Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• antigen binding ability. Improper antibody conjugation influences antigen binding affinity and specificity. Once injected into the body, the ACNPs face both physical and biological barriers (such as diffusion, flow and shear forces, aggregation, protein adsorption, phagocytic sequestration, and clearance

• increasing the antigen binding capacity and the conjugation efficiency [61]. These covalent conjugation methods are highly stable but associated with some drawbacks. These include aggregation and polymerization, cross-linking at multiple sites on the antibodies, the need for additional purification steps for

A wearable nanoscale heart sound sensor based on P(VDF-TrFE)/ZnO/GR and its application in cardiac disease detection

• Yi Luo,
• Jian Liu,
• Jiachang Zhang,
• Yu Xiao,
• Ying Wu and
• Zhidong Zhao

Beilstein J. Nanotechnol. 2023, 14, 819–833, doi:10.3762/bjnano.14.67

• . SEM images of a pure PVDF film in Figure 8a and Figure 8b exhibit filamentous fibers with a relatively smooth surface. In contrast, Figure 8c and Figure 8d show that the addition of ZnO to the P(VDF-TrFE) filaments leads to a rough and granular surface, caused by the aggregation of ZnO particles that

• embed onto the filament surface. By examining Figure 8e and Figure 8f, we observe that trace amounts of GR effectively inhibit the aggregation of ZnO particles, resulting in a smoother surface of P(VDF-TrFE)/ZnO/GR nanofilm filaments compared to P(VDF-TrFE)/ZnO. The average fiber diameters of P(VDF-TrFE

Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity

• Nguyen Thi Thanh Tu,
• T. Lan-Anh Vo,
• T. Thu-Trang Ho,
• Kim-Phuong T. Dang,
• Van-Dung Le,
• Phan Nhat Minh,
• Chi-Hien Dang,
• Vinh-Thien Tran,
• Van-Su Dang,
• Tran Thi Kim Chi,
• Hieu Vu-Quang,
• Radek Fajgar,
• Thi-Lan-Huong Nguyen,
• Van-Dat Doan and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64

• , with the highest inhibition zone diameters recorded at pH 6 against S. aureus (10.8 ± 0.57 mm) and S. typhi (9.3 ± 1.34 mm). In contrast, the nanocomposite showed no inhibition in highly basic media (pH 11 and 12) because of the aggregation of nanoparticles, which hindered the leaching of silver into

•  10. The zeta potentials of the nanocomposite were −23.3, −27.5, and −13.3 mV at pH 4, 6, and 12, respectively, indicating that the stability of the nanocomposite was low in highly acidic and basic media, leading to the aggregation of nanoparticles. TEM images demonstrated significant variations in

• the morphology of the nanocomposite in different media. At pH 4, AgNPs aggregated to form larger particles compared to those formed at pH 6. In contrast, at pH 12, the nanocomposite was disrupted, leading to the aggregation of gel and a reduced interaction between AgNPs and the bacterial cell wall

Carboxylic acids and light interact to affect nanoceria stability and dissolution in acidic aqueous environments

• Matthew L. Hancock,
• Eric A. Grulke and
• Robert A. Yokel

Beilstein J. Nanotechnol. 2023, 14, 762–780, doi:10.3762/bjnano.14.63

• resulted in loss or overcoating of the surface citrate, and, in some cases, agglomeration [10]. Exposure to vitamin C and glutathione led to dissolution-accompanied aggregation of mesoporous silica CeO2 nanoparticles [35]. The shortening of ceria nanorods from 25 to 8 nm after 14 days at 200 °C was

• aggregation of nanoceria was also shown by Muhammad and co-workers [35]. TEM analysis TEM analysis was conducted on two samples, citric and β-hydroxybutyric acid, to compare to the DLS results. They were chosen to represent samples from groups one and four. In the presence of light, nanoceria exposed to

In situ magnesiothermic reduction synthesis of a Ge@C composite for high-performance lithium-ion batterie anodes

• Ha Tran Huu,
• Ngoc Phi Nguyen,
• Vuong Hoang Ngo,
• Huy Hoang Luc,
• Minh Kha Le,
• Minh Thu Nguyen,
• My Loan Phung Le,
• Hye Rim Kim,
• In Young Kim,
• Sung Jin Kim,
• Van Man Tran and
• Vien Vo

Beilstein J. Nanotechnol. 2023, 14, 751–761, doi:10.3762/bjnano.14.62

• performance of Ge-based anodes, a carbon matrix is the most popular choice to disperse nanoparticles, avoiding their aggregation and reducing the internal stress induced by volume variation, because of its flexible structure and high conductivity [30][31][32]. In our recent study, the combination of Ge

Control of morphology and crystallinity of CNTs in flame synthesis with one-dimensional reaction zone

• Muhammad Hilmi Ibrahim,
• Norikhwan Hamzah,
• Mohd Zamri Mohd Yusop,
• Ni Luh Wulan Septiani and
• Mohd Fairus Mohd Yasin

Beilstein J. Nanotechnol. 2023, 14, 741–750, doi:10.3762/bjnano.14.61

• temperatures at lower and higher HAB values. The lowest HAB value shows the highest temperature reading, which linearly decreases with increasing HAB values. The temperature differences are expected to produce different particle size distributions due to aggregation of particles on the surface of the nickel

Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review

• Akeem Adeyemi Oladipo,
• Saba Derakhshan Oskouei and
• Mustafa Gazi

Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52

• developing luminescent sensors include their toxicity, ease of aggregation, photobleachability, and low capacity for adsorption of the target analyte. Numerous luminescent materials, including semiconductors, metal complexes, metal-based fluorescent nanoparticles, MOFs, and inorganic phosphors doped with

Molecular nanoarchitectonics: unification of nanotechnology and molecular/materials science

• Katsuhiko Ariga

Beilstein J. Nanotechnol. 2023, 14, 434–453, doi:10.3762/bjnano.14.35

• expression through nanoarchitectonics. Shi and co-workers created nanoparticle surfactants at liquid–liquid interfaces by exploiting the interaction between nanoparticles and polymer ligands [101]. They showed that a size-dependent aggregation of nanoparticle surfactants can be generated at the interface

Evaluation of electrosynthesized reduced graphene oxide–Ni/Fe/Co-based (oxy)hydroxide catalysts towards the oxygen evolution reaction

• Karolina Cysewska,
• Marcin Łapiński,
• Marcin Zając,
• Jakub Karczewski,
• Piotr Jasiński and
• Sebastian Molin

Beilstein J. Nanotechnol. 2023, 14, 420–433, doi:10.3762/bjnano.14.34

• friendly nature [11]. Even though transition-metal-based catalysts still suffer from low surface areas [12], dissolution and aggregation of metallic phase and metal oxides during the active OER process occurs [13]. Hence, Ni-, Fe- and/or Co-based catalysts have been synthesized as hybrid catalysts with

Plasmonic nanotechnology for photothermal applications – an evaluation

• A. R. Indhu,
• L. Keerthana and
• Gnanaprakash Dharmalingam

Beilstein J. Nanotechnol. 2023, 14, 380–419, doi:10.3762/bjnano.14.33

• nanocomposites. A detailed investigation of the essential, but often ignored, concept of thermal, chemical, and aggregation stability of nanoparticles is another part of this review. The challenges that remain, as well as prospective directions and chemistries, regarding nanomaterials for PT conversion are

Quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles: one-pot synthesis, characterization, and anticancer and antibacterial activities

• Akif Hakan Kurt,
• Elif Berna Olutas,
• Fatma Avcioglu,
• Hamza Karakuş,
• Mehmet Ali Sungur,
• Cansu Kara Oztabag and
• Muhammet Yıldırım

Beilstein J. Nanotechnol. 2023, 14, 362–376, doi:10.3762/bjnano.14.31

• medium [74]. Since NPs are exposed to various forces that affect their stability and size in such environments (containing electrolytes, proteins and lipids), they may tend to collapse and aggregate. Although no aggregation and turbidity were observed during the preparation stage with the naked eye and

• . In other words, in the presence of the medium for cell culture (i.e., DMEM without phenol red), the possible formation of larger structures through the aggregation of Ag NPs will cause a shift in the position of the SPR peak toward the longer-wavelength side of the spectrum. Therefore, to get an

• insight into the aggregation and the stability of the Ch/Q- and Ch/CA-Ag NPs in the cell culture medium, UV–vis absorption measurements were carried out (see Supporting Information File 1, Figure S2). As can be seen in Figure S2 (Supporting Information File 1), the SPR peak emerges at 428 and 440 nm for

The steep road to nonviral nanomedicines: Frequent challenges and culprits in designing nanoparticles for gene therapy

• Yao Yao,
• Yeongun Ko,
• Grant Grasman,
• Jeffery E. Raymond and
• Joerg Lahann

Beilstein J. Nanotechnol. 2023, 14, 351–361, doi:10.3762/bjnano.14.30

• ). Laser scanning or spinning disc confocal microscopy, typically used for qualitative determination of NP uptake, can provide valuable insights into relative distribution and aggregation of NPs, which has been widely used in the field of nonviral gene delivery (reported in 82% of the papers, Figure 1a

• ultracentrifugation provide ensemble detection of size distributions with their own issues and complexities (e.g., gradient-induced aggregation and pressure-induced particle reconfiguration) [65]. Determination of size on a per-particle basis, such as that obtained from NTA or the aforementioned cryo-TEM/solution AFM

Biocatalytic synthesis and ordered self-assembly of silica nanoparticles via a silica-binding peptide

• Mustafa Gungormus

Beilstein J. Nanotechnol. 2023, 14, 280–290, doi:10.3762/bjnano.14.25

• becomes growth by monomer addition to the surface of the particles. At 1 mM concentration, however, the SiBP alters this profile and delays the aggregation of early approx. 10 nm particles into larger particles (Figure 4b). The most likely mechanism for this is the SiBP binding on the surface of the

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

• Qixiong Lin,
• Yueyou Peng,
• Yanyan Wen,
• Xiaoqiong Li,
• Donglian Du,
• Weibin Dai,
• Wei Tian and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2023, 14, 262–279, doi:10.3762/bjnano.14.24

• different types of tumors through homotypic aggregation to homologous tissues [23]. The encapsulated NPs can specifically accumulate in the tumor tissue and reduce early clearance, thereby prolonging the residence time of the drugs they carry and reducing their systemic side effects [24]. Furthermore

• fast growth and easy metastasis [28]. After circulating tumor cells are released from the primary tumor site into the bloodstream, they participate in the main metastasis process and tend to form multicellular homoaggregates at major attachment sites [29][30]. The homotypic aggregation of cancer cells

• mediates solid tumorigenesis and metastatic behavior [31]. The mechanism of homotypic aggregation is the result of multifactorial action and is closely related to tumor-specific antigens (e.g., Thomsen–Friedenreich antigen [29], carcinoembryonic antigen [32], and glycoprotein 100 [33]) and other adhesion

Cyclodextrins as eminent constituents in nanoarchitectonics for drug delivery systems

• Makoto Komiyama

Beilstein J. Nanotechnol. 2023, 14, 218–232, doi:10.3762/bjnano.14.21

• them, a linear polymer was constructed through consecutive inclusion of adamantane in β-CyD units. Upon further addition of poly(ethylene glycol) bearing adamantane at the terminus nanoparticles were formed (Figure 7B). In these nanoparticles, aggregation of porphyrins is suppressed because of steric

• encapsulating (a part of) the photosensitizer in the cavities, its self-aggregation was suppressed to accomplish a high quantum yield of 1O2 production. The aggregation of porphyrin was photocontrolled by using complex formation of β-CyD with photoresponsive azobenzene [78]. By delivering nitrogen oxide (NO

A novel approach to pulsed laser deposition of platinum catalyst on carbon particles for use in polymer electrolyte membrane fuel cells

• Bogusław Budner,
• Wojciech Tokarz,
• Sławomir Dyjak,
• Andrzej Czerwiński,
• Bartosz Bartosewicz and
• Bartłomiej Jankiewicz

Beilstein J. Nanotechnol. 2023, 14, 190–204, doi:10.3762/bjnano.14.19

• carbon black-like materials, the primary carbon particles agglomerate into spherical agglomerates of ca. 200 nm and then merge into larger moieties of several micrometers, giving rise to an extensive meso–macroporous network. Such character of particle aggregation is observed for many types of carbon

Antimicrobial and mechanical properties of functionalized textile by nanoarchitectured photoinduced Ag@polymer coating

• Jessica Plé,
• Marine Dabert,
• Helene Lecoq,
• Sophie Hellé,
• Lydie Ploux and
• Lavinia Balan

Beilstein J. Nanotechnol. 2023, 14, 95–109, doi:10.3762/bjnano.14.11

• difficult to implement and tend to cause NP self-aggregation. In situ methods are therefore generally preferred and typically require the polymer film surface to be treated with a metal precursor solution (layer-by-layer [37][38], sol–gel [39]) before undergoing thermal [40] or chemical reduction reactions

• non-bonding doublets of oxygen atoms create steric hindrance and avoid their aggregation. The coating, colorless before irradiation, becomes progressively pale yellow, orange, then finally brown. Due to the strong increase of AgNPs, the measurement system reaches the detection limit (OD > 3) after 15

Solvent-induced assembly of mono- and divalent silica nanoparticles

• Bin Liu,
• Etienne Duguet and
• Serge Ravaine

Beilstein J. Nanotechnol. 2023, 14, 52–60, doi:10.3762/bjnano.14.6

• previous work on the assembly of 1-PSN with larger PPSR ranging from 0.69 to 1.54 in a THF/ethanol mixture has shown that colloids with a low aggregation number (e.g., dimers, trimers, tetramers, and spherical micelles) could be obtained at a low incubation time. Also, the higher the PPSR value, the more

• by using pure water (Figure 4b) or salty water (Figure 4c) instead of ethanol in different fractions. We observed that, except for 1-PSN with PPSR ≤ 0.3, assembly was possible and led to dimers and possibly to clusters of low aggregation number for the highest PPSR values. These results first

Non-stoichiometric magnetite as catalyst for the photocatalytic degradation of phenol and 2,6-dibromo-4-methylphenol – a new approach in water treatment

• Joanna Kisała,
• Anna Tomaszewska and
• Przemysław Kolek

Beilstein J. Nanotechnol. 2022, 13, 1531–1540, doi:10.3762/bjnano.13.126

• catalysts were semiconductors rather than conductors. The morphology of the Fe3O4 catalysts is shown in Figure 2. The images show nanocrystal agglomerates with particle sizes of 100–400 nm for M1 and of 25–100 nm for M2 (Figure 2). The aggregation of M2 particles is much stronger than that of M1. Hence, M2

Rapid and sensitive detection of box turtles using an electrochemical DNA biosensor based on a gold/graphene nanocomposite

• Abu Hashem,
• M. A. Motalib Hossain,
• Ab Rahman Marlinda,
• Mohammad Al Mamun,
• Khanom Simarani and
• Mohd Rafie Johan

Beilstein J. Nanotechnol. 2022, 13, 1458–1472, doi:10.3762/bjnano.13.120

•  2a, the wrinkled area represents folded Gr sheets [52]. In Figure 2b, octahedron-like gold particles [53] are clearly visible in the corresponding FESEM image. The particle size of AuNPs seems to be larger than expected, which may be due to self-aggregation during the formation of the nanocomposite

Facile preparation of Au- and BODIPY-grafted lipid nanoparticles for synergized photothermal therapy

• Yuran Wang,
• Xudong Li,
• Haijun Chen and
• Yu Gao

Beilstein J. Nanotechnol. 2022, 13, 1432–1444, doi:10.3762/bjnano.13.118

• distinctive optical properties. However, AuNPs are easily aggregate and are difficult to eliminate in vivo. In a previous reported work, we synthesized LNPs grafted with tiny gold nanoclusters (Au-LNPs) to solve issues regarding aggregation and metabolism [8]. However, PTT of Au-LNPs is limited by the low

LED-light-activated photocatalytic performance of metal-free carbon-modified hexagonal boron nitride towards degradation of methylene blue and phenol

• Nirmalendu S. Mishra and
• Pichiah Saravanan

Beilstein J. Nanotechnol. 2022, 13, 1380–1392, doi:10.3762/bjnano.13.114

• –desorption hysteresis for HBN and MBN-80 have been schematized in Figure 4. The BET surface area and pore volume decreased in MBN-80 and could be attributed to the structural pore collapse or excess carbon aggregation [25]. However, the increase in carbon content contributed to the improvised light

Design of surface nanostructures for chirality sensing based on quartz crystal microbalance

• Yinglin Ma,
• Xiangyun Xiao and
• Qingmin Ji

Beilstein J. Nanotechnol. 2022, 13, 1201–1219, doi:10.3762/bjnano.13.100

• , is the main cause of neurodegenerative diseases. Qing et al. used a chiral cysteine- (L/R-Cys) modified graphene oxide (GO) to study the chirality of the aggregation process of the chiral amyloid β-protein(1-40) (Aβ(1-40)) [152]. The adsorption behaviors of Aβ(1–40) monomers and oligomers by QCM

Recent advances in green carbon dots (2015–2022): synthesis, metal ion sensing, and biological applications

• Aisha Kanwal,
• Naheed Bibi,
• Sajjad Hyder,
• Arif Muhammad,
• Hao Ren,
• Jiangtao Liu and
• Zhongli Lei

Beilstein J. Nanotechnol. 2022, 13, 1068–1107, doi:10.3762/bjnano.13.93

Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• these nanomaterials to fabricate a scaffold that can potentially mimic the natural structure and function of the bones. The addition of nanomaterials to chitosan provides several advantages including the retaining of biological activities of nanomaterials and prevention of particle aggregation [24][25