Surfactant catalyzed convenient and greener synthesis of tetrahydrobenzo[a]xanthene-11-ones at ambient temperature

• Pravin V. Shinde,
• Amol H. Kategaonkar,
• Bapurao B. Shingate and
• Murlidhar S. Shingare

Beilstein J. Org. Chem. 2011, 7, 53–58, doi:10.3762/bjoc.7.9

• employed organic solvents from various health and environmental reasons [1]. From the green chemistry point of view, water would be the perfect solvent to carry out chemical operations since it is safe, non-toxic, inexpensive and poses no threat to the environment [2]. However, water is rarely used or even

Novel 2-(ω-phosphonooxy-2-oxaalkyl)acrylate monomers for self-etching self-priming one part adhesive

• Joachim E. Klee and
• Uwe Lehmann

Beilstein J. Org. Chem. 2010, 6, 766–772, doi:10.3762/bjoc.6.95

• consuming procedure that is prone to failure during the procedure. Therefore, a reduction of the complexity of the adhesives during application was desirable. Furthermore, the adhesion procedure should be more safe, easy and robust. In order to fulfill these demands some generations of adhesives were

Synthesis and crystallographic analysis of meso-2,3-difluoro-1,4-butanediol and meso-1,4-dibenzyloxy-2,3-difluorobutane

• Bruno Linclau,
• Leo Leung,
• Jean Nonnenmacher and
• Graham Tizzard

Beilstein J. Org. Chem. 2010, 6, No. 62, doi:10.3762/bjoc.6.62

• a solution of 5 in toluene at room temperature, followed by the addition of pyridine [28] and heating the reaction mixture for a prolonged period gave the desired vicinal difluoride in good yield. Nevertheless, while this procedure was deemed sufficiently safe to conduct at about the 50 mmol scale

Synthesis of some novel hydrazono acyclic nucleoside analogues

• Mohammad N. Soltani Rad,
• Ali Khalafi-Nezhad and
• Somayeh Behrouz

Beilstein J. Org. Chem. 2010, 6, No. 49, doi:10.3762/bjoc.6.49

• has led to an ongoing search for safe and efficient chemotherapeutic agents with potent broad-spectrum antifungal activities. Some of the best known antifungal azole drugs having rational versatility in structures are miconazole (A), oxiconazole (B) and related compounds, namely aryl azoles (Figure 1

N-alkyl-N-(phosphonoethyl) substituted (meth)acrylamides – new adhesive monomers for self-etching self-priming one part dental adhesive

• Joachim E. Klee and
• Uwe Lehmann

Beilstein J. Org. Chem. 2009, 5, No. 72, doi:10.3762/bjoc.5.72

• adhesion procedure more safe, easy and robust several generations of adhesives were developed which combined the etch and prime function or the prime and bond function in one part together. At present, self-etching, self-priming dental adhesives are composed of two-part systems due to low hydrolytic

Flow through reactors for organic chemistry: directly electrically heated tubular mini reactors as an enabling technology for organic synthesis

• Ulrich Kunz and
• Thomas Turek

Beilstein J. Org. Chem. 2009, 5, No. 70, doi:10.3762/bjoc.5.70

• the very convenient use of microwave ovens comparable to kitchen equipment and safe operation in a closed cabinet, are the reasons for the success of this technology. The high cost and dimensions in the sub millimeter range led us to the question: what other methods are available to heat small flow

Oxidative cyclization of alkenols with Oxone using a miniflow reactor

• Yoichi M. A. Yamada,
• Kaoru Torii and
• Yasuhiro Uozumi

Beilstein J. Org. Chem. 2009, 5, No. 18, doi:10.3762/bjoc.5.18

• miniflow systems thus rendering exothermic and/or potentially explosive reactions safe and practical. Consequently, oxidative transformations with potentially explosive oxidants would be ideal target reactions for miniflow systems. We wish to report the oxidative construction of furanyl and pyranyl alkyl

One-pot preparation of substituted pyrroles from α-diazocarbonyl compounds

• Fernando de C. da Silva,
• Mauricio G. Fonseca,
• Renata de S. Rianelli,
• Anna C. Cunha,
• Maria C. B. V. de Souza and
• Vitor F. Ferreira

Beilstein J. Org. Chem. 2008, 4, No. 45, doi:10.3762/bjoc.4.45

• definition of the ideal synthesis agrees with several demanding tasks mentioned before in such way that the target molecules should be made from readily available starting materials in one simple, safe, environmentally acceptable operation. Additionally, they also should proceed quickly, in quantitative

Synthesis of (–)-Indolizidine 167B based on domino hydroformylation/cyclization reactions

• Giuditta Guazzelli,
• Raffaello Lazzaroni and
• Roberta Settambolo

Beilstein J. Org. Chem. 2008, 4, No. 2, doi:10.1186/1860-5397-4-2

• multi-step domino reaction sequences which are a very convenient approach to complex architectures in one simple, safe, environmentally acceptable and resource-effective operation [12][13][14]. The mechanistic as well as synthetic implications of the oxo reaction involving vinyl and allyl aromatic and

Transition- metal/Lewis acid free synthesis of acyl benzothiophenes via C-C bond forming reaction

• Sarbani Pal,
• Mohammad Ashrafuddin Khan,
• P. Bindu and
• P. K. Dubey

Beilstein J. Org. Chem. 2007, 3, No. 35, doi:10.1186/1860-5397-3-35

• starting materials and mild reaction conditions, ii) environmentally safe as the protocol is free from the use of inorganic Lewis acids as well as chlorinated hydrocarbons as solvent, iii) simple operational procedure. However, formation of a mixture of regioisomers is the major drawback of this protocol

Development of potential manufacturing routes for substituted thiophenes – Preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides

• John W. Hull Jr.,
• Duane R. Romer,
• David E. Podhorez,
• Mezzie L. Ash and
• Christine H. Brady

Beilstein J. Org. Chem. 2007, 3, No. 23, doi:10.1186/1860-5397-3-23

• the experimental insecticide target molecules XR-693 and XR-906 will be the topic of a forthcoming paper. Background Since the near world-wide ban on agricultural uses of the chlorinated insecticide DDT which began in the 1970's and 1980's, [1] the search for effective and safe insecticides that

• exhibit low bio-persistence and low toxicity to birds, mammals, and aquatic life has intensified. The requirement for safe insecticides is driven by a continuing need to control malaria and to feed a growing world population. Indeed, it has been estimated that up to 15% of annual global food crops are

An improved synthesis of 1,3,5-triaryl- 2-pyrazolines in acetic acid aqueous solution under ultrasound irradiation

• Ji-Tai Li,
• Xiao-Hui Zhang and
• Zhi-Ping Lin

Beilstein J. Org. Chem. 2007, 3, No. 13, doi:10.1186/1860-5397-3-13

• biochemical processes. As a reaction solvent, water offers many practical and economic advantages including low cost, safe handling and environmental compatibility. Recently, many organic reactions in aqueous media have been described in the literature. [10] Ultrasound has increasingly been used in organic

Asymmetric aza-Diels- Alder reaction of Danishefsky's diene with imines in a chiral reaction medium

• Bruce Pégot,
• Olivier Nguyen Van Buu,
• Didier Gori and
• Giang Vo-Thanh

Beilstein J. Org. Chem. 2006, 2, No. 18, doi:10.1186/1860-5397-2-18

• . [20][21][22] However, the process resulted in low enantioselectivities not to mention the complication in preparing the solvent and the ridiculously high cost. It is, therefore, safe to say that chiral ILs are much more efficient than the traditional chiral solvent in asymmetric induction, due to the

EcoScale, a semi- quantitative tool to select an organic preparation based on economical and ecological parameters

• Koen Van Aken,
• Lucjan Strekowski and
• Luc Patiny

Beilstein J. Org. Chem. 2006, 2, No. 3, doi:10.1186/1860-5397-2-3

• the better preparation (#3). Conclusion In general, the EcoScale favours high-yielding, low-cost and safe reaction conditions and an easy purification. The analysis (1) is straightforward (it takes into account all important parameters), (2) is transparent (it is clear how the final score is obtained