Scavenging of reactive oxygen species by phenolic compound-modified maghemite nanoparticles

• Małgorzata Świętek,
• Yi-Chin Lu,
• Rafał Konefał,
• Liliana P. Ferreira,
• M. Margarida Cruz,
• Yunn-Hwa Ma and
• Daniel Horák

Beilstein J. Nanotechnol. 2019, 10, 1073–1088, doi:10.3762/bjnano.10.108

• , targeting tumor sites using an external magnetic field, MRI contrast agents, or magnetic hyperthermia. Under physiological conditions, the nanoparticle surface is exposed to the action of biomolecules, oxygen, peroxides, and radicals, which changes particle properties and behavior. Moreover, Fe2+ ions can

Enhanced inhibition of influenza virus infection by peptide–noble-metal nanoparticle conjugates

• Zaid K. Alghrair,
• David G. Fernig and
• Bahram Ebrahimi

Beilstein J. Nanotechnol. 2019, 10, 1038–1047, doi:10.3762/bjnano.10.104

• allows for the detection at very low levels, using a range of approaches, from absorbance [17][18] to photothermal microscopy [19] and various extensions of the latter [20][21]. Noble-metal nanoparticles can be passivated and functionalised with biomolecules such that they possess the biological

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

• Katrin Partikel,
• Robin Korte,
• Dennis Mulac,
• Hans-Ulrich Humpf and
• Klaus Langer

Beilstein J. Nanotechnol. 2019, 10, 1002–1015, doi:10.3762/bjnano.10.101

• ]. Nevertheless, FBS is still widely used as protein source for the investigation of the reaction at the interface between NPs and biomolecules [14][18]. Consequently, we propose to examine the protein corona formation in the respective medium of the desired species (e.g., murine or human) for a better prediction

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

• Boris N. Khlebtsov,
• Andrey M. Burov,
• Timofey E. Pylaev and
• Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

• ], Fe3O4 [35], graphene [36], and many others [37][38]. The PDA shell surface contains numerous catechol and quinone groups suitable for click conjugation with various biomolecules through Michael addition and Schiff-base reaction [39][40]. The high loading capacity and biocompatibility of the PDA layer

Mechanical and thermodynamic properties of Aβ₄₂, Aβ₄₀, and α-synuclein fibrils: a coarse-grained method to complement experimental studies

• Adolfo B. Poma,
• Horacio V. Guzman,
• Mai Suan Li and
• Panagiotis E. Theodorakis

Beilstein J. Nanotechnol. 2019, 10, 500–513, doi:10.3762/bjnano.10.51

• experimental observations. Keywords: β-amyloid; atomic force microscopy, mechanical deformation; molecular simulation; proteins; α-synuclein; Introduction All-atom molecular dynamics (MD) simulations have been employed to study the physical and chemical behaviour of the fundamental biomolecules of life (e.g

• ], AFM base-force spectroscopy [51], or by the design of sophisticated microelectromechanical systems (MEMS) [52]. These techniques have been successfully used to predict the elastic properties of several biomolecules. However, OT are limited to applied loads below 0.1 nN and AFM has delicate calibration

• range of applications of AFM technique span from biomolecules to single cells [31][56][57]. The AFM nanoindentation force–distance curves typically depend on the correct determination of the cantilever stiffness and only measurements of biological fibrils located at the centre of the fibril are

Surface plasmon resonance enhancement of photoluminescence intensity and bioimaging application of gold nanorod@CdSe/ZnS quantum dots

• Siyi Hu,
• Yu Ren,
• Yue Wang,
• Jinhua Li,
• Junle Qu,
• Liwei Liu,
• Hanbin Ma and
• Yuguo Tang

Beilstein J. Nanotechnol. 2019, 10, 22–31, doi:10.3762/bjnano.10.3

• and they show excellent quantum confinement for charge carrier and lattice mismatch. In such cases, the energy range of the QDs depends on the relative conduction and valence band offsets for the two materials, and this characteristic can enable many chemical materials or biomolecules to conjugate

The nanoscaled metal-organic framework ICR-2 as a carrier of porphyrins for photodynamic therapy

• Jan Hynek,
• Sebastian Jurík,
• Martina Koncošová,
• Jaroslav Zelenka,
• Ivana Křížová,
• Tomáš Ruml,
• Kaplan Kirakci,
• Ivo Jakubec,
• František Kovanda,
• Kamil Lang and
• Jan Demel

Beilstein J. Nanotechnol. 2018, 9, 2960–2967, doi:10.3762/bjnano.9.275

• internalisation by cells [18]. Moreover, the downsizing of MOFs also facilitates the diffusion of O2(1∆g), and makes interactions with bulky biomolecules inside the cells more effective. This concept was successfully applied using the UiO-66 family of MOFs: nanoparticles made of Hf6-based SBUs with dicarboxylic

Charged particle single nanometre manufacturing

• Philip D. Prewett,
• Cornelis W. Hagen,
• Claudia Lenk,
• Steve Lenk,
• Marcus Kaestner,
• Tzvetan Ivanov,
• Ahmad Ahmad,
• Ivo W. Rangelow,
• Xiaoqing Shi,
• Stuart A. Boden,
• Alex P. G. Robinson,
• Dongxu Yang,
• Sangeetha Hari,
• Marijke Scotuzzi and
• Ejaz Huq

Beilstein J. Nanotechnol. 2018, 9, 2855–2882, doi:10.3762/bjnano.9.266

• example, is interesting for the localisation and analysis of biomolecules. Miyazoe [91] used a conventional SEM fitted with an external reservoir for precursor injection to etch holes as small as 18 nm in diameter in a thin carbon membrane using both H2O and XeF2. Yemini [92] fabricated a nanopore array

Accurate control of the covalent functionalization of single-walled carbon nanotubes for the electro-enzymatically controlled oxidation of biomolecules

• Naoual Allali,
• Veronika Urbanova,
• Mathieu Etienne,
• Xavier Devaux,
• Martine Mallet,
• Brigitte Vigolo,
• Jean-Joseph Adjizian,
• Chris P. Ewels,
• Sven Oberg,
• Alexander V. Soldatov,
• Edward McRae,
• Yves Fort,
• Manuel Dossot and
• Victor Mamane

Beilstein J. Nanotechnol. 2018, 9, 2750–2762, doi:10.3762/bjnano.9.257

• putting oxidative defects on their sidewalls and extremities to decrease their hydrophobicity, ii) to use non-covalent interaction with hydrophilic biomolecules or surfactants [15][16][17][18] or iii) to use covalently grafted polyethyleneglycol (PEG) linkers, as described by us [9][11][12]. Many studies

Low cost tips for tip-enhanced Raman spectroscopy fabricated by two-step electrochemical etching of 125 µm diameter gold wires

• Antonino Foti,
• Francesco Barreca,
• Enza Fazio,
• Cristiano D’Andrea,
• Paolo Matteini,
• Onofrio Maria Maragò and
• Pietro Giuseppe Gucciardi

Beilstein J. Nanotechnol. 2018, 9, 2718–2729, doi:10.3762/bjnano.9.254

• tested on dyes, pigments and biomolecules and enhancement factors higher than 105 are observed. TERS mapping with a spatial resolution of 5 nm is demonstrated. Keywords: amyloid; enhanced spectroscopy; gold tips; plasmonics; TERS; Introduction Tip-enhanced Raman spectroscopy (TERS) combines the

• times of approximately 2 min. The tips can be easily manipulated and safely mounted, by gluing or clamping them into STM- or ShF-based TERS setups. The good performance of the tips is highlighted by TERS spectra of dyes, pigments and biomolecules. The enhancement factor in the range of 104–105 was found

• on the shaft (red line). Typical laser powers are 1.0–2.5 mW and integration times are 0.5–1.0 s per pixel. TERS spectra of dyes, pigments and biomolecules The tips have been applied to evaluate the spectra of analyze standard dye molecules such as rhodamine 6G (R6G), crystal violet (CV), methylene

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe₂O₃ nanoparticles towards human tumor cells

• Zdeněk Plichta,
• Yulia Kozak,
• Rostyslav Panchuk,
• Viktoria Sokolova,
• Matthias Epple,
• Lesya Kobylinska,
• Pavla Jendelová and
• Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

• chemical attachment of target biomolecules, reduces cytotoxicity, and controls particle uptake by the cells [10]. Coatings can be either of low molecular weight, such are carbohydrates and organic acids (ethylenediaminetetraacetic acid, tartaric acid, citric acid, succinic acid, bisphosphonic acid), or of

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

• Shanid Mohiyuddin,
• Saba Naqvi and
• Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

• nanomaterial was found to be toxic in some metal-based NPs (e.g., gold, silver, iron, and copper), while the bulk counterparts showed less toxicity [9]. The metal ions present at the surface of the particles were found to interact with biomolecules at a comparatively higher rate in nanoformulations compared to

ZnO-nanostructure-based electrochemical sensor: Effect of nanostructure morphology on the sensing of heavy metal ions

• Marina Krasovska,
• Vjaceslavs Gerbreders,
• Irena Mihailova,
• Andrejs Ogurcovs,
• Eriks Sledevskis,
• Andrejs Gerbreders and
• Pavels Sarajevs

Beilstein J. Nanotechnol. 2018, 9, 2421–2431, doi:10.3762/bjnano.9.227

• molecular recognition device based on the nanostructures of metal oxides for biomolecules detection”.

Electrospun one-dimensional nanostructures: a new horizon for gas sensing materials

• Muhammad Imran,
• Nunzio Motta and
• Mahnaz Shafiei

Beilstein J. Nanotechnol. 2018, 9, 2128–2170, doi:10.3762/bjnano.9.202

Quantitative comparison of wideband low-latency phase-locked loop circuit designs for high-speed frequency modulation atomic force microscopy

• Kazuki Miyata and
• Takeshi Fukuma

Beilstein J. Nanotechnol. 2018, 9, 1844–1855, doi:10.3762/bjnano.9.176

• subnanometer-scale imaging of biomolecules [15][16][17]. Moreover, three-dimensional (3D) imaging techniques have been developed based on FM-AFM and used to visualize 3D distributions of hydration structures as well as flexible surface structures at solid–liquid interfaces [18][19][20][21][22]. Although FM-AFM

• enables atomic-scale measurements to be performed in vacuum and in liquids, its imaging speed is relatively slow (ca. 1 min/frame). High-speed amplitude modulation AFM has been developed [23] and employed to visualize the dynamic behavior of biomolecules in liquids at 10–100 ms/frame [24]. However, its

A visible-light-controlled platform for prolonged drug release based on Ag-doped TiO₂ nanotubes with a hydrophobic layer

• Caihong Liang,
• Jiang Wen and
• Xiaoming Liao

Beilstein J. Nanotechnol. 2018, 9, 1793–1801, doi:10.3762/bjnano.9.170

• comprised of UV light, which can cause the denaturation or decomposition of some biomolecules and organic matter. As a result, such a trigger mechanism may not be the ideal way in an environment with adequate solar or natural light. Xu et al. [25] found a solution for enhancing the utilization of natural

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

• Jaison Jeevanandam,
• Ahmed Barhoum,
• Yen S. Chan,
• Alain Dufresne and
• Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

Mechanistic insights into plasmonic photocatalysts in utilizing visible light

• Kah Hon Leong,
• Azrina Abd Aziz,
• Lan Ching Sim,
• Pichiah Saravanan,
• Min Jang and
• Detlef Bahnemann

Beilstein J. Nanotechnol. 2018, 9, 628–648, doi:10.3762/bjnano.9.59

• , algae, bacteria and yeasts [156][157][158][159][160][161]. Different types of biomolecules available in plants, for example, polysaccharides, phenolics, or flavonoids are capable of producing metal nanoparticles of different sizes and shapes [162]. This phytosynthesis is more favourable than that which

Wafer-scale bioactive substrate patterning by chemical lift-off lithography

• Chong-You Chen,
• Chang-Ming Wang,
• Hsiang-Hua Li,
• Hong-Hseng Chan and
• Wei-Ssu Liao

Beilstein J. Nanotechnol. 2018, 9, 311–320, doi:10.3762/bjnano.9.31

• with controllable density, and offers sufficient space for biorecognition under the adjustment of experimental conditions. We believe that this CLL-treated surface can be used in conjunction with various biomolecules and a convenient approach to fabricate large-scale bioactive substrates with well

Liquid-crystalline nanoarchitectures for tissue engineering

• Baeckkyoung Sung and
• Min-Ho Kim

Beilstein J. Nanotechnol. 2018, 9, 205–215, doi:10.3762/bjnano.9.22

• phase or in a 3D orthorhombic phase. Examples of bioengineered materials displaying LC phases DNA is one of the most frequently used biomolecules in the field of biomedical engineering and bioinspired technology [35]. The DNA mesophase has been exploited for several applications, including biosensors

Patterning of supported gold monolayers via chemical lift-off lithography

• Liane S. Slaughter,
• Kevin M. Cheung,
• Sami Kaappa,
• Huan H. Cao,
• Qing Yang,
• Thomas D. Young,
• Andrew C. Serino,
• Sami Malola,
• Jana M. Olson,
• Stephan Link,
• Hannu Häkkinen,
• Anne M. Andrews and
• Paul S. Weiss

Beilstein J. Nanotechnol. 2017, 8, 2648–2661, doi:10.3762/bjnano.8.265

• ]. We have used CLL on gold to control the placement and nanoscale environment around surface-immobilized biomolecules and to simplify patterning steps in device fabrication [1][2][7][8][9][10][11][12][13]. Two-dimensional (2D) materials have proven to be extremely rich in terms of new and potentially

Direct writing of gold nanostructures with an electron beam: On the way to pure nanostructures by combining optimized deposition with oxygen-plasma treatment

• Domagoj Belić,
• Mostafa M. Shawrav,
• Emmerich Bertagnolli and
• Heinz D. Wanzenboeck

Beilstein J. Nanotechnol. 2017, 8, 2530–2543, doi:10.3762/bjnano.8.253

• Figure 5b, indicate that the O-plasma cleaning exposed some of the embedded Au nanocrystallites to the exterior. Such purified patterned nanostructures are deemed very suitable for further functionalization, e.g., for immobilization of biomolecules or similar applications where having clean Au surfaces

Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology

• Clelia Galati,
• Natalia Spinella,
• Lucio Renna,
• Danilo Milardi,
• Francesco Attanasio,
• Michele Francesco Maria Sciacca and
• Corrado Bongiorno

Beilstein J. Nanotechnol. 2017, 8, 2446–2453, doi:10.3762/bjnano.8.243

• features of the used system [27]. An additional advantage is the ease of implementing on it consolidated coating methods for the hosting of biomolecules. In this work, for peptide immobilization in a microarray format, we propose one of the most common functionalization methods (an epoxysilane) although

• methods for the hosting of biomolecules and its simple structure which allows a fabrication with high reproducibility. In particular, the ability of two different peptides to bind full-length Aβ peptides has simultaneously been studied, using concentrations in a range in which the Aβ peptide is known to

Expanding the molecular-ruler process through vapor deposition of hexadecanethiol

• Alexandra M. Patron,
• Timothy S. Hooker,
• Daniel F. Santavicca,
• Corey P. Causey and
• Thomas J. Mullen

Beilstein J. Nanotechnol. 2017, 8, 2339–2344, doi:10.3762/bjnano.8.233

• the field allow for the fabrication of molecular-scale features into surfaces that template the assembly and growth of metals, polymers, biomolecules, and cellular structures [3][4][5][6][7][8][9][10][11]. In addition, these surface assemblies have been utilized as molecular-scale resists for

Advances and challenges in the field of plasma polymer nanoparticles

• Andrei Choukourov,
• Pavel Pleskunov,
• Daniil Nikitin,
• Valerii Titov,
• Artem Shelemin,
• Mykhailo Vaidulych,
• Anna Kuzminova,
• Pavel Solař,
• Jan Hanuš,
• Jaroslav Kousal,
• Ondřej Kylián,
• Danka Slavínská and
• Hynek Biederman

Beilstein J. Nanotechnol. 2017, 8, 2002–2014, doi:10.3762/bjnano.8.200

• of plasma polymers has been considered to be of paramount importance, especially in terms of retention of primary amines which are attractive in biomedical applications as linkers for binding biomolecules. Yet, it has been recently argued that primary amines find it difficult to survive the influence