Supramolecular hydration structure of graphene-based hydrogels: density functional theory, green chemistry and interface application

• Hon Nhien Le,
• Duy Khanh Nguyen,
• Minh Triet Dang,
• Huyen Trinh Nguyen,
• Thi Bang Tam Dao,
• Trung Do Nguyen,
• Chi Nhan Ha Thuc and
• Van Hieu Le

Beilstein J. Nanotechnol. 2025, 16, 806–822, doi:10.3762/bjnano.16.61

• coating on polymer substrates, typically polylactide films. Interfacial adhesion of graphene-based nanosheets on polylactide substrates made the antibacterial coating stable for several application purposes. In general, supramolecular graphene-based hydrogels are bioinspired hydration structures to

• nanosheets. Large GO nanosheets are important to provide effective surface area for coating adhesion to the flat substrate and cross-linking in the coating network. Interactions at the interface between the coating and substrate include electrostatic interaction, hydrogen bonding, and van der Waals

• due to the load transfer from the polylactide substrate to the graphene-based coating during the tensile process. Effective coating adhesion to the substrate and high elastic modulus of graphene-based nanosheets contributed to the higher tensile properties. Supporting Information File 1, Figure S6

The impact of tris(pentafluorophenyl)borane hole transport layer doping on interfacial charge extraction and recombination

• Konstantinos Bidinakis and
• Stefan A. L. Weber

Beilstein J. Nanotechnol. 2025, 16, 678–689, doi:10.3762/bjnano.16.52

• )amine] (PTAA) [24]. These compounds exhibit favorable solubility, reasonable energetic alignment with most perovskites, and an amorphous nature. The main issues that arise from their usage involve poor conductivity and mechanical stability [25], the existence of pinholes, and a poor adhesion with the

Colloidal few layered graphene–tannic acid preserves the biocompatibility of periodontal ligament cells

• Teissir Ben Ammar,
• Naji Kharouf,
• Dominique Vautier,
• Housseinou Ba,
• Nivedita Sudheer,
• Philippe Lavalle and
• Vincent Ball

Beilstein J. Nanotechnol. 2025, 16, 664–677, doi:10.3762/bjnano.16.51

• , demonstrating no cytotoxicity to periodontal ligament cells up to 200 µg·mL−1 while promoting cellular adhesion and maintaining chromatin integrity. Overall, because of its favorable biocompatibility FLG–TA holds promise as a novel biomaterial for dental applications. Keywords: antioxidant properties

• demonstrated that cell adhesion may influence metabolic programming through regulation of adhesion molecules and glucose transport pathways [26][27]. Additionally, the molecular structure of tannic acid allows for potential enzymatic conversion into glucose derivatives via cellular metabolic pathways [28][29

• scavenging ROS, thus enhancing biocompatibility. Second, TA molecules potentially modify graphene’s surface structure, improving cellular adhesion. The effect of FLG–TA on ROS production in PDL cells was investigated. PDL cells were exposed to FLG–TA at concentrations of 1, 25, and 200 μg·mL−1, and ROS

Polyurethane/silk fibroin-based electrospun membranes for wound healing and skin substitute applications

• Iqra Zainab,
• Zohra Naseem,
• Syeda Rubab Batool,
• Muhammad Waqas,
• Ahsan Nazir and
• Muhammad Anwaar Nazeer

Beilstein J. Nanotechnol. 2025, 16, 591–612, doi:10.3762/bjnano.16.46

• ) on these scaffolds and adding CGF. The results demonstrated that the SF/CS/nHA scaffold combined with CGF promoted better cell adhesion, proliferation, and osteogenic differentiation of BMSCs than other groups. In vivo, a rabbit model with major bone defects was used to assess the scaffold’s

• exhibit slower degradation [101]. Additionally, there is a direct correlation between immune cell infiltration and silk degradation. Although other cell types may contribute to silk degradation, immune cells are primarily responsible for this process [102]. Silk can be modified, allowing for cell adhesion

• also be modified to improve cell adhesion and proliferation, facilitating its integration with biological systems [116]. Moreover, PU can be tailored to have particular mechanical characteristics and controlled degradation rates, allowing it to be adapted to various biological environments [117]. Its

Functionalized gold nanoflowers on carbon screen-printed electrodes: an electrochemical platform for biosensing hemagglutinin protein of influenza A H1N1 virus

• Carlos Enrique Torres-Méndez,
• Sharmilee Nandi,
• Klara Martinovic,
• Patrizia Kühne,
• Yifan Liu,
• Sam Taylor,
• Maria Lysandrou,
• Maria Ines Berrojo Romeyro Mascarenhas,
• Viktoria Langwallner,
• Javier Enrique Sebastián Alonso,
• Ivana Jovanovic,
• Maike Lüftner,
• Georgia-Vasiliki Gkountana,
• David Bern,
• Abdul-Raouf Atif,
• Ehsan Manouchehri Doulabi,
• Gemma Mestres and
• Masood Kamali-Moghaddam

Beilstein J. Nanotechnol. 2025, 16, 540–550, doi:10.3762/bjnano.16.42

• process, forming stable AuNFs that remain at the surface of the electrode upon contact with water and ethanol as no change in the CV was observed after contact with these solvents (Supporting Information File 1, Figure S1). This suggests strong mechanical adhesion of the AuNFs to the CSPE surface. The

N₂⁺-implantation-induced tailoring of structural, morphological, optical, and electrical characteristics of sputtered molybdenum thin films

• Usha Rani,
• Kafi Devi,
• Divya Gupta and
• Sanjeev Aggarwal

Beilstein J. Nanotechnol. 2025, 16, 495–509, doi:10.3762/bjnano.16.38

• electron beam evaporation [10] have been reported in the literature. RF sputtering is the predominant technique for thin film deposition because of its benefits regarding layer adhesion, uniformity, composition, and deposition rate compared to other methods [11]. In the deposition of molybdenum films, RF

Synthetic-polymer-assisted antisense oligonucleotide delivery: targeted approaches for precision disease treatment

• Ana Cubillo Alvarez,
• Dylan Maguire and
• Ruairí P. Brannigan

Beilstein J. Nanotechnol. 2025, 16, 435–463, doi:10.3762/bjnano.16.34

Biomimetics and bioinspired surfaces: from nature to theory and applications

• Rhainer Guillermo Ferreira,
• Thies H. Büscher,
• Manuela Rebora,
• Poramate Manoonpong,
• Zhendong Dai and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2025, 16, 418–421, doi:10.3762/bjnano.16.32

• understanding the biological systems and their potential as inspiration for innovation in producing biomimetic and bioinspired surfaces. Key topics included bioinspired micro- and nanostructured surfaces, and their tribological properties like friction, wear resistance, and adhesion. Discussions also addressed

Development of a mucoadhesive drug delivery system and its interaction with gastric cells

• Ahmet Baki Sahin,
• Serdar Karakurt and
• Deniz Sezlev Bilecen

Beilstein J. Nanotechnol. 2025, 16, 371–384, doi:10.3762/bjnano.16.28

• surface area for adhesion. Also, mucus penetration would be hindered because of the mesh-like structure of mucin. For therapeutics that have gastric mucosa as target, this might limit the efficiency and decrease the drug absorption at the site. A smaller particle size, however, is advantageous because of

Pulsed laser in liquid grafting of gold nanoparticle–carbon support composites

• Madeleine K. Wilsey,
• Teona Taseska,
• Qishen Lyu,
• Connor P. Cox and
• Astrid M. Müller

Beilstein J. Nanotechnol. 2025, 16, 349–361, doi:10.3762/bjnano.16.26

• nanoparticles with their surface attachment and solves longstanding nanoparticle adhesion and electrical contact issues. Irradiation of hydrophilic carbon fiber paper submerged in aqueous HAuCl4 solution by nanosecond laser pulses produced composites with uniform distribution of gold nanoparticles on carbon

• unattached catalyst material, which is especially problematic with precious catalysts. Overall, separate nanoparticle synthesis–attachment produces composites with adhesion, durability, electrical contact, and concomitant energy efficiency issues. Here, we report a new one-step pulsed laser grafting process

• that integrates the generation of nonequilibrium gold nanoparticles with their surface attachment on carbon fiber paper. This pulsed laser grafting approach solves longstanding adhesion and electrical contact issues. Instead of attaching ligand-capped nanoparticles to supports, nanoparticles are seeded

Fabrication and evaluation of BerNPs regarding the growth and development of Streptococcus mutans

• Tuyen Huu Nguyen,
• Hong Thanh Pham,
• Kieu Kim Thanh Nguyen,
• Loan Hong Ngo,
• Anh Ngoc Tuan Mai,
• Thu Hoang Anh Lam,
• Ngan Thi Kim Phan,
• Dung Tien Pham,
• Duong Thuy Hoang,
• Thuc Dong Nguyen and
• Lien Thi Xuan Truong

Beilstein J. Nanotechnol. 2025, 16, 308–315, doi:10.3762/bjnano.16.23

• , BerNPs demonstrated the ability to inhibit biofilm formation at various concentrations (Figure 5). The biofilm formation of S. mutans relies on the secretion of glycosyltransferase enzymes and several membrane-bound proteins [38]. SrtA, a surface protein involved in adhesion, biofilm formation, and

Enhancing mechanical properties of chitosan/PVA electrospun nanofibers: a comprehensive review

• Nur Areisman Mohd Salleh,
• Amalina Muhammad Afifi,
• Fathiah Mohamed Zuki and
• Hanna Sofia SalehHudin

Beilstein J. Nanotechnol. 2025, 16, 286–307, doi:10.3762/bjnano.16.22

• nanofibers provide topographic guidance to cells, promoting cell adhesion, proliferation, and migration. Most importantly, aligned fibers are a prominent type of nanofiber that closely mimics the fibers in the ECM of native tissue [194]. Radially aligned nanofiber patches of chitosan/PVA with thyme essential

• is needed to address this limitation. This method should not only support cell spreading, cell adhesion, and ECM synthesis but also

Radiosensitizing properties of dual-functionalized carbon nanostructures loaded with temozolomide

• Radmila Milenkovska,
• Nikola Geskovski,
• Dushko Shalabalija,
• Ljubica Mihailova,
• Petre Makreski,
• Dushko Lukarski,
• Igor Stojkovski,
• Maja Simonoska Crcarevska and
• Kristina Mladenovska

Beilstein J. Nanotechnol. 2025, 16, 229–251, doi:10.3762/bjnano.16.18

• [13]. It was also shown that the CNs impair extracellular adhesion and regulate adhesion-dependent pathways (such as EGFR/AKT/mTOR and β-catenin) [14], inhibit angiogenesis via the NF-κB pathway [15], inhibit several signal transduction pathways (WNT/β-catenin, Notch, and JAK-STAT) [16], promote

Recent advances in photothermal nanomaterials for ophthalmic applications

• Jiayuan Zhuang,
• Linhui Jia,
• Chenghao Li,
• Rui Yang,
• Jiapeng Wang,
• Wen-an Wang,
• Heng Zhou and
• Xiangxia Luo

Beilstein J. Nanotechnol. 2025, 16, 195–215, doi:10.3762/bjnano.16.16

• , aiding in the precise identification of treated areas. Au nanorods, when combined with anti-epithelial cell adhesion molecule (EpCAM), accurately target EpCAM+Y79 retinoblastoma cancer cells [108]. The targeted cells are deemed to be destroyed by VNBs induced by optimally parameterized femtosecond

A review of metal-organic frameworks and polymers in mixed matrix membranes for CO₂ capture

• Charlotte Skjold Qvist Christensen,
• Nicholas Hansen,
• Mahboubeh Motadayen,
• Nina Lock,
• Martin Lahn Henriksen and
• Jonathan Quinson

Beilstein J. Nanotechnol. 2025, 16, 155–186, doi:10.3762/bjnano.16.14

• considerably impaired compared to that of the pristine MOF [86]. The major issue arising from such incompatibility is the formation of void defects within the MMM due to insufficient adhesion between the MOF interface and the polymer matrix. Such voids act as non-specific permeation sites [80]. Consequently

• , the penetration of different molecules is no longer determined by the selectivity of the MOF, but rather by the size of the void. The voids arise from poor adhesion between the MOF and the polymer, emphasizing the importance of utilizing compatible components for MMMs [76][78][87][89][92][113

• functionalization, Figure 7c,d, reducing filler sizes, in situ MOF growth, or applying annealing treatments. Interfacial adhesion can also be improved using ionic liquids (Figure 7e). MOF functionalization is commonly employed in MMM research. For example, in the study by Katayama et al. [113] mentioned earlier

Bioinspired nanofilament coatings for scale reduction on steel

• Siad Dahir Ali,
• Mette Heidemann Rasmussen,
• Jacopo Catalano,
• Christian Husum Frederiksen and
• Tobias Weidner

Beilstein J. Nanotechnol. 2025, 16, 25–34, doi:10.3762/bjnano.16.3

• applications of mimicking the liquid-repelling properties of their skin to address a common industrial challenge: The scaling of steel surfaces. Scaling, a pervasive issue in various industries, results from unwanted water adhesion and mineral deposition, leading to corrosion, reduced efficiency, and increased

Biomimetic nanocarriers: integrating natural functions for advanced therapeutic applications

• Hugo Felix Perini,
• Beatriz Sodré Matos,
• Carlo José Freire de Oliveira and
• Marcos Vinicius da Silva

Beilstein J. Nanotechnol. 2024, 15, 1619–1626, doi:10.3762/bjnano.15.127

• , leukocytes, stem cells, tumor components) or other biocomponents (e.g., platelets), can enhance the functionality of carriers and meet the requirements for human applications [19]. The cellular membranes of cancer cells exhibit adhesion molecules crucial to cancer development and metastasis. Heterotypic or

Natural nanofibers embedded in the seed mucilage envelope: composite hydrogels with specific adhesive and frictional properties

• Agnieszka Kreitschitz and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2024, 15, 1603–1618, doi:10.3762/bjnano.15.126

• the mucilage envelope, primarily in the context of its structure and physical properties, as well as biological functions associated with these properties. Keywords: adhesion; cellulose; friction; hydrogel; mucilage envelope; seeds; Introduction The definition of hydrogels describes them as

• ][28]. Hydrated mucilage can very strongly adhere to surfaces (e.g., stone or glass) when completely dried out after contact, with pull-off forces reaching values around 6.5 N [29]. Such strong adhesion can enable seed attachment to the soil, preventing removal and damage by other organisms [16][30

• absorb water is due to the presence of hydrophilic groups, such as carboxyl or hydroxyl groups. At the same time, hydrogels are insoluble in water because of their cross-linked network structure [38][92]. Two main physical properties of mucilage, friction and adhesion, are directly connected with the

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

• Selin Akpinar Adscheid,
• Akif E. Türeli,
• Nazende Günday-Türeli and
• Marc Schneider

Beilstein J. Nanotechnol. 2024, 15, 1400–1414, doi:10.3762/bjnano.15.113

• approximately 30% compared to non-coated counterparts, where this derivative was chosen because of its solubility at physiological nasal pH [97]. Additionally, the powder form of the formulation showed stronger mucin adhesion and better enzymatic degradation protection [98]. Moreover, researchers developed in

A biomimetic approach towards a universal slippery liquid infused surface coating

• Ryan A. Faase,
• Madeleine H. Hummel,
• AnneMarie V. Hasbrook,
• Andrew P. Carpenter and
• Joe E. Baio

Beilstein J. Nanotechnol. 2024, 15, 1376–1389, doi:10.3762/bjnano.15.111

• surface coatings based on the slick surfaces of carnivorous pitcher plants (Nepenthes), termed slippery liquid-infused porous surfaces (SLIPS). This study introduces a simplified method to produce SLIPS using a polydopamine (PDA) anchor layer, inspired by mussel adhesion. SLIPS layers were formed on

• adhesion to the surface. This hemocompatibility work suggests that PDA SLIPS coatings slow or prevent clotting, but the observation of both FXII activation and the presence of adherent and activated platelets at the PDA SLIPS samples imply that this formulation of a SLIPS coating is not completely

• removal and or repulsion of these important molecules that control the clotting cascade. The most prominent of the methods are ones that aim to reduce non-specific protein adsorption, increase adhesion resistance, use biomolecules to remove targets of interest, and enhance endothelial cell attachment. One

Hymenoptera and biomimetic surfaces: insights and innovations

• Vinicius Marques Lopez,
• Carlo Polidori and
• Rhainer Guillermo Ferreira

Beilstein J. Nanotechnol. 2024, 15, 1333–1352, doi:10.3762/bjnano.15.107

• [78][80]. Additionally, the interaction between bee mandibles and propolis highlights the potential for developing anti-adhesive surfaces [81]. Bioinspired surfaces based on honeybee mandibles have been shown to reduce propolis adhesion by over 40% compared to control surfaces, demonstrating

• their ability to cling to vertical surfaces and construct large leaf nests, utilize dense arrays of tarsal friction hairs on their tarsomeres to boost adhesion on heavily sculpted surfaces [132][133]. Similarly, females of Anastatus bifasciatus (Eupelmidae) employ these structures to achieve a firm grip

Functional morphology of cleaning devices in the damselfly Ischnura elegans (Odonata, Coenagrionidae)

• Silvana Piersanti,
• Gianandrea Salerno,
• Wencke Krings,
• Stanislav Gorb and
• Manuela Rebora

Beilstein J. Nanotechnol. 2024, 15, 1260–1272, doi:10.3762/bjnano.15.102

• tasks through the presence of micro- and nanostructures located on its cuticular surface, serving functions from sensory reception to surface adhesion, air retention, food grinding, thermoregulation, and color production (reviews in [4][5]). The insect cuticle is frequently exposed to a variety of

• the tarsi and maintaining the adhesion of attachment pads [14][15][16]. Cleaning behavior plays an exceptionally important role in social insects like ants, for example, to guarantee precise nestmate/non-nestmate discrimination [17] or in mutual grooming [18]. Additionally, grooming plays a pivotal

• hairs, while the soft tips ensure effective contact between the attachment system and the substrate. Similarly, the material gradient in grooming devices may enhance adhesion to foreign materials for grooming body surfaces. The soft tip and soft lateral cuticular lamina adapt to various surface

Realizing active targeting in cancer nanomedicine with ultrasmall nanoparticles

• André F. Lima,
• Giselle Z. Justo and
• Alioscka A. Sousa

Beilstein J. Nanotechnol. 2024, 15, 1208–1226, doi:10.3762/bjnano.15.98

• experiences reduced interference from autofluorescence and photon scattering in tissues. The authors further conjugated the AuNCs with an antibody against the epithelial cell adhesion molecule (CD326), a well-known marker for various human carcinomas. Conjugation was achieved through host–guest complexation

Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers

• Ömür Acet,
• Pavel Kirsanov,
• Burcu Önal Acet,
• Inessa Halets-Bui,
• Dzmitry Shcharbin,
• Şeyda Ceylan Cömert and
• Mehmet Odabaşı

Beilstein J. Nanotechnol. 2024, 15, 1189–1196, doi:10.3762/bjnano.15.96

• onto clear 96-well plates at a concentration of 1 × 105 cells/mL in a volume of 100 µL of cell suspension in fresh complete culture medium (DMEM with stable glutamine, 4.5 g/L glucose, 10% FBS, 100 U/mL penicillin, and 0.1 mg/mL streptomycin). The cells were preincubated for 24 h for cell adhesion and

Recent updates in applications of nanomedicine for the treatment of hepatic fibrosis

• Damai Ria Setyawati,
• Fransiska Christydira Sekaringtyas,
• Riyona Desvy Pratiwi,
• A’liyatur Rosyidah,
• Rohimmahtunnissa Azhar,
• Nunik Gustini,
• Gita Syahputra,
• Idah Rosidah,
• Etik Mardliyati,
• Tarwadi and
• Sjaikhurrizal El Muttaqien

Beilstein J. Nanotechnol. 2024, 15, 1105–1116, doi:10.3762/bjnano.15.89

• effects of TiO2 NPs, with diameters around 20 and 200 nm, and SiO2 NPs on proliferation, fibrosis, adhesion, and migration of LX-2 cells as a model of HSC activation were studied. The results show that the internalization of both TiO2 NPs and SiO2 NPs suppressed classical outcomes of cellular fibrosis