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Search for "Candida albicans" in Full Text gives 61 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides

  • Ayesha Saeed,
  • Shahana Ehsan,
  • Muhammad Zia-ur-Rehman,
  • Erin M. Marshall,
  • Sandra Loesgen,
  • Abdus Saleem,
  • Simone Giovannuzzi and
  • Claudiu T. Supuran

Beilstein J. Org. Chem. 2025, 21, 348–357, doi:10.3762/bjoc.21.25

Graphical Abstract
  • and 13C NMR spectroscopy. All compounds were tested against five human microbial strains including three different strains of Staphylococcus aureus (ATCC 25923, ATCC BAA-41, and ATCC BAA-44), Escherichia coli (ATCC 8739), and Candida albicans (ATCC 90027) to evaluate their antibiotic potential. The
  • (ATCC 25923), Escherichia coli (ATCC 8739), and Candida albicans (ATCC 90027). Pathogens were treated with 125 μg/mL of tested compounds in duplicate. Two compounds, 7b and 7h, showed significant antibacterial activity against the susceptible strain of S. aureus. Moreover, some compounds showed moderate
  • evaluation of the targeted compounds was carried out against five different pathogens including Staphylococcus aureus (susceptible, ATCC 25923; methicillin-resistant, ATCC BAA-41; multidrug-resistant, ATCC BAA-44), Escherichia coli ATCC 8739, and Candida albicans ATCC 90027. Reference antibiotics and final
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Published 12 Feb 2025

Antibiofilm and cytotoxic metabolites from the entomopathogenic fungus Samsoniella aurantia

  • Rita Toshe,
  • Syeda J. Khalid,
  • Blondelle Matio Kemkuignou,
  • Esteban Charria-Girón,
  • Paul Eckhardt,
  • Birthe Sandargo,
  • Kunlapat Nuchthien,
  • J. Jennifer Luangsa-ard,
  • Till Opatz,
  • Hedda Schrey,
  • Sherif S. Ebada and
  • Marc Stadler

Beilstein J. Org. Chem. 2025, 21, 327–339, doi:10.3762/bjoc.21.23

Graphical Abstract
  • dilution assay spanning concentrations from 67 to 0.5 µg/mL. The experimental design followed established protocols [20][21]. The minimum inhibitory concentration (MIC) against a diverse spectrum of pathogens was determined, including five fungal species: Candida albicans (DSM 1665), Mucor hiemalis (DSM
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Published 11 Feb 2025

Synthesis and antimycotic activity of new derivatives of imidazo[1,2-a]pyrimidines

  • Dmitriy Yu. Vandyshev,
  • Daria A. Mangusheva,
  • Khidmet S. Shikhaliev,
  • Kirill A. Scherbakov,
  • Oleg N. Burov,
  • Alexander D. Zagrebaev,
  • Tatiana N. Khmelevskaya,
  • Alexey S. Trenin and
  • Fedor I. Zubkov

Beilstein J. Org. Chem. 2024, 20, 2806–2817, doi:10.3762/bjoc.20.236

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  • in clinical use, suggest that they may possess antifungal activity against Candida albicans. Keywords: 2-aminoimidazole; antimycotic activity; imidazo[1,2-a]pyrimidine; molecular docking; N-arylitaconimides; N-substituted maleimides; recyclization; Introduction Nitrogen-containing heterocyclic
  • this work was a preliminary evaluation of the potential bioactivity of the obtained compounds. In particular, a molecular docking experiment to investigate the binding mechanisms to the CYP51 enzyme and an evaluation of the antifungal activity of imidazo[1,2-a]pyrimidines against Candida albicans were
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Published 05 Nov 2024

Natural resorcylic lactones derived from alternariol

  • Joachim Podlech

Beilstein J. Org. Chem. 2024, 20, 2171–2207, doi:10.3762/bjoc.20.187

Graphical Abstract
  • could be confirmed by total syntheses [217][218]. Alterlactone showed antimicrobial activity against Bacillus subtilis (IC50 value of 41 µM) [210], Candida albicans, Trichophyton rubrum (MIC80: 17, 36 µg/mL) [211], Staphylococcus aureus (MIC: 31 µg/mL) [214], Trypanosoma brucei rhodesiense and
  • fumigatus, A. niger, and Candida albicans (zones of inhibition: 16, 15, 12 mm, respectively, at 200 µg/disc) [229], and against Alternaria alternata (MIC: 1 µg/mL) [236]. It irreversibly inactivated Escherichia coli biotin protein ligase opening a potential application as antimicrobial or biocide [237]. It
  • antibacterial activity of altenuene was already mentioned in the first report on this compound [38]. It later showed antimicrobial activity against Staphylococcus aureus, Candida albicans (IC50: 39, 13.7 µg/mL, respectively) [138][162][211], and Bacillus subtilis (zones of inhibition of 20 mm at 100 µg/disc
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Published 30 Aug 2024

O,S,Se-containing Biginelli products based on cyclic β-ketosulfone and their postfunctionalization

  • Kateryna V. Dil and
  • Vitalii A. Palchykov

Beilstein J. Org. Chem. 2024, 20, 2143–2151, doi:10.3762/bjoc.20.184

Graphical Abstract
  • of condensed thiazoles and tetrazoles. In silico assessment of ADMET parameters shows that most compounds meet the lead-likeness requirements. The biological profiles of new compounds demonstrate high probability levels of activity against the following pathogens/diseases: Candida albicans, Alphis
  • biotargets (pathogens, species, diseases) for new synthesized compounds. If we focus on high levels of biological activity probability (80% and above), the following pathogens and diseases may be potential areas of interest: Alphis gossypii, Tripomastigote Chagas, Candida albicans, Tcruzi amastigota
  • potential high activity against diseases associated with these species: Alphis gossypii, Tripomastigote Chagas, Candida albicans, Tcruzi amastigota, Leishmania amazonensis, Tcruzi epimastigota, Dengue larvicida, and for selected cases Alzheimer and Sars-COVID. Number of aryl-substituted Biginelli-type
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Published 27 Aug 2024

Syntheses and medicinal chemistry of spiro heterocyclic steroids

  • Laura L. Romero-Hernández,
  • Ana Isabel Ahuja-Casarín,
  • Penélope Merino-Montiel,
  • Sara Montiel-Smith,
  • José Luis Vega-Báez and
  • Jesús Sandoval-Ramírez

Beilstein J. Org. Chem. 2024, 20, 1713–1745, doi:10.3762/bjoc.20.152

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  • , while antibacterial activity was tested against Gram-positive and Gram-negative bacteria. Unfortunately, all compounds exhibited very low activity in these assays. However, the oxathiaphospholanes were evaluated for their antifungal properties against Candida albicans and Saccharomyces cerevisiae, where
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Published 24 Jul 2024

Chemical and biosynthetic potential of Penicillium shentong XL-F41

  • Ran Zou,
  • Xin Li,
  • Xiaochen Chen,
  • Yue-Wei Guo and
  • Baofu Xu

Beilstein J. Org. Chem. 2024, 20, 597–606, doi:10.3762/bjoc.20.52

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  • all isolated compounds against a panel of microorganisms (Table 4), including Escherichia coli (ATCC 25922), Candida albicans (ATCC 76485), Staphylococcus aureus (ATCC 27154), Pseudomonas fulva (CGMCC 1.15147), and Enterobacter hormaechei (CGMCC 1.10608). The results indicated that compounds 3, 5, 6
  • , 7, and 12 were active against Candida albicans. Notably, compound 12 showed particularly promising inhibitory activity against this fungal pathogen. Genome sequencing analysis The genome sequencing yielded 7,118,236 reads with an average read length of 1,858.7 bp. The assembled genome is 34,621,366
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Published 15 Mar 2024

A new analog of dihydroxybenzoic acid from Saccharopolyspora sp. KR21-0001

  • Rattiya Janthanom,
  • Yuta Kikuchi,
  • Hiroki Kanto,
  • Tomoyasu Hirose,
  • Arisu Tahara,
  • Takahiro Ishii,
  • Arinthip Thamchaipenet and
  • Yuki Inahashi

Beilstein J. Org. Chem. 2024, 20, 497–503, doi:10.3762/bjoc.20.44

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  • -positive bacteria, Kocuria rhizophila ATCC 9341 and Bacillus subtilis ATCC 6633; two strains of Gram-negative bacteria, Escherichia coli Europe NIHJ and Xanthomona campestis pv. oryzae KB 88; and two strains of fungi, Candida albicans ATCC 64548 and Mucor racemosus IFO 4581. All strains were tested by
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Published 29 Feb 2024

Synthesis and biological evaluation of Argemone mexicana-inspired antimicrobials

  • Jessica Villegas,
  • Bryce C. Ball,
  • Katelyn M. Shouse,
  • Caleb W. VanArragon,
  • Ashley N. Wasserman,
  • Hannah E. Bhakta,
  • Allen G. Oliver,
  • Danielle A. Orozco-Nunnelly and
  • Jeffrey M. Pruet

Beilstein J. Org. Chem. 2023, 19, 1511–1524, doi:10.3762/bjoc.19.108

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  • cereus, Bacillus subtilis, Staphylococcus epidermidis, Corynebacterium pseudodiphtheriticum), four Gram-negative bacteria (Escherichia coli, Proteus mirabilis, Enterobacter aerogenes, Enterobacter cloacae), and three fungi (Saccharomyces cerevisiae, Candida albicans, Penicillium chrysogenum). The goal of
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Published 29 Sep 2023

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities

  • Jorge de Lima Neto and
  • Paulo Henrique Menezes

Beilstein J. Org. Chem. 2023, 19, 399–427, doi:10.3762/bjoc.19.31

Graphical Abstract
  • taxol® is the most potent antitumor drug, showing GI50 ranging from pmol to nmol against different types of cancer cell lines [77]. When combretastatins D-2, D-4, and some synthetic intermediates were evaluated against Candida albicans (ATCC 90028), Cryptococcus neoformans (ATCC 90112), Micrococcus
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Published 29 Mar 2023

Combining the best of both worlds: radical-based divergent total synthesis

  • Kyriaki Gennaiou,
  • Antonios Kelesidis,
  • Maria Kourgiantaki and
  • Alexandros L. Zografos

Beilstein J. Org. Chem. 2023, 19, 1–26, doi:10.3762/bjoc.19.1

Graphical Abstract
  • properties, such as potent inhibition of 11-β-hydroxysteroid dehydrogenase type I and inhibition of Candida albicans [48]. Although earlier syntheses have been reported recently for magninoids [50][51], Lou’s group envisioned a divergent plan based on a late-stage bioinspired semipinacol rearrangement
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Published 02 Jan 2023

Cyclometalated iridium complexes-catalyzed acceptorless dehydrogenative coupling reaction: construction of quinoline derivatives and evaluation of their antimicrobial activities

  • Hongling Shui,
  • Yuhong Zhong,
  • Renshi Luo,
  • Zhanyi Zhang,
  • Jiuzhong Huang,
  • Ping Yang and
  • Nianhua Luo

Beilstein J. Org. Chem. 2022, 18, 1507–1517, doi:10.3762/bjoc.18.159

Graphical Abstract
  • compounds was evaluated against Staphylococcus aureus (Gram-positive), Escherichia coli (Gram-negative), and Candida albicans (fungi) mainly by examining the minimum inhibitory concentration (MIC) (Table 4). As shown in Table 4, the compounds 3ab, 3ah, and 3ad showed high antibacterial activities against
  • Gram-positive bacteria and Candida albicans. Conclusion In summary, we have developed a new route for the efficient synthesis of quinoxaline and its derivatives with high yield and good chemoselectivity via the ADC reaction of 2-aminobenzyl alcohol and aryl aryl/heteroaryl/alkyl secondary alcohols
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Published 27 Oct 2022

Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment

  • Anas J. Rasras,
  • Mohamed El-Naggar,
  • Nesreen A. Safwat and
  • Raed A. Al-Qawasmeh

Beilstein J. Org. Chem. 2022, 18, 631–638, doi:10.3762/bjoc.18.63

Graphical Abstract
  • biological activities such as anti-COVID-19 [5], anticancer [6][7][8], antibacterial activity against Staphylococcus aureus and Bacillus subtilis [9][10], antifungal agents against Candida albicans and phytopathogenic fungi [11][12], and antiproliferative against different cell lines (e.g., PC3, HCT-116, and
  • against the pathogenic fungal strains Aspergillus fumigatus and Candida albicans. The sensitivity of the organisms was assayed against the activity of tested compounds solutions (at 10 mg/mL concentration) using a modified agar well diffusion method with determination of the inhibition zone diameter in mm
  • , 4p and 4c, respectively. Besides, the order of antifungal activity against the pathogenic yeast Candida albicans was 4g, 4i, 4q, 4j, 4o, 4p, 4m, 4k, 4s, 4t, 4n, 4v, 4d, 4e, 4h, 4l, 4c and 4r, respectively (Table 1). Likewise, no antimicrobial activities could be detected for compound 4f under these
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Published 31 May 2022

Tenacibactins K–M, cytotoxic siderophores from a coral-associated gliding bacterium of the genus Tenacibaculum

  • Yasuhiro Igarashi,
  • Yiwei Ge,
  • Tao Zhou,
  • Amit Raj Sharma,
  • Enjuro Harunari,
  • Naoya Oku and
  • Agus Trianto

Beilstein J. Org. Chem. 2022, 18, 110–119, doi:10.3762/bjoc.18.12

Graphical Abstract
  • Antimicrobial activity was examined as previously reported [41]. Kocuria rhizophila ATCC9341, Staphylococcus aureus FDA209P JC-1, Ralstonia solanacearum SUPP1541, Escherichia coli NIHJ JC-2, Rhizobium radiobacter NBRC14554, and Candida albicans NBRC0197 were used as indication strains. Cytotoxicity against 3Y1
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Published 13 Jan 2022

Unsaturated fatty acids and a prenylated tryptophan derivative from a rare actinomycete of the genus Couchioplanes

  • Shun Saito,
  • Kanji Indo,
  • Naoya Oku,
  • Hisayuki Komaki,
  • Masashi Kawasaki and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2021, 17, 2939–2949, doi:10.3762/bjoc.17.203

Graphical Abstract
  • , Rhizobium radiobacter and Escherichia coli, or a yeast Candida albicans (MIC > 100 μg/mL). Compounds 1–5 were marginally active against Kocuria rhizophila (MIC = 100 μg/mL). Conclusion In this study, five unsaturated fatty acids (1–5) and one prenylated tryptophan derivative (6) were isolated as new natural
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Published 16 Dec 2021

Biological properties and conformational studies of amphiphilic Pd(II) and Ni(II) complexes bearing functionalized aroylaminocarbo-N-thioylpyrrolinate units

  • Samet Poyraz,
  • Samet Belveren,
  • Sabriye Aydınoğlu,
  • Mahmut Ulger,
  • Abel de Cózar,
  • Maria de Gracia Retamosa,
  • Jose M. Sansano and
  • H. Ali Döndaş

Beilstein J. Org. Chem. 2021, 17, 2812–2821, doi:10.3762/bjoc.17.192

Graphical Abstract
  • . Antifungal activity of the novel compounds was also evaluated against Candida albicans, Candida tropicalis and Candida glabrata strains. Antibacterial and antituberculosis (TB) activities From the observed data (Table 1) it can be seen that the tested compounds showed moderate antibacterial activity, in the
  • supplement at the same solutions. Microdilution broth method [31][32] was used to determine the MIC values of the target compounds against to Candida albicans (ATCC 14053), C. tropicalis (ATCC 1369) and C. glabrata (ATCC 15126) standard strains (which were provided from Refik Saydam Hıfzıssıhha Institute in
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Published 02 Dec 2021

Nomimicins B–D, new tetronate-class polyketides from a marine-derived actinomycete of the genus Actinomadura

  • Zhiwei Zhang,
  • Tao Zhou,
  • Taehui Yang,
  • Keisuke Fukaya,
  • Enjuro Harunari,
  • Shun Saito,
  • Katsuhisa Yamada,
  • Chiaki Imada,
  • Daisuke Urabe and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2021, 17, 2194–2202, doi:10.3762/bjoc.17.141

Graphical Abstract
  • antimicrobial activity against Kocuria rhizopila with a MIC value of 6.5 μg/mL and 1 and 2 were also active against Bacillus subtilis with a MIC value of 12.5 μg/mL. Compounds 1–3 were inactive against Staphylococcus aureus, Ralstonia solanacearum, Rhizobium radiobacter, and Candida albicans. In addition, 1 and
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Published 27 Aug 2021

Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

  • Nikita Brodyagin,
  • Martins Katkevics,
  • Venubabu Kotikam,
  • Christopher A. Ryan and
  • Eriks Rozners

Beilstein J. Org. Chem. 2021, 17, 1641–1688, doi:10.3762/bjoc.17.116

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Published 19 Jul 2021

Double-headed nucleosides: Synthesis and applications

  • Vineet Verma,
  • Jyotirmoy Maity,
  • Vipin K. Maikhuri,
  • Ritika Sharma,
  • Himal K. Ganguly and
  • Ashok K. Prasad

Beilstein J. Org. Chem. 2021, 17, 1392–1439, doi:10.3762/bjoc.17.98

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Published 08 Jun 2021

Nocarimidazoles C and D, antimicrobial alkanoylimidazoles from a coral-derived actinomycete Kocuria sp.: application of 1JC,H coupling constants for the unequivocal determination of substituted imidazoles and stereochemical diversity of anteisoalkyl chains in microbial metabolites

  • Md. Rokon Ul Karim,
  • Enjuro Harunari,
  • Amit Raj Sharma,
  • Naoya Oku,
  • Kazuaki Akasaka,
  • Daisuke Urabe,
  • Mada Triandala Sibero and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 2719–2727, doi:10.3762/bjoc.16.222

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  • the same as those for 1 (Table 1). The antimicrobial activity of 1–4 was tested against Gram-positive bacteria Kocuria rhizophila and Staphylococcus aureus, Gram-negative bacteria Escherichia coli and Rhizobium radiobacter, a yeast Candida albicans, and two fungi Glomerella cingulata and Trichophyton
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Published 05 Nov 2020

Synthesis of 1,4-benzothiazinones from acylpyruvic acids or furan-2,3-diones and o-aminothiophenol

  • Ekaterina E. Stepanova,
  • Maksim V. Dmitriev and
  • Andrey N. Maslivets

Beilstein J. Org. Chem. 2020, 16, 2322–2331, doi:10.3762/bjoc.16.193

Graphical Abstract
  • (detailed data on biological assays is given in Supporting Information File 1). Unfortunately, we found that tested BTAs 3 did not show any significant antimicrobial activity (against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Candida
  • albicans, Cryptococcus neoformans var. grubii, Mycobacterium tuberculosis) in vitro. Acute toxicity of BTA 3a in mice was determined to be higher than 1000 mg/kg, which means that BTA 3a can be considered as low toxic. Conclusion In conclusion, we developed two interchangeable approaches to enaminones
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Published 21 Sep 2020

4-Hydroxy-3-methyl-2(1H)-quinolone, originally discovered from a Brassicaceae plant, produced by a soil bacterium of the genus Burkholderia sp.: determination of a preferred tautomer and antioxidant activity

  • Dandan Li,
  • Naoya Oku,
  • Yukiko Shinozaki,
  • Yoichi Kurokawa and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 1489–1494, doi:10.3762/bjoc.16.124

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  • aureus FDA209P JC-1 (Gram-positive bacterium), Rhizobium radiobacter NBRC14554, Ralstonia solanacearum SUPP1541, Tenacibaculum maritimum NBRC16015 (Gram-negative bacteria), Candida albicans NBRC0197, and Saccharomyces cerevisiae S100 (yeasts). Oxidative burst, which is a transient production of massive
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Published 26 Jun 2020

A cyclopeptide and three oligomycin-class polyketides produced by an underexplored actinomycete of the genus Pseudosporangium

  • Shun Saito,
  • Kota Atsumi,
  • Tao Zhou,
  • Keisuke Fukaya,
  • Daisuke Urabe,
  • Naoya Oku,
  • Md. Rokon Ul Karim,
  • Hisayuki Komaki and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 1100–1110, doi:10.3762/bjoc.16.97

Graphical Abstract
  • inactive against Staphylococcus aureus, Escherichia coli, Rhizobium radiobacter, and Candida albicans. The antimicrobial potency of 2 and 3 were similar, implying that the acyl side chain at C13 of compound 2 had no influence on the activity. In addition, compounds 1–4 showed moderate cytotoxicity against
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Published 25 May 2020

Two antibacterial and PPARα/γ-agonistic unsaturated keto fatty acids from a coral-associated actinomycete of the genus Micrococcus

  • Amit Raj Sharma,
  • Enjuro Harunari,
  • Naoya Oku,
  • Nobuyasu Matsuura,
  • Agus Trianto and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2020, 16, 297–304, doi:10.3762/bjoc.16.29

Graphical Abstract
  • interesting contrast. No appreciable antimicrobial activity was observed for both compounds against bacterial strains of Micrococcus luteus ATCC9341, Staphylococcus aureus FDA209P JC-1, and Escherichia coli NIHJ JC-2 and yeast strains of Candida albicans NBRC0197 and Saccharomyces cerevisiae S100, nor
  • bacteria, Micrococcus luteus ATCC9341, Staphylococcus aureus FDA209P JC-1, Rhizobium radiobacter NBRC14554, Escherichia coli NIHJ JC-2, Tenacibaculum maritimum NBRC16015, and two yeasts, Candida albicans NBRC0197 and Saccharomyces cerevisiae S100, as indication strains. Mueller–Hinton Broth (Difco
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Published 02 Mar 2020

Skeletocutins M–Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa

  • Tian Cheng,
  • Clara Chepkirui,
  • Cony Decock,
  • Josphat C. Matasyoh and
  • Marc Stadler

Beilstein J. Org. Chem. 2019, 15, 2782–2789, doi:10.3762/bjoc.15.270

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  • coli (E. coli) DSM498, Chromobacterium violaceum (C. violaceum) DSM30191, and Pseudomonas aeruginosa (P. aeruginosa) PA14. Moreover, the filamentous fungus Mucor plumbeus (M. plumbeus) MUCL49355 and the yeasts Candida tenuis (C. tenuis) MUCL29892, Pichia anomala (P. anomala) DSM6766, and Candida
  • albicans (C. albicans) DSM1665 were applied. The assays were conducted in 96-well plates and Mueller–Hinton Broth (MHB) for bacteria, or yeast, malt, and gluocse (YMG) medium for filamentous fungus and yeasts. Cytotoxicity assay In vitro cytotoxicity, using IC50 values as a measure, was evaluated against
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Published 19 Nov 2019
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