Search results
Search for "ADMET" in Full Text gives 13 result(s) in Beilstein Journal of Organic Chemistry.
Synthesis of the 1,5-disubstituted tetrazole-methanesulfonylindole hybrid system via high-order multicomponent reaction
Beilstein J. Org. Chem. 2024, 20, 3077–3084, doi:10.3762/bjoc.20.256
- potential in anticancer drug design. However, it should be taken into account that the sulfonyl group can radically change the pharmacokinetic properties of a drug, so the effect it may have on its ADMET properties should be determined in an additional study. Conclusion A novel synthetic strategy has been
Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines
Beilstein J. Org. Chem. 2024, 20, 2806–2817, doi:10.3762/bjoc.20.236
- desired pharmacological properties. Therefore, the design and synthesis of new compounds of this class with improved ADMET (absorption, distribution, metabolism, excretion, toxicity) pharmacological properties is an urgent task. Molecular docking was carried out to identify potential binding positions of
O,S,Se-containing Biginelli products based on cyclic β-ketosulfone and their postfunctionalization
Beilstein J. Org. Chem. 2024, 20, 2143–2151, doi:10.3762/bjoc.20.184
- of condensed thiazoles and tetrazoles. In silico assessment of ADMET parameters shows that most compounds meet the lead-likeness requirements. The biological profiles of new compounds demonstrate high probability levels of activity against the following pathogens/diseases: Candida albicans, Alphis
- oxidations of rare Biginelli products are discussed in Supporting Information File 1 using compound 2a as an example. In silico evaluation of ADMET parameters and biological profile We performed in silico screening of the biological properties of Biginelli products 2a–r and their postfunctionalized
- derivatives 3–7 using SwissADME (http://www.swissadme.ch) [44], ProTox 3.0 (https://tox-new.charite.de) [45], and MolPredictX (https://www.molpredictx.ufpb.br) [46] free online software. Considering ADMET [47] and other crucial properties, we found that all compounds (except for the nitro derivative 2e) do
The Groebke–Blackburn–Bienaymé reaction in its maturity: innovation and improvements since its 21st birthday (2019–2023)
Beilstein J. Org. Chem. 2024, 20, 1839–1879, doi:10.3762/bjoc.20.162
Hoveyda–Grubbs catalysts with an N→Ru coordinate bond in a six-membered ring. Synthesis of stable, industrially scalable, highly efficient ruthenium metathesis catalysts and 2-vinylbenzylamine ligands as their precursors
Beilstein J. Org. Chem. 2019, 15, 769–779, doi:10.3762/bjoc.15.73
- , ring-opening metathesis polymerization – ROMP and acyclic diene metathesis – ADMET. This motivates the investigations into the development of new, efficient, stable, and highly selective catalytic systems based on ruthenium complexes. However, in reality, a limited set of commercially available
Design of indole- and MCR-based macrocycles as p53-MDM2 antagonists
Beilstein J. Org. Chem. 2019, 15, 513–520, doi:10.3762/bjoc.15.45
- -pot procedure with one purification step), much better yields, no need of expensive catalysts as in ring-closing metathesis (RCM) reaction and higher complexity/diversity on the macrocyclic ring, e.g., insertion of heteroatoms that could improve the ADMET properties (Scheme 1) [4]. Results and
Aqueous olefin metathesis: recent developments and applications
Beilstein J. Org. Chem. 2019, 15, 445–468, doi:10.3762/bjoc.15.39
- metathesis (ADMET), ring-closing metathesis (RCM), ring-opening metathesis (ROM), and cross-metathesis (CM). Catalytic cycle for metathesis proposed by Chauvin. First aqueous ROMP reactions catalyzed by ruthenium(III) salts. Degradation pathway of first generation Grubbs catalyst (G-I) in methanol. Synthesis
Application of olefin metathesis in the synthesis of functionalized polyhedral oligomeric silsesquioxanes (POSS) and POSS-containing polymeric materials
Beilstein J. Org. Chem. 2019, 15, 310–332, doi:10.3762/bjoc.15.28
- silsesquioxanes (POSS) and POSS-containing polymeric materials. Three types of processes, i.e., cross metathesis (CM) of vinyl-substituted POSS with terminal olefins, acyclic diene metathesis (ADMET) copolymerization of divinyl-substituted POSS with α,ω-dienes and ring-opening metathesis polymerization (ROMP) of
- metathesis in chemistry of unsaturated derivatives of POSS is limited to three types of processes, i.e., cross metathesis (CM) of vinyl-substituted POSS with terminal olefins, acyclic diene metathesis (ADMET) copolymerization of divinyl-substituted POSS with α,ω-dienes and ring-opening metathesis
- the application of ADMET in the synthesis of oligomers or polymers containing a POSS unit in the main chain. Marciniec disclosed ADMET copolymerization of DDSQ-2SiVi with dienes in the stereoselective synthesis of a new class of vinylene–arylene copolymers containing double-decker silsesquioxanes in
Olefin metathesis in multiblock copolymer synthesis
Beilstein J. Org. Chem. 2019, 15, 218–235, doi:10.3762/bjoc.15.21
- . Keywords: ADMET; macromolecular cross metathesis; multiblock copolymers; olefin metathesis; ROMP; Introduction Nowadays, olefin metathesis has become a well-established field of organic and polymer chemistry. The discovery of metallocarbene initiators that are capable of catalyzing metathesis
- multiple click reactions of the diazido-telechelic PBD with a dialkynyl-containing azobenzene chromophore. The newly formed triazole moieties can tune and improve the photoresponsive properties of PBD. α,ω-Functional telechelic polymers also can be synthesized by acyclic diene metathesis (ADMET
- ) polymerization. This approach was implemented for the preparation of fluorene-containing multiblock copolymers [62][63]. Poly(9,9-di-n-octylfluorene-2,7-vinylene, PFV) obtained by ADMET polymerization of 2,7-divinyl-9,9-di-n-octylfluorene in the presence of Gr2 under reduced pressure (Scheme 4), possessed
The reductive decyanation reaction: an overview and recent developments
Beilstein J. Org. Chem. 2017, 13, 267–284, doi:10.3762/bjoc.13.30
- . Rojas et al. proposed a convenient two-step pathway for the preparation of alkyl α,ω-dienes 3. These dienes are well-known precursors in ring-closing metathesis (RCM) and acyclic diene metathesis (ADMET) chemistry [32]. They first reported the quantitative α-alkylation of primary nitriles 1 [33]. In a
Recent advances in metathesis-derived polymers containing transition metals in the side chain
Beilstein J. Org. Chem. 2015, 11, 2747–2762, doi:10.3762/bjoc.11.296
- ) polymerization [15][16], living ionic polymerizations, specifically ring-opening polymerization (ROP) [17], as well as migration insertion polymerization (MIP) [18], acyclic diene metathesis polymerization (ADMET) [19][20] and ring-opening metathesis polymerization (ROMP) [21][22][23][24][25][26][27]. These
About the activity and selectivity of less well-known metathesis catalysts during ADMET polymerizations
Beilstein J. Org. Chem. 2010, 6, 1149–1158, doi:10.3762/bjoc.6.131
- , Department of Colloid Chemistry, Potsdam, Germany 10.3762/bjoc.6.131 Abstract We report on the catalytic activity of commercially available Ru-indenylidene and “boomerang” complexes C1, C2 and C3 in acyclic diene metathesis (ADMET) polymerization of a fully renewable α,ω-diene. A high activity of these
- ADMET polymerizations were studied in detail. The isomerization reactions were investigated by degradation of the prepared polyesters via transesterification with methanol, yielding diesters. These diesters, representing the repeat units of the polyesters, were then quantified by GC-MS. Keywords: ADMET
- the isomerization of a number of allylic ethers and long chain aliphatic alkenes during RCM and cross metathesis [21]. In the context of ADMET, isomerization of a terminal to an internal olefin, followed by a productive metathesis step with a terminal olefin, would liberate an α-olefin, such as
Synthesis and crossover reaction of TEMPO containing block copolymer via ROMP
Beilstein J. Org. Chem. 2010, 6, No. 59, doi:10.3762/bjoc.6.59
- achieved extensively via living polymerization methods. Thus, besides acyclic diene metathesis polymerization (ADMET) [2], ring opening metathesis polymerization (ROMP) [3][4][5] is another type of olefin metathesis polymerization that can be used for the synthesis of block copolymers. Early examples of
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