Ferroptosis induction by engineered liposomes for enhanced tumor therapy

• Alireza Ghasempour,
• Mohammad Amin Tokallou,
• Mohammad Reza Naderi Allaf,
• Mohsen Moradi,
• Hamideh Dehghan,
• Mahsa Sedighi,
• Mohammad-Ali Shahbazi and
• Fahimeh Lavi Arab

Beilstein J. Nanotechnol. 2025, 16, 1325–1349, doi:10.3762/bjnano.16.97

• advantages and impact on cancer therapy and diagnosis [17]. Therapies based on nanotechnology, such as the progressive delivery of nanoscale drugs, can provide precisely targeted treatment of malignant tissue with fewer side effects than traditional approaches [5][18]. Key benefits of nanodrug delivery

Deep-learning recognition and tracking of individual nanotubes in low-contrast microscopy videos

• Vladimir Pimonov,
• Said Tahir and
• Vincent Jourdain

Beilstein J. Nanotechnol. 2025, 16, 1316–1324, doi:10.3762/bjnano.16.96

• overall performance, although potentially reducing recognition accuracy. Automating recognition and tracking is essential for high-throughput video analysis, which is critical for understanding and modeling complex nanoscale phenomena. The differential video treatment approach, combined with the deep

Wavelength-dependent correlation of LIPSS periodicity and laser penetration depth in stainless steel

• Nitin Chaudhary,
• Chavan Akash Naik,
• Shilpa Mangalassery,
• Jai Prakash Gautam and
• Sri Ram Gopal Naraharisetty

Beilstein J. Nanotechnol. 2025, 16, 1302–1315, doi:10.3762/bjnano.16.95

• ); maximum LIPSS; penetration depth; Introduction Nanostructuring on surfaces plays a pivotal role in governing surface properties, and laser-induced periodic surface structures (LIPSS) have emerged as a potent method for achieving nanoscale surface modifications. Over the past decade, LIPSS and laser

• first time, we demonstrated the fabrication of ladder-like LIPSS over a large area, with controllable periodicities ranging from 250 to 1200 nm by selecting the appropriate femtosecond laser irradiation wavelength. These controlled nanoscale LIPSS can be created over a large surface area, limited only

Acrocomia aculeata oil-loaded nanoemulsion: development, anti-inflammatory properties, and cytotoxicity evaluation

• Verónica Bautista-Robles,
• Hady Keita,
• Edgar Julián Paredes Gamero,
• Layna Tayná Brito Leite,
• Jessica de Araújo Isaías Muller,
• Mônica Cristina Toffoli Kadri,
• Ariadna Lafourcade Prada and
• Jesús Rafael Rodríguez Amado

Beilstein J. Nanotechnol. 2025, 16, 1277–1288, doi:10.3762/bjnano.16.93

• counterpart [47]. The superior pharmacological response of the nanoemulsion may be attributed to the nanoscale droplet size, which increases the surface area-to-volume ratio, enhances solubility and stability, and promotes rapid absorption and cellular uptake [56]. The nanometric scale facilitates more

Better together: biomimetic nanomedicines for high performance tumor therapy

• Imran Shair Mohammad,
• Gizem Kursunluoglu,
• Anup Kumar Patel,
• Hafiz Muhammad Ishaq,
• Cansu Umran Tunc,
• Dilek Kanarya,
• Mubashar Rehman,
• Omer Aydin and
• Yin Lifang

Beilstein J. Nanotechnol. 2025, 16, 1246–1276, doi:10.3762/bjnano.16.92

• release behavior, targeting ability, and surface modifications [12][13][14][15]. A variety of nanoparticles have been researched including liposomes, polymer NPs, solid lipid NPs, and hybrid NPs [16]. Nanoscale drug carriers with the advantage of high penetration, long circulation, and significant

Functional bio-packaging enhanced with nanocellulose from rice straw and cinnamon essential oil Pickering emulsion for fruit preservation

• Tuyen B. Ly,
• Duong D. T. Nguyen,
• Hieu D. Nguyen,
• Yen T. H. Nguyen,
• Bup T. A. Bui,
• Kien A. Le and
• Phung K. Le

Beilstein J. Nanotechnol. 2025, 16, 1234–1245, doi:10.3762/bjnano.16.91

• ]. Encapsulation strategies, like Pickering emulsions (PEs) stabilized by bio-based particles, address these challenges [37]. Nanocellulose is a promising candidate for stabilizing Pickering emulsions because of its high surface area, nanoscale dimensions, and amphiphilic nature [20]. This not only improves the

Hydrogels and nanogels: effectiveness in dermal applications

• Jéssica da Cruz Ludwig,
• Diana Fortkamp Grigoletto,
• Daniele Fernanda Renzi,
• Wolf-Rainer Abraham,
• Daniel de Paula and
• Najeh Maissar Khalil

Beilstein J. Nanotechnol. 2025, 16, 1216–1233, doi:10.3762/bjnano.16.90

• prevention of the spontaneous combustion of coal [29]. The development of chemically functional materials on the nanoscale appears to be of fundamental importance when it comes to health applications. Nanogels are an excellent alternative for the manufacture of biomaterials due to their physical and chemical

• [158] and surface chemical functionalization [159], which helps to achieve high drug levels at the target site. Several strategies have been developed to obtain nanoscale or micrometric gels instead of macroscopic networks formed by a simple gelation process [20][160][161]. In emulsion polymerization

• polymerization before forming a continuous gel, the formation of small branched polymers at the nanoscale is favored over microgels [163]. This occurs because the growing chains are further apart, which makes bonds between different chains (intermolecular) more difficult and favors bonds within the same chain

Mechanical stability of individual bacterial cells under different osmotic pressure conditions: a nanoindentation study of Pseudomonas aeruginosa

• Lizeth García-Torres,
• Idania De Alba Montero,
• Eleazar Samuel Kolosovas-Machuca,
• Facundo Ruiz,
• Sumati Bhatia,
• Jose Luis Cuellar Camacho and
• Jaime Ruiz-García

Beilstein J. Nanotechnol. 2025, 16, 1171–1183, doi:10.3762/bjnano.16.86

• sample at the nanoscale. The force applied by the AFM tip on the sample is controlled by monitoring the deflection of an extremity of a micrometer mechanical lever onto which the tip is attached. In the study of pathogens, AFM excels in providing high-resolution topographic images while measurements are

• hypertonic conditions. Force–volume AFM demonstrated its capacity for testing the mechanical properties of multiple bacteria at once. This mechanical nanoscale mapping allowed us to successfully discriminate the minute variations in the surface topography of bacteria (h), their mechanical resistance to

Crystalline and amorphous structure selectivity of ignoble high-entropy alloy nanoparticles during laser ablation in organic liquids is set by pulse duration

• Robert Stuckert,
• Felix Pohl,
• Oleg Prymak,
• Ulrich Schürmann,
• Christoph Rehbock,
• Lorenz Kienle and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 1141–1159, doi:10.3762/bjnano.16.84

• can be classified as a kinetically controlled synthesis method, with thermodynamic contributions at the nanoscale which set the final NP structure during cooling [68]. Hence, thermodynamically metastable NP structures are generated, which are stable at elevated temperatures [69] and even under harsh

• ]. Those rules are very high cooling rates, the presence of at least three constituting elements, atomic size differences over 12%, a significant negative heat of mixing of major elements, small material dimensions (preferably at the nanoscale, favoring high cooling rates), and post-processing effects

Towards a quantitative theory for transmission X-ray microscopy

• James G. McNally,
• Christoph Pratsch,
• Stephan Werner,
• Stefan Rehbein,
• Andrew Gibbs,
• Jihao Wang,
• Thomas Lunkenbein,
• Peter Guttmann and
• Gerd Schneider

Beilstein J. Nanotechnol. 2025, 16, 1113–1128, doi:10.3762/bjnano.16.82

• nm, from which quantitative data are often extracted. For example, in materials science applications, nanoscale spectromicroscopy [5][6][7][8] is used to examine a sample around its absorption edges, which provides insights into its electronic structure. In biomedical applications [9][10][11][12

Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts

• Sevin Adiguzel,
• Nilay Cicek,
• Zehra Cobandede,
• Feray B. Misirlioglu,
• Hulya Yilmaz and
• Mustafa Culha

Beilstein J. Nanotechnol. 2025, 16, 1068–1081, doi:10.3762/bjnano.16.78

• microscopy (PFM, Nanomagnetic Instruments, UK) was applied to evaluate nanoscale piezoelectric behavior using self-aligned conducting EFM probes with a spring constant of 2.8 N/m and a resonance frequency of 75 kHz. In vitro analyses To investigate the influence of hBNs and BaTiO3 with US therapy on

Soft materials nanoarchitectonics: liquid crystals, polymers, gels, biomaterials, and others

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2025, 16, 1025–1067, doi:10.3762/bjnano.16.77

• development of more sophisticated functional materials. Concurrently with the transition from hard to soft, there is also a significant trend in the advancement of materials sciences from the macroscale to the nanoscale. In other words, the ability to control the structures of materials at the nanoscale (i.e

• such as quantum dots [95][96][97][98][99], the nanoscale of size and dimensions can result in properties that are not attainable with bulk materials. In other words, the key to developing functionality and improving properties lies in controlling the nanostructure in addition to the creation of the

• construction of functional materials from nanoscale units using a variety of materials processes (Figure 1) [125]. It is evident that the integration of knowledge and technology from both nanotechnology and materials sciences is imperative. Nanoarchitectonics may be regarded as a convergence of nanotechnology

Time-resolved probing of laser-induced nanostructuring processes in liquids

• Maximilian Spellauge,
• David Redka,
• Mianzhen Mo,
• Changyong Song,
• Heinz Paul Huber and
• Anton Plech

Beilstein J. Nanotechnol. 2025, 16, 968–1002, doi:10.3762/bjnano.16.74

• scattering; Review Introduction Laser synthesis and processing of materials with emphasis on structure formation on the nanoscale offers a multitude of pathways to desired structure-related functions [1]. In green processes, nanostructures and nanoparticles (NPs) can be produced that serve applications in

• ) simulations [36][37] are widely used to predict phase transitions or structure formation on the nanoscale [38][39], but ultimately also require interfacing the simulations with other models, such as TTM [40][41] or large-scale hydrodynamics [42][43][44][45]. This integration approach leads to computationally

• single-pulse, single-particle imaging using XFELs has enabled nanoscale-resolution observations of ultrafast irreversible processes. XFELs’ unique combination of spatial coherence, ultrahigh brightness, and femtosecond pulse durations provides a powerful probe for studying interactions between strong

Synthesis of biowaste-derived carbon-dot-mediated silver nanoparticles and the evaluation of electrochemical properties for supercapacitor electrodes

• Navya Kumari Tenkayala,
• Chandan Kumar Maity,
• Md Moniruzzaman and
• Subramani Devaraju

Beilstein J. Nanotechnol. 2025, 16, 933–943, doi:10.3762/bjnano.16.71

• PG-CDs exhibited intense blue fluorescence (inset in Figure 1a), indicating the successful formation and photoluminescent nature of CDs. The formation of PG-CDs-AgNPs in the nanoscale is established by UV–visible spectroscopy by the appearance of SPR peaks at 475 nm [26]. The gradual emergence of

• PG-CDs-AgNPs was determined using the Brunauer–Emmett–Teller (BET) analysis via the N2 adsorption–desorption method, and equivalent BET isotherms are depicted in Supporting Information File 1, Figure S1a. The surface area of PG-CDs-AgNPs was found to be 83.04 m2/g. A uniform nanoscale particle

Synthesis and magnetic transitions of rare-earth-free Fe–Mn–Ni–Si-based compositionally complex alloys at bulk and nanoscale

• Shabbir Tahir,
• Tatiana Smoliarova,
• Carlos Doñate-Buendía,
• Michael Farle,
• Natalia Shkodich and
• Bilal Gökce

Beilstein J. Nanotechnol. 2025, 16, 823–836, doi:10.3762/bjnano.16.62

• for Ge-based CCA and Tc = 263 K for Al-based CCA. At the nanoscale, both Ge- and Al-based NPs exhibit superparamagnetic behaviour, with blocking temperatures of TB ≈ 120 K for Ge-based NPs (xc = 13.4 ± 15.5 nm, average particle size) and TB ≈ 100 K for Al-based NPs (xc = 18.4 ± 9.1 nm, average

• particle size), demonstrating the intrinsic superparamagnetic nature of NPs. While the Ge-based CCA demonstrates almost twice the saturation magnetization (Ms) and ≈20% lower hysteresis (Hc) in bulk form, the Al-based CCA exhibits comparable Ms and ≈45% lower Hc at the nanoscale at 5 K. These results

• indicate that the Al-based CCA is a promising, cost-effective alternative to Ge-based CCA at nanoscale, providing an economically viable and cost-effective alternative for nanoscale-based applications. Keywords: compositionally complex alloys; magnetic phase transition; nanoparticles; pulsed laser

Supramolecular hydration structure of graphene-based hydrogels: density functional theory, green chemistry and interface application

• Hon Nhien Le,
• Duy Khanh Nguyen,
• Minh Triet Dang,
• Huyen Trinh Nguyen,
• Thi Bang Tam Dao,
• Trung Do Nguyen,
• Chi Nhan Ha Thuc and
• Van Hieu Le

Beilstein J. Nanotechnol. 2025, 16, 806–822, doi:10.3762/bjnano.16.61

• advance nanoscale properties and nanotechnology applications. Keywords: antibacterial coating; bioinspired hydration; density functional theory; graphene-based hydrogel; supramolecular structure; Introduction Biological cells are assemblies of biomolecules that are hydrated with water molecules. The

• plays an important role in the stability and functionality of nanoscale structures. Van der Waals forces are supramolecular intermolecular interactions that govern the agglomeration of nanomaterials. Carbon nanostructures with π-conjugated systems (fullerene, carbon nanotube, and graphene) have π–π

• hydrogel in Figure 2a is biomimetic to the natural system of biological cells described in Figure 2b. Hydration shells on GO-SG-ZH nanosheets, particularly the first interfacial water layer, generate hydration forces to maintain intersheet distances and nanoscale structures in the artificial system. The

Changes of structural, magnetic and spectroscopic properties of microencapsulated iron sucrose nanoparticles in saline

• Sabina Lewińska,
• Pavlo Aleshkevych,
• Roman Minikayev,
• Anna Bajorek,
• Mateusz Dulski,
• Krystian Prusik,
• Tomasz Wojciechowski and
• Anna Ślawska-Waniewska

Beilstein J. Nanotechnol. 2025, 16, 762–784, doi:10.3762/bjnano.16.59

• nonintentional dopants in the FS0 sample, while the Cu and Cr peaks are related to technical aspects of the measurement. TEM results of the FST sample (Figure 3g,h) state in contrast to the FS0 sample. Many irregular, nanoscale objects attached to micrometer ones can be distinguished, however the core–shell

• structure vanished. In the TEM dark-field images, the metallic cores were not stated, which suggests that observed nanoscale structures represent post-dissolution residues such as water-insoluble SiO2 or cellulose. The lack of core–shell structures in TEM images taken from FST does not indicate their total

• nanoscale amorphous grains exhibit averaged, broad X-ray scattering maxima, in contrast to the sharp diffraction maxima from a crystalline material [30][31]. The prediction of the amorphous iron-containing phase is based on XRD contrasts with the TEM images, which registered the crystalline structure of the

Thickness dependent oxidation in CrCl₃: a scanning X-ray photoemission and Kelvin probe microscopies study

• Shafaq Kazim,
• Rahul Parmar,
• Maryam Azizinia,
• Matteo Amati,
• Muhammad Rauf,
• Andrea Di Cicco,
• Seyed Javid Rezvani,
• Dario Mastrippolito,
• Luca Ottaviano,
• Tomasz Klimczuk,
• Luca Gregoratti and
• Roberto Gunnella

Beilstein J. Nanotechnol. 2025, 16, 749–761, doi:10.3762/bjnano.16.58

• correlation between the microscopic results and the surface potential of CrCl3 flakes at the nanoscale level using Kelvin probe force microscopy (KPFM) [28]. KPFM is mainly employed to measure the local contact potential difference between the conductive AFM tip and the sample, allowing for high-resolution

Synthesis of a multicomponent cellulose-based adsorbent for tetracycline removal from aquaculture water

• Uyen Bao Tran,
• Ngoc Thanh Vo-Tran,
• Khai The Truong,
• Dat Anh Nguyen,
• Quang Nhat Tran,
• Huu-Quang Nguyen,
• Jaebeom Lee and
• Hai Son Truong-Lam

Beilstein J. Nanotechnol. 2025, 16, 728–739, doi:10.3762/bjnano.16.56

• Field-emission SEM analysis was performed using a Merlin Compact instrument (Carl Zeiss, Jena, Germany) with an SE2 detector. The sample was mounted on a clean silicon wafer and coated with a nanoscale platinum layer using an ion sputter coater (Q150T Plus, Quorum Technologies, UK). EDX analysis was

Efficiency of single-pulse laser fragmentation of organic nutraceutical dispersions in a circular jet flow-through reactor

• Tina Friedenauer,
• Maximilian Spellauge,
• Alexander Sommereyns,
• Verena Labenski,
• Tuba Esatbeyoglu,
• Christoph Rehbock,
• Heinz P. Huber and
• Stephan Barcikowski

Beilstein J. Nanotechnol. 2025, 16, 711–727, doi:10.3762/bjnano.16.55

• iron phthalocyanines (FePc), but also some purely organic dyes such as naphthalocyanides [25], perylenes [26], perylene diimides [27][28], fullerenes [29][30], and quinacridones [2][31] have been successfully downsized to the nanoscale using nanosecond- and femtosecond-LFL with wavelengths in the UV

• greater intracellular uptake and increased cytotoxicity on rat C6 glioma cells [36]. Laser-generated nanoscale cinnamon was also synthesized and showed enhanced antibacterial activity against Gram-negative and Gram-positive bacteria after particle size reduction compared to the unirradiated educt [37

Nanostructured materials characterized by scanning photoelectron spectromicroscopy

• Matteo Amati,
• Alexey S. Shkvarin,
• Alexander I. Merentsov,
• Alexander N. Titov,
• María Taeño,
• David Maestre,
• Sarah R. McKibbin,
• Zygmunt Milosz,
• Ana Cremades,
• Rainer Timm and
• Luca Gregoratti

Beilstein J. Nanotechnol. 2025, 16, 700–710, doi:10.3762/bjnano.16.54

• four decades, several important upgrades have spread the original ability of XPS of chemical analysis to include, for instance, band mapping through angle resolved measurements (ARPES), spin detection, and imaging or spectromicroscopy at a nanoscale spatial resolution [9][10]. It is worth noting that

• several improvements have been developed at synchrotron light facilities where unique properties of X-ray radiation can be found. Scanning photoelectron microscopy (SPEM) combines XPS analysis with lateral resolution; chemical imaging as well as XPS spectroscopy at nanoscale sized areas can be performed

• operando studies of technologically relevant nanoscale heterostructure devices. Self-organized NiO microcavity arrays fabricated by thermal treatments In the class of the very few p-type oxides, NiO stands out as one of the most versatile and promising materials in diverse applications including

Nanoscale capacitance spectroscopy based on multifrequency electrostatic force microscopy

• Pascal N. Rohrbeck,
• Lukas D. Cavar,
• Franjo Weber,
• Peter G. Reichel,
• Mara Niebling and
• Stefan A. L. Weber

Beilstein J. Nanotechnol. 2025, 16, 637–651, doi:10.3762/bjnano.16.49

• method for nanoscale capacitance characterization at arbitrary frequencies above the second cantilever resonance. Besides a high spatial resolution, the key advantage of the multifrequency approach of MFH-EFM is that it measures the second-order capacitance gradient at almost arbitrary frequencies

• nanoscale systems across materials science, biology, and nanotechnology, complementing established methods in the field. Keywords: atomic force microscopy; capacitance gradients; dielectric constant; dielectric spectroscopy; heterodyne frequency mixing; Kelvin probe force microscopy; multifrequency AFM

• understanding of material properties, particularly at the nanoscale, where phenomena such as quantum confinement, interface effects, and defect dynamics play a critical role. Innovations in characterization techniques have enabled researchers to explore these properties with unprecedented precision, paving the

Focused ion and electron beams for synthesis and characterization of nanomaterials

• Aleksandra Szkudlarek

Beilstein J. Nanotechnol. 2025, 16, 613–616, doi:10.3762/bjnano.16.47

• effects noted in water-assisted graphene etching [11]. While controlling the purity of deposits appears more straightforward, achieving precise nanoscale shapes remains challenging, particularly when structures are fabricated in close proximity. Experimental results demonstrate that FEBID, followed by

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• that respond to light are novel technologies in medicine. They are administered to improve the healing of wounds by responding to particular light wavelengths. Such sophisticated materials are enabled by micro- and nanoscale structures that enhance their tissue interactions and provide more focused

Nanomaterials in targeting amyloid-β oligomers: current advances and future directions for Alzheimer's disease diagnosis and therapy

• Shiwani Randhawa,
• Trilok Chand Saini,
• Manik Bathla,
• Rahul Bhardwaj,
• Rubina Dhiman and
• Amitabha Acharya

Beilstein J. Nanotechnol. 2025, 16, 561–580, doi:10.3762/bjnano.16.44

• detection and treatment of AβOs in AD. Because of their nanoscale size, NMs can interact with biological systems in ways that traditional treatments cannot. Their unique properties such as high surface area, quantum effects, and specific physicochemical traits make them ideal for developing advanced

• potential utility as diagnostic biomarkers for early AD detection [81][82]. Researchers are exploring the potential of exosomes as diagnostic tools, leveraging their ability to carry these pathological proteins. Exosomes hold significant diagnostic potential because of their nanoscale size and the distinct