Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• . Keywords: active targeting; cancer; nanoclusters; renal clearance; ultrasmall nanoparticles; Review 1 Introduction Nanotechnology has opened new avenues for tackling unmet challenges in medicine [1][2][3]. In the field of oncology, a notable application involves the use of engineered nanoparticles (NPs

Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers

• Ömür Acet,
• Pavel Kirsanov,
• Burcu Önal Acet,
• Inessa Halets-Bui,
• Dzmitry Shcharbin,
• Şeyda Ceylan Cömert and
• Mehmet Odabaşı

Beilstein J. Nanotechnol. 2024, 15, 1189–1196, doi:10.3762/bjnano.15.96

• ; temperature- and pH-sensitive nanopolymer; Introduction Almost one in six deaths worldwide is from cancer, and cancer caused approximately 10 million deaths in 2020. Today, nanotechnology is emerging as an effective way to enable rapid diagnosis and treatment of cancer diseases [1][2][3]. The chemotherapy

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• development of nanotechnology, more and more MONPs including zinc, iron, titanium, and copper are being explored in therapeutic applications such as drug delivery, bioimaging, biosensing, bioelectronics, and tissue engineering applications [4][5][6]. Simultaneously, many of these particles also presented

• ecosystems. For example, nanoparticles with lower toxicity profiles, as predicted by the nano-qRASTR model, can be prioritized for use in environmental cleanup projects. Additionally, the exploration of MONP toxicity through this advanced modeling aligns with the broader goals of sustainable nanotechnology

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• ingredients. Cancer nanomedicine represents the most extensively studied nanotechnology application in the field of pharmaceutics and pharmacology since the first nanodrug for cancer treatment, liposomal doxorubicin (Doxil®), has been approved by the FDA. The advancement of cancer nanomedicine and its

• fact that there are over 50 nanotechnology-based medical products approved by regulatory bodies worldwide for various medical purposes, including AmBisome® (liposomal amphotericin B) for fungal infections, Visudyn® (liposomal vertepor) for macular degeneration, and Onpattro® (lipid nanoparticles with

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• delivery methods that can effectively cross the blood–brain barrier are essential for delivering therapeutic agents to the brain [40]. Nanotechnology has emerged as a promising tool in smart delivery systems. Nanoparticles can be designed to pass through biological barriers and reach specific sites in the

Interface properties of nanostructured carbon-coated biological implants: an overview

• Mattia Bartoli,
• Francesca Cardano,
• Erik Piatti,
• Stefania Lettieri,
• Andrea Fin and
• Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

• lecture entitled “There’s Plenty of Room at the Bottom”, in which he discussed the possibility of the manipulation of individual atoms and molecules [1]. Traditionally, this first lecture was recognized as the birth of nanotechnology, although the term was first used only later by Norio Taniguchi in 1974

Therapeutic effect of F127-folate@PLGA/CHL/IR780 nanoparticles on folate receptor-expressing cancer cells

• Thi Ngoc Han Pham,
• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan Thang Cao,
• Thanh-Danh Nguyen,
• Vy Tran Anh and
• Hieu Vu_Quang

Beilstein J. Nanotechnol. 2024, 15, 954–964, doi:10.3762/bjnano.15.78

• /IR780 nanoparticles, as shown by the MTT experiment. In conclusion, the proposed folate@PLGA/CHL/IR780 nanoparticles might be deemed a viable nanotechnology-based application technique for CHL and IR780 in theragnostic. (A) Hydrodynamic size of F127-folate@PLGA/CHL/IR780 and F127@PLGA/CHL/IR780 in 0.1

Electrospun nanofibers: building blocks for the repair of bone tissue

• Tuğrul Mert Serim,
• Gülin Amasya,
• Tuğba Eren-Böncü,
• Ceyda Tuba Şengel-Türk and
• Ayşe Nurten Özdemir

Beilstein J. Nanotechnol. 2024, 15, 941–953, doi:10.3762/bjnano.15.77

• widespread with the developments in nanotechnology after the 1980s, the foundations of this method are much older. Electrospinning was first tried by Rayleigh in 1897, upon William Gilbert's discovery that fluid dynamics was influenced by electrical fields in the 16th century. In the early 1900s, Zeleny

Identification of structural features of surface modifiers in engineered nanostructured metal oxides regarding cell uptake through ML-based classification

• Indrasis Dasgupta,
• Totan Das,
• Biplab Das and
• Shovanlal Gayen

Beilstein J. Nanotechnol. 2024, 15, 909–924, doi:10.3762/bjnano.15.75

• advancement of nanotechnology has led to the widespread utilization of engineered nanostructured metal oxides (ENMOs) in various industrial and biomedical applications [1]. Nanoparticles (NPs) are described by the International Organization for Standardization as structures characterized by one, two, or three

When nanomedicines meet tropical diseases

• Eder Lilia Romero,
• Katrien Van Bocxlaer and
• Fabio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 830–832, doi:10.3762/bjnano.15.69

• ; Chagas disease; leishmaniasis; nanomedicine; nanotechnology; neglected tropical diseases; schistosomiasis; In May 2021, the World Health Assembly from the World Health Organization (WHO) decided to officially recognize January 30th as the World Neglected Tropical Diseases Day. This initiative was done

Green synthesis of biomass-derived carbon quantum dots for photocatalytic degradation of methylene blue

• Dalia Chávez-García,
• Mario Guzman,
• Viridiana Sanchez and
• Rubén D. Cadena-Nava

Beilstein J. Nanotechnol. 2024, 15, 755–766, doi:10.3762/bjnano.15.63

• ][12][13][14]. Researchers are exploring innovative approaches, such as advanced oxidation processes, nanotechnology-based methods, and biological treatment systems, which show promise in effectively removing pollutants from wastewater [14][15][16]. In this research, we focus on the synthesis of carbon

• potential of nanotechnology in developing sustainable solutions. Experimental Materials/material synthesis The synthesis of CQDs involved the utilization of biomass-derived precursors. The method employed was based on the hydrothermal approach reported by Yuan et al. [40] with modifications in terms of

Gold nanomakura: nanoarchitectonics and their photothermal response in association with carrageenan hydrogels

• Nabojit Das,
• Vikas,
• Akash Kumar,
• Sanjeev Soni and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 678–693, doi:10.3762/bjnano.15.56

• biomedical soft materials [21]. Similarly, a very recent introduction of kappa-carrageenan (k-CG) into the field of nanotechnology has shown immense potential in the synthesis of plasmonic metal nanoparticles [22]. K-carrageenan is well known and is being used in several biomedical applications due to its

AFM-IR investigation of thin PECVD SiO_x films on a polypropylene substrate in the surface-sensitive mode

• Hendrik Müller,
• Hartmut Stadler,
• Teresa de los Arcos,
• Adrian Keller and
• Guido Grundmeier

Beilstein J. Nanotechnol. 2024, 15, 603–611, doi:10.3762/bjnano.15.51

• refined and found its way into many and highly diverse fields of application, including virology, DNA nanotechnology, polymer science, and materials science [5][6][7][8][9]. The importance of AFM-IR steadily grew over the past decade and its development has been described in detail in several review

On the additive artificial intelligence-based discovery of nanoparticle neurodegenerative disease drug delivery systems

• Shan He,
• Julen Segura Abarrategi,
• Harbil Bediaga,
• Sonia Arrasate and
• Humberto González-Díaz

Beilstein J. Nanotechnol. 2024, 15, 535–555, doi:10.3762/bjnano.15.47

• ), accuracy (Ac), chi-square (χ2), and the p-level [77][78]. IFPTML-LDA vs cross linear model In the Introduction section, we indicated the use of ML approaches as a promising strategy in order to tackle practical problems of nanotechnology, such as reducing the number of experiments [79][80][81][82][83][84

Aero-ZnS prepared by physical vapor transport on three-dimensional networks of sacrificial ZnO microtetrapods

• Veaceslav Ursaki,
• Tudor Braniste,
• Victor Zalamai,
• Emil Rusu,
• Vladimir Ciobanu,
• Vadim Morari,
• Daniel Podgornii,
• Pier Carlo Ricci,
• Rainer Adelung and
• Ion Tiginyanu

Beilstein J. Nanotechnol. 2024, 15, 490–499, doi:10.3762/bjnano.15.44

• , Chisinau, Republic of Moldova Institute of Electronic Engineering and Nanotechnology „D. Ghitu”, Technical University of Moldova, Chisinau, Republic of Moldova Institute of Applied Physics, State University of Moldova, Chisinau, Republic of Moldova Department of Physics, University of Cagliari, Italy

Sidewall angle tuning in focused electron beam-induced processing

• Sangeetha Hari,
• Willem F. van Dorp,
• Johannes J. L. Mulders,
• Piet H. F. Trompenaars,
• Pieter Kruit and
• Cornelis W. Hagen

Beilstein J. Nanotechnol. 2024, 15, 447–456, doi:10.3762/bjnano.15.40

• nanotechnology programme of the Dutch Government and 130 partners.

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• nanotechnology, nanomaterials have emerged as a promising solution to improve the limitations of natural antioxidants because of their high stability, easy storage, time effectiveness, and low cost. Among various types of nanomaterials exhibiting antioxidant activity, metal-based nanoantioxidants show excellent

• nanomaterials in medicine and healthcare are also discussed. This review provides a deeper understanding of the mechanisms of metal-based nanoantioxidants and a guideline for using these nanomaterials in medicine and healthcare. Keywords: antioxidant nanomaterial; healthcare; medicine; nanotechnology

• natural antioxidants because of their high stability, easy storage, time effectiveness, and low cost. Also, progress in nanotechnology enables us to easily control size, morphology, surface coating, and chemical configuration, which are highly related to the antioxidant activities. The integration of

On the mechanism of piezoresistance in nanocrystalline graphite

• Sandeep Kumar,
• Simone Dehm and
• Ralph Krupke

Beilstein J. Nanotechnol. 2024, 15, 376–384, doi:10.3762/bjnano.15.34

• Sandeep Kumar Simone Dehm Ralph Krupke Institute of Nanotechnology, Karlsruhe Institute of Technology, Kaiserstr. 12, 76131 Karlsruhe, Germany Institute of Quantum Materials and Technologies, Karlsruhe Institute of Technology, Kaiserstr. 12, 76131 Karlsruhe, Germany Institute of Materials Science

Investigating ripple pattern formation and damage profiles in Si and Ge induced by 100 keV Ar⁺ ion beam: a comparative study

• Indra Sulania,
• Harpreet Sondhi,
• Tanuj Kumar,
• Sunil Ojha,
• G R Umapathy,
• Ambuj Mishra,
• Ambuj Tripathi,
• Richa Krishna,
• Devesh Kumar Avasthi and
• Yogendra Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 367–375, doi:10.3762/bjnano.15.33

• electron microscopy; Introduction Scientific research varying from electronics to photonics, homeland security, high-resolution parallel patterning of magnetic media, biotechnology, and medicine are based upon nanotechnology. These applications require nanopatterning techniques to fabricate devices or

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• including Abraxane, the first formulation based on protein nanotechnology launched in 2005 [86]. Nearly 10% are inorganic nanoparticles such as the radiosensitizer Hensify, which in 2019 obtained CE Mark approval in the European Union for the treatment of locally advanced soft tissue sarcoma. This category

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• passive targeting and offer multimodal tumor therapy. In recent years, the use of nanotechnology-based cancer drugs has emerged as a promising alternative treatment approach. Utilizing various nanostructures as specific vehicles for drug delivery enhances efficacy and pharmacokinetic properties of

Quantitative wear evaluation of tips based on sharp structures

• Ke Xu and
• Houwen Leng

Beilstein J. Nanotechnol. 2024, 15, 230–241, doi:10.3762/bjnano.15.22

• nanotechnology [1][2][3][4][5]. Compared to optical and electron microscopy, AFM enables three-dimensional (3D) measurements of nanostructures in air and liquid environments [6]. The interaction between the tip and sample influences the measurement results of AFM by convoluting the tip topography with the sample

Ion beam processing of DNA origami nanostructures

• Leo Sala,
• Agnes Zerolová,
• Violaine Vizcaino,
• Alain Mery,
• Alicja Domaracka,
• Hermann Rothard,
• Philippe Boduch,
• Dominik Pinkas and
• Jaroslav Kocišek

Beilstein J. Nanotechnol. 2024, 15, 207–214, doi:10.3762/bjnano.15.20

• nanopatterning approach. Direct combination of this approach with top-down nanotechnology, such as ion beams, has not been considered because of the soft nature of the DNA material. Here we demonstrate that the shape of 2D DNA origami nanostructures deposited on Si substrates is well preserved upon irradiation

• unperturbed. Present stability and nature of damages on DNA origami nanostructures enable fusion of DNA origami advantages such as shape and positioning control into novel ion beam nanofabrication approaches. Keywords: DNA nanotechnology; DNA origami; FIB; heavy ions; Introduction Ion beam interaction with

• of various factors concerning material properties and the parameters of the impinging ion beam [22][23][24][25]. While crucial for modern nanotechnology, SHI cause severe damage to DNA [26][27][28]. This challenges the use of DNA-based nanomaterials for combined top-down and bottom-up nanoprocessing

Graphene removal by water-assisted focused electron-beam-induced etching – unveiling the dose and dwell time impact on the etch profile and topographical changes in SiO₂ substrates

• Aleksandra Szkudlarek,
• Jan M. Michalik,
• Inés Serrano-Esparza,
• Zdeněk Nováček,
• Veronika Novotná,
• Piotr Ozga,
• Czesław Kapusta and
• José María De Teresa

Beilstein J. Nanotechnol. 2024, 15, 190–198, doi:10.3762/bjnano.15.18

• Aleksandra Szkudlarek Jan M. Michalik Ines Serrano-Esparza Zdenek Novacek Veronika Novotna Piotr Ozga Czeslaw Kapusta Jose Maria De Teresa Academic Centre for Materials and Nanotechnology, AGH University of Krakow, av. A. Mickiewicza 30, 30-059 Krakow, Poland Department of Solid State Physics

Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions

• Pathirannahalage Sahan Samuditha,
• Nadeesh Madusanka Adassooriya and
• Nazeera Salim

Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11

• efficient, novel sources of Zn fertilizers for cultivated crops through the integration of nanotechnology has been the focus of considerable research in the past decade [10]. Nanoparticles have garnered the interest of researchers, leading to their wide application in agriculture due to their enhanced

• kcps, a duration of 50 s. Water was used as a dispersant with a NP concentration of 25 ppm following sonication for 30 min at 45 kHz using a GT SONIC-L3 sonicator. Particle size and shape of ZnO NPs were analyzed using Hitachi SU6600 FE (Field Emission)-SEM at the Sri Lankan Institute of Nanotechnology