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Search for "biocompatibility" in Full Text gives 238 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects
Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118
- , lipids provide more space for drug encapsulation and biocompatibility of the system. Therefore, the advancement in the LPHNPs yields better and prolonged therapeutic efficacy. Different types and structural advantages of PLHNPs are illustrated in Figure 1 and are discussed in detail as follows. Polymer
- . This leads to improved bioavailability and allows for sustained release of the encapsulated therapeutic agents [64][65][66]. The advantages of PEGylated PLHNPs include enhanced biocompatibility and reduced immunogenicity. The PEG layer creates a hydrophilic barrier around the nanoparticles, which
- and lipid-based carriers, providing stability, biocompatibility, and efficient drug encapsulation. Applications of stimuli-responsive PLHNPs are vast and impactful. In cancer therapy, they are used to deliver chemotherapeutic agents specifically to tumor sites, where the acidic microenvironment or
Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals
Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113
- advantages of liposomes include, but are not limited to, high biocompatibility, biodegradability, and prolonged retention in the blood stream when pegylated [91]. Despite their significant advantages, liposomes could also suffer from disadvantages such as short half-life in the body environment and drug
- drug reach the brain. Recent literature highlights SLNs, NLCs, liposomes, polymeric NPs, and emulsions. While lipid-based NPs are favorable because of their lipophilicity and biocompatibility, polymeric NPs offer greater control over drug release, stability, and mechanical properties [123]. Furthermore
A biomimetic approach towards a universal slippery liquid infused surface coating
Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111
- omniphobic. Keywords: biocompatibility; biomimetic; blood-contacting; hemocompatibility; non-fouling; Introduction Clot formation and the overall compatibility of artificial materials within the body remains a common complication of blood contacting surfaces [1][2][3][4][5][6][7][8]. A critical hurdle in
- any foreign surface. Materials coated with SLIPS have demonstrated effectiveness in resisting corrosion, reducing bio-fouling, and preventing icing [1][2][3][6][8]. There is also evidence that SLIPS are a promising strategy for increasing the biocompatibility of materials [4][11]. SLIPS are generally
- and a Tukey post-hoc comparison were performed to determine differences between means. For biocompatibility data that was normalized to glass, the error from glass is imbedded in the reported standard deviation. Sample sizes for presented data is included in the figure captions and reported as the
Hymenoptera and biomimetic surfaces: insights and innovations
Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107
- Hymenopteran venom delivery systems, advanced microinjection devices can be crafted for laboratory applications, boasting painless insertion and extraction, minimal dermal injuries, mechanical durability, and suitable biocompatibility [172]. Furthermore, the capacity to induce mechanical tissue damage may vary
Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans
Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105
- that changes in the oxygen content of GO may improve its biocompatibility. They found that GO sheets with reduced oxygen content and relatively more –COOH groups did not presented the common GO toxicity effects to C. elegans, such as increased intestinal permeability, microvilli damage, material
Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles
Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98
- functions [54][69][70][71][72][73][74][75]. Therefore, a thorough evaluation of their biocompatibility is necessary before advancing their clinical applications. In the context of cancer treatment, the efficient renal clearance and short blood elimination half-life of usNPs raise questions about their
- microenvironment, thus enhancing treatment efficacy. The study revealed that 64Cu-Cu@CuOx-ECL1i exhibited suitable biodistribution and biocompatibility. Moreover, 64Cu-Cu@CuOx-ECL1i-Gem was able to induce tumor inhibition and to prolong survival in a syngeneic xenograft mouse model of PDAC. 5.7 Antibody-based
AI-assisted models to predict chemotherapy drugs modified with C60 fullerene derivatives
Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95
- , such as water solubility, biodegradability, biocompatibility, and hypoallergic response. It has been shown that PHFs can inhibit cancer tumor growth and positively regulate the immune system [26]. The same is valid for carboxylated fullerenes [27]; for instance, C60[C(COOH)2]3 is well known for its
Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications
Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88
- , biocompatibility, biodegradability, and water solubility of alginate have expanded opportunities in material and biomedical sciences. Recently, research on alginate-based nanoparticles and their applications has begun. These materials are gaining popularity because of their wide usage potential in the biomedical
- several excellent properties that can be crucial in drug delivery, such as low cost, antioxidant and antibacterial activity, non-toxicity, biodegradability, and biocompatibility. Biopolymeric nanoparticles (NPs) can be used in DDSs, and they can protect the drugs from the adverse conditions of the
- variable chemical compositions, customizable characteristics, easy processability, great biocompatibility and biodegradability, and nontoxicity, opening up new avenues for the creation of flexible sensing technologies [26][27]. Alginate-based nanomaterials are among the most widely studied biopolymers for
Interface properties of nanostructured carbon-coated biological implants: an overview
Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85
- within the field. Keywords: biocompatibility; carbon nanotubes; coatings; graphene; nanodiamonds; surfaces; Introduction For centuries, the simple manipulation of natural resources has represented the only available strategy for the realization of artifacts, buildings, and innovations, until the
- biocompatibility because the implant interfaces are the first line of contact between a foreign body and living organisms. The bulk materials used in implants are carefully chosen to minimize adverse reactions, but the immune system may still recognize them as external entities and trigger inflammatory responses
- nanosized and nanostructured carbon materials clearly represents a disruptive advancement in the field, leading to prolonged implant life, increased biocompatibility, and reduction of adverse inflammatory reactions. The big family of low-dimensional carbon materials is a great reservoir for tuning the
Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells
Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78
- ) (PLA) and poly(glycolic acid) (PGA), has been employed in the synthesis of nanoparticles for cancer diagnostics and therapy because of its excellent biocompatibility and biodegradability [1][2][3]. PLGA nanoparticles can be prepared via a variety of techniques, including single emulsion, double
- CHL, IR780, and PLGA nanoparticles in order to create a carrier that could deliver the drug, track the location of the tumor, and control the release of the drug. The nanoparticles would increase the drug’s biocompatibility and stability. In addition, the nanoparticles were modified with the targeting
- , and the crystal violet precipitate was dissolved with DMSO. The samples were then measured at 562 nm. The untreated cell was employed as a negative control. The cells treated with CHL served as a positive control. Results and Discussion Controlled release, biocompatibility, targeted distribution
Electrospun nanofibers: building blocks for the repair of bone tissue
Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77
- [33]. In addition, given their compatibility with various active molecules, the polymers are the most essential formulation components in providing long-term controlled release of drugs. Biodegradability, biocompatibility, hydrophilicity, and mechanical properties of polymers are important criteria
Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material
Beilstein J. Nanotechnol. 2024, 15, 781–796, doi:10.3762/bjnano.15.65
- they are flexible, variable in weight, have excellent biocompatibility, are resistant to biochemical degradation, and have suitable physical and mechanical characteristics. Moreover, they can be formed to the desired shape [6]. It is also worth mentioning that different drugs or other additives can be
- [29][30][31][32]. Based on the special requirements to fulfill as a wound dressing material, such as biocompatibility, biodegradability, good gas permeability, and water retention capacity, polysuccinimide (PSI) was used for the preparation of electrostatic fibers. Polysuccinimide is a nontoxic [33
Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels
Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56
- excellent biocompatibility. However, its thermoresponsive behaviour in association with anisotropic gold nanoparticles is yet to be explored towards photothermal response [23]. In the present work, we developed pillow-shaped (called nanomakura in Japanese) AuNPs using surfactants myristyltrimethylammonium
Photocatalytic degradation of methylene blue under visible light by cobalt ferrite nanoparticles/graphene quantum dots
Beilstein J. Nanotechnol. 2024, 15, 475–489, doi:10.3762/bjnano.15.43
- degradation and other dyes. Keywords: cobalt ferrite; graphene quantum dots; methylene blue; Introduction Graphene quantum dots (GQDs) have unique properties, including photoluminescence, biocompatibility, slight chemical toxicity, inertness, and excellent photostability [1][2]. Graphene quantum dots
Classification and application of metal-based nanoantioxidants in medicine and healthcare
Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36
- homeostasis in tumors through a series of cascade reactions but also establish cyclic regeneration of relevant substrates. Another study combined MnO2 nanoparticles with bovine serum albumin (BSA) to obtain GPx activity [47]. The in vitro results showed excellent biocompatibility of the MnO2-BSA nanoparticles
- three key components: (1) edaravone and nanoceria were responsible for ROS scavenging; (2) poly(ethylene glycol) increased biocompatibility, monodispersity, and extended the half-life in the bloodstream; and (3) angiopep-2 served as targeting ligand, which specifically binds to the low-density
- delivery but also enhances stability and biocompatibility. Recently, Shang et al. used a Au/Cu1.6O/P–C3N5/Arg@HA nanocomposite hydrogel spray coupled with ultrasound for diabetic wound healing (Figure 4) [162]. This nanocomposite spray exhibited five types of enzyme-like activities, that is, CAT-, SOD
Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors
Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27
- biocompatibility on NP toxicity. These properties of NPs determine their toxicity and interaction with the cell membrane damaging human health and the environment [12]. The toxic effect of NPs can be used as a medical treatment for diseases at the cellular level, that is, targeting and destroying cancerous cells
Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study
Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24
- nanostructures employed, particular emphasis has been placed on iron oxide (Fe3O4) nanoparticles. The biocompatibility and low toxicity of Fe3O4 nanoparticles have garnered significant attention in magnetic drug delivery for cancer diagnosis and treatment, primarily because of their magnetic properties [11][12
- neurotransmitter naturally occurring in the brain and can spontaneously polymerize into polydopamine (PDA) under alkaline conditions without oxidants [22]. Polydopamine can form a coating with biocompatibility advantages, achieving up to 40% photothermal conversion efficiency, nanoscale dimensions, and
- morphology and a size of 18 nm. After coating with PDA at different ratios, the size reaches up to 28, 61, and 225 nm. Another point is that PEGylation has been applied using SH-PEG polymer to enhance biocompatibility. Notably, our study demonstrates a significantly higher drug loading efficiency of 98
Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions
Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11
- , which may be top-down or bottom-up approaches, has facilitated the synthesis of nanoparticles of differing shapes, sizes and properties [11]. When considering zinc oxide nanoparticles (ZnO NPs) in particular, their low toxicity, high biocompatibility, and low cost [12] have enabled them to be applied as
Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti
Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10
- ]. Biocompatibility assessment is an essential aspect of the development of NEs, particularly for biomedical and cosmetic applications, as it determines the safety and efficacy of the formulations. The assessment involves evaluating the potential cytotoxicity and genotoxicity of the NEs on different cell types and
- present work was (i) to develop stable oil-in-water nanoemulsions containing myrcene or cymene as the dispersed phase, (ii) to determine the required rHLB values for emulsion stability, (iii) to assess the biocompatibility via in vitro and in vivo assays, and (iv) to evaluate the bioefficacy of the NE
- evaluation of the biocompatibility in human cells is an important step in the development and commercialization of any drug [46]. Here, the toxicity of the terpene-based formulations was evaluated in the HaCAT cell line (Table 6). The results show that the IC50 values of the free terpenes were lower those of
Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency
Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7
- strongly affect the release behavior of the drug from nanofiber scaffolds [14][17][18][19]. Polylactic acid (PLA), a synthetic polymer that has been approved by the FDA for biomedical usage, is commonly used for drug delivery systems due to its biocompatibility and biodegradability [20]. Yuan et al. [17
Influence of conductive carbon and MnCo2O4 on morphological and electrical properties of hydrogels for electrochemical energy conversion
Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6
- history and a wide range of applications, especially in biology, medicine, tissue engineering, and pharmacy. The multitude of application areas is related to their exceptional properties: biocompatibility, biodegradability, nontoxicity, good permeability for substances dissolved in water (e.g., oxygen and
Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review
Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4
- such as enhanced stability, low toxicity, increased shelf life, improved drug loading capacity, and biocompatibility over other conventional lipid-based nanocarriers, such as nanoemulsions and solid lipid nanoparticles [91]. Due to their properties, the use of NLCs has been a successful strategy for
- impact specific drug release kinetics and increase biocompatibility [60]. Different biodegradable polymers have been used for the development of targeted PNPs for the treatment of leishmaniasis [102]. In this scenario, chitosan is an interesting polymer for NP synthesis due to its positive charge, which
- nanoparticles due to its special features such as biocompatibility, biodegradability, low toxicity, and adjuvanticity [109][110]. Given these properties, Tiwari and co-workers produced curcumin-loaded Eudragit-PLGA-nanoparticles (curc-E-PLGA-NPs) and evaluated their leishmanicidal activity with miltefosine
Nanotechnological approaches in the treatment of schistosomiasis: an overview
Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2
- Administration since 1989 [21] and, although no human data attests to chitosan safety, many animal tests prove its safety [22]. Eudragit L 100 is another polymer commonly used in literature because of its biocompatibility [8]. Overall, it is used when a delayed release is required. It is derived from polyacid
- classic nanocarriers are not present in SLN, such as lack of biocompatibility, difficulty to produce on a large scale, and high raw material cost [36]. Many methods are used to prepare SLN, and they are divided into (1) high-energy methods, for dispersion of the lipid phase (such as high-pressure
- molecule, and excellent biocompatibility and safety [38]. Liposomes can also be modified to selectively deliver a drug to a specific site. This is very valuable because it can reduce potential side effects and increase the maximum tolerated dose, which improves therapeutic benefits [39]. For example
Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells
Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100
- applications, especially because of their biocompatibility. We synthesized and characterized fluorescent PDA NPs of 10–25 nm diameter based on a protein containing a lysine–glutamate diad (bovine serum albumin, BSA) and determined whether they can penetrate and accumulate in bacterial cells to serve as a
- bacteria. Inspired by the eumelanin aggregates in human skin, polydopamine nanoaggregates (here referred to as nanoparticles, i.e., PDA NPs) have emerged as promising nanovectors for biomedical applications [11][12], especially because of their biocompatibility [13][14] and photothermic properties [15][16
A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH3)2Cl]2
Beilstein J. Nanotechnol. 2023, 14, 1178–1199, doi:10.3762/bjnano.14.98
- ; quantum chemical calculation; ultrahigh vacuum; Introduction In recent years, gold nanostructures have received much attention owing to their dielectric properties [1], their biocompatibility [2], and their electrical properties [3][4], which enable a multitude of exciting applications in the field of
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