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Search for "antifungal activity" in Full Text gives 62 result(s) in Beilstein Journal of Organic Chemistry.
Anti-invasive and cytotoxic evaluation of a (+)-pinoresinol-based semisynthetic library against glioblastoma
Beilstein J. Org. Chem. 2026, 22, 691–704, doi:10.3762/bjoc.22.54
- corrected as shown in Figure 1. The most abundant metabolite isolated during these chemical studies was (+)-pinoresinol (2), which has been reported to exhibit a variety of bioactivities. These include antifungal activity against the human pathogens Candida albicans (MIC = 12.5 µM), Trichosporon beigelii
Sustainable electrochemical synthesis of aliphatic nitro-NNO-azoxy compounds employing ammonium dinitramide and their in vitro evaluation as potential nitric oxide donors and fungicides
Beilstein J. Org. Chem. 2025, 21, 2739–2754, doi:10.3762/bjoc.21.211
- fungi that cause a global threat to crop production and public health [95][96][97][98][99]. Herein, the synthesized nitro-NNO-azoxy alkanes were screened for antifungal activity against phytopathogenic fungi representing several taxonomic classes: Venturia inaequalis (V.i., ascomycete causing the apple
Total synthesis of asperdinones B, C, D, E and terezine D
Beilstein J. Org. Chem. 2025, 21, 2730–2738, doi:10.3762/bjoc.21.210
- contains a prenyl group at various positions in the indole ring [11]. The importance of the indole core structure and the nature and position of prenylation is reflected by the observation that 6-prenylindole but not 6-isopropylindole has been reported to exhibit antifungal activity [6]. Tryptophans
- metabolite and cyclic dipeptide consisting of a 7-prenylated ʟ-tryptophan and ʟ-alanine was isolated from the liquid cultures of S. teretispora containing potato broth in the medium. Its structure was based on extensive spectroscopic studies (Figure 1). Terezine D (6) exhibited modest in vitro antifungal
- activity [20]. A related metabolite lacking the C7 prenyl group had been isolated from the cultures of Aspergillus chevalieri in 1976 [21]. The structure and absolute stereochemistry were confirmed by synthesis from tryptophan and ʟ-alanine [22]. The isolation of terezine D (6) and more recently, the (3R
Transformation of the cyclohexane ring to the cyclopentane fragment of biologically active compounds
Beilstein J. Org. Chem. 2025, 21, 2416–2446, doi:10.3762/bjoc.21.185
- ], the mechanism and factors controlling the selectivity of the oxidative ring contraction in cyclic α-formyl ketones under the action of H2O2 were studied in detail. Due to their complex architecture and diverse biological activities, including antiviral, antitumor, antimalarial, and antifungal activity
Recent advances in Norrish–Yang cyclization and dicarbonyl photoredox reactions for natural product synthesis
Beilstein J. Org. Chem. 2025, 21, 2315–2333, doi:10.3762/bjoc.21.177
- viable intermediates in the total synthesis of γ-rubromycin, emphasizing the need to avoid C7-oxygenation at early stages. 3.2 Preussomerins Preussomerins EG1 (97), EG2 (98), and EG3 (99) – isolated from the endophytic fungus Edenia gomezpompae in Callicarpa acuminata – exhibit strong antifungal activity
C2 to C6 biobased carbonyl platforms for fine chemistry
Beilstein J. Org. Chem. 2025, 21, 2103–2172, doi:10.3762/bjoc.21.165
- prepared using this process. Antifungal activity assays against four general plant fungi demonstrated that several of the synthesized new furan products exhibited also broad and strong biological activities (Scheme 21) [95]. A metal-free efficient strategy was developed by the Gu group for the synthesis of
Fe-catalyzed efficient synthesis of 2,4- and 4-substituted quinolines via C(sp2)–C(sp2) bond scission of styrenes
Beilstein J. Org. Chem. 2025, 21, 1799–1807, doi:10.3762/bjoc.21.142
- 6-bromo-2,4-diphenylquinoline (3g), both recognized for their antifungal activity [10], were successfully synthesized on a gram scale, showcasing the scalability and efficiency of the process (Scheme 3). After having demonstrated the broad substrate compatibility and the synthetic potential of this
Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines
Beilstein J. Org. Chem. 2024, 20, 2806–2817, doi:10.3762/bjoc.20.236
- in clinical use, suggest that they may possess antifungal activity against Candida albicans. Keywords: 2-aminoimidazole; antimycotic activity; imidazo[1,2-a]pyrimidine; molecular docking; N-arylitaconimides; N-substituted maleimides; recyclization; Introduction Nitrogen-containing heterocyclic
- this work was a preliminary evaluation of the potential bioactivity of the obtained compounds. In particular, a molecular docking experiment to investigate the binding mechanisms to the CYP51 enzyme and an evaluation of the antifungal activity of imidazo[1,2-a]pyrimidines against Candida albicans were
Natural resorcylic lactones derived from alternariol
Beilstein J. Org. Chem. 2024, 20, 2171–2207, doi:10.3762/bjoc.20.187
- sp. [172][180] and Rhizopycnis vagum [171]. Palmariol A and B showed weak antifungal activity against Mucor racemosus (8 mm inhibition zone at 20 μM/disc) and palmariol A was furthermore active against Bacillus subtilis (9 mm) [178]. Palmariol B was found to show a higher antimicrobial activity than
Syntheses and medicinal chemistry of spiro heterocyclic steroids
Beilstein J. Org. Chem. 2024, 20, 1713–1745, doi:10.3762/bjoc.20.152
- 9763), displaying selective antifungal activity akin to nystatin, alongside with low cytotoxicity on cancer cell lines (HeLa, MDA-MB-453, and MDA-MB-361). Additionally, they exhibited robust activity against leukemia K562 cells [51]. Spiro-1,2,4-triazolidin-3-one steroids Sharma et al. developed a
- the spiro compounds showed similar activity to that of nystatin (2.46–4.86 mM vs 0.89–2.70 mM for nystatin). Based on the comparable antifungal activity observed between 108 and 109, the authors proposed that the oxathiaphospholane ring contributes to this bioactivity. Spiro steroids with six-membered
(Bio)isosteres of ortho- and meta-substituted benzenes
Beilstein J. Org. Chem. 2024, 20, 859–890, doi:10.3762/bjoc.20.78
- increased by bioisosteric replacement of ortho-benzene with 1,2-BCHs, the metabolic stability as determined by intrinsic clearance rate in human liver microsomes (Clint) and half-time of metabolic decomposition (t1/2) decreased. Mykhailiuk and co-workers also reported the antifungal activity of fluxapyroxad
- and boscalid biosisosteres (±)-55 and (±)-56 (Figure 6) [36]. The comparison of the antifungal activity over a wide range of concentrations showed that while biological activity is preserved upon incorporation of the 1,2-BCH scaffold, it is significantly reduced. This was also the case for the
- clearance rate in human liver microsomes (CLint) than fluxapyroxad (lower metabolic stability) but boscalid bioisostere (±)-71 had a lower CLint and was more metabolically stable than boscalid. Importantly, Mykhailiuk and co-workers also compared the antifungal activity of fluxapyroxad, boscalid and the
Synthesis and biological evaluation of Argemone mexicana-inspired antimicrobials
Beilstein J. Org. Chem. 2023, 19, 1511–1524, doi:10.3762/bjoc.19.108
- against all Gram-positive strains, with exceptional activity against S. epidermidis. This variant further enhanced the bacterial selectivity, as its heightened antibacterial levels were coupled with notable decreases in antifungal activity as compared to berberine. A graph showing a complete comparison of
Cyclometalated iridium complexes-catalyzed acceptorless dehydrogenative coupling reaction: construction of quinoline derivatives and evaluation of their antimicrobial activities
Beilstein J. Org. Chem. 2022, 18, 1507–1517, doi:10.3762/bjoc.18.159
- Gram-positive bacteria. In particular, the antibacterial activity of compound 3ad against Staphylococcus aureus (MIC = 2 μg/mL) was much higher than that of the positive control norfloxacin. Meanwhile, the antifungal activity of compound 3ck (MIC = 64 μg/mL) was stronger than norfloxacin. However, 3an
- and other compounds showed similar or lower antifungal activity than norfloxacin. Unfortunately, all compounds were less effective against Gram-negative bacteria (MIC > 128 μg/mL) than the parent drug norfloxacin. To sum up, the synthesized compounds exhibited enhanced antibacterial activity against
The stereochemical course of 2-methylisoborneol biosynthesis
Beilstein J. Org. Chem. 2022, 18, 818–824, doi:10.3762/bjoc.18.82
- in other foodstuff such as fish and coffee contaminations with 1 are perceived as unpleasant flavor constituents [15][16][17][18]. Despite its occurrence in fungi, 1 also has moderate antifungal activity as observed for its inhibition of mycelial growth and sporulation in Fusarium moniliforme [19
Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment
Beilstein J. Org. Chem. 2022, 18, 631–638, doi:10.3762/bjoc.18.63
- for their in vitro antibacterial potential against Staphylococcus aureus and Bacillus subtilis as examples of Gram-positive bacteria as well as against Escherichia coli and Proteus vulgaris as examples of Gram-negative bacteria [35]. They were also evaluated for their in vitro antifungal activity
- , 4p and 4c, respectively. Besides, the order of antifungal activity against the pathogenic yeast Candida albicans was 4g, 4i, 4q, 4j, 4o, 4p, 4m, 4k, 4s, 4t, 4n, 4v, 4d, 4e, 4h, 4l, 4c and 4r, respectively (Table 1). Likewise, no antimicrobial activities could be detected for compound 4f under these
- . Compounds 4g and 4i showed good antifungal activity against C. albicans. Compounds 4t, 4i, 4p, and 4c were the most active derivatives against S. aureus with MIC values between 31 and 70 µg/mL, while compound 4p showed good activity against Bacillus subtilis with a MIC value of 70 µg/mL. Further development
Sesquiterpenes from the soil-derived fungus Trichoderma citrinoviride PSU-SPSF346
Beilstein J. Org. Chem. 2022, 18, 479–485, doi:10.3762/bjoc.18.50
- amount were evaluated for their antibacterial activity against S. aureus ATCC25923 and methicillin-resistant S. aureus SK1, antifungal activity against C. neoformans ATCC90113 as well as cytotoxic activity against KB, MCF-7, and noncancerous Vero (African green monkey kidney fibroblast) cells. None of
Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity
Beilstein J. Org. Chem. 2022, 18, 243–250, doi:10.3762/bjoc.18.29
- . Keywords: antifungal activity; nucleophilic substitution; oxidative cyclization; [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines; Introduction Azolo-annulated azines can be regarded as purine isosteres and are of great interest for modern medicinal chemistry as potential biologically active compounds. In
- of [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazine fragment on antifungal activity of the synthesized compounds, we have tested the activity of their analogues, unannulated 1,2,4,5-tetrazines 2c,g, containing the amidine moiety, and isomeric [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines. For a comparative
- analysis of antifungal activity, the previously described [37] 3-methyl- and 3-phenyltriazolo[4,3-b][1,2,4,5]tetrazines 10a,b were used as structural analogues of compounds 3a,b. Furthermore, in the reactions of compound 10a with methanol, heptylamine and morpholine, new derivatives 11a–c have been
Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units
Beilstein J. Org. Chem. 2021, 17, 2812–2821, doi:10.3762/bjoc.17.192
- spectroscopic techniques. The biological properties of the freshly prepared compounds were screened against S. aureus, B. subtilis, A. hydrophila, E. coli, and A. baumannii bacteria and antituberculosis activity against M. tuberculosis H37Rv strains. Also, the antifungal activity was studied against C. albicans
- . Antifungal activity of the novel compounds was also evaluated against Candida albicans, Candida tropicalis and Candida glabrata strains. Antibacterial and antituberculosis (TB) activities From the observed data (Table 1) it can be seen that the tested compounds showed moderate antibacterial activity, in the
- tested against the M. tuberculosis H37Rv strain with 3.90 μg/mL. It seems that the presence of the indole ring has enhanced the activity of complex L3-Ni when comparing with other Ni complexes such as L1-Ni and L2-Ni. Antifungal activity The screened complexes showed antifungal activity, in the range of
Synthesis and antimicrobial activity of 1H-1,2,3-triazole and carboxylate analogues of metronidazole
Beilstein J. Org. Chem. 2021, 17, 2377–2384, doi:10.3762/bjoc.17.154
- elements (metronidazole core and triazole moiety) were considered as rigid motif with an alkyl/aryl group attached to the triazole unit. A diverse array of functional groups in the aromatic ring influencing the antimicrobial activity of the molecules have been utilized. Antifungal activity of compounds The
- antifungal activity of all compounds were evaluated by inhibiting the growth of Didymella sp. (Figure 7 and Table 3). The fungal colony after 7 days of control treatment was noted to be 8.6 cm in diameter. Whereas, the growth of the fungal colony was detected maximum, i.e., 8.8 ± 0.2 and 9.0 ± 0.3 cm against
- codes: carbon = grey, nitrogen = blue, oxygen = red, hydrogen = white. General structural feature of the synthesized molecules 5. The graph representing the antifungal activity of Didymella sp. against compounds 5a–i and 7a–e. The graph representing the antibacterial activity of E. coli against
Double-headed nucleosides: Synthesis and applications
Beilstein J. Org. Chem. 2021, 17, 1392–1439, doi:10.3762/bjoc.17.98
Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.
Beilstein J. Org. Chem. 2021, 17, 1385–1391, doi:10.3762/bjoc.17.97
- moderate antifungal activity. A recent find of a Marasmius species in Northern Thailand led, however, to the isolation and identification of five novel derivatives of this carotane-type sesquiterpenoid. The present study is dedicated to describing their isolation, and biological and physicochemical
- fulvoferruginins A–F (1–6), aside from the known antifungal activity of fulvoferruginin (1), no other antimicrobial activities were observed (Table S2 in Supporting Information File 1). All metabolites were also tested against the murine fibroblast cell line L929 and the cervix carcinoma cell line KB3.1. While all
Progress in the total synthesis of inthomycins
Beilstein J. Org. Chem. 2021, 17, 58–82, doi:10.3762/bjoc.17.7
- Omura’s group in 1995 [3]. Inthomycin A ((+)-1) displays moderate antifungal activity against cellulose-containing Phytophthora parasitica and Phytophthora capsici [4]. Inthomycins were reported to possess many interesting biological properties, which include the specific inhibition of the cellular
Copper-catalyzed O-alkenylation of phosphonates
Beilstein J. Org. Chem. 2020, 16, 611–615, doi:10.3762/bjoc.16.56
- chemistry [1][2][3]. In particular, O-alkenyl phosphonate esters (i.e., enol phosphonates) have been described as potent insecticides and show antifungal activity [4]. While several methods are available for the preparation of cyclic enol phosphonates [5][6][7][8][9][10], the synthesis of the acyclic
Fluorinated maleimide-substituted porphyrins and chlorins: synthesis and characterization
Beilstein J. Org. Chem. 2019, 15, 2704–2709, doi:10.3762/bjoc.15.263
- . Maleimides are considered as a biologically important scaffold that possess almost all types of biological activities including antibacterial and antifungal activity [24], anticancer activity [25], cox-2 inhibitor and anti-inflammatory, antidiabetic activity [26] and photodynamic activity [27]. Attaching of
Synthesis of pyrrolo[1,2-a]quinolines by formal 1,3-dipolar cycloaddition reactions of quinolinium salts
Beilstein J. Org. Chem. 2019, 15, 1480–1484, doi:10.3762/bjoc.15.149
- with a quinoline. Pyrroloquinolines have been found to show antibacterial and antifungal activity, to be ligands for the NK1 receptor, and to be effective against the Hif hypoxia pathway in cancer cell lines [36][37][38]. Almost all of the examples of dipolar cycloaddition reactions involving
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