Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti

• Matheus Alves Siqueira de Assunção,
• Douglas Dourado,
• Daiane Rodrigues dos Santos,
• Gabriel Bezerra Faierstein,
• Mara Elga Medeiros Braga,
• Severino Alves Junior,
• Rosângela Maria Rodrigues Barbosa,
• Herminio José Cipriano de Sousa and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 1566–1575, doi:10.3762/bjnano.15.123

• cells, and in vivo models such as Danio rerio (zebrafish). Conclusion Nanotechnology has great potential in current medicinal and agricultural systems, where pests and disease vectors are controlled by chemical pesticides that are toxic to non-target species and harmful to soil fertility and ecosystems

Introducing third-generation periodic table descriptors for nano-qRASTR modeling of zebrafish toxicity of metal oxide nanoparticles

• Supratik Kar and
• Siyun Yang

Beilstein J. Nanotechnol. 2024, 15, 1142–1152, doi:10.3762/bjnano.15.93

• zebrafish toxicity for 24 MONPs. Previously established 23 first- and second-generation periodic table descriptors, along with five newly proposed third-generation descriptors derived from the periodic table, were employed. Subsequently, to enhance the quality and predictive capability of the nano-QSTR

• models. Finally, the developed nano-qRASTR model was applied to predict toxicity data for an external dataset comprising 35 MONPs, addressing gaps in zebrafish toxicity assessment. Keywords: metal nanoparticles; metal oxide nanoparticles; nano-qRASTR; periodic table descriptors; QSAR; zebrafish

• from human studies, researchers have turned to zebrafish and their embryos for toxicological investigations. Zebrafish embryos are commonly used to identify environmental heavy metal pollution [13]. As a multicellular organism, zebrafish can offer more comprehensive insights into nanomaterials

A review on the structural characterization of nanomaterials for nano-QSAR models

• Salvador Moncho,
• Eva Serrano-Candelas,
• Jesús Vicente de Julián-Ortiz and
• Rafael Gozalbes

Beilstein J. Nanotechnol. 2024, 15, 854–866, doi:10.3762/bjnano.15.71

• other independent tests. Hence, differences in equivalent tests should be related to underlying differences in the nanostructure. The wide range of attributes selected by Liu et al. [85] in their predictive method of toxicity based on a combined index for zebrafish (EZ metric) included the synthesis

Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• and increased the survival rate of cells under high H2O2 concentration. In vivo results of another experiment demonstrated the ROS scavenging ability of Au@Cu2O heterostructures in a zebrafish model, which is an organism with morphological and physiological functions similar to those of humans [48

• thyroid hormone disruption in zebrafish larvae co-exposed to tetrabromobisphenol A by promoting its bioaccumulation and bioavailability [192]. Xu et al. demonstrated that TiO2 nanoparticles can promote damage to adipose derived stromal cells at low concentrations [193]. Accordingly, the surface chemistry

Prediction of cytotoxicity of heavy metals adsorbed on nano-TiO₂ with periodic table descriptors using machine learning approaches

• Joyita Roy,
• Souvik Pore and
• Kunal Roy

Beilstein J. Nanotechnol. 2023, 14, 939–950, doi:10.3762/bjnano.14.77

• ability of TiO2 NPs to adsorb heavy metals and to increase their transport rate into hosts, increasing their concentration in the cell. Hu et al. [10] investigated the joint effect of TiO2 NPs and humic acid (HA) on Cd2+ bioaccumulation in zebrafish. In another study, Yang et al. [11] showed that TiO2 NPs

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

Identifying diverse metal oxide nanomaterials with lethal effects on embryonic zebrafish using machine learning

• Richard Liam Marchese Robinson,
• Haralambos Sarimveis,
• Philip Doganis,
• Xiaodong Jia,
• Marianna Kotzabasaki,
• Christiana Gousiadou,
• Stacey Lynn Harper and
• Terry Wilkins

Beilstein J. Nanotechnol. 2021, 12, 1297–1325, doi:10.3762/bjnano.12.97

• , embryonic zebrafish (Danio Rerio) are recognised as a key human safety relevant in vivo test system. Hence, machine learning models were developed for identifying metal oxide nanomaterials causing lethality to embryonic zebrafish up to 24 hours post-fertilisation, or excess lethality in the period of 24–120

• these modelling results are on truly external data, which were not used to select the single descriptor model. This will require further laboratory work to generate comparable data to those studied herein. Keywords: data augmentation; embryonic zebrafish; machine learning; nanosafety; nano-QSAR

• . Increasingly, there is interest in using (embryonic) zebrafish (Danio Rerio) as experimental test subjects to assess potential human safety concerns of chemicals [22] and materials, including nanomaterials [23][24]. It is argued that embryonic zebrafish provide “the power of whole-animal investigations

A review on the biological effects of nanomaterials on silkworm (Bombyx mori)

• Sandra Senyo Fometu,
• Guohua Wu,
• Lin Ma and
• Joan Shine Davids

Beilstein J. Nanotechnol. 2021, 12, 190–202, doi:10.3762/bjnano.12.15

• graphene quantum dots on its motor nervous system. The locomotion of the nematodes deteriorated following the exposure to these nanomaterials with damages in the dopaminergic and glutamatergic neurons [46]. Fast embryonic development outside the parent zebrafish is an attractive feature that allows for the

• cell development to be examined from the outside [47]. The exposure of zebrafish to Ag NPs inhibited the hatching rates and caused high embryo mortality. Bar-Ilan et al. [48] reported that colloidal Ag caused a higher mortality of zebrafish embryos when compared to colloidal Au 120 h post-fertilization

• . Asharani et al. [49] also reported the toxic effects of Ag NPs on zebrafish embryo mortality, delay in hatching, heart rate reduction in the embryo and also non-lethal effects of Au NPs on embryo development. Muller et al. [50] stated that 1.88 μM of dissolved Cu2+ inhibited the proteolytic activity of the

Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics

• Stefania Lettieri,
• Marta d’Amora,
• Adalberto Camisasca,
• Alberto Diaspro and
• Silvia Giordani

Beilstein J. Nanotechnol. 2017, 8, 1878–1888, doi:10.3762/bjnano.8.188

• recent reports have shown that CNOs exhibit weak inflammatory potential and low cytotoxicity [16], and they are readily internalized by cancer cells and localize in the lysosomes [18][19]. Moreover, our in vivo studies performed on zebrafish (Danio Rerio) during the development stage demonstrated their

Needs and challenges for assessing the environmental impacts of engineered nanomaterials (ENMs)

• Michelle Romero-Franco,
• Hilary A. Godwin,
• Muhammad Bilal and
• Yoram Cohen

Beilstein J. Nanotechnol. 2017, 8, 989–1014, doi:10.3762/bjnano.8.101

• nanoparticles in human volunteers and quantum dots ‘QDs’ in rat skin) and cause irritation (e.g., nano ZnO in zebrafish models) [10]. Oral exposure to ENMs can result in subsequent absorption in the GI tract and organ damage (e.g., nano Cu in mice via oral gavage damaged liver, spleen and kidneys, and nano ZnO

Nanoinformatics for environmental health and biomedicine

• Rong Liu and
• Yoram Cohen

Beilstein J. Nanotechnol. 2015, 6, 2449–2451, doi:10.3762/bjnano.6.253

• for brain cancer [13]. As an imported aspect of nanoinformatics, recent advances in data mining/machine learning of nano-data are also reported in this Thematic Series. In one study, the toxicity of ZnO nanoparticles to zebrafish (measured by mortality rate (%)) was correlated to two principal

Predicting cytotoxicity of PAMAM dendrimers using molecular descriptors

• David E. Jones,
• Hamidreza Ghandehari and
• Julio C. Facelli

Beilstein J. Nanotechnol. 2015, 6, 1886–1896, doi:10.3762/bjnano.6.192

• techniques in this field. For instance, Liu et al. analyzed a number of attributes of a variety of nanoparticles in order to predict the 24 hour postfertilization mortality in zebrafish [3]. Horev-Azaria and colleagues used predictive modeling to explore the effect of cobalt–ferrite nanoparticles on the

Analysis of soil bacteria susceptibility to manufactured nanoparticles via data visualization

• Rong Liu,
• Yuan Ge,
• Patricia A. Holden and
• Yoram Cohen

Beilstein J. Nanotechnol. 2015, 6, 1635–1651, doi:10.3762/bjnano.6.166

• tend to accumulate in soil and sediment [16][17]. Various studies [18][19][20][21][22] have reported that MNPs could lead to adverse environmental impacts. For example, Ag and Pt MNPs may interfere with zebrafish embryo hatching [23]; ZnO MNPs may cause compositional changes in soil bacterial

The eNanoMapper database for nanomaterial safety information

• Nina Jeliazkova,
• Charalampos Chomenidis,
• Philip Doganis,
• Bengt Fadeel,
• Roland Grafström,
• Barry Hardy,
• Janna Hastings,
• Markus Hegi,
• Vedrin Jeliazkov,
• Nikolay Kochev,
• Pekka Kohonen,
• Cristian R. Munteanu,
• Haralambos Sarimveis,
• Bart Smeets,
• Pantelis Sopasakis,
• Georgia Tsiliki,
• David Vorgrimmler and
• Egon Willighagen

Beilstein J. Nanotechnol. 2015, 6, 1609–1634, doi:10.3762/bjnano.6.165

• % missing values). The two most comprehensive species in the dataset are Daphnia magna (water flea) and Danio rerio (zebrafish), with 34 and 14 assays each. The best represented endpoint for Daphnia is “Mortality”, and we were able to extract about forty “LC50” and sixty “% survival” data entries. In both

Influence of surface chemical properties on the toxicity of engineered zinc oxide nanoparticles to embryonic zebrafish

• Zitao Zhou,
• Jino Son,
• Bryan Harper,
• Zheng Zhou and
• Stacey Harper

Beilstein J. Nanotechnol. 2015, 6, 1568–1579, doi:10.3762/bjnano.6.160

• , chemical modifications are often performed on the NPs surface; however, the roles of these alterations play in determining the toxicity of ZnO NPs are still not well understood. As such, we investigated the toxicity of 17 diverse ZnO NPs varying in both size and surface chemistry to developing zebrafish

• estimations were then used to develop a contour map based on mortality data as a response. This study illustrates how the intrinsic properties of NPs, including surface chemical modifications and capping agents, are useful to separate and identify ZnO NP toxicity to zebrafish (Danio rerio). Keywords: kriging

• surface ligands of engineered ZnO NPs alter their toxicity and 2) to determine if these features can be used to model the developmental toxicity of ZnO nanoparticles to embryonic zebrafish (Danio rerio) (Figure 1). Zebrafish embryos were selected as vertebrate test species as their transparent tissues

Using natural language processing techniques to inform research on nanotechnology

• Nastassja A. Lewinski and
• Bridget T. McInnes

Beilstein J. Nanotechnol. 2015, 6, 1439–1449, doi:10.3762/bjnano.6.149

• Interactions (NBI) knowledge base. The NBI includes data on the mortality, delayed development and morphological malformations of embryonic zebrafish due to the toxicity of various nanomaterials including metal nanoparticles, dendrimer, metal oxide and polymeric materials [40]. Java Applets were used to

Influence of gold, silver and gold–silver alloy nanoparticles on germ cell function and embryo development

• Ulrike Taylor,
• Daniela Tiedemann,
• Christoph Rehbock,
• Wilfried A. Kues,
• Stephan Barcikowski and
• Detlef Rath

Beilstein J. Nanotechnol. 2015, 6, 651–664, doi:10.3762/bjnano.6.66

• , especially zebrafish, because such embryos can be obtained easily and in great numbers. A highly repeatable finding in these studies was the severe embryotoxicity of silver nanoparticles, while gold nanoparticles elicited hardly any adverse response [87][88][89][90] unless administered in very small sizes

In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?

• Moritz Nazarenus,
• Qian Zhang,
• Mahmoud G. Soliman,
• Pablo del Pino,
• Beatriz Pelaz,
• Susana Carregal-Romero,
• Joanna Rejman,
• Barbara Rothen-Rutishauser,
• Martin J. D. Clift,
• Reinhard Zellner,
• G. Ulrich Nienhaus,
• James B. Delehanty,
• Igor L. Medintz and
• Wolfgang J. Parak

Beilstein J. Nanotechnol. 2014, 5, 1477–1490, doi:10.3762/bjnano.5.161

• prediction of NP interactions, for instance, in the human body or in ecotoxicology. Some NPs have been mistaken to elicit limited to no adverse effects upon zebrafish assays, as they had precipitated to the bottom, and thus, the fish had not been directly exposed to them. After correct solubilization

• , however, the same NPs turned out to be highly detrimental to zebrafish health [90]. Colloidal stability does not only interfere with size but also with other parameters such as shape. An agglomerated bundle of sharp NPs may no longer be "sharp". Thus, colloidal stability is the paramount parameter to

Molecular biology approaches in bioadhesion research

• Marcelo Rodrigues,
• Birgit Lengerer,
• Thomas Ostermann and
• Peter Ladurner

Beilstein J. Nanotechnol. 2014, 5, 983–993, doi:10.3762/bjnano.5.112

• [40][49][50][51][52], chicken [43][53][54], zebrafish [55], mekada fish [56][57], the fruit fly Drosophila [47][58], the frog Xenopus [59][60][61][62] and the ascidian Ciona intestinalis [63][64][65][66]. These screens demonstrate the potential of large-scale ISH for the discovery of new genes. In