Search results

Search for "cytotoxicity" in Full Text gives 195 result(s) in Beilstein Journal of Nanotechnology.

The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model

  • Qura Tul Ain,
  • Samina Hyder Haq,
  • Abeer Alshammari,
  • Moudhi Abdullah Al-Mutlaq and
  • Muhammad Naeem Anjum

Beilstein J. Nanotechnol. 2019, 10, 901–911, doi:10.3762/bjnano.10.91

Graphical Abstract
  • accompanied by reduced activity levels of antioxidant enzymes directly indicated that all organs were in oxidative stress after the intraperitoneal administration of PEG-nGO. These studies further reiterated the cytotoxicity of graphite oxide in vivo. Further safety evaluation and research must be undertaken
PDF
Album
Full Research Paper
Published 18 Apr 2019

Tungsten disulfide-based nanocomposites for photothermal therapy

  • Tzuriel Levin,
  • Hagit Sade,
  • Rina Ben-Shabbat Binyamini,
  • Maayan Pour,
  • Iftach Nachman and
  • Jean-Paul Lellouche

Beilstein J. Nanotechnol. 2019, 10, 811–822, doi:10.3762/bjnano.10.81

Graphical Abstract
  • [19], or dermal application [20]. More recent studies conducted on rhenium-doped MoS2 nanoparticles showed no acute toxic risk, neither by oral administration nor by dermal application [21][22]. A few years ago, Teo et al. compared the cytotoxicity of exfoliated MoS2, WS2, and WSe2 to that of their
PDF
Album
Supp Info
Full Research Paper
Published 02 Apr 2019

Polydopamine-coated Au nanorods for targeted fluorescent cell imaging and photothermal therapy

  • Boris N. Khlebtsov,
  • Andrey M. Burov,
  • Timofey E. Pylaev and
  • Nikolai G. Khlebtsov

Beilstein J. Nanotechnol. 2019, 10, 794–803, doi:10.3762/bjnano.10.79

Graphical Abstract
  • used a Cary Eclipse spectrofluorometer. Cytotoxicity assay The in vitro cytotoxicity was measured using a standard resazurin (Alamar blue) assay following the manufacturer instructions. HeLa cells (1 × 105 cells/well) were seeded into 96-well cell-culture plate and then incubated for 24 h at 37 °C
PDF
Album
Supp Info
Full Research Paper
Published 01 Apr 2019

Characterization and influence of hydroxyapatite nanopowders on living cells

  • Przemyslaw Oberbek,
  • Tomasz Bolek,
  • Adrian Chlanda,
  • Seishiro Hirano,
  • Sylwia Kusnieruk,
  • Julia Rogowska-Tylman,
  • Ganna Nechyporenko,
  • Viktor Zinchenko,
  • Wojciech Swieszkowski and
  • Tomasz Puzyn

Beilstein J. Nanotechnol. 2018, 9, 3079–3094, doi:10.3762/bjnano.9.286

Graphical Abstract
  • and J774.1 to assess the influence of the nanoparticles on immune, reproductive and respiratory systems. Keywords: nanomaterials safety; biomaterials; tissue engineering; microscopic characterization; cytotoxicity; hydroxyapatite; Introduction Engineered nanomaterials have found applications in many
  • significantly limits the insight of underlying mechanisms that affect living cells. There is a wide range of available cell lines to study possible organism reactions and cytotoxicity mechanisms, such as endothelial, neural, hepatic, phagocytic or cancer cells [26][27]. Still, systematic studies describing
  • nanoparticle cytotoxicity: chinese hamster ovary cell line (CHO) showing the effect on cells of the reproductive system, mouse monocyte macrophage cell line (J774.1) showing the effect on cells of the immune system, human bronchial epithelial cell line (BEAS-2B) and human lung adenocarcinoma epithelial cell
PDF
Album
Full Research Paper
Published 27 Dec 2018

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

  • Anouchka Plan Sangnier,
  • Romain Aufaure,
  • Laurence Motte,
  • Claire Wilhelm,
  • Erwann Guenin and
  • Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

Graphical Abstract
  • (Figure 3a) with an IC50 equal to 100 µM for both systems whereas Au@HMBP-PEG NPs [39] do not exhibit any cytotoxicity (Supporting Information File 1, Figure S3). Under similar cell-treatment conditions, this IC50 value is consistent with values obtained for free alendronate with other cancer cell lines
PDF
Album
Supp Info
Letter
Published 27 Nov 2018

Comparative biological effects of spherical noble metal nanoparticles (Rh, Pd, Ag, Pt, Au) with 4–8 nm diameter

  • Alexander Rostek,
  • Marina Breisch,
  • Kevin Pappert,
  • Kateryna Loza,
  • Marc Heggen,
  • Manfred Köller,
  • Christina Sengstock and
  • Matthias Epple

Beilstein J. Nanotechnol. 2018, 9, 2763–2774, doi:10.3762/bjnano.9.258

Graphical Abstract
  • /bjnano.9.258 Abstract For a comparative cytotoxicity study, nanoparticles of the noble metals Rh, Pd, Ag, Pt, and Au (spherical, average diameter 4 to 8 nm) were prepared by reduction in water and colloidally stabilized with poly(N-vinyl pyrrolidone) (PVP). Thus, their shape, size, and surface
  • , palladium, platinum, gold) that do not release ions are not cytotoxic under these conditions. Keywords: cytotoxicity; electron microscopy; metals; nanoparticles; nanotoxicity; Introduction Inorganic and metallic nanoparticles represent a well-established part of materials science, heterogeneous catalysis
  • human cells [24][26][27], whereas in other studies, these effects were not observed [28][29][30]. With ultrasmall gold nanoparticles and gold clusters, different biological events are triggered that can lead to a higher cytotoxicity of very small particles (<3 nm) [31]. Very little is known about the
PDF
Album
Full Research Paper
Published 29 Oct 2018

Size-selected Fe3O4–Au hybrid nanoparticles for improved magnetism-based theranostics

  • Maria V. Efremova,
  • Yulia A. Nalench,
  • Eirini Myrovali,
  • Anastasiia S. Garanina,
  • Ivan S. Grebennikov,
  • Polina K. Gifer,
  • Maxim A. Abakumov,
  • Marina Spasova,
  • Makis Angelakeris,
  • Alexander G. Savchenko,
  • Michael Farle,
  • Natalia L. Klyachko,
  • Alexander G. Majouga and
  • Ulf Wiedwald

Beilstein J. Nanotechnol. 2018, 9, 2684–2699, doi:10.3762/bjnano.9.251

Graphical Abstract
  • tested by several methods. Standard MTS assay (Figure 7, Table S2, Supporting Information File 1) was conducted to investigate the NP cytotoxicity. These results are supplemented with apoptosis/necrosis activation (Figures S4 and S6, Supporting Information File 1) and production of reactive oxygen
PDF
Album
Supp Info
Full Research Paper
Published 16 Oct 2018

Cytotoxicity of doxorubicin-conjugated poly[N-(2-hydroxypropyl)methacrylamide]-modified γ-Fe2O3 nanoparticles towards human tumor cells

  • Zdeněk Plichta,
  • Yulia Kozak,
  • Rostyslav Panchuk,
  • Viktoria Sokolova,
  • Matthias Epple,
  • Lesya Kobylinska,
  • Pavla Jendelová and
  • Daniel Horák

Beilstein J. Nanotechnol. 2018, 9, 2533–2545, doi:10.3762/bjnano.9.236

Graphical Abstract
  • stability in aqueous media and limited internalization by the cells, however, enabled adhesion to the cell surface. While the neat PHPMA-coated particles proved to be non-toxic, doxorubicin-conjugated particles exhibited enhanced cytotoxicity in both drug-sensitive and drug-resistant tumor cells compared to
  • free doxorubicin. The newly developed doxorubicin-conjugated PHPMA-coated magnetic particles seem to be a promising magnetically targeted vehicle for anticancer drug delivery. Keywords: cytotoxicity; doxorubicin; magnetic; nanoparticles; poly[N-(2-hydroxypropyl)methacrylamide]; Introduction Severe
  • chemical attachment of target biomolecules, reduces cytotoxicity, and controls particle uptake by the cells [10]. Coatings can be either of low molecular weight, such are carbohydrates and organic acids (ethylenediaminetetraacetic acid, tartaric acid, citric acid, succinic acid, bisphosphonic acid), or of
PDF
Album
Full Research Paper
Published 25 Sep 2018

Enhanced antineoplastic/therapeutic efficacy using 5-fluorouracil-loaded calcium phosphate nanoparticles

  • Shanid Mohiyuddin,
  • Saba Naqvi and
  • Gopinath Packirisamy

Beilstein J. Nanotechnol. 2018, 9, 2499–2515, doi:10.3762/bjnano.9.233

Graphical Abstract
  • problems in medical prognoses such as nonspecific cytotoxicity, insignificant survival rate, re-initialization of cancer, in vitro evolution of multidrug resistance, and unwanted side effects [2]. The failure of conventional therapeutic strategies indicates that additional efforts should be focused
  • prior to arriving at the targeted site resulted in serious nonspecific cytotoxicity [4]. Alternative drug delivery strategies using inorganic nanoparticles have also been applied. A magneto-electric nanoparticle (MEN) system was reported as a controlled drug delivery platform for the drug paclitaxel in
  • CaP NPs in HCT-15 cell lines (Figure 4C). The same was found in 22.3% and 18.68% of inhibition in A549 and NIH 3T3 cell lines as demonstrated in Figure 4B and Figure 4A, respectively. The comparative low cytotoxicity of CaP NPs as a carrier (even at a higher concentration of 100 µg/mL) reveals the
PDF
Album
Supp Info
Full Research Paper
Published 20 Sep 2018

Fabrication of photothermally active poly(vinyl alcohol) films with gold nanostars for antibacterial applications

  • Mykola Borzenkov,
  • Maria Moros,
  • Claudia Tortiglione,
  • Serena Bertoldi,
  • Nicola Contessi,
  • Silvia Faré,
  • Angelo Taglietti,
  • Agnese D’Agostino,
  • Piersandro Pallavicini,
  • Maddalena Collini and
  • Giuseppe Chirico

Beilstein J. Nanotechnol. 2018, 9, 2040–2048, doi:10.3762/bjnano.9.193

Graphical Abstract
  • photothermal effect [6][24]. Moreover, the LSPR peak located in the second biotransparent window (1000–1400 nm) is more attractive for in vivo applications due to the deeper penetration of NIR light [26]. Since GNSs are weakly stable if coated only with surfactant, and also considering the cytotoxicity of
PDF
Album
Supp Info
Full Research Paper
Published 23 Jul 2018

Biomimetic and biodegradable cellulose acetate scaffolds loaded with dexamethasone for bone implants

  • Aikaterini-Rafailia Tsiapla,
  • Varvara Karagkiozaki,
  • Veroniki Bakola,
  • Foteini Pappa,
  • Panagiota Gkertsiou,
  • Eleni Pavlidou and
  • Stergios Logothetidis

Beilstein J. Nanotechnol. 2018, 9, 1986–1994, doi:10.3762/bjnano.9.189

Graphical Abstract
  • . Cytotoxicity studies were performed by using MTT assay, methylene-blue staining and SEM fixation and showed very good cell adhesion and proliferation, indicating the cytocompatibility of these fibrous scaffolds. Drug-release kinetics was measured for the evaluation of a controllable and sustained release of
  • was measured at the absorption wavelength of the drug, using a 96-well plate reader (Luminometer Promega Glomax multi detection system). After that, the remaining samples were placed back in the incubator until the next measurement. In vitro cytotoxicity assays MTT assay direct test and methylene blue
  • staining: L929 mouse fibroblasts were used to examine the cytotoxicity levels due to their properties and biological characteristics (biological responses and reproducible growth rates). The samples were placed inside a well-plate and 1 mL of medium was added and the whole system was left in the incubator
PDF
Album
Full Research Paper
Published 13 Jul 2018

Preparation of micro/nanopatterned gelatins crosslinked with genipin for biocompatible dental implants

  • Reika Makita,
  • Tsukasa Akasaka,
  • Seiichi Tamagawa,
  • Yasuhiro Yoshida,
  • Saori Miyata,
  • Hirofumi Miyaji and
  • Tsutomu Sugaya

Beilstein J. Nanotechnol. 2018, 9, 1735–1754, doi:10.3762/bjnano.9.165

Graphical Abstract
  • surface patterning material or crosslinking agent used can also subsequently influence cytotoxicity and cell behavior [32][33]. Rizwan et al. have reported that micro/nanopillars comprised of gelatin could be fabricated through a combination of molding and polymerization of the gelatin with methacrylate
  • attachment. Moreover, the live/dead cell viability assay demonstrated that gelatin crosslinked with genipin showed low cytotoxicity (Figure 4). The low cytotoxicity for Saos-2 cells on our gelatin patterns was in agreement with the low cytotoxicity for fibroblasts on genipin-crosslinked gelatin [66
PDF
Album
Full Research Paper
Published 11 Jun 2018

Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules

  • María Francisca Matus,
  • Martín Ludueña,
  • Cristian Vilos,
  • Iván Palomo and
  • Marcelo M. Mariscal

Beilstein J. Nanotechnol. 2018, 9, 1328–1338, doi:10.3762/bjnano.9.126

Graphical Abstract
  • have shown that PEGylation of NPs allows improved blood circulation, clearance, biocompatibility and less cytotoxicity [15][16][17][18][19]. Hydrophilic polymer chains at the surface of NPs act as a steric barrier, reducing the opsonization and the subsequent phagocytosis [20][21][22]. This amphiphilic
PDF
Album
Full Research Paper
Published 02 May 2018

Review on nanoparticles and nanostructured materials: history, sources, toxicity and regulations

  • Jaison Jeevanandam,
  • Ahmed Barhoum,
  • Yen S. Chan,
  • Alain Dufresne and
  • Michael K. Danquah

Beilstein J. Nanotechnol. 2018, 9, 1050–1074, doi:10.3762/bjnano.9.98

Graphical Abstract
  • extensive studies reported that Ag NPs demonstrated a size, morphology, and dosage-dependent higher cytotoxicity to humans and animals cells than asbestos [91][116][117][118][119][120]. The hazardous effects of other NPs present in consumer products are unknown and are still under research. Naturally
PDF
Album
Review
Published 03 Apr 2018

Green synthesis of fluorescent carbon dots from spices for in vitro imaging and tumour cell growth inhibition

  • Nagamalai Vasimalai,
  • Vânia Vilas-Boas,
  • Juan Gallo,
  • María de Fátima Cerqueira,
  • Mario Menéndez-Miranda,
  • José Manuel Costa-Fernández,
  • Lorena Diéguez,
  • Begoña Espiña and
  • María Teresa Fernández-Argüelles

Beilstein J. Nanotechnol. 2018, 9, 530–544, doi:10.3762/bjnano.9.51

Graphical Abstract
  • characterized by means of UV–vis, fluorescence, Fourier transform infrared and Raman spectroscopy, dynamic light scattering and transmission electron microscopy. The optical performance showed an outstanding ability for imaging purposes, with quantum yields up to 43.6%. Thus, the cytotoxicity of the above
  • surface of the C-dots might be responsible for the selective cytotoxicity, as suggested by the presence of piperine in the surface of black pepper C-dots analysed by ESI-QTOF-MS. Keywords: bioimaging; carbon quantum dots; fluorescence; spices; Introduction Recent developments in nanotechnology have led
  • pepper C-dots) were tested in vitro for cytotoxicity in epithelial human kidney cells (HK-2) and in glioblastoma LN-229 cells (results obtained for each type of C-dots are displayed in detail in Figures S5–S9, Supporting Information File 1). Please, notice that the range of carbon dot concentrations used
PDF
Album
Supp Info
Full Research Paper
Published 13 Feb 2018

Nanoparticle delivery to metastatic breast cancer cells by nanoengineered mesenchymal stem cells

  • Liga Saulite,
  • Karlis Pleiko,
  • Ineta Popena,
  • Dominyka Dapkute,
  • Ricardas Rotomskis and
  • Una Riekstina

Beilstein J. Nanotechnol. 2018, 9, 321–332, doi:10.3762/bjnano.9.32

Graphical Abstract
  • drug efflux transporter P-glycoprotein, which ensures rapid excretion of toxic substances from MSCs. Thus, MSCs are an excellent vector for low cytotoxicity anticancer drugs [4]. Sadhukha et al. demonstrated that nanoengineered MSCs home to A549 lung cancer in vivo and remain there for at least 3 h
  • , which could be sufficient time to release drugs into the tumour. The encapsulation of NP-linked anticancer drugs could ensure metered drug release in tumours [2]. QD linkage to photosensitisers, such as chlorin e6, causes damage to MiaPaCa2 cancer cells via light-induced cytotoxicity, demonstrating a
PDF
Album
Supp Info
Full Research Paper
Published 29 Jan 2018

Co-reductive fabrication of carbon nanodots with high quantum yield for bioimaging of bacteria

  • Jiajun Wang,
  • Xia Liu,
  • Gesmi Milcovich,
  • Tzu-Yu Chen,
  • Edel Durack,
  • Sarah Mallen,
  • Yongming Ruan,
  • Xuexiang Weng and
  • Sarah P. Hudson

Beilstein J. Nanotechnol. 2018, 9, 137–145, doi:10.3762/bjnano.9.16

Graphical Abstract
  • in bioimaging thanks to their low cytotoxicity. Keywords: bioimaging; carbon nanodots; collaborative reduction; hydrothermal; Introduction Over recent years, carbon nanomaterials have remarkably influenced the growth of a wide range of fields, including electronics, photonics, energy, catalysis and
  • water, low photobleaching and low cytotoxicity. They show great potential for bioimaging, photocatalysis, energy conversion, fluorescent ink and sensing applications [1][2][3]. In a bioimaging application perspective, the detection of bacteria by microscopic visualization is an essential benchmark
  • (Figure 5B). After confirming the bright feature behavior, Sb was further used to evaluate its bioimaging properties and bacteria viability range. First of all, a cytotoxicity quantification related to the applicable C-dot concentration range was assessed. Xag viability was evaluated following incubation
PDF
Album
Supp Info
Full Research Paper
Published 12 Jan 2018

Hyperthermic intracavitary nanoaerosol therapy (HINAT) as an improved approach for pressurised intraperitoneal aerosol chemotherapy (PIPAC): Technical description, experimental validation and first proof of concept

  • Daniel Göhler,
  • Stephan Große,
  • Alexander Bellendorf,
  • Thomas Albert Falkenstein,
  • Mehdi Ouaissi,
  • Jürgen Zieren,
  • Michael Stintz and
  • Urs Giger-Pabst

Beilstein J. Nanotechnol. 2017, 8, 2729–2740, doi:10.3762/bjnano.8.272

Graphical Abstract
  • benefits of hyperthermia (e.g., thermal cytotoxicity, increased drug penetration due to reduced intratumoral pressure, increased drug deposition due to improved thermophoretic conditions), both the liquid reservoir of the LAU as well as the aerosol that exits the LAU can be heated in a controlled manner to
PDF
Album
Full Research Paper
Published 18 Dec 2017

Involvement of two uptake mechanisms of gold and iron oxide nanoparticles in a co-exposure scenario using mouse macrophages

  • Dimitri Vanhecke,
  • Dagmar A. Kuhn,
  • Dorleta Jimenez de Aberasturi,
  • Sandor Balog,
  • Ana Milosevic,
  • Dominic Urban,
  • Diana Peckys,
  • Niels de Jonge,
  • Wolfgang J. Parak,
  • Alke Petri-Fink and
  • Barbara Rothen-Rutishauser

Beilstein J. Nanotechnol. 2017, 8, 2396–2409, doi:10.3762/bjnano.8.239

Graphical Abstract
  • Morada 11 megapixel camera (Münster, Germany). Lactate dehydrogenase assay (LDH) One millilitre of the supernatant of each experiment was collected and stored at 4 °C to determine cytotoxicity. Triton X (0.2% in unsupplemented RPMI) was used for cell lysis as a positive control. The supernatant of
  • untreated cells was used as negative control. The LDH assay was performed with the Cytotoxicity Detection Kit (Roche Applied Science, Mannheim, Germany) according to the supplier's manual. Trypan blue exclusion assay The assay was carried out according to the manufacturer’s manual (Sigma Aldrich, Steinheim
PDF
Album
Supp Info
Full Research Paper
Published 14 Nov 2017

Evaluating the toxicity of TiO2-based nanoparticles to Chinese hamster ovary cells and Escherichia coli: a complementary experimental and computational approach

  • Alicja Mikolajczyk,
  • Natalia Sizochenko,
  • Ewa Mulkiewicz,
  • Anna Malankowska,
  • Michal Nischk,
  • Przemyslaw Jurczak,
  • Seishiro Hirano,
  • Grzegorz Nowaczyk,
  • Adriana Zaleska-Medynska,
  • Jerzy Leszczynski,
  • Agnieszka Gajewicz and
  • Tomasz Puzyn

Beilstein J. Nanotechnol. 2017, 8, 2171–2180, doi:10.3762/bjnano.8.216

Graphical Abstract
  • obtained cytotoxicity data were analyzed by means of computational methods (quantitative structure–activity relationships, QSAR approach). Based on a combined experimental and computational approach, predictive models were developed, and relationships between cytotoxicity, size, and specific surface area
  • bactericidal activity (towards Gram-positive B. subtilis and Gram-negative P. putida) than NPs activated by UV [4]. At the same time, no significant cytotoxicity has been detected for TiO2 doped with nitrogen (N), gold (Au) or selenium (Sn) [20][21]. Whereas, copper oxide-doped TiO2 and iron/nitrogen co-doped
  • approach is based on defining mathematical dependencies between the variance in molecular structures, encoded by so-called molecular descriptors, and the variance in a given physicochemical property or biological (e.g., cytotoxicity) property in a set of compounds (“endpoints”) [5][25][26][27][28][29][30
PDF
Album
Full Research Paper
Published 17 Oct 2017

Carbon nano-onions as fluorescent on/off modulated nanoprobes for diagnostics

  • Stefania Lettieri,
  • Marta d’Amora,
  • Adalberto Camisasca,
  • Alberto Diaspro and
  • Silvia Giordani

Beilstein J. Nanotechnol. 2017, 8, 1878–1888, doi:10.3762/bjnano.8.188

Graphical Abstract
  • recent reports have shown that CNOs exhibit weak inflammatory potential and low cytotoxicity [16], and they are readily internalized by cancer cells and localize in the lysosomes [18][19]. Moreover, our in vivo studies performed on zebrafish (Danio Rerio) during the development stage demonstrated their
  • dye molecules (Table 2). Cytotoxicity studies The possible adverse effects of fluo-CNOs on HeLa cells were tested by using a colorimetric assay (WST1). Cells were exposed to different concentrations of fluo-CNOs (1, 2, 5, 10 and 20 μg mL−1) for different time periods (12, 24, 48 and 72 h). Cells
  • objective. In order to switch the fluorescence on and off, the cells were incubated respectively with an acidic PBS solution (pH 4.5) and a basic PBS solution (pH 8.5) for 1 h before imaging. Viability assay For the cytotoxicity assays, the cells were seeded at 5 × 104 cells in in 96-well plates and
PDF
Album
Supp Info
Full Research Paper
Published 07 Sep 2017

Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents

  • Dovile Baziulyte-Paulaviciene,
  • Vitalijus Karabanovas,
  • Marius Stasys,
  • Greta Jarockyte,
  • Vilius Poderys,
  • Simas Sakirzanovas and
  • Ricardas Rotomskis

Beilstein J. Nanotechnol. 2017, 8, 1815–1824, doi:10.3762/bjnano.8.183

Graphical Abstract
  • , Tween 80-coated core–shell nanoparticles presented enhanced optical and MR signal intensity, good colloidal stability, low cytotoxicity and nonspecific internalization into two different breast cancer cell lines, which indicates that these nanoparticles could be applied as an efficient, dual-modal
  • . Our results showed that Tween 80-coated UCNPs exhibited low cytotoxicity even at a high-dose concentration. Results and Discussion The SEM images of the NaGdF4:Yb,Er core and NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles are shown in Figure 1. Core nanoparticles are monodisperse, and have a spherical
  • to 100 μg/mL, the viability of human breast cancer MCF-7 cells remained over 92–100% and the viability of MDA-MB-231 cells remained 85–93%. These results clearly express that core–shell gadolinium-based UCNPs have low cytotoxicity and are in good agreement with previous studies [35][36]. Conclusion
PDF
Album
Supp Info
Full Research Paper
Published 01 Sep 2017

Uptake and intracellular accumulation of diamond nanoparticles – a metabolic and cytotoxic study

  • Antonín Brož,
  • Lucie Bačáková,
  • Pavla Štenclová,
  • Alexander Kromka and
  • Štěpán Potocký

Beilstein J. Nanotechnol. 2017, 8, 1649–1657, doi:10.3762/bjnano.8.165

Graphical Abstract
  • ][27], particle size reduction [22] and surface oxidation (i.e., the surface is covered by defined starting functional groups). The cytotoxicity of NDs depends on their origin (i.e., DNDs or HPHT NDs), their size (distribution), their tendency to form aggregates (surface charge), the presence of
  • impurities, and surface functionalization groups. Adverse effects on cell viability have been reported when using DNDs [24][28][29][30][31][32], while HPHT NDs often appear to be nontoxic [33][34]. Factors influencing the cytotoxicity of nanoparticles are their size [24][35][36] and surface functionalization
  • [37]. In this work, we focus on cytotoxicity studies of NDs as a function of their synthesis route (DNDs versus HPHT NDs), their concentration in the medium (from 10 to 1000 mg/mL, 3 to 300 µg/cm2), their size (5 nm DND, 18–210 nm HPHT NDs) and their surface potential/termination (as-received and
PDF
Album
Supp Info
Full Research Paper
Published 10 Aug 2017

Luminescent supramolecular hydrogels from a tripeptide and nitrogen-doped carbon nanodots

  • Maria C. Cringoli,
  • Slavko Kralj,
  • Marina Kurbasic,
  • Massimo Urban and
  • Silvia Marchesan

Beilstein J. Nanotechnol. 2017, 8, 1553–1562, doi:10.3762/bjnano.8.157

Graphical Abstract
  • by rheometry, fluorescence, circular dichroism (CD), FTIR spectroscopy, transmission electron microscopy (TEM), and differential scanning calorimetry (DSC). Given that this tripeptide is capable of forming a hydrogel with mild antimicrobial activity and a lack of cytotoxicity in vitro [26], this new
PDF
Album
Supp Info
Full Research Paper
Published 01 Aug 2017

A nanocomplex of C60 fullerene with cisplatin: design, characterization and toxicity

  • Svitlana Prylutska,
  • Svitlana Politenkova,
  • Kateryna Afanasieva,
  • Volodymyr Korolovych,
  • Kateryna Bogutska,
  • Andriy Sivolob,
  • Larysa Skivka,
  • Maxim Evstigneev,
  • Viktor Kostjukov,
  • Yuriy Prylutskyy and
  • Uwe Ritter

Beilstein J. Nanotechnol. 2017, 8, 1494–1501, doi:10.3762/bjnano.8.149

Graphical Abstract
  • compounds. The genotoxicity of С60 fullerene, Cis and their complex was evaluated in vitro with the comet assay using human resting lymphocytes and lymphocytes after blast transformation. The cytotoxicity of the mentioned compounds was estimated by Annexin V/PI double staining followed by flow cytometry
PDF
Album
Full Research Paper
Published 20 Jul 2017
Other Beilstein-Institut Open Science Activities