Photocatalytic degradation of methylene blue under visible light by cobalt ferrite nanoparticles/graphene quantum dots

• Vo Chau Ngoc Anh,
• Le Thi Thanh Nhi,
• Le Thi Kim Dung,
• Dang Thi Ngoc Hoa,
• Nguyen Truong Son,
• Nguyen Thi Thao Uyen,
• Nguyen Ngoc Uyen Thu,
• Le Van Thanh Son,
• Le Trung Hieu,
• Tran Ngoc Tuyen and
• Dinh Quang Khieu

Beilstein J. Nanotechnol. 2024, 15, 475–489, doi:10.3762/bjnano.15.43

• hydrolyse the starch. Then, the mixture was transferred to a 100 mL Teflon-lined autoclave and heated at 200 °C for 24 h. After hydrolysis, the product was cooled to room temperature. The brown solid was centrifuged, washed several times with distilled water, and calcinated at 700 °C for 3 h to obtain

• ratio of 2:1:4.5:540 was dissolved in a flask and heated to 80–85 °C for 1 h to hydrolyse the starch. Then, the mixture was transferred to a 100 mL Teflon-line autoclave and heated at 140, 180, and 200 °C for 24 h. The brown solid was centrifuged, washed several times with distilled water, and dried at

• , available to react with H2O to produce •OH radicals. The electrons in the CB band directly reduce MB to its degradation products or interact with oxygen in the aqueous solution to form peroxy anion radicals (). A part of h+ oxidizes water to form hydroxyl radicals (•OH), or it can oxidize directly MB to its

Fabrication of nanocrystal forms of ᴅ-cycloserine and their application for transdermal and enteric drug delivery systems

• Hsuan-Ang Tsai,
• Tsai-Miao Shih,
• Theodore Tsai,
• Jhe-Wei Hu,
• Yi-An Lai,
• Jui-Fu Hsiao and
• Guochuan Emil Tsai

Beilstein J. Nanotechnol. 2024, 15, 465–474, doi:10.3762/bjnano.15.42

• improve the bioavailability. In this study, for the first time, DCS, a highly water-soluble compound, has formed nanocrystals and this was confirmed by scanning electronic microscopy and X-ray powder diffraction. Furthermore, DCS nanocrystals were applied to several formulations to test their stability

• , matrix, and microneedle systems [24][25][26]. In addition, enteric-coated solid dosage forms for oral administration have shown significant improvement in providing better absorption and targeted delivery [27][28]. In this study, due to high water solubility of DCS (Log P = −1.72) and difficulty to

• dissolving DCS in organic solvents to fabricate the matrix patch formulation, only reservoir patch formulations of DCS in well-suspended (DCS nanocrystals) or emulsified (DCS water solution) forms were feasible to evaluate transdermal drug delivery. Coating drugs with pharmaceutically biocompatible enteric

Sidewall angle tuning in focused electron beam-induced processing

• Sangeetha Hari,
• Willem F. van Dorp,
• Johannes J. L. Mulders,
• Piet H. F. Trompenaars,
• Pieter Kruit and
• Cornelis W. Hagen

Beilstein J. Nanotechnol. 2024, 15, 447–456, doi:10.3762/bjnano.15.40

• by etching with water and it is shown, using transmission electron microscopy imaging, that the sidewall angle can be tuned from outward to inward by controlling the etch position on the sidewall. A surprising under-etching due to the emission of secondary electrons from the deposit was observed

• , which was not indicated by a simple model based on etching. An analytical model was developed to include continued etching once the deposit has been removed at the exposed pixel. At this stage the secondary electrons from the substrate then cause the adsorbed water molecules to become effective in

• qualitative agreement with the experimental observations. As a demonstration, the proposed method is applied to a carbon FEBID structure whose sidewall is etched using FEBIE with water in an SEM, using SE signal monitoring to determine when a vertical sidewall has been achieved. Results Sidewall slope

Potential of a deep eutectic solvent in silver nanoparticle fabrication for antibiotic residue detection

• Le Hong Tho,
• Bui Xuan Khuyen,
• Ngoc Xuan Dat Mai and
• Nhu Hoa Thi Tran

Beilstein J. Nanotechnol. 2024, 15, 426–434, doi:10.3762/bjnano.15.38

• stirring, the obtained Ag NPs-DES were washed with DI water several times, and the pellets were re-dispersed in DI water for further use. The Ag NPs-DES thin film was prepared following the procedure for self-assembly monolayer construction. A clean glass substrate was treated with oxygen plasma to form

Insect attachment on waxy plant surfaces: the effect of pad contamination by different waxes

• Elena V. Gorb and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 385–395, doi:10.3762/bjnano.15.35

• septempunctata (L.) (Coleoptera, Coccinellidae) on microporous substrates able to absorb both polar (water) and non-polar (oil) fluids clearly showed a strong reduction of the attachment force on these substrates compared to reference smooth solid substrates [24]. The latter result has been explained by

On the mechanism of piezoresistance in nanocrystalline graphite

• Sandeep Kumar,
• Simone Dehm and
• Ralph Krupke

Beilstein J. Nanotechnol. 2024, 15, 376–384, doi:10.3762/bjnano.15.34

• flexible glass was preferred for the Raman measurements because the spectra of NCG cannot be resolved on PET as a result of a strong Raman signal of the substrate itself. The 50 μm thick flexible glass was acquired from Schott. The glass loses its flexibility at 600 °C and also in water [23]. To keep the

• flexibility, the NCG film was grown on both sides of the glass substrate. There are three reasons for that. First, the negative thermal expansion coefficient of NCG prevents the release of stress initially present in the glass [25]. Second, the film protects the glass from any corrosion from water if the

• etching of SiO2. Using a clean glass wafer, the NCG/PMMA film was transferred from the NaOH solution to a clean water beaker and allowed to float on the top. The cleaning was repeated three times to ensure the no residues of NaOH remained on the NCG film. The film was then removed from the water using a

Controllable physicochemical properties of WO_x thin films grown under glancing angle

• Rupam Mandal,
• Aparajita Mandal,
• Alapan Dutta,
• Rengasamy Sivakumar,
• Sanjeev Kumar Srivastava and
• Tapobrata Som

Beilstein J. Nanotechnol. 2024, 15, 350–359, doi:10.3762/bjnano.15.31

• thin films were deposited on ultrasonically cleaned p-Si (100) and soda lime glass substrates of 1 × 1 cm2 dimension using a rf magnetron sputtering setup (Excel Instruments). Trichloroethylene, propanol, acetone, and DI water were used to carry out ultrasonication of the substrates for removing

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• soluble drugs are those whose solubility is below 1 mg/mL over the physiological pH range and the BNZ solubility in distilled water or simulated gastric and enteric fluids oscillates between 0.2 and 0.4 mg/mL [29][30], BNZ is considered a poorly soluble drug. Some authors classify BNZ as a class-II drug

• self-nanoemulsified drug delivery systems (SNEDDSs). SNEEDSs provide a pediatric liquid formulation of BNZ, which is only marketed as solid tablets. SNEDDSs are isotropic mixtures of oil, surfactants, and co-surfactants that form submicrometer-droplet emulsions under agitation in water or

• nanoparticulate vaccine is the anti-malarial Mosquirix™ (RTS, S/AS01), recommended by the World Health Organization in four doses for children in 2021. Mosquirix™ employs a liposome-based adjuvant, AS01 (GlaxoSmithKline) [103] that contains 3-O-desacyl-monophosphoryl lipid A and QS-21, a water-soluble triterpene

Comparative electron microscopy particle sizing of TiO₂ pigments: sample preparation and measurement

• Ralf Theissmann,
• Christopher Drury,
• Markus Rohe,
• Thomas Koch,
• Jochen Winkler and
• Petr Pikal

Beilstein J. Nanotechnol. 2024, 15, 317–332, doi:10.3762/bjnano.15.29

• application laboratory in Waldbronn, Germany, and the particle counting threshold was set at 30 nm. The samples were first intensively dispersed by ultrasonication in a polyphosphate solution in water (562 J/mL, 2.5% pigment, 2% polyphosphate) one day before measurement. The energy of 562 J/mL was chosen

• as in [11], differences in method M1 with respect to [11][21] are described below. These three methods differ substantially in all their characteristic steps, including ultrasonic bath dispersion in water, dry dispersion in a solid polymer, and the powdering onto a sticky sample stub without

• KRONOS INT. Inc., Research Services, involving the dispersion of 2.5% TiO2 in a polyphosphate solution in water (with 2% polyphosphate for stabilisation). Dispersion was performed by an ultrasonic finger (13 mm tip) for 5 min at 250 W and 60% amplitude, equivalent to 562 J/mL. It is worth noting that

Exploring the relationships between physiochemical properties of nanoparticles and cell damage to combat cancer growth using simple periodic table-based descriptors

• Joyita Roy and
• Kunal Roy

Beilstein J. Nanotechnol. 2024, 15, 297–309, doi:10.3762/bjnano.15.27

• a vital role in adhesion to the hydro–water interface and solid surfaces, providing an idea about the viability and permeability of the cell membrane under stress. As most of the cell surface carries a negative charge, metals with higher zeta potential can easily enter the cell and increase the

Determining by Raman spectroscopy the average thickness and N-layer-specific surface coverages of MoS₂ thin films with domains much smaller than the laser spot size

• Felipe Wasem Klein,
• Jean-Roch Huntzinger,
• Vincent Astié,
• Damien Voiry,
• Romain Parret,
• Houssine Makhlouf,
• Sandrine Juillaguet,
• Jean-Manuel Decams,
• Sylvie Contreras,
• Périne Landois,
• Ahmed-Azmi Zahab,
• Jean-Louis Sauvajol and
• Matthieu Paillet

Beilstein J. Nanotechnol. 2024, 15, 279–296, doi:10.3762/bjnano.15.26

Vinorelbine-loaded multifunctional magnetic nanoparticles as anticancer drug delivery systems: synthesis, characterization, and in vitro release study

• Zeynep Özcan and
• Afife Binnaz Hazar Yoruç

Beilstein J. Nanotechnol. 2024, 15, 256–269, doi:10.3762/bjnano.15.24

• three times with distilled water, and the PDA/Fe3O4 NPs were dried in a vacuum oven at 55 °C. Surface functionalization of PDA/Fe3O4 nanoparticles with SH-PEG For the surface modification process with SH-PEG, 50 mg of PDA/Fe3O4 NPs were added to 50 mL of Tris-HCl solution. Then, 100 mg of thiol

• particles were removed by washing with distilled water. The PEGylation PDA/Fe3O4 NPs were then dried in a vacuum oven at 45 °C. The PDA-coated Fe3O4 nanoparticles were modified with SH-PEG to facilitate their accumulation in tumour regions. In similar studies, the conjugation of SH-PEG onto the surface of

• was separated with the assistance of a magnet, followed by three thorough rinses with distilled water. All wash supernatants were collected to measure the VNB loading content based on UV–vis spectrophotometry. The resulting nanostructure underwent vacuum drying at 45 °C. The loading entrapment

Multiscale modelling of biomolecular corona formation on metallic surfaces

• Parinaz Mosaddeghi Amini,
• Ian Rouse,
• Julia Subbotina and
• Vladimir Lobaskin

Beilstein J. Nanotechnol. 2024, 15, 215–229, doi:10.3762/bjnano.15.21

• analogues (SCA) within the system [33][34]. The AMBER force field is a widely recognized and extensively validated force field that provides accurate descriptions of molecular systems [35]. We evaluated the short-range PMFs between 22 SCAs and an Al slab in a solvent environment comprising water and salt

• water density profiles obtained from MD simulations for the slab–water system in the context of Al surfaces revealed characteristics that were previously observed for other simulated metallic surfaces [2][28]. The profiles exhibited two distinct regions with elevated water density located approximately

• 0.15–0.18 nm and 0.42–0.48 nm away from the aluminum surface. These regions corresponded to the first and second water layers adjacent to the metal surface, respectively (as depicted in Supporting Information File 1, Figure S1). Further examination of the ion density profiles indicated the presence of

Ion beam processing of DNA origami nanostructures

• Leo Sala,
• Agnes Zerolová,
• Violaine Vizcaino,
• Alain Mery,
• Alicja Domaracka,
• Hermann Rothard,
• Philippe Boduch,
• Dominik Pinkas and
• Jaroslav Kocišek

Beilstein J. Nanotechnol. 2024, 15, 207–214, doi:10.3762/bjnano.15.20

• additional MilliQ water to reach the desired final volume (usually 100 μL for a standard synthesis). We used a higher excess of the staple strands because of the already long storage time of our staple stock solution [34]. The mixture was then annealed to 90 °C and slowly cooled down at a rate of −7 °C·min−1

Graphene removal by water-assisted focused electron-beam-induced etching – unveiling the dose and dwell time impact on the etch profile and topographical changes in SiO₂ substrates

• Aleksandra Szkudlarek,
• Jan M. Michalik,
• Inés Serrano-Esparza,
• Zdeněk Nováček,
• Veronika Novotná,
• Piotr Ozga,
• Czesław Kapusta and
• José María De Teresa

Beilstein J. Nanotechnol. 2024, 15, 190–198, doi:10.3762/bjnano.15.18

• extraordinary mechanical and electronic properties. Although many years have passed since its discovery, manipulating single graphene layers is still challenging using standard resist-based lithography techniques. Recently, it has been shown that it is possible to etch graphene directly in water-assisted

• on the direct delivery of water molecules into the scanning electron microscope chamber. This process is called focused electron-beam-induced etching (FEBIE) and was already demonstrated for thin amorphous carbon membranes a decade ago [15]. Oxygen or water vapor can be used for etching graphene [16

• of concept of water-assisted graphene etching. Moreover, the effects of changes in the topography of Si/SiO2 substrate during this process have not been addressed so far, as they may be observed only under certain experimental conditions. In a standard scanning electron microscope, the morphological

Nanocarrier systems loaded with IR780, iron oxide nanoparticles and chlorambucil for cancer theragnostics

• Phuong-Thao Dang-Luong,
• Hong-Phuc Nguyen,
• Loc Le-Tuan,
• Xuan-Thang Cao,
• Vy Tran-Anh and
• Hieu Vu Quang

Beilstein J. Nanotechnol. 2024, 15, 180–189, doi:10.3762/bjnano.15.17

• oxide NPs were synthesized using a modified coprecipitation method [13]. Firstly, 10 mmol of FeSO4·7H2O and 5 mmol of FeCl3·6H2O were dissolved in 50 mL of deionized water in a N2 atmosphere. Then, 1 M of NaOH was carefully added into the solution while swirling until the pH reached 14. Next, 1 mL of

• and allowed to evaporate overnight in a dark area at room temperature. In the next day, the nanoparticles were centrifuged at 12,000 rpm for 30 min, then resuspended in 600 µL of distilled water. The nanoparticles were then separated into three 200 μL suspension tubes. Then, 2 mg of F127-folate or 2

• mg of F127 was separately added to the tubes, and the ligand exchange was performed at 4 °C for one week. The tube without added polymer was designated as PVA@PLGA/IO/CHL/IR780 (PVA@NP). Then, the nanoparticles were centrifuged for 30 min at 12,000 rpm and resuspended in distilled water. The final

Modification of graphene oxide and its effect on properties of natural rubber/graphene oxide nanocomposites

• Nghiem Thi Thuong,
• Le Dinh Quang,
• Vu Quoc Cuong,
• Cao Hong Ha,
• Nguyen Ba Lam and
• Seiichi Kawahara

Beilstein J. Nanotechnol. 2024, 15, 168–179, doi:10.3762/bjnano.15.16

• of NR composite. The usage of GO-VTES may be suitable for the preparation of NR composites for tire applications as the composite may reduce water permeability and enhance the abrasion resistance of commercial products [30]. Experimental Materials The natural rubber used in this work is high-ammonia

• agent and SDS as a surfactant. About 80 g of HANR (60% DRC) was incubated with 80 g of water containing 1.6 g of SDS and 0.16 g of urea for 1 h before the 1st centrifugation at 10,000 rpm at 15 °C for 30 min. The cream recovered after centrifugation was redispersed in 80 g of water containing 0.8 g SDS

• and subjected to a 2nd centrifugation under the same condition. The cream fraction was again redispersed in water containing 0.16 g of SDS before the 3rd centrifugation. The final cream was diluted in a certain amount of SDS solution to obtain deproteinized natural rubber (DPNR) with DRC (20%) and SDS

In situ optical sub-wavelength thickness control of porous anodic aluminum oxide

• Aleksandrs Dutovs,
• Raimonds Popļausks,
• Oskars Putāns,
• Vladislavs Perkanuks,
• Aušrinė Jurkevičiūtė,
• Tomas Tamulevičius,
• Uldis Malinovskis,
• Iryna Olyshevets,
• Donats Erts and
• Juris Prikulis

Beilstein J. Nanotechnol. 2024, 15, 126–133, doi:10.3762/bjnano.15.12

• the reflectance spectra to a multilayer model of a water–PAAO–aluminum system using the transfer-matrix method (TMM) [22]. Previously, TMM has been employed only for post-production thickness analysis of PAAO-based stratified systems [13][23]. In the present study, it allowed for continuous in situ

• consistent thickness determination during anodization using reflectance measurements at normal incidence, it was sufficient to assume a single PAAO layer with the effective RI neff. A simplified model consisting of an Al substrate with the complex RI [29], PAAO with constant neff, and water with RI [30

• for Al [29] and water [30]. The model function calculated the reflectance spectra with two fitting parameters, that is, PAAO thickness hPAAO and a constant multiplier for intensity correction of the reference spectrum. Fitting was done using the Levenberg–Marquardt (LM) algorithm as described in the

Assessing phytotoxicity and tolerance levels of ZnO nanoparticles on Raphanus sativus: implications for widespread adoptions

• Pathirannahalage Sahan Samuditha,
• Nadeesh Madusanka Adassooriya and
• Nazeera Salim

Beilstein J. Nanotechnol. 2024, 15, 115–125, doi:10.3762/bjnano.15.11

• 3492 cm−1 is attributed to the characteristic vibrational mode of the O–H bond which comes from water adsorbed by the ZnO NPs from the humid atmosphere [31]. Typically, bulk ZnO particles show a characteristic absorption edge of 400 nm in UV–vis spectra. Hence, ZnO NPs show blue shifting and have an

• and water uptake in the presence of Zn [39], or else by accelerating the activity of carbonic anhydrase [2]. Several published information is available on the effect of Zn on photosynthetic pigments of other crops. Nanopriming Triticum aestivum seeds with 10 mg/L of ZnO resulted in a significant

• rpm in a magnetic stirrer and NaOH was added dropwise, the mixture was kept under constant stirring for 2 more hours and then sealed and kept overnight. The Zn(OH)2 obtained from the reaction was collected by centrifugation, washed with distilled water, and calcined at 400 °C for 2 h to obtain ZnO NPs

Development and characterization of potential larvicidal nanoemulsions against Aedes aegypti

• Jonatas L. Duarte,
• Leonardo Delello Di Filippo,
• Anna Eliza Maciel de Faria Mota Oliveira,
• Rafael Miguel Sábio,
• Gabriel Davi Marena,
• Tais Maria Bauab,
• Cristiane Duque,
• Vincent Corbel and
• Marlus Chorilli

Beilstein J. Nanotechnol. 2024, 15, 104–114, doi:10.3762/bjnano.15.10

• naturally occurring in essential oils (EOs) of various aromatic plants, including the genera Artemisia, Protium, Origanum, and Thymus. Myrcene is an acyclic monoterpene found in hops, lemongrass, basil, and mangos [10]. Some intrinsic characteristics of monoterpenes, mainly poor water solubility and high

• volatility, make their formulation a true challenge. In this regard, nanoemulsions (NEs), which are dispersions of two immiscible liquids with one of them dispersed as small droplets [11][12], stand out as new delivery vehicles for these bioactive compounds. They are especially important to enhance the water

• availability of poorly water-soluble compounds, which is achieved when the oil constitutes the internal phase. In this case, oil-in-water nanoemulsions or aqueous nanoemulsions are obtained. The main advantage of NEs is their better kinetic stability compared to macroemulsions. Also, the NEs protect the EO

New application of bimetallic Ag/Pt nanoplates in a colorimetric biosensor for specific detection of E. coli in water

• Azam Bagheri Pebdeni,
• Mohammad N. AL-Baiati and
• Morteza Hosseini

Beilstein J. Nanotechnol. 2024, 15, 95–103, doi:10.3762/bjnano.15.9

• . This nanobiosensor has the ability to specifically bind to E. coli, increasing the peroxidase activity of the apt-Ag/Pt NPL. Finally, the blue color of the solution in the contaminated water samples was increased in the presence of 3,3′,5,5′-tetramethylbenzidine (TMB) as a substrate and H2O2. The assay

• can be completed in 30 min and the presence of E. coli levels can be distinguished with the naked eye. The absorbance at 652 nm is proportional to pathogen concentration from 10 to 108 CFU·mL−1, with a detection limit of 10 CFU·mL−1. The percent recovery for the water samples spiked with E. coli is 95

• %. The developed assay should serve as a general platform for detecting other pathogenic bacteria which affect water and food quality. The proposed E. coli detection strategy has appealing characteristics such as high sensitivity, simple operation, short testing time, and low cost. Keywords: aptamer

Study of the reusability and stability of nylon nanofibres as an antibody immobilisation surface

• Inés Peraile,
• Matilde Gil-García,
• Laura González-López,
• Nushin A. Dabbagh-Escalante,
• Juan C. Cabria-Ramos and
• Paloma Lorenzo-Lozano

Beilstein J. Nanotechnol. 2024, 15, 83–94, doi:10.3762/bjnano.15.8

• has to be taken into account, but also ease of handling, on-site use, and low production cost. Thus, several authors, such as Janik-Karpinska and colleagues in 2022 [3], have pointed out that rapid detection of pathogens and toxins in food, water, and the environment is a paramount health and safety

• determination of exogenously produced biotoxins and virulence factors, as well as for the detection of viruses and biomarkers in clinical samples (e.g., hormones and biomolecules). (4) The data could be generalised not only for the measurement of warfare agents, but also for the diagnosis of water and food

Berberine-loaded polylactic acid nanofiber scaffold as a drug delivery system: The relationship between chemical characteristics, drug-release behavior, and antibacterial efficiency

• Le Thi Le,
• Hue Thi Nguyen,
• Liem Thanh Nguyen,
• Huy Quang Tran and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2024, 15, 71–82, doi:10.3762/bjnano.15.7

• treatment of central nervous system disorders [2], digestive system diseases [3], cancer, diabetes, inflammation, and infections. Nevertheless, BBR has a low bioavailability due to its poor water solubility, which imposes a regular intake of BBR drugs at a high dose. Recently, innovative technologies have

• , iron oxide, and mesoporous silica nanoparticles) [4]. Additionally, nanocarrier-free systems, such as drug nanocrystals, are also used to improve the delivery of poorly soluble drugs [5][6]. In our previous study, the saturation concentration of BBR in water was 2.0 mg/mL, while BBR nanoparticles

• ]. The core/shell nanofiber structure can also prolong the drug release since the polymer shell plays a role as a rate-control barrier [15]. On the other hand, the nanofiber scaffolds fabricated using suitable hydrophilic or water-soluble polymers are used to improve the dissolution profile and

Influence of conductive carbon and MnCo₂O₄ on morphological and electrical properties of hydrogels for electrochemical energy conversion

• Sylwia Pawłowska,
• Karolina Cysewska,
• Yasamin Ziai,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2024, 15, 57–70, doi:10.3762/bjnano.15.6

• ; hydrogel; hydrogen; oxygen evolution reaction; polymer composites; Introduction Hydrogels are defined as a group of polymeric materials with an insoluble hydrophilic structure which gives them the ability to absorb and hold large amounts of water (up to over 99 wt %) in their three-dimensional network

• . The phenomenon in which hydrogels swell in water while not dissolving in it is due to hydrophilic functional groups attached to the polymer backbone and cross-links between the network chains. High water content makes hydrogel materials similar in terms of microstructure and flexibility to living

• tissues. The amount of water absorbed depends on factors such as the structure of the hydrogel, the composition of the precursor hydrogel solution, the cross-link density, and the technique of its synthesis. The simple reaction of one or more monomers is used for the production of this kind of material [1

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• promising activity, this molecule shows poor water solubility, high metabolism, and fast elimination impair, which results in low systemic bioavailability and poor in vivo pharmacological effect. In this context, molecules with similar limitations have been combined with nanotechnology tools to allow their