Thiazolidinones: novel insights from microwave synthesis, computational studies, and potentially bioactive hybrids

• Luan A. Martinho,
• Victor H. J. G. Praciano,
• Guilherme D. R. Matos,
• Claudia C. Gatto and
• Carlos Kleber Z. Andrade

Beilstein J. Org. Chem. 2025, 21, 2618–2636, doi:10.3762/bjoc.21.203

• ], diammonium phosphate (DAP) [43], and tetrabutylammonium bromide (TBAB) [44]. Organic bases like morpholine [45], triethylamine [46], ethanolamine, and piperidine [47] and heterogeneous catalysts from Cu [48], Ti [49], and Zn [50] metal compounds have also been used. Common solvents are ethanol [51], toluene

C2 to C6 biobased carbonyl platforms for fine chemistry

• Jingjing Jiang,
• Muhammad Noman Haider Tariq,
• Florence Popowycz,
• Yanlong Gu and
• Yves Queneau

Beilstein J. Org. Chem. 2025, 21, 2103–2172, doi:10.3762/bjoc.21.165

Microwave-enhanced additive-free C–H amination of benzoxazoles catalysed by supported copper

• Andrei Paraschiv,
• Valentina Maruzzo,
• Filippo Pettazzi,
• Stefano Magliocco,
• Paolo Inaudi,
• Daria Brambilla,
• Gloria Berlier,
• Giancarlo Cravotto and
• Katia Martina

Beilstein J. Org. Chem. 2025, 21, 1462–1476, doi:10.3762/bjoc.21.108

• , to the best of our knowledge, this study represents one of the few examples of a heterogeneous catalysed copper-mediated C–H amination of benzoxazole. The pursuit for greener methodologies in organic synthesis and transitioning from traditional homogeneous catalysis to the use of heterogeneous

• catalysts for direct C–H amination processes could be a significant breakthrough in optimising these reactions. Despite recent progress in site-selective C–H functionalisation [49], most reactions have remained reliant on homogeneous catalysis due to its molecularly defined nature. By contrast, the

Chitosan-supported CuI-catalyzed cascade reaction of 2-halobenzoic acids and amidines for the synthesis of quinazolinones

• Xuhong Zhao,
• Weishuang Li,
• Mengli Yang,
• Bojie Li,
• Yaoyao Zhang,
• Lizhen Huang and
• Lei Zhu

Beilstein J. Org. Chem. 2025, 21, 839–844, doi:10.3762/bjoc.21.67

• under optimized conditions (Scheme 4a). The recyclability of heterogeneous catalysts is a critical factor in assessing their practical utility in transition metal-catalyzed reactions. Therefore, the recyclability of CS@CuI was evaluated in the reaction of 2-iodobenzoic acid (1a) with 2a, as illustrated

Beyond symmetric self-assembly and effective molarity: unlocking functional enzyme mimics with robust organic cages

• Keith G. Andrews

Beilstein J. Org. Chem. 2025, 21, 421–443, doi:10.3762/bjoc.21.30

• heterogeneous catalysts, and since they are the lattice versions of MOCs and organic cages (Figure 6A) we mention them briefly for completeness. The catalytic properties of MOFs compared to MOCs have been discussed [22]. As heterogeneous multisite catalysts, MOFs and COFs are harder to compare to the other

Emerging trends in the optimization of organic synthesis through high-throughput tools and machine learning

• Pablo Quijano Velasco,
• Kedar Hippalgaonkar and
• Balamurugan Ramalingam

Beilstein J. Org. Chem. 2025, 21, 10–38, doi:10.3762/bjoc.21.3

• chemistry. Packed bed reactors are used when solid heterogeneous catalysts and reagents (e.g., inorganic bases) are handled. Specialized reactors for electro- [36][37] and photochemical [38][39][40] experiments have also been developed. Depending on the flow of the reaction mixture, flow reactions can be

Factors influencing the performance of organocatalysts immobilised on solid supports: A review

• Zsuzsanna Fehér,
• Dóra Richter,
• Gyula Dargó and
• József Kupai

Beilstein J. Org. Chem. 2024, 20, 2129–2142, doi:10.3762/bjoc.20.183

• and an environmental perspective. An efficient catalytic process is characterised by the fact that the catalyst can be easily and, if possible, completely separated from the reaction mixture. Catalysts can be classified into homogeneous and heterogeneous catalysts. In homogeneous catalysis, the

• . Heterogeneous catalysts are easy to handle and can be easily separated from the reaction mixture by filtration, centrifugation or magnetic force, thus allowing catalysts to be recycled multiple times. Most highly stable and recyclable catalysts are attached to solid supports [11]. Solid supports are generally

Synthetic applications of the Cannizzaro reaction

• Bhaskar Chatterjee,
• Dhananjoy Mondal and
• Smritilekha Bera

Beilstein J. Org. Chem. 2024, 20, 1376–1395, doi:10.3762/bjoc.20.120

• KSF clays as recyclable and heterogeneous catalysts to catalyze the Cannizzaro reaction by 1,4-diazabicyclo[2.2.2]octane under microwave irradiation and solvent-free conditions giving the products in excellent yields within seconds. The solid clay applied in the first cycle can be recovered and reused

Green and sustainable approaches for the Friedel–Crafts reaction between aldehydes and indoles

• Periklis X. Kolagkis,
• Eirini M. Galathri and
• Christoforos G. Kokotos

Beilstein J. Org. Chem. 2024, 20, 379–426, doi:10.3762/bjoc.20.36

1-Butyl-3-methylimidazolium tetrafluoroborate as suitable solvent for BF₃: the case of alkyne hydration. Chemistry vs electrochemistry

• Marta David,
• Elisa Galli,
• Richard C. D. Brown,
• Marta Feroci,
• Fabrizio Vetica and
• Martina Bortolami

Beilstein J. Org. Chem. 2023, 19, 1966–1981, doi:10.3762/bjoc.19.147

• identification of new catalysts as well as increasingly mild, economic and sustainable reaction conditions remain fundamental objectives for research in the field of organic chemistry. In recent years, alternative methods have been developed, including the use of different heterogeneous catalysts, to ensure

Application of N-heterocyclic carbene–Cu(I) complexes as catalysts in organic synthesis: a review

• Nosheen Beig,
• Varsha Goyal and
• Raj K. Bansal

Beilstein J. Org. Chem. 2023, 19, 1408–1442, doi:10.3762/bjoc.19.102

• bulky azide 134 to afford 1-(2,6-dimesityl)phenyl-4-(2-pyridyl)-1,2,3-triazole (135), which is otherwise difficult to achieve (Scheme 51). Oro and co-workers employed complexes 78a and 78a-MCH-41 (Scheme 27) as homogeneous and heterogeneous catalysts, respectively, for the [3 + 2] cycloaddition of

Inline purification in continuous flow synthesis – opportunities and challenges

• Jorge García-Lacuna and
• Marcus Baumann

Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182

• only. This is facilitated when using heterogeneous catalysts or immobilized enzymes that are retained in cartridge reactors. For instance, Paradisi and co-workers reported an N-acetylation approach to produce melatonin analogs, where the pure product is obtained in the organic phase after evaporation

Heterogeneous metallaphotoredox catalysis in a continuous-flow packed-bed reactor

• Wei-Hsin Hsu,
• Susanne Reischauer,
• Peter H. Seeberger,
• Bartholomäus Pieber and
• Dario Cambié

Beilstein J. Org. Chem. 2022, 18, 1123–1130, doi:10.3762/bjoc.18.115

• combination of solid photocatalysts (i.e., semiconductors) and homogeneous nickel complexes are feasible, but the fact that the nickel complex is in solution reduces the benefits of packed-bed reactor types [19][23][24]. Recently, several bifunctional heterogeneous catalysts that combine the photo- and the

• these heterogeneous catalysts, using a packed-bed reactor. The use of a packed-bed reactor for these solid–liquid reactions is attractive as reaction and separation can be combined in one step. This is particularly notable in our case since, after complexing poly-czbpy with nickel (Ni@poly-czbpy), the

Electrochemical hydrogenation of enones using a proton-exchange membrane reactor: selectivity and utility

• Koichi Mitsudo,
• Haruka Inoue,
• Yuta Niki,
• Eisuke Sato and
• Seiji Suga

Beilstein J. Org. Chem. 2022, 18, 1055–1061, doi:10.3762/bjoc.18.107

• hydrogenation of enones using homogeneous and heterogeneous catalysts. Meanwhile, electrochemical systems using a proton-exchange membrane (PEM) reactor have been shown to be powerful tools for electrochemical hydrogenation [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. A PEM reactor

Inductive heating and flow chemistry – a perfect synergy of emerging enabling technologies

• Conrad Kuhwald,
• Sibel Türkhan and
• Andreas Kirschning

Beilstein J. Org. Chem. 2022, 18, 688–706, doi:10.3762/bjoc.18.70

• ]. 3.2.2 Using chemically active fixed-beds (stoichiometric reagents): Flow chemistry can be advantageously combined with the use of chemically active fixed-bed materials, especially heterogeneous catalysts. Here, too, the reactor material can either be heated directly by induction or there are additives

Menadione: a platform and a target to valuable compounds synthesis

• Acácio S. de Souza,
• Ruan Carlos B. Ribeiro,
• Dora C. S. Costa,
• Fernanda P. Pauli,
• David R. Pinho,
• Matheus G. de Moraes,
• Fernando de C. da Silva,
• Luana da S. M. Forezi and
• Vitor F. Ferreira

Beilstein J. Org. Chem. 2022, 18, 381–419, doi:10.3762/bjoc.18.43

• ]. Chang’s group reported the use of 3D crystalline polyoxometalate-based coordination polymers (POMCPs) as heterogeneous catalysts, with H2O2, to synthesize 10 and the best result was obtained using H[CuII(ttb)(H2O)3]2[CuII(ttb)Cl]2[PW12O40]·4H2O (Httb = 1-(tetrazol-5-yl)-4-(triazol-1-yl)benzene) as the

Green synthesis of C5–C6-unsubstituted 1,4-DHP scaffolds using an efficient Ni–chitosan nanocatalyst under ultrasonic conditions

• Soumyadip Basu,
• Sauvik Chatterjee,
• Suman Ray,
• Suvendu Maity,
• Prasanta Ghosh,
• Asim Bhaumik and
• Chhanda Mukhopadhyay

Beilstein J. Org. Chem. 2022, 18, 133–142, doi:10.3762/bjoc.18.14

• for industrial purposes [1][2][3]. In this regard, different insoluble supports, such as alumina [4], silica [5], zeolites [6], polymers [7], carbon nanotubes [8], etc. have been reported. Recently, the use of bio-based natural polymers became one of the interesting features of heterogeneous catalysts

Recent advances and perspectives in ruthenium-catalyzed cyanation reactions

• Thaipparambil Aneeja,
• Cheriya Mukkolakkal Abdulla Afsina,
• Padinjare Veetil Saranya and
• Gopinathan Anilkumar

Beilstein J. Org. Chem. 2022, 18, 37–52, doi:10.3762/bjoc.18.4

• miscellaneous. To the best of our knowledge, this is the first review summarizing an overview of ruthenium-catalyzed cyanation reactions covering literature up to 2021. Review 1 Cyanation of amines 1.1 Cyanation of amines using heterogeneous catalysts Sain and co-workers investigated the ability of starch

• arenes and heteroarenes using heterogeneous catalysts In 2012, a novel strategy for the 3-cyanation of indole in the presence of Ru(III)-exchanged NaY zeolite (RuY) was reported [36]. In this reaction K4[Fe(CN)6] was utilized as the cyano source in DMF at 110 °C. The Cu(OAc)2 and O2 (1 atm) was found

• reactive complexes of ruthenium and the high reusability and easy separation procedures of heterogeneous catalysts have proven the fact that this metal serve as highly effective catalyst for a wide range of organic transformations. It will surely motivate the scientific community to develop more

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

• Guido Gambacorta,
• James S. Sharley and
• Ian R. Baxendale

Beilstein J. Org. Chem. 2021, 17, 1181–1312, doi:10.3762/bjoc.17.90

[2 + 1] Cycloaddition reactions of fullerene C₆₀ based on diazo compounds

• Yuliya N. Biglova

Beilstein J. Org. Chem. 2021, 17, 630–670, doi:10.3762/bjoc.17.55

• the substrate on two sites, namely a metal and a fullerene [53]. This allows to level out some negative features that are characteristic of heterogeneous catalysts. Thus, in dehydrogenation processes, catalytic amounts of a coordinated fullerene in metal fullerides act as a hydrogen acceptor in

Valorisation of plastic waste via metal-catalysed depolymerisation

• Francesca Liguori,
• Carmen Moreno-Marrodán and
• Pierluigi Barbaro

Beilstein J. Org. Chem. 2021, 17, 589–621, doi:10.3762/bjoc.17.53

• -, Zn-, Al-, Cu- or Fe-decorated heterogeneous catalysts [157][158]. An oil yield around 89% was obtained at 450 °C over 20% Fe@Mt, composed by 51%, 10% and 6% (wt) styrene, toluene and ethylbenzene, respectively, and additional oligomers. 3.2 Polyesters 3.2.1 PET: PET is one of the most widely used

A new and efficient methodology for olefin epoxidation catalyzed by supported cobalt nanoparticles

• Lucía Rossi-Fernández,
• Viviana Dorn and
• Gabriel Radivoy

Beilstein J. Org. Chem. 2021, 17, 519–526, doi:10.3762/bjoc.17.46

• have been developed, most of them using expensive or scarce metals (Au or Pd [18][19][20][21], groups IV and V metal oxides [22][23]) and mainly through homogeneous catalytic processes [24][25][26]. From a practical, economic and environmental point of view, reusable heterogeneous catalysts based on

• heterogeneous catalysts [27] that are wide in substrate scope, active enough and highly selective. As part of our continuing interest in the development of new synthetic methodologies based on the use of catalysis by non-noble transition metal nanoparticles (MNPs) for their application in a wide range of

A novel and robust heterogeneous Cu catalyst using modified lignosulfonate as support for the synthesis of nitrogen-containing heterocycles

• Bingbing Lai,
• Meng Ye,
• Ping Liu,
• Minghao Li,
• Rongxian Bai and
• Yanlong Gu

Beilstein J. Org. Chem. 2020, 16, 2888–2902, doi:10.3762/bjoc.16.238

• . For comparison, two controlled heterogeneous catalysts, namely Resin-Cu and LS-FM-Cu were prepared using commercially available Amberlyst-15 and the material [13] was synthesized by condensation of formaldehyde and LS as supports, respectively (see Supporting Information File 1, Figure S1 and Figure

One-pot multicomponent green Hantzsch synthesis of 1,2-dihydropyridine derivatives with antiproliferative activity

• Giovanna Bosica,
• Kaylie Demanuele,
• José M. Padrón and
• Adrián Puerta

Beilstein J. Org. Chem. 2020, 16, 2862–2869, doi:10.3762/bjoc.16.235

• derivatives using heterogenized phosphotungstic acid on alumina support (40 wt %). High yields of over 75% have been accomplished in just 2–3.5 h after screening several heterogeneous catalysts and investigating the optimal reaction conditions. The catalyst chosen has passed the heterogeneity test and was

• Hantzsch synthesis between benzaldehyde (1a), ethyl acetoacetate (2), and ammonium acetate (3) as well as the synthesis highlighted in this work. Screening of acidic heterogeneous catalysts. Screening of different substrates. Results obtained when using the aliphatic aldehydes 1 in the Hantzsch synthesis

Palladium nanoparticles supported on chitin-based nanomaterials as heterogeneous catalysts for the Heck coupling reaction

• Tony Jin,
• Malickah Hicks,
• Davis Kurdyla,
• Sabahudin Hrapovic,
• Edmond Lam and
• Audrey Moores

Beilstein J. Org. Chem. 2020, 16, 2477–2483, doi:10.3762/bjoc.16.201

• ], environmental remediation [5], and catalysis [6]. With their high solubility and presence of functionalities such as hydroxy groups, sulfate half-esters, and carboxylates, CNCs are able to stabilize highly disperse metal nanoparticles (NPs), which can act as heterogeneous catalysts for a wide array of organic

• deposit Pd NPs directly onto both ChNCs and ChsNCs, and the as-made heterogeneous catalysts were tested with the Heck coupling reaction as a model for catalytic activity. Findings The fabrication of ChNC and ChsNCs was conducted using a procedure previously reported by our group (Lam) (see Supporting

• organic solvents (4:1 DMF/H2O) [26]. Conclusion ChNCs and ChsNCs were explored as sustainable supports for immobilizing Pd NPs to fabricate heterogeneous catalysts for the Heck coupling reaction. Through TEM and XPS analysis, metallic Pd NPs were formed and dispersed on the surface of the supports, while