Liver-targeting iron oxide nanoparticles and their complexes with plant extracts for biocompatibility

• Shushanik A. Kazaryan,
• Seda A. Oganian,
• Gayane S. Vardanyan,
• Anatolie S. Sidorenko and
• Ashkhen A. Hovhannisyan

Beilstein J. Nanotechnol. 2024, 15, 1593–1602, doi:10.3762/bjnano.15.125

• cell labeling [17][18][19][20][21][22]. Their biocompatibility and stability fill the niche of applications that require properties unattainable by organic materials. Size control, prevention of aggregation through coating, specific interactions and dispersion, and the ability to penetrate cellular and

• tissue barriers all give iron oxide MNPs an advantage over other metallic nanoparticles. Because of their small size, nanoparticles have a high surface-to-volume ratio, making them more appealing. However, since the large surface area provides numerous active sites for interactions, it can also lead to

Facile synthesis of size-tunable L-carnosine-capped silver nanoparticles and their role in metal ion sensing and catalytic degradation of p-nitrophenol

• Akash Kumar,
• Ridhima Chadha,
• Abhishek Das,
• Nandita Maiti and
• Rayavarapu Raja Gopal

Beilstein J. Nanotechnol. 2024, 15, 1576–1592, doi:10.3762/bjnano.15.124

• simultaneously via ionic interactions between the exposed functional groups of the capping agent and metal ions. This issue can be addressed using ʟ-carnosine-capped nanosilver because the interaction of ʟ-carnosine with different metal ions has already been reported [19]. The electrochemical detection of Hg2

• spectroscopy, TEM, SEM-EDX, and XRD. This comprehensive analysis elucidates the optical absorbance, sizes, surface charges, functional group interactions, elemental compositions, and diffraction patterns of ʟ-car-AgNPs. Furthermore, different sizes of ʟ-car-AgNPs (ʟ-car-AgNP1 to ʟ-car-AgNP5) were explored

Ultrablack color in velvet ant cuticle

• Vinicius Marques Lopez,
• Wencke Krings,
• Juliana Reis Machado,
• Stanislav Gorb and
• Rhainer Guillermo-Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1554–1565, doi:10.3762/bjnano.15.122

• defenses against predators. Given their characteristics and life habits, such as diurnal activity, striking colors, and inability to fly, it is expected that they would be frequent targets for predators. However, there is limited observational and experimental evidence documenting interactions between

The round-robin approach applied to nanoinformatics: consensus prediction of nanomaterials zeta potential

• Dimitra-Danai Varsou,
• Arkaprava Banerjee,
• Joyita Roy,
• Kunal Roy,
• Giannis Savvas,
• Haralambos Sarimveis,
• Ewelina Wyrzykowska,
• Mateusz Balicki,
• Tomasz Puzyn,
• Georgia Melagraki,
• Iseult Lynch and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 1536–1553, doi:10.3762/bjnano.15.121

• use of in silico methods allows for the identification of potential hazardous effects caused by NMs’ interactions with biological systems with a simultaneous decrease of workload, cost, research duration, and use of laboratory animals. Several computational approaches [7][8][9] and predictive models

• [26][27]. The computational prediction of the ZP of NMs (Figure 1) has been of high interest in the area of nanoinformatics during the last decade, given the role of surface charge in determining NMs interactions with membranes and in driving toxicity, whereby positively charged particles are

• the NanoSolveIT Hamaker tool (https://hamaker.cloud.nanosolveit.eu/). The Hamaker constant is a material-specific value that quantifies the strength of van der Waals interactions between NPs, depending on the materials and the surrounding medium. A higher (positive) Hamaker constant indicates stronger

Integrating high-performance computing, machine learning, data management workflows, and infrastructures for multiscale simulations and nanomaterials technologies

• Fabio Le Piane,
• Mario Vozza,
• Matteo Baldoni and
• Francesco Mercuri

Beilstein J. Nanotechnol. 2024, 15, 1498–1521, doi:10.3762/bjnano.15.119

• time and length scales, from atomic and molecular-level interactions to the macroscale, that govern the structural, mechanical, and thermal properties of materials [4][5]. More recently, data-driven approaches, such as machine learning (ML) and artificial intelligence (AI), are revolutionizing

• concept involves utilizing models to represent the underlying physics or chemistry of the system, while incorporating data-driven approaches to enhance the accuracy and predictive power of these models. Data-driven techniques provide valuable insights into the complex relationships and interactions within

• . Physics-based models are built upon fundamental principles and equations, capturing the underlying physics or chemistry of materials. These models describe the interactions between atoms, molecules, or particles, allowing researchers to simulate and predict material properties and behavior at different

Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

• Iqra Rahat,
• Pooja Yadav,
• Aditi Singhal,
• Mohammad Fareed,
• Jaganathan Raja Purushothaman,
• Mohammed Aslam,
• Raju Balaji,
• Sonali Patil-Shinde and
• Md. Rizwanullah

Beilstein J. Nanotechnol. 2024, 15, 1473–1497, doi:10.3762/bjnano.15.118

• , gut microbiota, and individual genetic differences. This variability leads to inconsistent therapeutic outcomes among different individuals, and food–drug interactions can further complicate dosing regimens and efficacy [32][33]. Further, conventional delivery methods often lack specificity, resulting

• , including phospholipids, cholesterol, and surfactants, play a crucial role in solubilizing lipophilic phytochemicals and facilitating interactions with biological membranes. The polymers provide structural stability, controlled release properties, and protection against premature degradation [40][41

Strain-induced bandgap engineering in 2D ψ-graphene materials: a first-principles study

• Kamal Kumar,
• Nora H. de Leeuw,
• Jost Adam and
• Abhishek Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 1440–1452, doi:10.3762/bjnano.15.116

• converged 8 × 8 × 1 k-point mesh, and the electronic wave functions were expanded within a basis set of plane waves with a 600 eV cutoff energy. The unwanted interactions between the periodic images of 2D sheets have been mitigated by incorporating a generous vacuum space of 13 Å into our simulation cell

Ion-induced surface reactions and deposition from Pt(CO)₂Cl₂ and Pt(CO)₂Br₂

• Mohammed K. Abdel-Rahman,
• Patrick M. Eckhert,
• Atul Chaudhary,
• Johnathon M. Johnson,
• Jo-Chi Yu,
• Lisa McElwee-White and
• D. Howard Fairbrother

Beilstein J. Nanotechnol. 2024, 15, 1427–1439, doi:10.3762/bjnano.15.115

• ability of data acquired from fundamental UHV surface science studies to provide insights that can be used to better understand the interactions between ions and precursors during IBID from inorganic precursors. Keywords: deposition; ion beam; nanostructure; organometallic; precursor; Introduction

• largely avoided by using noble gas ions like He+ [32][35] or Ar+ [21], which are commonly used in helium ion microscopes and focused ion beam milling instruments. In FIBID, ion-induced interactions can initiate a complex mixture of different processes including ion-induced deposition, secondary electron

• slower sputtering of Ru [23]. Another important factor unique to FIBID that governs deposit purity can be the chemical identity of the ion [33][59][60][61][62][63][64]. Interactions between ions and adsorbed precursors are momentum-driven, which results in the formation of nonvolatile deposits as well as

Lithium niobate on insulator: an emerging nanophotonic crystal for optimized light control

• Midhun Murali,
• Amit Banerjee and
• Tanmoy Basu

Beilstein J. Nanotechnol. 2024, 15, 1415–1426, doi:10.3762/bjnano.15.114

• light–matter interactions and enabling precise control over quantum states [4]. Attaining optimal light confinement represents a crucial goal in photonics, given that the inherent constraints on light confinement in conventional optical media or devices hinder the miniaturization and integration of

• and driving coherent interactions with the organic semiconductor molecules. Secondly, enabling the measurement of the evolution of stored energy and the differential reflectivity induced by the pump pulse, which is essential for monitoring the charging dynamics at a femtosecond resolution. The

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• ]. These direct anatomical interactions make the olfactory region the primary target for N2B delivery and bypass the BBB [21][44]. However, some factors, such as high mucociliary clearance and short retention time, small dosage volume, and the need for a drug delivery device, limit N2B delivery (Figure 2

• alternative route of administration [60]. For instance, Dhaliwal et al. presented a cationic liposomal formulation loaded with luciferase mRNA to evaluate the intranasal delivery to the brain in a murine model. Positively charged liposomes both enhance the interactions with anionic mRNA, leading to complexes

A biomimetic approach towards a universal slippery liquid infused surface coating

• Ryan A. Faase,
• Madeleine H. Hummel,
• AnneMarie V. Hasbrook,
• Andrew P. Carpenter and
• Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

• identifying the specific interactions between platelets and surfaces independent of protein adsorption or other events that may take place within whole blood and plasma studies. In our purified platelet system, we observed a 150% increase in adherent platelets on PDA–FDT–PFD compared to BSA and a 50% decrease

• gather information on isolated surface interactions, whereas the fibrin generation study was performed using PPP to investigate comprehensive hematologic behavior of the surfaces. This suggests that the SLIPS coating could have a high affinity for a passivating blood protein or low affinity for an active

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• structures. Simulating the cleaning strokes of the tarsal notch and tibial spur on contaminated antennae in Camponotus rufifemur ants demonstrated that both components effectively removed particles [141]. The cleaning occurs through both macroscopic contact and microscopic interactions between the cleaning

Nanoarchitectonics with cetrimonium bromide on metal nanoparticles for linker-free detection of toxic metal ions and catalytic degradation of 4-nitrophenol

• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2024, 15, 1312–1332, doi:10.3762/bjnano.15.106

• does not allow for interactions with ligands via ion–ion interactions. Therefore, multiple surface modifications or linkers must be used for selective interaction between ligand and CTAB-capped gold and silver nanoparticles [7][9]. Contaminants in form of heavy metals and pollutant such as 4

• ). Centrifuged CTAB-AuNR10.5 without NaOH showed no metal detection (Supporting Information File 1, Figure S11). Apart from the amount of added NaOH, the nanoparticle concentration in terms of OD also plays a significant role in the nanoparticle–metal interactions. Increasing the nanoparticle concentration

• NaOH (5–20 µL) (Supporting Information File 1, Figure S12). Color or plasmon band changes can be attributed to nanoparticle–metal interactions [51]. Other researchers also explored the role of NaOH; they found that NaOH is a potent molecule that helps to remove CTAB from nanoparticles by reducing the

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

• Romana Petry,
• James M. de Almeida,
• Francine Côa,
• Felipe Crasto de Lima,
• Diego Stéfani T. Martinez and
• Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

• -dependent mitigating effect on the toxicity of GO, which can be attributed not only to the surface interactions between the molecule and the material but also to the inherent biological properties of TA in C. elegans. Our findings contribute to a deeper understanding of GO’s environmental behavior and

• toxicity and highlight the potential of tannic acid for the synthesis and surface functionalization of graphene-based nanomaterials, offering insights into safer nanotechnology development. Keywords: biodistribution; density functional theory; ecotoxicity; molecular dynamics; surface interactions

• ions [8][9][10]. The physicochemical changes and interactions undergone by GO in the environment greatly influence the biological effects of this material. Recently, Bortolozzo et al. [11] showed that GO degradation by sodium hypochlorite resulted in the mitigation of GO toxicity to Caenorhabditis

New design of operational MEMS bridges for measurements of properties of FEBID-based nanostructures

• Bartosz Pruchnik,
• Krzysztof Kwoka,
• Ewelina Gacka,
• Dominik Badura,
• Piotr Kunicki,
• Andrzej Sierakowski,
• Paweł Janus,
• Tomasz Piasecki and
• Teodor Gotszalk

Beilstein J. Nanotechnol. 2024, 15, 1273–1282, doi:10.3762/bjnano.15.103

• structural effects present in the opMEMS bridges. Of particular importance was the presence of eigenstrains [39], which would affect the shape of the RoI after FIB milling. Eigenstrains can occur due to mismatches between the crystalline lattices of the deposited materials or due to interactions between

• shown that the leakage was not affected by gallium FIB milling or conductive FEBID deposition in the vicinity of the RoI. This is particularly important in the field of high-resistivity materials (e.g., FEBID) where the elimination of parasitic interactions is critical to the measurement. More

Dual-functionalized architecture enables stable and tumor cell-specific SiO₂NPs in complex biological fluids

• Iris Renata Sousa Ribeiro,
• Raquel Frenedoso da Silva,
• Romênia Ramos Domingues,
• Adriana Franco Paes Leme and
• Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

• -functionalized SiO2NPs involves their capability to generate reactive species of oxygen, along with electrostatic interactions of deprotonated silanol groups with membrane proteins and tetra alkyl ammonium groups, which are also present in red blood cell membranes [47][48][49][50]. The addition of the ZW

• compound possibly prevents these interactions, ensuring the colloidal stability of NPs without increasing hemolysis. It is noteworthy that for a material to be considered hemolytic, it must cause a percentage of hemolysis greater than 5% [36]. When the incubation was performed in DMEM (10% FBS), no

• hemolytic activity was observed, even for the non-functionalized NPs (Figure 3b). According to the literature [51][52], the protein corona suppresses hemolytic activity, as proteins induce modifications on the surfaces of NPs, altering the interactions between NPs and blood cells. When the functionalized

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• interface between small molecules and conventional NPs, and so they provide a unique opportunity to leverage distinctive properties inherent to both domains [25][29][30]. On one hand, usNPs and their conjugates can behave as biomolecules in terms of biomolecular interactions and physiological behavior [31

• imaging [20][40], and positron emission tomography [45][46]. In therapeutic applications, usNPs have been used for drug delivery as well as served as phototherapeutic agents and radiosensitizers [47][48][49][50][51]. A distinguishing feature of usNPs is their transient, short-lived interactions with

• proteins (Figure 2A) [52][53][54][55][56][57][58]. This occurs because of the small size and high surface curvature of usNPs, which restrict the binding interface for proteins. As a result, protein spreading and denaturation on the usNP surface are minimized, and fewer non-covalent interactions form

A low-kiloelectronvolt focused ion beam strategy for processing low-thermal-conductance materials with nanoampere currents

• Annalena Wolff,
• Nico Klingner,
• William Thompson,
• Yinghong Zhou,
• Jinying Lin and
• Yin Xiao

Beilstein J. Nanotechnol. 2024, 15, 1197–1207, doi:10.3762/bjnano.15.97

• community. This is partly due to the increased use of FIB-SEMs in biology as well as the development of complex materials, such as polymers, which need to be analyzed. The work presented here looks at the physics behind the ion beam–sample interactions and the effect of the incident ion energy (set by the

• light interactions with biological tissue [18] as well as focused electron beam-induced deposition (FEBID) [19]. The general approach to assess the beam-induced heat damage and undesired artifacts, regardless if working with ions [17], photons [18], or electrons [19], compares experiments to models

• based on heat transfer and to Monte Carlo or finite element simulations [17][18][19]. Open source programs that assess heat deposition and diffusion are readily available to assess damage in light–tissue interactions [18]. For electron beams, multidimensional models predicting electron beam-induced

AI-assisted models to predict chemotherapy drugs modified with C₆₀ fullerene derivatives

• Jonathan-Siu-Loong Robles-Hernández,
• Dora Iliana Medina,
• Katerin Aguirre-Hurtado,
• Marlene Bosquez,
• Roberto Salcedo and
• Alan Miralrio

Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95

• descriptors for predictive models. Besides, Pearson’s hard–soft acid–base (HSAB) theory suggests other descriptors to describe and predict the interactions between chemical species, such as those between a drug molecule as a ligand and a protein [32]. These quantitative values are based on the vertical

• theoretical study on the interactions and stability of paracetamol complexes with C60–COOH [35]. Consequently, this work proposes the interaction of C60–COOH fullerene with anticancer drugs. As a complement, a water-soluble fullerene predicted as stable at the normal human body temperature was proposed to

• study the interactions with doxorubicin and gemcitabine [36]. The water-soluble fullerene is introduced to avoid known mutagenic reactions related to breast cancer [36]. It was also studied as a potential carrier for bedaquiline, an agent against tuberculosis [37]. The current study only considered

Quantum-to-classical modeling of monolayer Ge₂Se₂ and its application in photovoltaic devices

• Anup Shrivastava,
• Shivani Saini,
• Dolly Kumari,
• Sanjai Singh and
• Jost Adam

Beilstein J. Nanotechnol. 2024, 15, 1153–1169, doi:10.3762/bjnano.15.94

• , respectively. All optimized structural parameters excellently match with previously reported values [41][42]. In addition to the lattice parameters for the monolayer Ge2Se2, we have optimized the vacuum slab in a normal direction to avoid interlayer interactions. The optimized vacuum level was found to be 23 Å

• (LDA) [67] or generalized gradient approximation (GGA) [68] for modeling the exchange–correlation. Hence, for greater accuracy, we have used the Perdew–Burke–Ernzerhof (PBE) [69] and Heyd–Scuseria–Ernzerhof (HSE06) [70] functionals to model the exchange–correlation interactions with a screening

• interlayer interactions. The stability of the Ge2Se2 monolayer was estimated by phonon dispersion. The phonon dispersion has been calculated using density functional perturbation theory (DFPT), as implemented in the QE package. To compute the phonon spectra, we have estimated the second-order interatomic

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• the outer electrons in larger atoms, which might reduce the efficiency of electronic interactions essential for binding or catalytic activity. Our nano-QSTR model suggests that the enzymatic activity of ZHE1 in zebrafish is influenced negatively by the total electronegativity of metals and the atomic

• . Conversely, MONPs with larger atomic radii and crystal ionic radii tend to exhibit a lower surface area-to-volume ratio, which can reduce their cellular interactions and uptake. This reduction in uptake can lead to less cellular dysfunction and toxicity. Larger atomic radii may result in MONPs that are less

Local work function on graphene nanoribbons

• Daniel Rothhardt,
• Amina Kimouche,
• Tillmann Klamroth and
• Regina Hoffmann-Vogel

Beilstein J. Nanotechnol. 2024, 15, 1125–1131, doi:10.3762/bjnano.15.91

• were covered by Au from the sample surface because of tip–sample interactions as we have observed a tip–sample contact prior to taking the data used here. All calculations were done using the Vienna Ab initio Simulation Package [28][29] (vasp-5.4.4) with the PBE functional [30] and a projector

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• interactions The accumulation of any type of NPs in the liver is generally accomplished because of the central role of the liver itself as a main metabolic and excretory organ in the body. The presence of fenestrations in the layers of liver sinusoidal endothelial cells (LSECs) and the absence of the

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• solvent using the Doppler approach, which measures particle velocity as a function of voltage. The determination of the zeta potential is crucial in understanding the mechanism of drug–nanoparticle interactions [66]. In addition to the methods described above, Fourier-transform infrared spectroscopy is

• modified alginate materials for mucoadhesive drug delivery. Scientists combined the alginate hydroxy groups with maleimid-terminated PEG. This novel mucoadhesive biopolymer exhibited polymer–mucus glycoprotein interactions. The results showed that the new alginate-based mucoadhesive matrix can enhance the

Effect of wavelength and liquid on formation of Ag, Au, Ag/Au nanoparticles via picosecond laser ablation and SERS-based detection of DMMP

• Sree Satya Bharati Moram,
• Chandu Byram and
• Venugopal Rao Soma

Beilstein J. Nanotechnol. 2024, 15, 1054–1069, doi:10.3762/bjnano.15.86

• material with the incoming beam, including absorption, reflection, and scattering [47][48]. These interactions significantly vary across the wavelengths from 1064 down to 355 nm, with a unique response of different materials at each wavelength [49]. A key to enhancing the yield is choosing the laser