can also develop outside the patient in the environment
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Published 11 Oct 2018

Synergistic approach to polycycles through Suzuki–Miyaura cross coupling and metathesis as key steps

  • Sambasivarao Kotha,
  • Milind Meshram and
  • Chandravathi Chakkapalli

Beilstein J. Org. Chem. 2018, 14, 2468–2481, doi:10.3762/bjoc.14.223

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  • and ruthenium impurities in minor amounts from the reaction mixture. This aspect is also important in the pharmaceutical industry [4][55]. Biography of the Authors Sambasivarao Kotha graduated with M.Sc. degree in Chemistry from the University of Hyderabad and obtained his Ph.D. in Organic Chemistry
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Published 21 Sep 2018

A novel and practical asymmetric synthesis of eptazocine hydrobromide

  • Ruipeng Li,
  • Zhenren Liu,
  • Liang Chen,
  • Jing Pan,
  • Kuaile Lin and
  • Weicheng Zhou

Beilstein J. Org. Chem. 2018, 14, 2340–2347, doi:10.3762/bjoc.14.209

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  • Ruipeng Li Zhenren Liu Liang Chen Jing Pan Kuaile Lin Weicheng Zhou State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, P. R
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Published 06 Sep 2018

A general and atom-efficient continuous-flow approach to prepare amines, amides and imines via reactive N-chloramines

  • Katherine E. Jolley,
  • Michael R. Chapman and
  • A. John Blacker

Beilstein J. Org. Chem. 2018, 14, 2220–2228, doi:10.3762/bjoc.14.196

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  • ][33]. Improved methods for the formation of amides remain an important goal for the pharma industry. In this regard, the reaction of N-chloramine with aldehydes, t-BuO2H and iron or copper catalysts to give secondary and tertiary amides was reported in batch recently [33][34], though safety concerns
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Published 24 Aug 2018

Selective formation of a zwitterion adduct and bicarbonate salt in the efficient CO2 fixation by N-benzyl cyclic guanidine under dry and wet conditions

  • Yoshiaki Yoshida,
  • Naoto Aoyagi and
  • Takeshi Endo

Beilstein J. Org. Chem. 2018, 14, 2204–2211, doi:10.3762/bjoc.14.194

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  • at room temperature and ambient moisture. Experimental General Materials and instruments All starting materials and dehydrated solvents were purchased from Wako Pure Chemical Industries (Osaka, Japan) and Tokyo Chemical Industry (Tokyo, Japan). CO2 (>99.999%, H2O < 5 ppm) was obtained from Yamagata
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Published 23 Aug 2018

Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry

  • Michael K. Bogdos,
  • Emmanuel Pinard and
  • John A. Murphy

Beilstein J. Org. Chem. 2018, 14, 2035–2064, doi:10.3762/bjoc.14.179

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  • pharmaceutical industry. This type of chemistry has also demonstrated a high degree of sustainability, especially when organic dyes can be employed in place of often toxic and environmentally damaging transition metals. The sections are arranged according to the general class of the presented reactions and the
  • . Examples of heterocyclic (e.g., pyridinyl) anilines would be more relevant to the pharmaceutical industry. Medicinal chemistry often requires particularly furnished hydrocarbon backbones as bioisosteric replacements. One such interesting group is the difluoromethyl group. Akita et al. have described a
  • chemistry is still quite sparse in the literature. Late-stage fluorination protocols are also rare and would be exhaustively used by the pharmaceutical industry. In addition, as has been pointed out in this review
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Published 03 Aug 2018

Direct electrochemical generation of organic carbonates by dehydrogenative coupling

  • Tile Gieshoff,
  • Vinh Trieu,
  • Jan Heijl and
  • Siegfried R. Waldvogel

Beilstein J. Org. Chem. 2018, 14, 1578–1582, doi:10.3762/bjoc.14.135

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  • ; dehydrogenative coupling; electrochemistry; organic carbonates; Introduction Polycarbonates are high-performance polymeric materials with versatile applications in various fields with economic impact, e.g., construction, food, and pharmaceutical industry [1]. For their technical large-scale production, organic
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Published 27 Jun 2018

Cobalt–metalloid alloys for electrochemical oxidation of 5-hydroxymethylfurfural as an alternative anode reaction in lieu of oxygen evolution during water splitting

  • Jonas Weidner,
  • Stefan Barwe,
  • Kirill Sliozberg,
  • Stefan Piontek,
  • Justus Masa,
  • Ulf-Peter Apfel and
  • Wolfgang Schuhmann

Beilstein J. Org. Chem. 2018, 14, 1436–1445, doi:10.3762/bjoc.14.121

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  • valuable product for the chemical industry with potential large scale use. Various cobalt–metalloid alloys (CoX; X = B, Si, P, Te, As) were investigated as potential catalysts for HMF oxidation. In this series, CoB required 180 mV less overpotential to reach a current density of 55 mA cm−2 relative to OER
  • -refinery based chemicals for a “green” chemical industry [6][7][8]. FDCA was suggested to replace, e.g., terephthalic acid as building block for the formation of polyamides, polyesters, and polyurethanes [6]. Especially, the polymer polyethylene terephthalate (PET), a perpetually used polymer, could be
  • Bundesministerium für Bildung und Forschung (BMBF) in the framework of the project “Mangan” (FKZ 03EK3548). U.-P. A. acknowledges financial support of the Fonds of the Chemical Industry (Liebig grant) and the Deutsche Forschungsgemeinschaft (Emmy Noether grant, AP242/2-1 and AP242/6-1).
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Published 13 Jun 2018

Spectroelectrochemical studies on the effect of cations in the alkaline glycerol oxidation reaction over carbon nanotube-supported Pd nanoparticles

  • Dennis Hiltrop,
  • Steffen Cychy,
  • Karina Elumeeva,
  • Wolfgang Schuhmann and
  • Martin Muhler

Beilstein J. Org. Chem. 2018, 14, 1428–1435, doi:10.3762/bjoc.14.120

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  • acid, mesoxalic acid and 1,3-dihydroxyacetone (DHA). These products are conventionally obtained by oxidation using rather unselective oxidants. Especially DHA is of great interest due to its use in the cosmetic industry, as a precursor for further value-added fine chemicals [9] and as a monomer for
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Published 12 Jun 2018

Enantioselective phase-transfer catalyzed alkylation of 1-methyl-7-methoxy-2-tetralone: an effective route to dezocine

  • Ruipeng Li,
  • Zhenren Liu,
  • Liang Chen,
  • Jing Pan and
  • Weicheng Zhou

Beilstein J. Org. Chem. 2018, 14, 1421–1427, doi:10.3762/bjoc.14.119

Graphical Abstract
  • Ruipeng Li Zhenren Liu Liang Chen Jing Pan Weicheng Zhou State Key Lab of New Drug & Pharmaceutical Process, Shanghai Key Lab of Anti-Infectives, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, No. 285, Gebaini Rd., Shanghai 201203, P. R. of China
  • separated by two times of resolution with L-tartaric acid and D-tartaric acid (Scheme 1). Phase-transfer asymmetric catalysis with cinchona alkaloid-derived quaternary ammonium compounds has become one of the topics in stereoselective synthesis in both industry and academia [6][7][8][9]. It was reported [10
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Published 11 Jun 2018

A survey of chiral hypervalent iodine reagents in asymmetric synthesis

  • Soumen Ghosh,
  • Suman Pradhan and
  • Indranil Chatterjee

Beilstein J. Org. Chem. 2018, 14, 1244–1262, doi:10.3762/bjoc.14.107

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  • challenging and application-oriented conversions that can be applied for the total synthesis of natural products as well as in industry related to pharmaceutical and medicinal chemistry. These environmentally friendly, cheap and readily available reagents will surely attract the attention of scientists
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Published 30 May 2018

Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

  • Mark Kelada,
  • John M. D. Walsh,
  • Robert W. Devine,
  • Patrick McArdle and
  • John C. Stephens

Beilstein J. Org. Chem. 2018, 14, 1222–1228, doi:10.3762/bjoc.14.104

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  • the pyrazolo[1,5-a]pyrimidinones, that employ one-pot syntheses and/or processes have been encouraged and have become a major focus for many synthetic chemists [11]. As such, a convenient and general method of preparing the scaffold would be of significant interest to the pharmaceutical industry
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Published 28 May 2018

Crystal structure of the inclusion complex of cholesterol in β-cyclodextrin and molecular dynamics studies

  • Elias Christoforides,
  • Andreas Papaioannou and
  • Kostas Bethanis

Beilstein J. Org. Chem. 2018, 14, 838–848, doi:10.3762/bjoc.14.69

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  • complexes by entrapping a wide range of guest molecules into its internal hydrophobic cavity. It is non-toxic, non-irritating, edible, chemically stable, easy separable and widely used in pharmaceutical, food and chemical industry [4]. Two major cyclodextrin applications dictate a meticulous study of their
  • reduced toxicity. In food industry β-CD has been used in many applications such as flavor protection and flavor delivery, controlled release of desired constituents and removal and masking of undesirable components [16]. But the most prevalent use of CD in this field is the removal of cholesterol from
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Published 11 Apr 2018

Nanoreactors for green catalysis

  • M. Teresa De Martino,
  • Loai K. E. A. Abdelmohsen,
  • Floris P. J. T. Rutjes and
  • Jan C. M. van Hest

Beilstein J. Org. Chem. 2018, 14, 716–733, doi:10.3762/bjoc.14.61

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  • concept of green chemistry has been recently defined to guide chemists towards minimizing any harmful outcome of chemical processes in either industry or research. Towards greener reactions, scientists have developed various approaches in order to decrease environmental risks while attaining chemical
  • . Unfortunately, most organic compounds and catalysts are not soluble in water, limiting its utility for most reactions [9][10]. For this reason, scientists across academia and industry have proposed many solutions in order to maximize the outcome of reactions (i.e., yields, enantioselectivities, etc.) in water
  • synthetic chemistry [24][31]. In a recent study the E-factors for different traditional coupling reactions used in the pharmaceutical industry were reported and compared to those achieved in micellar nanoreactors [45], showing for the latter a decrease of at least an order of magnitude, which underlines
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Published 29 Mar 2018

Biocatalytic synthesis of the Green Note trans-2-hexenal in a continuous-flow microreactor

  • Morten M. C. H. van Schie,
  • Tiago Pedroso de Almeida,
  • Gabriele Laudadio,
  • Florian Tieves,
  • Elena Fernández-Fueyo,
  • Timothy Noël,
  • Isabel W. C. E. Arends and
  • Frank Hollmann

Beilstein J. Org. Chem. 2018, 14, 697–703, doi:10.3762/bjoc.14.58

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  • ; alcohol oxidation; aldehyde; flow chemistry; Introduction trans-2-Hexenal is well-known as a major component of the Green Notes of fruits and vegetables such as apples, strawberries, cherries and more. It is widely used in the flavour and fragrance industry as fresh flavour ingredient in foods and
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Published 26 Mar 2018
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