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Search for "biomolecules" in Full Text gives 205 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.

Advances and challenges in the field of plasma polymer nanoparticles

  • Andrei Choukourov,
  • Pavel Pleskunov,
  • Daniil Nikitin,
  • Valerii Titov,
  • Artem Shelemin,
  • Mykhailo Vaidulych,
  • Anna Kuzminova,
  • Pavel Solař,
  • Jan Hanuš,
  • Jaroslav Kousal,
  • Ondřej Kylián,
  • Danka Slavínská and
  • Hynek Biederman

Beilstein J. Nanotechnol. 2017, 8, 2002–2014, doi:10.3762/bjnano.8.200

Graphical Abstract
  • of plasma polymers has been considered to be of paramount importance, especially in terms of retention of primary amines which are attractive in biomedical applications as linkers for binding biomolecules. Yet, it has been recently argued that primary amines find it difficult to survive the influence
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Published 25 Sep 2017

Optical techniques for cervical neoplasia detection

  • Tatiana Novikova

Beilstein J. Nanotechnol. 2017, 8, 1844–1862, doi:10.3762/bjnano.8.186

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  • a size of less than 100 nm (i.e., which are much smaller than normal human cells) with biomolecules such as receptors, enzymes, and antibodies on the cell surface and inside the cell [87]. By surface coating, functionalization, and integration with different bioconjugated targeting agents those
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Published 06 Sep 2017

Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents

  • Dovile Baziulyte-Paulaviciene,
  • Vitalijus Karabanovas,
  • Marius Stasys,
  • Greta Jarockyte,
  • Vilius Poderys,
  • Simas Sakirzanovas and
  • Ricardas Rotomskis

Beilstein J. Nanotechnol. 2017, 8, 1815–1824, doi:10.3762/bjnano.8.183

Graphical Abstract
  • water while protecting the surface from nonspecific adsorption of biomolecules. Our results show that Tween 80-coated NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles exhibit excellent dispersibility in a biological medium and are photostable. We also do not observe any changes in the overall upconversion
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Published 01 Sep 2017

Methionine-mediated synthesis of magnetic nanoparticles and functionalization with gold quantum dots for theranostic applications

  • Arūnas Jagminas,
  • Agnė Mikalauskaitė,
  • Vitalijus Karabanovas and
  • Jūrate Vaičiūnienė

Beilstein J. Nanotechnol. 2017, 8, 1734–1741, doi:10.3762/bjnano.8.174

Graphical Abstract
  • be obtained by the creation of proper linkers between magnetic NP and fluorescent or drug probes. One of these linkers is gold, because it is chemically stable, nontoxic and capable to link various biomolecules. In this study, we present a way for a simple and reliable decoration the surface of
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Published 22 Aug 2017

A biofunctionalizable ink platform composed of catechol-modified chitosan and reduced graphene oxide/platinum nanocomposite

  • Peter Sobolewski,
  • Agata Goszczyńska,
  • Małgorzata Aleksandrzak,
  • Karolina Urbaś,
  • Joanna Derkowska,
  • Agnieszka Bartoszewska,
  • Jacek Podolski,
  • Ewa Mijowska and
  • Mirosława El Fray

Beilstein J. Nanotechnol. 2017, 8, 1508–1514, doi:10.3762/bjnano.8.151

Graphical Abstract
  • feature that enables the selective detection of the target biomolecules. Our ink platform is designed to be modular; various possible biorecognition elements can be conjugated to the remaining amine groups of the catechol-modified chitosan, such as enzymes, antibodies, DNA probes, or aptamers. As a proof
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Published 24 Jul 2017

Low uptake of silica nanoparticles in Caco-2 intestinal epithelial barriers

  • Dong Ye,
  • Mattia Bramini,
  • Delyan R. Hristov,
  • Sha Wan,
  • Anna Salvati,
  • Christoffer Åberg and
  • Kenneth A. Dawson

Beilstein J. Nanotechnol. 2017, 8, 1396–1406, doi:10.3762/bjnano.8.141

Graphical Abstract
  • polarisation. Additionally, though it is known that biomolecules adsorbed to nanoparticles affect their cell adherence [35], uptake [26][35] and translocation [34], we wish to clarify their role in the full process, from adherence to translocation, in both undifferentiated and mature Caco-2 barriers. To this
  • may cause cell damage [36][38]. This is unlikely to happen in any realistic nanoparticle exposure scenario, where biomolecules adsorb to the nanoparticle to form a nanoparticle biomolecular corona which effectively protects the cells from such immediate damage [39][40][41]. Though the intestinal lumen
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Published 07 Jul 2017

Bright fluorescent silica-nanoparticle probes for high-resolution STED and confocal microscopy

  • Isabella Tavernaro,
  • Christian Cavelius,
  • Henrike Peuschel and
  • Annette Kraegeloh

Beilstein J. Nanotechnol. 2017, 8, 1283–1296, doi:10.3762/bjnano.8.130

Graphical Abstract
  • versatile tool for the modification of the silica surface with a variety of functional groups [30] or biomolecules [31]. This material also allows for the incorporation of dyes into the particle matrix without changing their optical properties [32]. However, the incorporation of fluorescent dyes into the
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Published 21 Jun 2017

Characterization of ferrite nanoparticles for preparation of biocomposites

  • Urszula Klekotka,
  • Magdalena Rogowska,
  • Dariusz Satuła and
  • Beata Kalska-Szostko

Beilstein J. Nanotechnol. 2017, 8, 1257–1265, doi:10.3762/bjnano.8.127

Graphical Abstract
  • .). Functionalization can ensure connection of the nanoparticle surface self-assembled layers with free active bonds [8]. The integration of nanostructures with biomolecules leads to the fabrication of a novel hybrid system that couples recognition or catalytic properties of biomaterials with attractive electronic
  • , optical, magnetic and structural characteristics of specific nanoparticles in one hierarchical structure [9]. In such systems, nanoparticles can be functionalized with various biomolecules through different linkage chemistry [10][11][12]. Nanocomposites based on magnetic nanoparticles have a huge
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Published 13 Jun 2017

Surface-enhanced Raman spectroscopy of cell lysates mixed with silver nanoparticles for tumor classification

  • Mohamed Hassoun,
  • Iwan W.Schie,
  • Tatiana Tolstik,
  • Sarmiza E. Stanca,
  • Christoph Krafft and
  • Juergen Popp

Beilstein J. Nanotechnol. 2017, 8, 1183–1190, doi:10.3762/bjnano.8.120

Graphical Abstract
  • demonstrate the principle, cell lysates were prepared by ultrasonication that disrupts the cell membrane and enables interaction of released cellular biomolecules to nanoparticles. This approach was applied to distinguish four cell lines – Capan-1, HepG2, Sk-Hep1 and MCF-7 – using SERS at 785 nm excitation
  • bonds. It probes the molecular vibrations of all cellular biomolecules, such as nucleic acids, proteins, lipids and carbohydrates and provides chemical fingerprint spectra of cells. The throughput of spontaneous Raman spectroscopy for cell classification is limited to the range of one cell per second by
  • to allow interaction between nanoparticles and bacterial biomolecules [24]. This gave very reproducible SERS spectra. The current study transfers this SERS approach to distinguish four human cancer cell lines. These cell lines are two liver cancer cell lines (HepG2 isolated from liver tissue of a
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Published 01 Jun 2017

Selective detection of Mg2+ ions via enhanced fluorescence emission using Au–DNA nanocomposites

  • Tanushree Basu,
  • Khyati Rana,
  • Niranjan Das and
  • Bonamali Pal

Beilstein J. Nanotechnol. 2017, 8, 762–771, doi:10.3762/bjnano.8.79

Graphical Abstract
  • various DNA detection schemes. The high sensitivity of the plasmon spectra towards the particle size and the local dielectric environment also offers new methods for the detection of free DNA or other biomolecules [2], where the detection signal is exclusively based on the color changes during assay or
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Published 03 Apr 2017

Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles

  • Olga Rotan,
  • Katharina N. Severin,
  • Simon Pöpsel,
  • Alexander Peetsch,
  • Melisa Merdanovic,
  • Michael Ehrmann and
  • Matthias Epple

Beilstein J. Nanotechnol. 2017, 8, 381–393, doi:10.3762/bjnano.8.40

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  • , Faculty of Biology, University of Duisburg-Essen, Universitaetsstr. 5-7, D-45117 Essen, Germany 10.3762/bjnano.8.40 Abstract The efficient intracellular delivery of (bio)molecules into living cells remains a challenge in biomedicine. Many biomolecules and synthetic drugs are not able to cross the cell
  • membrane, which is a problem if an intracellular mode of action is desired, for example, with a nuclear receptor. Calcium phosphate nanoparticles can serve as carriers for small and large biomolecules as well as for synthetic compounds. The nanoparticles were prepared and colloidally stabilized with either
  • different for dissolved HTRA1 and HTRA1-loaded nanoparticles. Keywords: calcium phosphate; endocytosis; nanoparticles; proteins; Introduction Many receptors for drugs or proteins are located inside cells [1][2]. However, because many biomolecules are not able to penetrate the cell membrane on their own, a
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Published 07 Feb 2017

Comparison of four methods for the biofunctionalization of gold nanorods by the introduction of sulfhydryl groups to antibodies

  • Xuefeng Wang,
  • Zhong Mei,
  • Yanyan Wang and
  • Liang Tang

Beilstein J. Nanotechnol. 2017, 8, 372–380, doi:10.3762/bjnano.8.39

Graphical Abstract
  • sulfhydryl groups to biomolecules to functionalize gold nanorods (GNRs) is an attractive method that involves the creation of a strong Au–S bond. Previously, we developed a facile method to functionalize GNR surfaces by thiolating antibodies using Traut’s reagent. In the current study, we evaluated several
  • immobilization onto the GNR surface, improved the efficacy of functionalized GNRs, and increased the sensitivity in response to target detection as a biosensor. Given that PEG6-CONHNH2 modification requires glycosylated biomolecules, Traut’s reagent and DTT thiolation are recommended as universal applications of
  • GNR biofunctionalization and can be easily extended to other sensing applications based on other gold nanostructures or new biomolecules. Keywords: biofunctionalization; biosensing; four methods; gold nanorod; introduction of sulfhydryl groups; Introduction Gold nanorods (GNRs) are widely used in
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Published 06 Feb 2017

Tailoring bifunctional hybrid organic–inorganic nanoadsorbents by the choice of functional layer composition probed by adsorption of Cu2+ ions

  • Veronika V. Tomina,
  • Inna V. Melnyk,
  • Yuriy L. Zub,
  • Aivaras Kareiva,
  • Miroslava Vaclavikova,
  • Gulaim A. Seisenbaeva and
  • Vadim G. Kessler

Beilstein J. Nanotechnol. 2017, 8, 334–347, doi:10.3762/bjnano.8.36

Graphical Abstract
  • size and morphology of the particles Previously it was shown that the introduction of alkyl groups along with 3-aminopropyl groups in the surface layer improves its hydrolytic stability [45] and enhances the adsorption of biomolecules [46][47]. In developing the synthesis in the present work we took
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Published 02 Feb 2017

Selective photodissociation of tailored molecular tags as a tool for quantum optics

  • Ugur Sezer,
  • Philipp Geyer,
  • Moritz Kriegleder,
  • Maxime Debiossac,
  • Armin Shayeghi,
  • Markus Arndt,
  • Lukas Felix and
  • Marcel Mayor

Beilstein J. Nanotechnol. 2017, 8, 325–333, doi:10.3762/bjnano.8.35

Graphical Abstract
  • yet generally scalable to covalently bound organic molecules. In particular, large biomolecules – which are interesting candidates for quantum-interference experiments and gas-phase metrology [7] – often neither ionize nor dissociate upon absorption of a single photon, not even at 7.9 eV photon energy
  • pathways in the gas-phase. For future applications in molecule interferometry with complex biomolecules, it will be important that beam depletion is possible at a wavelength which is not absorbed by the untagged molecule. Otherwise the photon would be dissipated without triggering any action. Our labels
  • are chosen such that they respond at 250–270 nm and 350–370 nm, i.e., at wavelengths longer than typical resonance lines in non-aromatic biomolecules. We expect photocleavage to become important for the realization of optical gratings and for the photoactivated change of the charge state in mesoscopic
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Published 02 Feb 2017

Comparison of four functionalization methods of gold nanoparticles for enhancing the enzyme-linked immunosorbent assay (ELISA)

  • Paula Ciaurriz,
  • Fátima Fernández,
  • Edurne Tellechea,
  • Jose F. Moran and
  • Aaron C. Asensio

Beilstein J. Nanotechnol. 2017, 8, 244–253, doi:10.3762/bjnano.8.27

Graphical Abstract
  • ]. AuNPs possess the advantages of easy synthesis and narrow size distribution together with an easy and efficient surface modification compatible with linkers or biomolecules [16]. A critical step for obtaining gold complexes is the conjugation of biomolecules to AuNPs. Increasingly, the process of
  • loading biomolecules to the nanoparticle surface it is considered more important, as its properties or biochemical activity can be changed. It was shown that several parameters such as surface chemistry, pH, stabilizing agents as well as addition procedure strongly affect final coverage and efficiency of
  • biomolecules [17][18]. Moreover, the AuNP–biomolecule binding can be completed by different procedures. Biomolecules can be simply adsorbed on the nanoparticle surface by means of electrostatic or hydrophobic interactions, leading to a high number of proteins per particle and random orientation of biomolecules
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Published 25 Jan 2017

A novel electrochemical nanobiosensor for the ultrasensitive and specific detection of femtomolar-level gastric cancer biomarker miRNA-106a

  • Maryam Daneshpour,
  • Kobra Omidfar and
  • Hossein Ghanbarian

Beilstein J. Nanotechnol. 2016, 7, 2023–2036, doi:10.3762/bjnano.7.193

Graphical Abstract
  • provide ultrasensitive quantitative measurements of specific biomolecules and even simultaneous evaluation of multiple analytes [19]. In addition, some novel approaches including the use of nanomaterials [20][21][22], semi-conductive/conductive polymers [23], and enzymatic strategies [24][25][26] have
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Published 19 Dec 2016

Layered composites of PEDOT/PSS/nanoparticles and PEDOT/PSS/phthalocyanines as electron mediators for sensors and biosensors

  • Celia García-Hernández,
  • Cristina García-Cabezón,
  • Fernando Martín-Pedrosa,
  • José Antonio De Saja and
  • María Luz Rodríguez-Méndez

Beilstein J. Nanotechnol. 2016, 7, 1948–1959, doi:10.3762/bjnano.7.186

Graphical Abstract
  • biosensors containing tyrosinase and laccase, and they combine the recognition and biocatalytic properties of biomolecules with the unique catalytic features of composite materials. The observed increase in the intensity of the responses allowed detection limits of 1 × 10−7 mol·L−1 to be attained. Keywords
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Published 08 Dec 2016

Controlled supramolecular structure of guanosine monophosphate in the interlayer space of layered double hydroxide

  • Gyeong-Hyeon Gwak,
  • Istvan Kocsis,
  • Yves-Marie Legrand,
  • Mihail Barboiu and
  • Jae-Min Oh

Beilstein J. Nanotechnol. 2016, 7, 1928–1935, doi:10.3762/bjnano.7.184

Graphical Abstract
  • )polytetrahydrofuran [10]. These G4 membranes showed potential in Na+/K+ artificial ion channels. Inspired by the above reports claiming that i) intermolecular interactions of biomolecules are strongly affected by the confined geometry of layered clays and that ii) guanosine derivatives form various supramolecular
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Published 06 Dec 2016

Facile fabrication of luminescent organic dots by thermolysis of citric acid in urea melt, and their use for cell staining and polyelectrolyte microcapsule labelling

  • Nadezhda M. Zholobak,
  • Anton L. Popov,
  • Alexander B. Shcherbakov,
  • Nelly R. Popova,
  • Mykhailo M. Guzyk,
  • Valeriy P. Antonovich,
  • Alla V. Yegorova,
  • Yuliya V. Scrypynets,
  • Inna I. Leonenko,
  • Alexander Ye. Baranchikov and
  • Vladimir K. Ivanov

Beilstein J. Nanotechnol. 2016, 7, 1905–1917, doi:10.3762/bjnano.7.182

Graphical Abstract
  • solubility, outstanding biocompatibility, resistance to photobleaching, chemical inertness and excellent suitability for biological applications (one- and multiphoton bioimaging [9][10][11][12][13][14][15][16], biosensorics [9][10][11][12][17] and biomolecules/drug delivery [12][13][15]). Since the discovery
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Published 02 Dec 2016

Effective intercalation of zein into Na-montmorillonite: role of the protein components and use of the developed biointerfaces

  • Ana C. S. Alcântara,
  • Margarita Darder,
  • Pilar Aranda and
  • Eduardo Ruiz-Hitzky

Beilstein J. Nanotechnol. 2016, 7, 1772–1782, doi:10.3762/bjnano.7.170

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  • prepared by intercalation of biomolecules such as lipids or proteins have been recently reported [23][24][25][26], resulting in so-called bio-organoclays useful as fillers in the preparation of bionanocomposites or as biointerfaces for adsorption of biological species. In the present case, the
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Published 18 Nov 2016

Nano- and microstructured materials for in vitro studies of the physiology of vascular cells

  • Alexandra M. Greiner,
  • Adria Sales,
  • Hao Chen,
  • Sarah A. Biela,
  • Dieter Kaufmann and
  • Ralf Kemkemer

Beilstein J. Nanotechnol. 2016, 7, 1620–1641, doi:10.3762/bjnano.7.155

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Published 08 Nov 2016

Development of adsorptive membranes by confinement of activated biochar into electrospun nanofibers

  • Mehrdad Taheran,
  • Mitra Naghdi,
  • Satinder K. Brar,
  • Emile Knystautas,
  • Mausam Verma,
  • Rao. Y. Surampalli and
  • Jose. R. Valero

Beilstein J. Nanotechnol. 2016, 7, 1556–1563, doi:10.3762/bjnano.7.149

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  • biomolecules, which makes them ideal candidates for environmental applications. There are many recent reports on the functionalization of NFMs for the removal of compounds of environmental concern. For example, Vanraes et al. used polyamide NFM in combination with electrical discharge to adsorb and degrade
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Published 01 Nov 2016

Antitumor magnetic hyperthermia induced by RGD-functionalized Fe3O4 nanoparticles, in an experimental model of colorectal liver metastases

  • Oihane K. Arriortua,
  • Eneko Garaio,
  • Borja Herrero de la Parte,
  • Maite Insausti,
  • Luis Lezama,
  • Fernando Plazaola,
  • Jose Angel García,
  • Jesús M. Aizpurua,
  • Maialen Sagartzazu,
  • Mireia Irazola,
  • Nestor Etxebarria,
  • Ignacio García-Alonso,
  • Alberto Saiz-López and
  • José Javier Echevarria-Uraga

Beilstein J. Nanotechnol. 2016, 7, 1532–1542, doi:10.3762/bjnano.7.147

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  • solvent dispersed, iron oxide nanocrystals must be transferred into aqueous phase and make them active in bioconjugation reactions with biomolecules [35]. In order to obtain the required aqueous stability, amphiphilic polymers like poly(maleic anhydride-alt-1-octadecene (PMAO) are able to form oil-in
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Published 28 Oct 2016

Photothermal effect of gold nanostar patterns inkjet-printed on coated paper substrates with different permeability

  • Mykola Borzenkov,
  • Anni Määttänen,
  • Petri Ihalainen,
  • Maddalena Collini,
  • Elisa Cabrini,
  • Giacomo Dacarro,
  • Piersandro Pallavicini and
  • Giuseppe Chirico

Beilstein J. Nanotechnol. 2016, 7, 1480–1485, doi:10.3762/bjnano.7.140

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  • printing because of their conductive and thermal properties [1][8]. Within the existing types of metal nanoparticles, the beneficial properties of gold, such as good biocompatibility, excellent resistance to oxidation and acids, and high affinity to thiol containing biomolecules promote the applicability
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Published 19 Oct 2016

Straightforward and robust synthesis of monodisperse surface-functionalized gold nanoclusters

  • Silvia Varela-Aramburu,
  • Richard Wirth,
  • Chian-Hui Lai,
  • Guillermo Orts-Gil and
  • Peter H. Seeberger

Beilstein J. Nanotechnol. 2016, 7, 1278–1283, doi:10.3762/bjnano.7.118

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  • L929 cells. Surface functionalization of Glc-NCs with biomolecules opens opportunities for drug delivery applications. A) One-pot synthesis of Glc-NCs at room temperature; B) UV–vis spectra of freshly synthesized Glc-NCs and after three days are indicative of stable particles; C) high-resolution TEM
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Published 08 Sep 2016
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