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Search for "physicochemical" in Full Text gives 309 result(s) in Beilstein Journal of Nanotechnology. Showing first 200.
Durable antimicrobial activity of fabrics functionalized with zeolite ion-exchanged nanomaterials against Staphylococcus aureus and Escherichia coli
Beilstein J. Nanotechnol. 2026, 17, 262–274, doi:10.3762/bjnano.17.18
- atom % are evaluated regarding their antimicrobial activity against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative), as well as regarding their physicochemical and mechanical properties. Scanning electron microscopy confirms the uniform distribution and successful
- leaves of some plants are water- or dust-repellent, and these repellent properties can be transferred to textiles by modifying the components involved in these mechanisms [24]. Among the physicochemical methods used for fabric functionalization with nanomaterials are coatings, electrospinning, assembling
- impregnated textile samples were studied against S. aureus and E. coli, and their physicochemical and mechanical properties are discussed. The obtained results suggest that the synthesized materials can be applied as an effective alternative to inhibit and reduce the spread of different types of viruses and
Structure-dependent thermochromism of PAZO thin films: theory and experiment
Beilstein J. Nanotechnol. 2026, 17, 186–199, doi:10.3762/bjnano.17.12
- physicochemical, optoelectronic, and even biophysical properties creates myriad opportunities for their application, especially as polymer thin films [1][2]. These films are widely used in modern life as they can be easily tailored to have specific properties like high conductivity, optical transparency, or
Safe and sustainable by design with ML/AI: A transformative approach to advancing nanotechnology
Beilstein J. Nanotechnol. 2026, 17, 176–185, doi:10.3762/bjnano.17.11
- , health, and safety (EHS) risks. The unique physicochemical properties of ENMs, including their high surface-to-volume ratio and reactivity, often result in unpredictable interactions with, and transformations by, biological and ecological systems [9][10]. Traditional risk assessment approaches, while
- complementary benefits within SSbD. First, predictive modelling tools, such as quantitative structure–activity relationship (QSAR) models, can forecast toxicological and physicochemical properties of emerging substances, reducing the reliance on time-consuming and costly experimental assays [24][25]. The
- effectiveness of ML/AI models for nanomaterials is often hindered by inconsistent and non-harmonized physicochemical data. Thus, improving data quality through standardization, metadata annotation, and curated databases is crucial to enhance the reliability and regulatory acceptance of predictions. Second, AI
From shield to spear: Charge-reversible nanocarriers in overcoming cancer therapy barriers
Beilstein J. Nanotechnol. 2026, 17, 159–175, doi:10.3762/bjnano.17.10
- advancements in nanocarrier-based cancer therapy, recent research has increasingly emphasised refining their physicochemical traits, especially surface charge, to boost therapeutic outcomes. A notable development in this context is the emergence of charge-reversible nanoscale drug delivery systems (CR-NDDSs
- physicochemical parameters, the surface charge is essential for determining nanocarrier interactions with biological membranes, cellular uptake, and biodistribution [17]. With a positive charge, the nanocarrier tends to be absorbed by high plasma proteins and cleared faster from the bloodstream. In contrast
- groups and the need for precise control over physicochemical characteristics further increase manufacturing costs and delay clinical development. Maintaining stability during storage is another critical concern, as environmental factors such as temperature fluctuations and light exposure may induce
Influence of surface characteristics on the in vitro stability and cell uptake of nanoliposomes for brain delivery
Beilstein J. Nanotechnol. 2026, 17, 139–158, doi:10.3762/bjnano.17.9
- the physicochemical characteristics and effectiveness of nanoliposomal (NLs) formulations. However, there has been minimal focus on elucidating nano–bio interactions and understanding the behavior of these formulations at organ and cellular levels. Specifically, it is widely recognized that when
- evolution of physicochemical characteristics and surface properties of NLs in biorelevant media. Additionally, in order to point out the influence of specific characteristics on the brain targeting potential of these formulations, we investigated interactions between NLs and blood–brain barrier (BBB, hCMEC
- therapeutic outcomes [3][5]. Namely, current research on NLs predominantly focuses on their physicochemical characteristics and efficiency, but minimal attention has been given to understanding the nano–bio interactions at organ and cellular levels. When exposed to biological fluids, nanodelivery systems like
Development and in vitro evaluation of liposomes and immunoliposomes containing 5-fluorouracil and R-phycoerythrin as a potential phototheranostic system for colorectal cancer
Beilstein J. Nanotechnol. 2026, 17, 97–121, doi:10.3762/bjnano.17.7
- lyophilized samples to Fourier-transform infrared (FTIR) spectroscopy in an FTIR spectrophotometer (IRTracer-100, Shimazdzu, Japan), with a horizontal attenuated total reflectance accessory. The scan was performed in the range of 500 to 4000 cm−1 [27]. 2.5 Stability study After physicochemical
- liposome formulations that showed the best performance are described in Table 3. Therefore, the increase in 5-FU encapsulation in liposomes upon adding R-PE was confirmed. 3.2 Development and characterization of immunoliposomes Table 4 presents the physicochemical characterization of immunoliposome
- were recorded. The shift in zeta potential to less negative values after incubation indicates partial neutralization of surface charges by the serum components, a typical phenomenon in physiological environments. This change, however, did not significantly compromise the physicochemical stability of
Quantitative estimation of nanoparticle/substrate adhesion by atomic force microscopy
Beilstein J. Nanotechnol. 2026, 17, 1–14, doi:10.3762/bjnano.17.1
- [5] and physicochemical properties [6]. Among these properties, particle adhesion (which is determined by the interaction between the NP and the substrate) and the interface formed between NPs and substrate [7][8] play a decisive role. Particularly when the contact area between NPs and the substrate
Missing links in nanomaterials research impacting productivity and perceptions
Beilstein J. Nanotechnol. 2025, 16, 2168–2176, doi:10.3762/bjnano.16.149
- frequently adapted from frameworks originally designed for bulk materials. These are inadequate for addressing the unique physicochemical properties, size-dependent behaviors, and long-term risks associated with nanoscale materials. As a result, scientifically appropriate, dedicated regulations for
Quality by design optimization of microemulsions for topical delivery of Passiflora setacea seed oil
Beilstein J. Nanotechnol. 2025, 16, 2116–2131, doi:10.3762/bjnano.16.146
- poor physicochemical and organoleptic properties. This study aimed to develop and optimize a topical microemulsion (ME) system incorporating P. setacea seed oil using quality by design principles to address formulation challenges. The oil was extracted via Soxhlet and characterized by gas
- undesirable physicochemical and organoleptic properties. These include (i) unfavorable sensorial characteristics (e.g., greasy texture, poor spreadability), (ii) strong odor, and (iii) susceptibility to oxidative degradation, which can negatively impact patient compliance and therapeutic efficacy [5]. To
- of the physicochemical properties and interactions of their constituents [7][9]. In this context, the quality by design (QbD) framework provides a systematic and scientifically grounded approach for pharmaceutical formulation development. QbD emphasizes predefined quality objectives, product and
Toward clinical translation of carbon nanomaterials in anticancer drug delivery: the need for standardisation
Beilstein J. Nanotechnol. 2025, 16, 2092–2104, doi:10.3762/bjnano.16.144
- nanotubes, and carbon dots, have attracted considerable interest as nanocarriers for drug delivery due to their unique physicochemical properties. Their high surface area, biocompatibility, and modifiable surface chemistry make them highly attractive for a range of biomedical applications. However, concerns
- nanomaterials (CNMs) have been largely developed as nanocarriers for drug delivery due to their biocompatibility, high surface area, tuneable physicochemical properties, and targeting capabilities [13][14]. However, CNMs also present a subset of challenges, including toxicity concerns, expensive and time
- remains substantial. This perspective uses oncology as a representative model for CNM nanocarriers, owing to cancer’s global health burden and the breadth of available studies [15][16]. Nevertheless, the underlying considerations, including synthesis, physicochemical and biological evaluation, and
Beyond the shell: exploring polymer–lipid interfaces in core–shell nanofibers to carry hyaluronic acid and β-caryophyllene
Beilstein J. Nanotechnol. 2025, 16, 2015–2033, doi:10.3762/bjnano.16.139
- critical gap persists in thoroughly understanding the complex polymer–lipid interactions, particularly in systems designed for the simultaneous co-encapsulation of compounds with vastly different physicochemical properties, such as hydrophilic HA and lipophilic βCp. An in-depth understanding of these
- important physicochemical properties of these structures are highly related to conformational changes in the polymeric chain caused by the spinning process [49][53]. Initially, the influence of the travel distance of the polymer jet on fiber formation was examined (Figure 4). This critical parameter exerts
- removal tests, which indicated the effective isolation of the bioactive components by the PLA shell. From a physicochemical perspective, the fibers presented good thermal stability without compromising the properties of the base polymer. The variation of electrospinning parameters revealed that small
Laser ablation in liquids for shape-tailored synthesis of nanomaterials: status and challenges
Beilstein J. Nanotechnol. 2025, 16, 1963–1997, doi:10.3762/bjnano.16.137
- ablation results in predominance of cubic shapes. However, the ablation of Ti in similar conditions in octane still only results in spherical NPs, which can be attributed to the difference of physicochemical processes occurring in both cases. These results demonstrate that the mechanisms and underlying
PEGylated lipids in lipid nanoparticle delivery dynamics and therapeutic innovation
Beilstein J. Nanotechnol. 2025, 16, 1914–1930, doi:10.3762/bjnano.16.133
- chains arrange on the nanoparticle surface and the potential impacts on LNPs’ physicochemical properties by varying surface PEG density or PEG chemistry. Subsequently, PEG conformations are discussed in terms of their modulation of protein corona formation, cellular uptake, and immunogenic responses
- review first reveals the localization and conformation of PEG lipids on the LNP surface, which is fundamental for understanding how PEG lipids contribute to nanoparticle stability and surface interactions. It then demonstrates how PEG density and chemical structure may influence the physicochemical
- lipid surface density and structure on LNP physicochemical properties Understanding the spatial organization of lipid components within LNPs is critical for optimizing their physicochemical characterization and stability. In particular, the localization of PEG lipids plays a significant role in
Targeting the vector of arboviruses Aedes aegypti with nanoemulsions based on essential oils: a review with focus on larvicidal and repellent properties
Beilstein J. Nanotechnol. 2025, 16, 1894–1913, doi:10.3762/bjnano.16.132
- at 25 °C for 30 days. The nanoemulsion showed physicochemical stability with an initial average size of 64.1 nm (±6.3), polydispersity index of 0.21 (±0.04), and initial pH of 5.8. After 30 days, the average size increased to 71.8 ± 8.3 nm, with a polydispersity index of 0.18 ± 0.03 and pH of 4.9
- the Amazon region. The chemical composition of the oil was dominated by p-cymene (27.70%) and α-pinene (22.31%), compounds recognized for their insecticidal activity [126][127]. The nanoemulsion was obtained by a low-energy method, presenting ideal physicochemical characteristics, with an average
- ultrasonication (40 kHz). This formulation demonstrated physicochemical stability, with good optical transparency and absence of phase separation. Characterization by TEM revealed spherical droplets with sizes between 20 and 40 nm. In the larvicidal bioassay, fourth-instar larvae of Ae. aegypti were exposed to
Self-assembly and adhesive properties of Pollicipes pollicipes barnacle cement protein cp19k: influence of pH and ionic strength
Beilstein J. Nanotechnol. 2025, 16, 1863–1872, doi:10.3762/bjnano.16.129
- protein forms amyloid fibres, potentially with diverse morphologies, under a variety of physicochemical conditions. Lysozyme and BSA (negative controls) and heat-denatured lysozyme (positive control) were used to validate the assay (Supporting Information File 1, Figure S3). Adhesion analysis rPpolcp19k
- study investigates the physicochemical conditions of fibril formation by recombinant P. pollicipes cp19k, a key protein involved in barnacle underwater adhesion. The results identify a combination of low pH and high salt concentration as optimal for fibril formation, whereas previous reports with cp19k
- quartz crystal microbalance-dissipation (QCM-D)-based studies of the adhesive properties of rPolcp19k-his monomers and fibres formed under different physicochemical conditions, as well as after a similar pH switch, are planned. Conclusion This study identifies a low pH and high salt concentration
On the road to sustainability – application of metallic nanoparticles obtained by green synthesis in dentistry: a scoping review
Beilstein J. Nanotechnol. 2025, 16, 1851–1862, doi:10.3762/bjnano.16.128
- ; sustainable development; Introduction Nanotechnology is an interdisciplinary field of science that involves the manipulation of materials at the nanoscale, typically ranging from 1 to 100 nm in inorganic nanomaterials, to generate structures with unique physicochemical properties [1][2][3]. Among the most
- of both physicochemical properties and biological effects (Figure 6). The most frequently reported biological activity among the selected studies was the inhibition of microbial growth (80.0%; n = 44), highlighting its prominence as a primary target in antimicrobial research. The studies primarily
- potential cytotoxicity of these nanoparticles within the complex and dynamic oral environment [15][20]. A significant number of selected studies (n = 23; 24.1%) also failed to perform advanced physicochemical characterizations, such as FTIR, SEM, or XRD, which are essential for confirming nanoparticle
Phytol-loaded soybean oil nanoemulsion as a promising alternative against Leishmania amazonensis
Beilstein J. Nanotechnol. 2025, 16, 1826–1836, doi:10.3762/bjnano.16.126
- performed. The results revealed nanodroplets with spherical and oval shapes and a homogeneous size distribution, with diameters up to 250 nm, consistent with the dynamic light scattering (DLS) data (Figure 1c,d). Colloidal and physicochemical stability The colloidal and physicochemical stability of the NEs
- period of up to 15 days. At the end of the 30-day stability study, both blank-NE and PHYT-NE remained stable with no changes in their initial macroscopic appearance (opaque, white, milky, and with low viscosity) and remained unchanged even after centrifugation. Among the physicochemical parameters
- in the treatment against cutaneous leishmaniasis. Although no permeation assay was conducted in the present study, the physicochemical profile of PHYT-NE supports its potential for efficient skin interaction and warrants further investigation in permeation studies. As a future perspective, ex vivo
Electrical, photocatalytic, and sensory properties of graphene oxide and polyimide implanted with low- and medium-energy silver ions
Beilstein J. Nanotechnol. 2025, 16, 1794–1811, doi:10.3762/bjnano.16.123
- multifunctional behavior of polymer systems. Keywords: ERDA; graphene oxide; ion implantation; photocatalysis; polyimide; RBS; Introduction Silver ion implantation is an effective strategy for controlling modification of the physicochemical properties of polymers and graphene-based materials. This method allows
Exploring the potential of polymers: advancements in oral nanocarrier technology
Beilstein J. Nanotechnol. 2025, 16, 1751–1793, doi:10.3762/bjnano.16.122
- in the application of polymers as oral nanocarriers, emphasizing key natural and synthetic polymers that enhance stability, bioavailability, and release. The physicochemical properties, biodegradability, and chemical modifications of these polymers, which promote mucoadhesion and epithelial
- particles. Materials reduced to this scale exhibit alterations in their physicochemical properties, enhancing their interactions with molecular and cellular processes. Consequently, nanotechnology has diverse pharmaceutical applications, as the nanoencapsulation of drugs improves solubility and
- made PNs a topic of growing interest in light of their small size and unique physicochemical properties [22][23]. These systems offer advantages for drug delivery, including the ability to protect labile compounds, control release kinetics, improve drug solubility and stability, enhance oral
Multifunctional anionic nanoemulsion with linseed oil and lecithin: a preliminary approach for dry eye disease
Beilstein J. Nanotechnol. 2025, 16, 1711–1733, doi:10.3762/bjnano.16.120
- , thus destabilizing bilayer formation. Conversely, lecithins with a higher proportion of saturated phospholipids are more likely to organize into stable bilayer vesicles like liposomes. These structural features of lecithin play a crucial role in determining the physicochemical properties of the
- using R v.4.5.1 [60], specifically the packages “tidyverse” v.2.0.0 [61] and “rstatix v.0.7.2 [62]. Supplementary statistical data are provided in spreadsheets and can be accessed in Supporting Information File 2. Results and Discussion Physicochemical properties of linseed oil The identification and
- optimal surfactant utilization. Finally, the third phase (illustrated by pre-formulations O/W(L-4%) and O/W(L-5%)) manifests an overabundance of lecithin, resulting in the formation of micellar structures within the pre-formulations. As electrical conductivity is a physicochemical parameter modulated by
Prospects of nanotechnology and natural products for cancer and immunotherapy
Beilstein J. Nanotechnol. 2025, 16, 1644–1667, doi:10.3762/bjnano.16.116
- immunotherapy is nanotechnology, as it presents physicochemical benefits for drugs. Among the advantages, nanotechnology can eliminate the limitations of using bioactive compounds in cancer treatment formulations, leading to increased bioavailability and pharmacokinetics [55]. The mechanisms behind the
- containing immunomodulators and checkpoint inhibitors to achieve a synergistic effect and consequently expand the clinical potential of nanotechnology containing natural products. Patent KR20220169108 was discussed in the article published by Dhandapani et al., which addresses the synthesis, physicochemical
- compounds must have properties that contribute to a stable formulation, difficulty in controlling physicochemical characteristics, such as particle size, which can affect reproducibility and scalability, and problems related to rapid clearance and interaction with non-target tissues, mainly due to the
Venom-loaded cationic-functionalized poly(lactic acid) nanoparticles for serum production against Tityus serrulatus scorpion
Beilstein J. Nanotechnol. 2025, 16, 1633–1643, doi:10.3762/bjnano.16.115
- physicochemical characterization of the nanoparticles revealed mean diameters below 230 nm, positive zeta potentials, and PDI below 0.3, corroborating other reports of PLA–PEI systems [14][38]. In addition, the high encapsulation efficiency can be attributed to the functionalizing agent (PEI), which demonstrates
- routes are very common for the administration of proteins with pharmacological activity and with particle sizes of around 200 nm [40]. Regarding stability, only minimal changes in physicochemical parameters were observed, indicating colloidal stability of the nanoparticle formulation. This is
- probably explain the immune response improvement since different nanoparticle types generated stronger Th1 and Th2 immune responses compared to other antigen types [45]. Although the present study provides physicochemical and immunological data supporting the potential of PLA–PEI nanoparticles as antigen
Nanotechnology-based approaches for the removal of microplastics from wastewater: a comprehensive review
Beilstein J. Nanotechnol. 2025, 16, 1607–1632, doi:10.3762/bjnano.16.114
- high water flux of 196.7 L·h−1·m−2·kPa−1 was recorded, surpassing or matching the performance of most membranes fabricated from unmodified two-dimensional nanomaterials. The material exhibits physicochemical stability, excellent permeability, and superior MP removal capabilities; hence, h-Ti3C2Tx
Laser processing in liquids: insights into nanocolloid generation and thin film integration for energy, photonic, and sensing applications
Beilstein J. Nanotechnol. 2025, 16, 1428–1498, doi:10.3762/bjnano.16.104
- al. [2] in one of the first reviews on laser ablation published in 2004. Their discussion addresses the physicochemical insights into key stages of these processes, including the behavior of the laser target, the formation of the plume, and the initial laser–target interactions. It offers a
- obtained. These mechanisms play a crucial role in determining the characteristics of the final products, whether they be spherical NPs, QDs, or other nanostructures, depending on the specific goals of the synthesis. NPs exhibit distinct mechanical and physicochemical properties that are influenced by
Photochemical synthesis of silver nanoprisms via green LED irradiation and evaluation of SERS activity
Beilstein J. Nanotechnol. 2025, 16, 1417–1427, doi:10.3762/bjnano.16.103
- -MBA) as a probe molecule. In this study, AgNPrs were synthesized photochemically using green LED 10 W irradiation. Seeds were prepared using 1 mM AgNO3 and stabilized with a trisodium citrate (TSC)/AgNO3 molar ratio of 5. Physicochemical analyses confirmed the successful formation of AgNPrs with high
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