Dual-functionalized architecture enables stable and tumor cell-specific SiO₂NPs in complex biological fluids

• Iris Renata Sousa Ribeiro,
• Raquel Frenedoso da Silva,
• Romênia Ramos Domingues,
• Adriana Franco Paes Leme and
• Mateus Borba Cardoso

Beilstein J. Nanotechnol. 2024, 15, 1238–1252, doi:10.3762/bjnano.15.100

• concentrated red blood cell (RBC) (type B+) plastic bags, collected according to their consent form for blood donation, were provided by the Hemocenter from the Faculty of Medicine at the University of Campinas, São Paulo, Brazil. First, the RBCs were washed three times with PBS (pH 7.4, 10 mM) followed by

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• . Keywords: active targeting; cancer; nanoclusters; renal clearance; ultrasmall nanoparticles; Review 1 Introduction Nanotechnology has opened new avenues for tackling unmet challenges in medicine [1][2][3]. In the field of oncology, a notable application involves the use of engineered nanoparticles (NPs

A low-kiloelectronvolt focused ion beam strategy for processing low-thermal-conductance materials with nanoampere currents

• Annalena Wolff,
• Nico Klingner,
• William Thompson,
• Yinghong Zhou,
• Jinying Lin and
• Yin Xiao

Beilstein J. Nanotechnol. 2024, 15, 1197–1207, doi:10.3762/bjnano.15.97

• Xiamen Medical College, Fujian, China School of Medicine and Dentistry, Griffith University, Gold Coast QLD 4222, Australia 10.3762/bjnano.15.97 Abstract Ion beam-induced heat damage in thermally low conductive specimens such as biological samples is gaining increased interest within the scientific

AI-assisted models to predict chemotherapy drugs modified with C₆₀ fullerene derivatives

• Jonathan-Siu-Loong Robles-Hernández,
• Dora Iliana Medina,
• Katerin Aguirre-Hurtado,
• Marlene Bosquez,
• Roberto Salcedo and
• Alan Miralrio

Beilstein J. Nanotechnol. 2024, 15, 1170–1188, doi:10.3762/bjnano.15.95

• in pharmacy and medicine is carbon-based nanomaterials because of their physicochemical, mechanical, electrical, thermal, and optical properties [19][20], as well as their capacity to modify existing drugs. Fullerene derivatives have been proposed recently, particularly those obtained from fullerene

• C60 [21]. The unmodified fullerene C60 is known as a “free radical sponge” because its double bonds tend to accept free radicals [22]. Because of its size, surface area, and capacity to extinguish or generate reactive oxygen species, C60 is very promising in medicine and clinical therapy [23][24]. It

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• Supratik Kar Siyun Yang Chemometrics and Molecular Modeling Laboratory, Department of Chemistry and Physics, Kean University, 1000 Morris Avenue, Union, NJ 07083, USA 10.3762/bjnano.15.93 Abstract Metal oxide nanoparticles (MONPs) are widely used in medicine and environmental remediation because

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• ), LAPTIAB 1, PUSPIPTEK, Tangerang Selatan 15314, Indonesia Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), LAPTIAB 1, PUSPIPTEK, Tangerang Selatan 15314, Indonesia 10.3762/bjnano.15.89 Abstract Over recent decades, nanomedicine has

• regenerative medicine. Aiming to improve the treatment outcomes, new nanomedicinal drugs and formulations have been reported on an almost daily basis for targeting various diseases. Until now, most nanomedicine applications have focused primarily on drug delivery and theranostic nanoplatforms for cancer

Unveiling the potential of alginate-based nanomaterials in sensing technology and smart delivery applications

• Shakhzodjon Uzokboev,
• Khojimukhammad Akhmadbekov,
• Ra’no Nuritdinova,
• Salah M. Tawfik and
• Yong-Ill Lee

Beilstein J. Nanotechnol. 2024, 15, 1077–1104, doi:10.3762/bjnano.15.88

• applications. Biodegradable and bioabsorbable polymers are an excellent choice for a variety of innovative drug delivery systems (DDSs). Biopolymers are also used in cutting-edge scientific applications such as gene expression, tissue engineering, smart drug delivery, and biosensors [11][19]. Modern medicine

• contamination with heavy metals are good examples of the need for sensors [23]. In addition, incurable diseases such as cancer can be detected by biosensors, and the application of biosensors is also very important for medicine and pharmaceuticals [18][24][25]. Natural biopolymers are abundant and exhibit

• ease discomfort. Gastric dressing occurs when sodium alginate and hydrochloric acid are combined in the stomach. Additionally, alginate can prevent obesity by lowering body weight [30]. All the qualities make sodium alginate indispensable for a wide range of applications in medicine and sensing. As a

Atomistic insights into the morphological dynamics of gold and platinum nanoparticles: MD simulations in vacuum and aqueous media

• Evangelos Voyiatzis,
• Eugenia Valsami-Jones and
• Antreas Afantitis

Beilstein J. Nanotechnol. 2024, 15, 995–1009, doi:10.3762/bjnano.15.81

• , from medicine and engineering to the environment and energy. Because of their small size, nanoparticles (NPs) have only been discovered relatively recently, although they have been present in the environment throughout earth’s and human history, emerging from various sources including biological

Identification of structural features of surface modifiers in engineered nanostructured metal oxides regarding cell uptake through ML-based classification

• Indrasis Dasgupta,
• Totan Das,
• Biplab Das and
• Shovanlal Gayen

Beilstein J. Nanotechnol. 2024, 15, 909–924, doi:10.3762/bjnano.15.75

• medicine, electronics, and environmental science. Understanding the structural aspects of surface modifiers in nanoparticles that govern their cellular uptake is crucial for optimizing their efficacy and minimizing potential cytotoxicity. The cellular uptake is influenced by multiple factors, namely, size

• nanoparticles consist of metal elements bonded with oxygen in intricate structures [3][4]. They exhibit exceptional physicochemical properties, which have led to their widespread utilization across various industries [5][6]. These nanomaterials are employed in, for example, electronics, cosmetics, and medicine

Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO₂/graphene quantum dot-modified electrode

• Vu Ngoc Hoang,
• Dang Thi Ngoc Hoa,
• Nguyen Quang Man,
• Le Vu Truong Son,
• Le Van Thanh Son,
• Vo Thang Nguyen,
• Le Thi Hong Phong,
• Ly Hoang Diem,
• Kieu Chan Ly,
• Ho Sy Thang and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 719–732, doi:10.3762/bjnano.15.60

• Vu Ngoc Hoang Dang Thi Ngoc Hoa Nguyen Quang Man Le Vu Truong Son Le Van Thanh Son Vo Thang Nguyen Le Thi Hong Phong Ly Hoang Diem Kieu Chan Ly Ho Sy Thang Dinh Quang Khieu University of Sciences, Hue University, Vietnam Tan Hiep High School, Kien giang, Vietnam University of Medicine and Pharmacy

Exfoliation of titanium nitride using a non-thermal plasma process

• Priscila Jussiane Zambiazi,
• Dolores Ribeiro Ricci Lazar,
• Larissa Otubo,
• Rodrigo Fernando Brambilla de Souza,
• Almir Oliveira Neto and
• Cecilia Chaves Guedes-Silva

Beilstein J. Nanotechnol. 2024, 15, 631–637, doi:10.3762/bjnano.15.53

• composition of TiN were preserved, the crystallite size was reduced. These TiN nanosheets have a great potential for a range of cutting-edge applications in fields such as medicine, catalysis, and energy-related technologies. Hence, further exploration and development of these TiN nanosheets are expected to

Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• (HUVECs) were obtained by Dr. Nancy Lorena Charó from the Institute of Experimental Medicine, CONICET-National Academy of Medicine, with the tenets of the Declaration of Helsinki and a protocol previously approved by the institution’s ethics committee. Briefly, the umbilical cord was collected after

Photocatalytic degradation of methylene blue under visible light by cobalt ferrite nanoparticles/graphene quantum dots

• Vo Chau Ngoc Anh,
• Le Thi Thanh Nhi,
• Le Thi Kim Dung,
• Dang Thi Ngoc Hoa,
• Nguyen Truong Son,
• Nguyen Thi Thao Uyen,
• Nguyen Ngoc Uyen Thu,
• Le Van Thanh Son,
• Le Trung Hieu,
• Tran Ngoc Tuyen and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 475–489, doi:10.3762/bjnano.15.43

• Vo Chau Ngoc Anh Le Thi Thanh Nhi Le Thi Kim Dung Dang Thi Ngoc Hoa Nguyen Truong Son Nguyen Thi Thao Uyen Nguyen Ngoc Uyen Thu Le Van Thanh Son Le Trung Hieu Tran Ngoc Tuyen Dinh Quang Khieu University of Pharmacy and Medicine, Hue University, Vietnam University of Sciences, Hue University

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• Biobehavioral Sciences, UCLA School of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095, USA 10.3762/bjnano.15.42 Abstract ᴅ-cycloserine (DCS), an FDA-approved medicine for the treatment of tuberculosis, is also a partial agonist at the glycine recognition site of N-methyl-ᴅ-aspartate (NMDA) receptor and

Potential of a deep eutectic solvent in silver nanoparticle fabrication for antibiotic residue detection

• Le Hong Tho,
• Bui Xuan Khuyen,
• Ngoc Xuan Dat Mai and
• Nhu Hoa Thi Tran

Beilstein J. Nanotechnol. 2024, 15, 426–434, doi:10.3762/bjnano.15.38

• , methemoglobinemia, allergy, damaged liver, nausea, and cancer [33][34][35][36]. Despite these side effects, they are illegally overused in the food industry and medicine, which threatens the human food chain and negatively affects public health [37]. By evaluating the SERS parameters of the Ag NPs-DES substrate

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• Nguyen Nhat Nam Nguyen Khoi Song Tran Tan Tai Nguyen Nguyen Ngoc Trai Nguyen Phuong Thuy Hoang Dang Khoa Do Nhu Hoa Thi Tran Kieu The Loan Trinh Applied Biology Center, School of Agriculture and Aquaculture, Tra Vinh University, Tra Vinh City 87000, Vietnam College of Korean Medicine, Gachon

• Antioxidants play an important role in the prevention of oxidative stress and have been widely used in medicine and healthcare. However, natural antioxidants have several limitations such as low stability, difficult long-term storage, and high cost of large-scale production. Along with significant advances in

• nanomaterials in medicine and healthcare are also discussed. This review provides a deeper understanding of the mechanisms of metal-based nanoantioxidants and a guideline for using these nanomaterials in medicine and healthcare. Keywords: antioxidant nanomaterial; healthcare; medicine; nanotechnology

Investigating ripple pattern formation and damage profiles in Si and Ge induced by 100 keV Ar⁺ ion beam: a comparative study

• Indra Sulania,
• Harpreet Sondhi,
• Tanuj Kumar,
• Sunil Ojha,
• G R Umapathy,
• Ambuj Mishra,
• Ambuj Tripathi,
• Richa Krishna,
• Devesh Kumar Avasthi and
• Yogendra Kumar Mishra

Beilstein J. Nanotechnol. 2024, 15, 367–375, doi:10.3762/bjnano.15.33

• electron microscopy; Introduction Scientific research varying from electronics to photonics, homeland security, high-resolution parallel patterning of magnetic media, biotechnology, and medicine are based upon nanotechnology. These applications require nanopatterning techniques to fabricate devices or

Ultrasensitive and ultrastretchable metal crack strain sensor based on helical polydimethylsiloxane

• Shangbi Chen,
• Dewen Liu,
• Weiwei Chen,
• Huajiang Chen,
• Jiawei Li and
• Jinfang Wang

Beilstein J. Nanotechnol. 2024, 15, 270–278, doi:10.3762/bjnano.15.25

• polydimethylsiloxane. Supporting Information Supporting Information File 16: Additional experimental data. Funding This work was financially supported by the Nursing Young Talent Project of Shanghai Jiao Tong University School of Medicine (No. JDHLRC-202304).

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• cancer cell growth, slowing their proliferation and disrupting mitotic regulation, leading to the stimulation of the tumor suppressor gene p53 and the inhibition or inactivation of various signaling pathways [31][32]. Its widespread adoption in medicine can be attributed to its strong therapeutic

Multiscale modelling of biomolecular corona formation on metallic surfaces

• Parinaz Mosaddeghi Amini,
• Ian Rouse,
• Julia Subbotina and
• Vladimir Lobaskin

Beilstein J. Nanotechnol. 2024, 15, 215–229, doi:10.3762/bjnano.15.21

• corona; Introduction The interface between biological systems and engineered materials has gained significant attention in recent years because of its wide range of applications, spanning from food to medicine and environmental science [1][2]. This interface plays a crucial role in ensuring the safety

Influence of conductive carbon and MnCo₂O₄ on morphological and electrical properties of hydrogels for electrochemical energy conversion

• Sylwia Pawłowska,
• Karolina Cysewska,
• Yasamin Ziai,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6

• history and a wide range of applications, especially in biology, medicine, tissue engineering, and pharmacy. The multitude of application areas is related to their exceptional properties: biocompatibility, biodegradability, nontoxicity, good permeability for substances dissolved in water (e.g., oxygen and

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• treatment of schistosomiasis Praziquantel It is not surprising that praziquantel is the most encapsulated drug. It remains the only effective frontline medicine to treat the disease, and is currently characterized by its exclusive and extensive use as an important antischistosomal drug [46]. However, PZQ

• is just one formulation of PZQ developed for pediatric use which is commercially available: Epiquantel (40 mg/kg), a liquid formulation produced by Eipico, an Egyptian pharmacy industry. However, this medicine is not distributed by WHO and, thus, few works tried to use nanotechnology to change the

• antioxidant, anticoagulant, anti-bacterial, immunostimulatory, and hepatotoxic protection properties [87][88][89]. Because of that, it has been used in traditional medicine to treat inflammation and pain [90]. Mohamed et al. [91] reported that bee venom administered in infected mice reduces worm burden, ova

Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment

• Lester Uy Vinzons,
• Guo-Chung Dong and
• Shu-Ping Lin

Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96

• Lester Uy Vinzons Guo-Chung Dong Shu-Ping Lin Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University, Taichung City 40227, Taiwan (R.O.C.) Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli County 35053

• . Acknowledgements Lester U. Vinzons carried out his thesis research under the auspices of the Doctoral Program in Tissue Engineering and Regenerative Medicine, National Chung Hsing University and National Health Research Institutes. The authors would like to thank Dr. Jiann-Yeu Chen and Hung-Yan Lin of the NCHU i

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• University, Phitsanulok 65000, Thailand Division of Microbiology, School of Medical Sciences, University of Phayao 56000, Thailand Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany 10.3762/bjnano.14.93 Abstract Curcumin (CUR), a polyphenolic compound, shows

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• Jonathan-Gabriel Nimz Pichayut Rerkshanandana Chiraphat Kloypan Ulrich Kalus Saranya Chaiwaree Axel Pruss Radostina Georgieva Yu Xiong Hans Baumler Institute of Transfusion Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany Division of Clinical Immunology and Transfusion Sciences

• 6000, Bulgaria 10.3762/bjnano.14.85 Abstract Hemoglobin-based oxygen carriers (HBOCs) as blood substitutes are one of the great hopes of modern transfusion and emergency medicine. After the major safety-relevant challenges of the last decades seem to be largely overcome, current developments have in

• might exist, independent of CD163 and also Hb. Keywords: CD163; HBOC; hemoglobin-based oxygen carriers; monocytes; phagocytosis; Introduction Blood transfusions save lives every day and have become an indispensable part of clinical practice in modern medicine. However, there have always been numerous