Synthesis and antifungal properties of papulacandin derivatives

• Marjolein van der Kaaden,
• Eefjan Breukink and
• Roland J. Pieters

Beilstein J. Org. Chem. 2012, 8, 732–737, doi:10.3762/bjoc.8.82

• Marjolein van der Kaaden Eefjan Breukink Roland J. Pieters Department of Medicinal Chemistry and Chemical Biology. Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands Department of Biochemistry of Membranes, Bijvoet Centre for

Continuous proline catalysis via leaching of solid proline

• Suzanne M. Opalka,
• Ashley R. Longstreet and
• D. Tyler McQuade

Beilstein J. Org. Chem. 2011, 7, 1671–1679, doi:10.3762/bjoc.7.197

• Suzanne M. Opalka Ashley R. Longstreet D. Tyler McQuade Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306 10.3762/bjoc.7.197 Abstract Herein, we demonstrate that a

Use of mixed Li/K metal TMP amide (LiNK chemistry) for the synthesis of [2.2]metacyclophanes

• Marco Blangetti,
• Patricia Fleming and
• Donal F. O'Shea

Beilstein J. Org. Chem. 2011, 7, 1249–1254, doi:10.3762/bjoc.7.145

• Marco Blangetti Patricia Fleming Donal F. O'Shea Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland 10.3762/bjoc.7.145 Abstract A new two-step general approach to [2.2]metacyclophane synthesis from

Multicomponent synthesis of artificial nucleases and their RNase and DNase activity

• Anton V. Gulevich,
• Lyudmila S. Koroleva,
• Olga V. Morozova,
• Valentina N. Bakhvalova,
• Vladimir N. Silnikov and
• Valentine G. Nenajdenko

Beilstein J. Org. Chem. 2011, 7, 1135–1140, doi:10.3762/bjoc.7.131

• Anton V. Gulevich Lyudmila S. Koroleva Olga V. Morozova Valentina N. Bakhvalova Vladimir N. Silnikov Valentine G. Nenajdenko Department of Chemistry, Moscow State University, 119992, Leninskie Gory, Moscow, Russia Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian

Efficient gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular hydroalkylation of unactivated alkenes with α-ketones

• Ya-Ping Xiao,
• Xin-Yuan Liu and
• Chi-Ming Che

Beilstein J. Org. Chem. 2011, 7, 1100–1107, doi:10.3762/bjoc.7.126

• Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China 10.3762/bjoc.7.126 Abstract The gold(I)/silver(I)-cocatalyzed cascade intermolecular N-Michael addition/intramolecular

Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation

• Jingjing Wu,
• Hui Li and
• Song Cao

Beilstein J. Org. Chem. 2011, 7, 1070–1074, doi:10.3762/bjoc.7.123

• Jingjing Wu Hui Li Song Cao Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China 10.3762/bjoc.7.123 Abstract Thirteen difluoromethyl-containing pseudopeptides were synthesized by Ugi reaction using the novel

Toward an integrated route to the vernonia allenes and related sesquiterpenoids

• Da Xu,
• Michael A. Drahl and
• Lawrence J. Williams

Beilstein J. Org. Chem. 2011, 7, 937–943, doi:10.3762/bjoc.7.104

• Da Xu Michael A. Drahl Lawrence J. Williams Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, NJ 08854, USA 10.3762/bjoc.7.104 Abstract The synthesis of a model endocyclic allene related to the vernonia allenes is described

Reciprocal polyhedra and the Euler relationship: cage hydrocarbons, C_nH_n and closo-boranes [B_xH_x]²⁻

• Michael J. McGlinchey and
• Henning Hopf

Beilstein J. Org. Chem. 2011, 7, 222–233, doi:10.3762/bjoc.7.30

• Michael J. McGlinchey Henning Hopf School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland Institut für Organische Chemie, Technische Universitaet Carolo-Wilhelmina zu Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany 10.3762/bjoc.7.30 Abstract The

The allylic chalcogen effect in olefin metathesis

• Yuya A. Lin and
• Benjamin G. Davis

Beilstein J. Org. Chem. 2010, 6, 1219–1228, doi:10.3762/bjoc.6.140

• examples of such a reaction on proteins. This led to a new benchmark in substrate complexity for cross-metathesis and expanded the potential of olefin metathesis for other applications in chemical biology. The enhanced reactivity of allyl sulfide, along with earlier reports of a similar effect by allylic

• is even compatible with amine and sulfur containing building blocks. Together with its high stability in various media and excellent chemoselectivity, olefin metathesis has been used on peptide substrates for various applications in chemical biology [5][6][7][8]. The development of water-soluble

• chalcogen effect has affected the way chemists use metathesis in synthesis and chemical biology. Complex molecules and metathesis partners can be joined efficiently with the aid of the natural affinity of ruthenium for allyl chalcogens. In this review, we have highlighted various applications of olefin

Brønsted acid-promoted azide–olefin [3 + 2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A

• Hubert Muchalski,
• Ki Bum Hong and
• Jeffrey N. Johnston

Beilstein J. Org. Chem. 2010, 6, 1206–1210, doi:10.3762/bjoc.6.138

• Hubert Muchalski Ki Bum Hong Jeffrey N. Johnston Vanderbilt University and Vanderbilt Institute of Chemical Biology, Nashville, TN 37235, United States 10.3762/bjoc.6.138 Abstract We report the first study of substrate-controlled diastereoselection in a double [3 + 2] dipolar cycloaddition of

β-Hydroxy carbocation intermediates in solvolyses of di- and tetra-hydronaphthalene substrates

• Jaya S. Kudavalli and
• Rory A. More O'Ferrall

Beilstein J. Org. Chem. 2010, 6, 1035–1042, doi:10.3762/bjoc.6.118

• Jaya S. Kudavalli Rory A. More O'Ferrall School of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland 10.3762/bjoc.6.118 Abstract Solvolysis of trichloroacetate esters of 2-methoxy-1,2-dihydro-1-naphthols shows a remarkably large difference in rates between the

Synthesis of 6-PEtN-α-D-GalpNAc-(1–>6)-β-D-Galp-(1–>4)-β-D-GlcpNAc-(1–>3)-β-D-Galp-(1–>4)-β-D-Glcp, a Haemophilus influenzae lipopolysacharide structure, and biotin and protein conjugates thereof

• Andreas Sundgren,
• Martina Lahmann and
• Stefan Oscarson

Beilstein J. Org. Chem. 2010, 6, 704–708, doi:10.3762/bjoc.6.80

• Andreas Sundgren Martina Lahmann Stefan Oscarson Department of Chemistry, Göteborg University, S-412 96 Gothenburg, Sweden The School of Chemistry, University of Bangor, Alun Roberts Building, Deiniol Road, Bangor, Gwynedd LL57 2UW, U.K. Centre for Synthesis and Chemical Biology, University

Synthesis of glycosylated β³-homo-threonine conjugates for mucin-like glycopeptide antigen analogues

• Florian Karch and
• Anja Hoffmann-Röder

Beilstein J. Org. Chem. 2010, 6, No. 47, doi:10.3762/bjoc.6.47

• proteins involved in fundamental biological recognition events of cell adhesion, cell differentiation and cell growth [1][2][3]. As a consequence, synthetic oligosaccharides and their conjugates are recognised as important tools for the expanding field of chemical biology [4]. Aberrant glycosylation of

Novel loop-like aromatic compounds: a further step on the road to nanobelts and nanotubes

• Venkataramana Rajuri,
• Dariush Ajami,
• Gaston R. Schaller,
• Christian Näther and
• Rainer Herges

Beilstein J. Org. Chem. 2010, 6, No. 30, doi:10.3762/bjoc.6.30

• Venkataramana Rajuri Dariush Ajami Gaston R. Schaller Christian Nather Rainer Herges Otto-Diels-Institut für Organische Chemie, Christian-Albrechts-Universität Kiel, Otto-Hahn-Platz 4, 24098 Kiel, Germany Otto-Diels-Institut für Organische Chemie, current address: The Skaggs Institute for Chemical

• Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, U.S. Institut für Anorganische Chemie, Christian-Albrechts-Universität Kiel, Otto-Hahn-Platz 6/7, 24098 Kiel, Germany 10.3762/bjoc.6.30 Abstract The synthesis and crystal structural

Concise methods for the synthesis of chiral polyoxazolines and their application in asymmetric hydrosilylation

• Wei Jie Li,
• Zun Le Xu and
• Sheng Xiang Qiu

Beilstein J. Org. Chem. 2010, 6, No. 29, doi:10.3762/bjoc.6.29

• Wei Jie Li Zun Le Xu Sheng Xiang Qiu Program for Natural Product Chemical Biology & Drug Discovery, South China Botanical Garden, Chinese Academy of Sciences, 723 Xingke Road, Tianhe District, Guangzhou 510650, China Department of Applied Chemistry, School of Chemistry and Chemical Engineering

Synthesis in the glycosciences

• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2010, 6, No. 16, doi:10.3762/bjoc.6.16

• presented in this series. Furthermore, carbohydrate chemistry is presented in the context of chemical biology together with organic chemistry making use of known chemical reactions as well as the stereochemical advantages of saccharides to construct novel molecules with unique properties. It has been a joy

The subtle balance of weak supramolecular interactions: The hierarchy of halogen and hydrogen bonds in haloanilinium and halopyridinium salts

• Kari Raatikainen,
• Massimo Cametti and
• Kari Rissanen

Beilstein J. Org. Chem. 2010, 6, No. 4, doi:10.3762/bjoc.6.4

• tables Supporting Information File 12: CIF data for compounds 1, 5, 6, 8, 9, 10 and 13 Acknowledgements The authors gratefully acknowledge the Academy of Finland (KRi: proj. no. 212588) and The National Graduate School of Organic Chemistry and Chemical Biology (KRa) for financial support.

Looking forward to volume six

• Jonathan Clayden

Beilstein J. Org. Chem. 2010, 6, No. 1, doi:10.3762/bjoc.6.1

• , from materials, through mechanism, synthesis and natural products, to chemical biology. In the last few months we have seen a rapid rise in the number of papers we are publishing. For example, 2009 saw an increase in submissions of 50% over the previous year, and the number of papers we have published

Control of stilbene conformation and fluorescence in self-assembled capsules

• Mark R. Ams,
• Dariush Ajami,
• Stephen L. Craig,
• Jye-Shane Yang and
• Julius Rebek Jr

Beilstein J. Org. Chem. 2009, 5, No. 79, doi:10.3762/bjoc.5.79

• Mark R. Ams Dariush Ajami Stephen L. Craig Jye-Shane Yang Julius Rebek Jr The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, U.S., Tel: 858 784 2250; Fax: 858 784 2876 Department of Chemistry

Diastereoselective functionalisation of benzo-annulated bicyclic sultams: Application for the synthesis of cis-2,4-diarylpyrrolidines

• Susan Kelleher,
• Pierre-Yves Quesne and
• Paul Evans

Beilstein J. Org. Chem. 2009, 5, No. 69, doi:10.3762/bjoc.5.69

• Susan Kelleher Pierre-Yves Quesne Paul Evans Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Dublin 4, Ireland 10.3762/bjoc.5.69 Abstract The cis-dibromination of unsaturated bicyclic bridgehead sultams 5a and 5b, and experiments

Review of “Stereochemistry Workbook, 191 Problems and Solutions” by K.-H. Hellwich and C. D. Siebert

• Roald Hoffmann

Beilstein J. Org. Chem. 2009, 5, No. 38, doi:10.3762/bjoc.5.38

• Roald Hoffmann Dept. of Chemistry and Chemical Biology, Cornell University, Baker Laboratory, Ithaca NY 14853, USA 10.3762/bjoc.5.38 Hellwich, K.-H.; Siebert, C. D. Stereochemistry Workbook, 191 Problems and Solutions. transl., A. D. Dunn Springer-Verlag: Berlin, Heidelberg, 2006. XI, 198 pages

A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed- bed microreactor

• Andrew Bogdan and
• D. Tyler McQuade

Beilstein J. Org. Chem. 2009, 5, No. 17, doi:10.3762/bjoc.5.17

• Andrew Bogdan D. Tyler McQuade Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, 14853 USA Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA. Fax (850) 644-8281 10.3762/bjoc.5.17 Abstract We demonstrate the preparation and

A facile synthesis and fungicidal activities of 2-(alkylamino)-5,6-dimethylthieno[2,3-d]pyrimidin- 4(3H)-ones

• Yang-Gen Hu,
• Ai-Hua Zheng,
• Xu-Zhi Ruan and
• Ming-Wu Ding

Beilstein J. Org. Chem. 2008, 4, No. 49, doi:10.3762/bjoc.4.49

• Yang-Gen Hu Ai-Hua Zheng Xu-Zhi Ruan Ming-Wu Ding Department of Medicinal Chemistry, Yunyang Medical College, Shiyan 442000, China Institute of Life Science, Affiliated Taihe Hospital, Yunyang Medical College, Shiyan 442000, China Key Laboratory of Pesticide & Chemical Biology of Ministry of

A practical synthesis of the ¹³C/¹⁵N- labelled tripeptide N-formyl- Met-Leu-Phe, useful as a reference in solid- state NMR spectroscopy

• Sven T. Breitung,
• Jakob J. Lopez,
• Gerd Dürner,
• Clemens Glaubitz,
• Michael W. Göbel and
• Marcel Suhartono

Beilstein J. Org. Chem. 2008, 4, No. 35, doi:10.3762/bjoc.4.35

• Sven T. Breitung Jakob J. Lopez Gerd Durner Clemens Glaubitz Michael W. Gobel Marcel Suhartono Institute of Organic Chemistry and Chemical Biology, Johann Wolfgang Goethe University Frankfurt, Max-von-Laue-Str. 7, D-60438 Frankfurt am Main, Germany Institute of Biophysical Chemistry, Johann

C₂-symmetric bisamidines: Chiral Brønsted bases catalysing the Diels- Alder reaction of anthrones

• Deniz Akalay,
• Gerd Dürner,
• Jan W. Bats and
• Michael W. Göbel

Beilstein J. Org. Chem. 2008, 4, No. 28, doi:10.3762/bjoc.4.28

• Deniz Akalay Gerd Durner Jan W. Bats Michael W. Gobel Johann Wolfgang Goethe University Frankfurt, Institute of Organic Chemistry and Chemical Biology, Max-von-Laue-Str. 7, D-60438 Frankfurt am Main, Germany. 10.3762/bjoc.4.28 Abstract C2-symmetric bisamidines 8 have been tested as chiral