Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• disease continues to be of utmost importance [9]. Current studies have highlighted curcumin as a promising antiparasitic alternative [10]. Curcumin (diferuloylmethane) is a yellow polyphenol extracted from the rhizome of Curcuma longa, popularly known as turmeric [11][12][13]. This molecule presents a

• high tolerance profile, and it has shown in vitro and in vivo leishmanicidal properties against different species of Leishmania spp. [11][14]. Despite its pharmacological potential, curcumin has some physicochemical and biopharmaceutical limitations that should be highlighted, such as: (i) low aqueous

• ) obtained from the rhizome of Curcuma longa and is the main curcuminoid present in this plant [11][12]. Due to its good tolerance profile and safety even at high doses (12 g/day), curc has been extensively studied as a therapeutic agent [11][14]. Numerous preclinical and clinical trials have concluded that

Measurements of dichroic bow-tie antenna arrays with integrated cold-electron bolometers using YBCO oscillators

• Leonid S. Revin,
• Dmitry A. Pimanov,
• Alexander V. Chiginev,
• Anton V. Blagodatkin,
• Viktor O. Zbrozhek,
• Andrey V. Samartsev,
• Anastasia N. Orlova,
• Dmitry V. Masterov,
• Alexey E. Parafin,
• Victoria Yu. Safonova,
• Anna V. Gordeeva,
• Andrey L. Pankratov,
• Leonid S. Kuzmin,
• Anatolie S. Sidorenko,
• Silvia Masi and
• Paolo de Bernardis

Beilstein J. Nanotechnol. 2024, 15, 26–36, doi:10.3762/bjnano.15.3

• efficiency. As a direct radiation detector, we consider using the cold-electron bolometer (CEB) concept [11][12]. These bolometers have high sensitivity with background-limited operation [13][14][15], a broad operating frequency range, as well as immunity to spurious cosmic rays [16]. Since CEB sizes are of

Nanotechnological approaches in the treatment of schistosomiasis: an overview

• Lucas Carvalho,
• Michelle Sarcinelli and
• Beatriz Patrício

Beilstein J. Nanotechnol. 2024, 15, 13–25, doi:10.3762/bjnano.15.2

• address all these issues related to PZQ and bring new treatment alternatives [10]. Nanotechnology involves the creation and use of materials and technologies at the nanoscale, while nanomedicine focuses on the application of nanotechnology to treat, monitor, and prevent diseases [11]. Nanomedicine uses

TEM sample preparation of lithographically patterned permalloy nanostructures on silicon nitride membranes

• Joshua Williams,
• Michael I. Faley,
• Joseph Vimal Vas,
• Peng-Han Lu and
• Rafal E. Dunin-Borkowski

Beilstein J. Nanotechnol. 2024, 15, 1–12, doi:10.3762/bjnano.15.1

• ], transmission electron microscopy (TEM) [1][8][9][10][11], scanning transmission X-ray microscopy [12][13], and magneto-optical Kerr effect microscopy [14][15]. Possible applications of Py nanodisks were proposed for zero-hysteresis magnet sensors, magnetic logic devices, and data storage [16]. Py is a nickel

unDrift: A versatile software for fast offline SPM image drift correction

• Tobias Dickbreder,
• Franziska Sabath,
• Lukas Höltkemeier,
• Ralf Bechstein and
• Angelika Kühnle

Beilstein J. Nanotechnol. 2023, 14, 1225–1237, doi:10.3762/bjnano.14.101

• the actual probe position; thus, the SPM image is distorted [1][2][4][8][9][10][11][12][13][14][15][16][17]. The determination of linear calibration parameters and scanner non-orthogonality based on atomic structures [1][2][3][8][9][18][19] and calibration gratings [1][20][21][22] have been discussed

• intensively. In addition to linear effects, non-linear scanner behavior such as creep [1][4][10][11][12][13] and hysteresis [1][2][4][10][14][15][16][17] has been analyzed and corrected. The second prominent artifact causing distortion of SPM images is (thermal) drift. Because of the serial nature of the

• to the experimental error, which we expect to be higher because of the exceptionally high drift velocity. We want to highlight that this is an extreme example where the absolute drift velocity (3.8 × 10−11 m·s−1) exceeds the scan velocity in the slow scan direction (3.7 × 10−11 m·s−1). For most

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

• Eloïse Equy,
• Jordana Hirtzel,
• Sophie Hellé,
• Béatrice Heurtault,
• Eric Mathieu,
• Morgane Rabineau,
• Vincent Ball and
• Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

• bacteria. Inspired by the eumelanin aggregates in human skin, polydopamine nanoaggregates (here referred to as nanoparticles, i.e., PDA NPs) have emerged as promising nanovectors for biomedical applications [11][12], especially because of their biocompatibility [13][14] and photothermic properties [15][16

• 0.25 to 3. However, a plateau value was reached above a ratio of 6, leading to BSA/PDA NPs of 11 ± 3 nm and 9 ± 3 nm in diameter for BSA/DA ratios of 6 and 10, respectively. The size of the BSA protein is probably the limiting factor to a further decrease of the NP size. Indeed, one BSA molecule has an

• deteriorated above pH 11 with, first, a decrease in size before the NP morphology changed into nanosheets [28]. However, in the case of BSA/PDA NPs, the NPs size increased when the pH value was above 6.5. In addition, precipitation, sedimentation, or degradation of the dispersion were not observed, showing

Determination of the radii of coated and uncoated silicon AFM sharp tips using a height calibration standard grating and a nonlinear regression function

• Perawat Boonpuek and
• Jonathan R. Felts

Beilstein J. Nanotechnol. 2023, 14, 1200–1207, doi:10.3762/bjnano.14.99

• angle yield the scanline profile of the tip with its slope angle for tip radius calculation. However, this geometry-based method relies on the tip slope angle, which varies for different types of tips [11]. In noncontact scanning mode, Maragliano et al. showed that a sharper tip (small tip radius

A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH₃)₂Cl]₂

• Elif Bilgilisoy,
• Ali Kamali,
• Thomas Xaver Gentner,
• Gerd Ballmann,
• Sjoerd Harder,
• Hans-Peter Steinrück,
• Hubertus Marbach and
• Oddur Ingólfsson

Beilstein J. Nanotechnol. 2023, 14, 1178–1199, doi:10.3762/bjnano.14.98

• structures, these precursor molecules are commonly organometallics that adsorb on the substrate and are decomposed by the electron beam irradiation. Ideally, a pure metal is deposited while fragmented volatile ligands are pumped away [11][12][13]. Several parameters affect the FEBID process, including the

Spatial variations of conductivity of self-assembled monolayers of dodecanethiol on Au/mica and Au/Si substrates

• Julian Skolaut,
• Jędrzej Tepper,
• Federica Galli,
• Wulf Wulfhekel and
• Jan M. van Ruitenbeek

Beilstein J. Nanotechnol. 2023, 14, 1169–1177, doi:10.3762/bjnano.14.97

• . This was avoided in later experiments by using eutectic GaIn (eGaIn) droplets [8][9][10][11]. These are much more viscous, to the point that they are almost solid. This reduces the amount of leak currents significantly and makes studies on the conductivity of SAMs much more reliable. A more widely

Hierarchically patterned polyurethane microgrooves featuring nanopillars or nanoholes for neurite elongation and alignment

• Lester Uy Vinzons,
• Guo-Chung Dong and
• Shu-Ping Lin

Beilstein J. Nanotechnol. 2023, 14, 1157–1168, doi:10.3762/bjnano.14.96

• microenvironment. While several of these focused on stem cell differentiation [9][10], a couple of studies explored their effects on axonal guidance. Lee et al. [11] found that nanorough microridges composed of laser-patterned Al/Al2O3 nanowires increase cell attachment and effectively guide dorsal root ganglia

Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems

• Agnes-Valencia Weiss and
• Marc Schneider

Beilstein J. Nanotechnol. 2023, 14, 1149–1156, doi:10.3762/bjnano.14.95

• system when they reach the end of their lifetime [11][12]. Similar data were reported for nanoparticulate systems [13]. Other examples are viruses [14] and cancer cells which can adapt their mechanical properties multiple times during the process of metastasis formation [15]. Looking at these examples

A multi-resistance wide-range calibration sample for conductive probe atomic force microscopy measurements

• François Piquemal,
• Khaled Kaja,
• Pascal Chrétien,
• José Morán-Meza,
• Frédéric Houzé,
• Christian Ulysse and
• Abdelmounaim Harouri

Beilstein J. Nanotechnol. 2023, 14, 1141–1148, doi:10.3762/bjnano.14.94

• versatility and high resolution in probing the local conductivity of materials, C-AFM has been extensively used in studying semiconductors [6][7], two-dimensional materials [8][9][10], memristive devices [11][12][13][14][15], photoelectric systems [16][17][18], dielectric films [19][20][21][22][23], molecular

• -AFM imaging and I–V curves measurement to define the conditions for calibrated measurements. Calibration sample design and fabrication The sample developed in this work consisted of a square fused silica substrate (11 mm wide, 2 mm thick), on which gold connection lines and pads were fabricated by

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• stability and solubility [9]. The complexation occurs mainly through hydrophobic interactions in protein cavities [10][11]. In a recent study, zein nanoparticles loaded with CUR have been studied for their potential in treating brain tumors, and the results have demonstrated a reduction in the proliferation

A bifunctional superconducting cell as flux qubit and neuron

• Dmitrii S. Pashin,
• Pavel V. Pikunov,
• Marina V. Bastrakova,
• Andrey E. Schegolev,
• Nikolay V. Klenov and
• Igor I. Soloviev

Beilstein J. Nanotechnol. 2023, 14, 1116–1126, doi:10.3762/bjnano.14.92

• millikelvin temperatures with zeptojoule energy efficiency [11][12][13][14][15][16][17]. In addition, the basic cells of adiabatic superconducting circuits can be used as a part of neuromorphic co-processors [18][19][20][21][22][23] working in conjunction with quantum computing systems [24][25][26][27][28][29

• the evolutionary operator up to the fourth order. This agreement indicates the correctness of the approximations used for the estimation. Based on the resulting expression for the linear coefficient expression (Equation 11) for ε(tLZ + τLZ), we use the well-known formula for calculating the

Sulfur nanocomposites with insecticidal effect for the control of Bactericera cockerelli

• Lany S. Araujo-Yépez,
• Juan O. Tigrero-Salas,
• Vicente A. Delgado-Rodríguez,
• Vladimir A. Aguirre-Yela and
• Josué N. Villota-Méndez

Beilstein J. Nanotechnol. 2023, 14, 1106–1115, doi:10.3762/bjnano.14.91

• , contamination of water bodies, degradation of agroecosystems, and damages to human health after direct or indirect exposure [11][12][13]. Therefore, new methods need to be considered to control the pest. Nanotechnology has emerged as a technological advance that can enhance modern agriculture by helping in the

Density functional theory study of Au-fcc/Ge and Au-hcp/Ge interfaces

• Olga Sikora,
• Małgorzata Sternik,
• Benedykt R. Jany,
• Franciszek Krok,
• Przemysław Piekarz and
• Andrzej M. Oleś

Beilstein J. Nanotechnol. 2023, 14, 1093–1105, doi:10.3762/bjnano.14.90

• 152, PL-31342 Kraków, Poland Marian Smoluchowski Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Łojasiewicza 11, 30348 Krakow, Poland Institute of Theoretical Physics, Jagiellonian University, Prof. Stanisława Łojasiewicza 11, PL-30348 Kraków

• power, the atomic structure and specific properties of various interfaces have been successfully studied using first principle calculations [8][9][10][11][12][13]. Up to very high pressures, gold crystallizes in the fcc phase [14] with the ABC repeating pattern of hexagonal planes in the [111] direction

• Ge–Au bonding in the modeled heterostructures can be illustrated by plots of charge distribution at the Au/Ge interface. Figure 11 presents isocharge surfaces (0.051 e/Å−3), connecting pairs of atoms if a bond is formed between them. Away from the interface, each germanium atom shares four covalent

Properties of tin oxide films grown by atomic layer deposition from tin tetraiodide and ozone

• Kristjan Kalam,
• Peeter Ritslaid,
• Tanel Käämbre,
• Aile Tamm and
• Kaupo Kukli

Beilstein J. Nanotechnol. 2023, 14, 1085–1092, doi:10.3762/bjnano.14.89

• precursor combinations for obtaining SnO2 in atomic layer deposition (ALD) processes [9]. Two of these processes have employed SnI4 as the metal precursor with either O2 [10][11][12][13][14] or H2O2 [10][11][15] as oxidizer. Of these two oxygen sources, O2 would be more desirable because with it a hydrogen

• [10][11][12][13][14] and achieving the maximum GPC of about 0.12 nm/cycle around 600 °C [13][14]. To date, a process using SnI4 and O3 has not been published. The present paper shows that using O3 instead of O2, the deposition temperature can be brought down to 225 °C and the GPC can be enhanced. The

• photoelectron spectra (Figure 10c) closely resemble those reported for SnO2 [28] with a dominant peak just below 5 eV and further distinct features at around 7.5 and 11 eV. This is in rather stark contrast to the SnO valence band, where mainly the occupied Sn 5s states give rise to a significant peak at ca. 2.5

Dual-heterodyne Kelvin probe force microscopy

• Benjamin Grévin,
• Fatima Husainy,
• Dmitry Aldakov and
• Cyril Aumaître

Beilstein J. Nanotechnol. 2023, 14, 1068–1084, doi:10.3762/bjnano.14.88

• illumination chain. This is for instance the case of intensity-modulated KPFM [7][8][9], pump-probe KPFM [4][10][11], or G-mode KPFM [12], to name a few (we refer the readers to review articles for a more comprehensive introduction to AFM-based time-resolved potentiometric and electrostatic modes [13][14

• plane of the substrate. Results and Discussion Dual-heterodyne Kelvin probe force microscopy under electrical pumping: benchmarking Similar to the case of pp-KPFM [11], we tested this new implementation by performing DHe-KPFM measurements under electrical pumping on a highly oriented pyrolytic graphite

• substrate (HOPG). For these tests, the sample was electrically connected to the AWG (channel 1 in Figure 1) by mounting the HOPG substrate onto a sample holder designed with in situ electrical contacts [11]. The results of four measurements with different pump signals are shown in Figure 2. In all cases the

Spatial mapping of photovoltage and light-induced displacement of on-chip coupled piezo/photodiodes by Kelvin probe force microscopy under modulated illumination

• Zeinab Eftekhari,
• Nasim Rezaei,
• Hidde Stokkel,
• Jian-Yao Zheng,
• Andrea Cerreta,
• Ilka Hermes,
• Minh Nguyen,
• Guus Rijnders and
• Rebecca Saive

Beilstein J. Nanotechnol. 2023, 14, 1059–1067, doi:10.3762/bjnano.14.87

• ]. However, the working principle of these techniques is based on optical interferometry mapping which can be challenging for light-sensitive devices. Furthermore, it can be advantageous to employ a method that also allows for mechanical contact and manipulation. Atomic force microscopy (AFM) [11][12][13][14

Experimental investigation of usage of POE lubricants with Al₂O₃, graphene or CNT nanoparticles in a refrigeration compressor

• Kayhan Dağıdır and
• Kemal Bilen

Beilstein J. Nanotechnol. 2023, 14, 1041–1058, doi:10.3762/bjnano.14.86

• refrigeration compressors are metal oxides and carbon-based nanoparticles [11][12]. It is emphasized that both kinds of nanoparticles have positive effects on system performance. Krishnan et al. [13]. examined the effects of addition of metal oxide nanoparticles of Al2O3, SiO2, ZrO2, and carbon-based

• and condensation temperatures. To validate the study, the actual refrigeration cycle with R1234yf is presented as in previous studies [36]. The pressure (P) – specific enthalpy (h) diagram obtained from the validation tests was given in Figure 11. Accordingly, it was seen that the actual P–h diagram

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• during development, namely nitrogen monoxide scavenging and associated hypertensive crises, massive renal damage due to tubular reabsorption of hemoglobin (Hb), decay into dimers [8][9][10][11][12][13], and oxidative stress [14][15]. Various approaches of intra- as well as intermolecular modifications of

A visible-light photodetector based on heterojunctions between CuO nanoparticles and ZnO nanorods

• Doan Nhat Giang,
• Nhat Minh Nguyen,
• Duc Anh Ngo,
• Thanh Trang Tran,
• Le Thai Duy,
• Cong Khanh Tran,
• Thi Thanh Van Tran,
• Phan Phuong Ha La and
• Vinh Quang Dang

Beilstein J. Nanotechnol. 2023, 14, 1018–1027, doi:10.3762/bjnano.14.84

• a particular wavelength [9][10][11][12][13][14] and broadband PDs that work over a wide wavelength range [15]. Many researchers have focused on developing sensing materials operating in the visible-light region because this region is the biggest fraction of the solar spectrum (around 43%) [16][17

Exploring internal structures and properties of terpolymer fibers via real-space characterizations

• Michael R. Roenbeck and
• Kenneth E. Strawhecker

Beilstein J. Nanotechnol. 2023, 14, 1004–1017, doi:10.3762/bjnano.14.83

• ® and UHMWPE [9][10][11][12][13]. Here we extend this technique to Technora® by notching individual fibers (Figure 1b), gently opening them along shear planes to expose internal surfaces, and then scanning across those surfaces using an atomic force microscope (AFM) (Figure 1c). AFM scans yield internal

• apparent skin–core differentiation in the microstructure (e.g., as in Kevlar®) is observed [11][13][14][15][16]. The lack of evidence for a skin–core structure in Technora® was referenced in an earlier study by Derombise et al. [17], but to our knowledge, this is the first time this has been directly shown

• to date, in Technora®, these features regularly merge and separate from one another, intersecting at nodes and splitting off into fibrils with distinct dimensions [9][10][11][12][13]. Likewise, some fibrils appear to protrude into and out from the primary surface exposed by FIB notching, suggesting

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• the detection limit of LFAs is only between millimolar and micromolar concentrations [10]. To overcome this, various modifications of LFAs have been explored [11][12]. For example, Petrakova et al. used different architectures of gold nanoparticles in LFAs to improve the sensitivity of the assays [11

Isolation of cubic Si₃P₄ in the form of nanocrystals

• Polina K. Nikiforova,
• Sergei S. Bubenov,
• Vadim B. Platonov,
• Andrey S. Kumskov,
• Nikolay N. Kononov,
• Tatyana A. Kuznetsova and
• Sergey G. Dorofeev

Beilstein J. Nanotechnol. 2023, 14, 971–979, doi:10.3762/bjnano.14.80

• ) Si3P4 to be energetically favored [9][10][11][12][13][14]. The calculated lattice constant a and the ratio c/a lie within the ranges of 4.961–5.093 Å and 0.994–1.003, respectively. Among the properties of silicon-based materials, one may note a high specific capacity, which is crucial for Li-ion

• calculations in the GGA approximation, a pseudocubic defective zinc blende Si3P4 phase was predicted to possess lattice constants a = 5.038 Å and c = 5.038 Å consistent with our experimental results [11]. Given that the values of the parameters a and c cannot be experimentally discerned, the lattice was

• parameters were reasonably close to that of [11] with a lattice parameter of 5.054 Å and bond length of 2.27 Å. The fully symmetric A1 vibration frequency was precisely determined in our calculations, while the others were off by up to ca. 34 cm−1 with respect to the experimental values. This discrepancy was