Graphene oxide–chloroquine conjugate induces DNA damage in A549 lung cancer cells through autophagy modulation

• Braham Dutt Arya,
• Sandeep Mittal,
• Prachi Joshi,
• Alok Kumar Pandey,
• Jaime E. Ramirez-Vick,
• Govind Gupta and
• Surinder P. Singh

Beilstein J. Nanotechnol. 2025, 16, 316–332, doi:10.3762/bjnano.16.24

• , until a dark brownish precipitate appeared, followed by addition of 1.5 mL of H2O2 (30%) and 100 mL of ice-cold ultrapure water to stop the oxidation reaction and eliminate unreacted KMnO4. The chemistry involved in the chemical exfoliation of graphite is shown in Figure 1. The purified graphitic sheets

• oxide involves chemical exfoliation and oxidation of graphite powder. We employed a method with slight modifications and optimizations to the original documented method by Dimiev et al. [26][27] as shown in Figure 1. The chemical synthesis of highly pure graphene oxide nanosheets depends on several

• possibly in combination with other chemotherapeutic drugs, which require further investigation, through unique DNA damage/autophagy synergy. Schematic representation for the process of chemical exfoliation and oxidation of graphite powder to obtain highly exfoliated graphene oxide nanosheets. (Figure 1 was

Out-of-plane polarization induces a picosecond photoresponse in rhombohedral stacked bilayer WSe₂

• Guixian Liu,
• Yufan Wang,
• Zhoujuan Xu,
• Zhouxiaosong Zeng,
• Lanyu Huang,
• Cuihuan Ge and
• Xiao Wang

Beilstein J. Nanotechnol. 2024, 15, 1362–1368, doi:10.3762/bjnano.15.109

• photoelectric detection. Experimental Device fabrication The 2D materials, WSe2 and graphene, were obtained from high-quality bulk crystals using the mechanical exfoliation method. The monolayer WSe2 nanoflakes were exfoliated onto a transparent polydimethylsiloxane (PDMS) film, selected based on optical

Interaction of graphene oxide with tannic acid: computational modeling and toxicity mitigation in C. elegans

• Romana Petry,
• James M. de Almeida,
• Francine Côa,
• Felipe Crasto de Lima,
• Diego Stéfani T. Martinez and
• Adalberto Fazzio

Beilstein J. Nanotechnol. 2024, 15, 1297–1311, doi:10.3762/bjnano.15.105

• in surface engineering of graphene-based nanomaterials. Methods Materials GO was synthesized via chemical exfoliation of graphite by modified Hummers method [69] according to [70]. Graphite (5.0 g) and NaNO3 (3.75 mg) are added to a reaction flask in a bath of ice and covered with concentrated H2SO4

Interface properties of nanostructured carbon-coated biological implants: an overview

• Mattia Bartoli,
• Francesca Cardano,
• Erik Piatti,
• Stefania Lettieri,
• Andrea Fin and
• Alberto Tagliaferro

Beilstein J. Nanotechnol. 2024, 15, 1041–1053, doi:10.3762/bjnano.15.85

• oxygen functionalities (hydroxy, epoxy, carbonyl, and carboxylic groups) arranged according to the Lerf–Klinowski model [45]. GO is generally produced through chemical oxidation and exfoliation of graphite flakes with different protocols to tune the oxygen content [46][47]. The defective structure of GO

Intermixing of MoS₂ and WS₂ photocatalysts toward methylene blue photodegradation

• Maryam Al Qaydi,
• Nitul S. Rajput,
• Michael Lejeune,
• Abdellatif Bouchalkha,
• Mimoun El Marssi,
• Steevy Cordette,
• Chaouki Kasmi and
• Mustapha Jouiad

Beilstein J. Nanotechnol. 2024, 15, 817–829, doi:10.3762/bjnano.15.68

• deposition (CVD) as previously reported [32]. This means that the samples are well preserved after exfoliation through the intense sonication process. Certain flakes can be observed to have bent. The edges in some flakes can be seen to lose the smoothness, which could be a result of the harsh sonication

• catalyst [49]. The total obtained mass was 200 mg after the exfoliation process and sonication. The obtained material sheets were then extracted from the solution after solvent evaporation, and their mass was determined by subtracting the weight of the sample before and after exfoliation. For all PD

Exfoliation of titanium nitride using a non-thermal plasma process

• Priscila Jussiane Zambiazi,
• Dolores Ribeiro Ricci Lazar,
• Larissa Otubo,
• Rodrigo Fernando Brambilla de Souza,
• Almir Oliveira Neto and
• Cecilia Chaves Guedes-Silva

Beilstein J. Nanotechnol. 2024, 15, 631–637, doi:10.3762/bjnano.15.53

• , Brazil 10.3762/bjnano.15.53 Abstract In this study, we present a novel approach for the exfoliation of titanium nitride (TiN) powders utilizing a rapid, facile, and environmentally friendly non-thermal plasma method. This method involves the use of an electric arc and nitrogen as the ambient gas at room

• successful exfoliation of TiN structures using our innovative non-thermal plasma method, opening up exciting possibilities for advanced material applications. Keywords: exfoliation; nanosheets; non-plasma method; titanium nitride; Introduction Since the groundbreaking discovery of graphene by Andre Geim

• and Konstantin Novoselov in 2004 [1], the field of nanostructures has witnessed remarkable advancements. Various methods to fabricate graphene, such as mechanical and chemical exfoliation, combined with innovative characterization techniques, have enabled the preparation of diverse layered two

Determining by Raman spectroscopy the average thickness and N-layer-specific surface coverages of MoS₂ thin films with domains much smaller than the laser spot size

• Felipe Wasem Klein,
• Jean-Roch Huntzinger,
• Vincent Astié,
• Damien Voiry,
• Romain Parret,
• Houssine Makhlouf,
• Sandrine Juillaguet,
• Jean-Manuel Decams,
• Sylvie Contreras,
• Périne Landois,
• Ahmed-Azmi Zahab,
• Jean-Louis Sauvajol and
• Matthieu Paillet

Beilstein J. Nanotechnol. 2024, 15, 279–296, doi:10.3762/bjnano.15.26

• flakes In this part, we report and discuss the advantages and limits of some Raman criteria that were found to be efficient to derive the thickness (i.e., the number of layers N) of large MoS2 flakes prepared by different ways, namely mechanical exfoliation and standard CVD (including twisted CVD 2L-MoS2

Modification of graphene oxide and its effect on properties of natural rubber/graphene oxide nanocomposites

• Nghiem Thi Thuong,
• Le Dinh Quang,
• Vu Quoc Cuong,
• Cao Hong Ha,
• Nguyen Ba Lam and
• Seiichi Kawahara

Beilstein J. Nanotechnol. 2024, 15, 168–179, doi:10.3762/bjnano.15.16

• XRD patterns for GO and silanized GO using acid and base catalysts. The sharp peak at 2θ = 11° is a diffraction pattern for GO [33]. This peak is evidence of the exfoliation of the GO sheet synthesized by the modified Hummers’ method. After modification with VTES, two diffracting patterns appeared in

On the use of Raman spectroscopy to characterize mass-produced graphene nanoplatelets

• Keith R. Paton,
• Konstantinos Despotelis,
• Naresh Kumar,
• Piers Turner and
• Andrew J. Pollard

Beilstein J. Nanotechnol. 2023, 14, 509–521, doi:10.3762/bjnano.14.42

• analysis is carried out on the averaged spectrum from all locations. This is then used to characterize the “quality” of the graphene produced, in particular the level of exfoliation for top-down manufactured materials. However, these have generally been developed using samples prepared with careful

• individual spectra, the limits of the published metrics can be tested, and recommendations can be made for improved Raman analysis approaches. Methods Rather than using commercial GNP products, we produced a dispersion by sonication-assisted liquid-phase exfoliation, using graphite (Sigma-Aldrich, UK

• of Raman spectroscopy to identify the presence of graphite in a GNP sample, of more relevance is the question of identifying unexfoliated sediment. In typical top-down exfoliation processes, the yield of few-layer graphene or graphene nanoplatelets is very small, often less than 1 wt %. Hence, there

Bismuth-based nanostructured photocatalysts for the remediation of antibiotics and organic dyes

• Akeem Adeyemi Oladipo and
• Faisal Suleiman Mustafa

Beilstein J. Nanotechnol. 2023, 14, 291–321, doi:10.3762/bjnano.14.26

• techniques have been developed to synthesise 3-D Bi-based nanostructures with different morphologies, including solvothermal/hydrothermal and sol–gel processes, mechanical exfoliation, solid-state reactions, chemical vapour deposition, and microwave-assisted techniques [106]. These 3-D photocatalysts have

Liquid phase exfoliation of talc: effect of the medium on flake size and shape

• Samuel M. Sousa,
• Helane L. O. Morais,
• Joyce C. C. Santos,
• Ana Paula M. Barboza,
• Bernardo R. A. Neves,
• Elisângela S. Pinto and
• Mariana C. Prado

Beilstein J. Nanotechnol. 2023, 14, 68–78, doi:10.3762/bjnano.14.8

• Horizonte – MG, 31270-901, Brazil Campus Ouro Preto, Instituto Federal de Minas Gerais, R. Pandiá Calógeras, 898, Ouro Preto – MG, 35400-000, Brazil 10.3762/bjnano.14.8 Abstract Industrial applications of nanomaterials require large-scale production methods, such as liquid phase exfoliation (LPE

• ). Regarding this, it is imperative to characterize the obtained materials to tailor parameters such as exfoliation medium, duration, and mechanical energy source to the desired applications. This work presents results of statistical analyses of talc flakes obtained by LPE in four different media. Talc is a

• phyllosilicate that can be exfoliated into nanoflakes with great mechanical properties. Sodium cholate at two different concentrations (below and at the critical micelar concentration), butanone, and Triton-X100 were employed as exfoliation medium for talc. Using recent published statistical analysis methods

Efficient liquid exfoliation of KP₁₅ nanowires aided by Hansen's empirical theory

• Zhaoxuan Huang,
• Zhikang Jiang,
• Nan Tian,
• Disheng Yao,
• Fei Long,
• Yanhan Yang and
• Danmin Liu

Beilstein J. Nanotechnol. 2022, 13, 788–795, doi:10.3762/bjnano.13.69

• temperature measurements of KP15 nanodevices. Keywords: Hansen's empirical theory; KP15; liquid exfoliation; nanodevices; nanowires; Raman; semiconductors; Introduction Low-dimensional materials have drawn significant attention in recent years. So far, not only new composite materials with excellent

• is beneficial for the development of high-performance nanodevices. Searching effective synthesis routes for nanoscale KP15 has become an urgent issue. Liquid-phase exfoliation is one of the most straightforward methods to prepare low-dimensional materials at a low cost and with simple processes and

• high flexibility. In this case, the surface of bulk materials is peeled off or corroded by physical or chemical reactions in a liquid medium, and finally low-dimensional materials are obtained. Based on the Hansen's empirical theory, the exfoliation efficiency of low-dimensional materials can be

A nonenzymatic reduced graphene oxide-based nanosensor for parathion

• Sarani Sen,
• Anurag Roy,
• Ambarish Sanyal and
• Parukuttyamma Sujatha Devi

Beilstein J. Nanotechnol. 2022, 13, 730–744, doi:10.3762/bjnano.13.65

• transparency due to the exfoliation of stacking layers of GO. This suggests an increased surface area due to delamination of graphene layers (thickness of about one to a few layers) by electrochemical reduction. The high-resolution TEM of ERGO shows a d-spacing of 0.413 nm (Figure 3E), indicating a reduced

• indicates that the effective electroactive surface area of ERGO has been improved by ≈71.14% due to exfoliation of graphene sheets. Electrochemical impedance spectroscopy was performed to investigate the electron transfer capability of ERGO (Figure 4B). Supporting Information File 1, Table S3 depicts the

Reliable fabrication of transparent conducting films by cascade centrifugation and Langmuir–Blodgett deposition of electrochemically exfoliated graphene

• Teodora Vićentić,
• Stevan Andrić,
• Vladimir Rajić and
• Marko Spasenović

Beilstein J. Nanotechnol. 2022, 13, 666–674, doi:10.3762/bjnano.13.58

• Physics, University of Belgrade, Mike Petrovića Alasa 12–14, 11351 Belgrade, Serbia 10.3762/bjnano.13.58 Abstract Electrochemical exfoliation is an efficient and scalable method to obtain liquid-phase graphene. Graphene in solution, obtained through electrochemical exfoliation or other methods, is

• no exfoliation experience to make use of widely available graphene materials. Keywords: 2D materials; cascade centrifugation; graphene; Langmuir–Blodgett deposition; transparent conductors; Introduction The interest in graphene and other 2D materials keeps growing, especially since the initial

• ) [3][4][5][6][7], epitaxial growth on different substrates [8][9], and the chemical reduction of graphene oxide (GO) [10][11]. In 2008, production of graphene by liquid-phase exfoliation (LPE) of graphite through sonication of graphite powder in N-methylpyrrolidone (NMP) was first proposed by Coleman

Local stiffness and work function variations of hexagonal boron nitride on Cu(111)

• Abhishek Grewal,
• Yuqi Wang,
• Matthias Münks,
• Klaus Kern and
• Markus Ternes

Beilstein J. Nanotechnol. 2021, 12, 559–565, doi:10.3762/bjnano.12.46

• -BN/Cu(111) substrate. Keywords: decoupling layers; hexagonal boron nitride; local stiffness; Moiré superstructure; work function variation; Introduction Two-dimensional hexagonal boron nitride (h-BN) is among the list of materials that garnered tremendous interest following the exfoliation of mono

ZnO and MXenes as electrode materials for supercapacitor devices

• Ameen Uddin Ammar,
• Ipek Deniz Yildirim,
• Feray Bakan and
• Emre Erdem

Beilstein J. Nanotechnol. 2021, 12, 49–57, doi:10.3762/bjnano.12.4

• density of 1.04 × 10−2 Wh·cm−3 [29]. Lin et al. synthesized titanium carbide Ti3C2 through exfoliation of the ternary carbide Ti3AlC2 and used it as electrode material in a supercapacitor. A maximum capacitance of 117 F·g−1 was reported in this research with high cycle stability and good capacitance

Nanomechanics of few-layer materials: do individual layers slide upon folding?

• Ronaldo J. C. Batista,
• Rafael F. Dias,
• Ana P. M. Barboza,
• Alan B. de Oliveira,
• Taise M. Manhabosco,
• Thiago R. Gomes-Silva,
• Matheus J. S. Matos,
• Andreij C. Gadelha,
• Cassiano Rabelo,
• Luiz G. L. Cançado,
• Ado Jorio,
• Hélio Chacham and
• Bernardo R. A. Neves

Beilstein J. Nanotechnol. 2020, 11, 1801–1808, doi:10.3762/bjnano.11.162

• materials, also called “2D materials”, after exfoliation, eventually creating folded edges across the resulting flakes. We investigate the adhesion and flexural properties of single-layered and multilayered 2D materials upon folding in the present work. This is accomplished by measuring and modeling

• material where it folds over itself during the exfoliation process. Our method is based on AFM measurements of the geometry and mechanical response of folded edges, and on the fitting of the experimental data by an analytical continuum model parameterized solely by α, κ, and the total thickness d of the

• exfoliated onto a silicon oxide substrate (blue shades). During the exfoliation/deposition processes, such a talc flake folds over itself, creating a well-defined folded edge, shown in orange shades. Figure 1b shows a schematic drawing of the morphology of the fold in Figure 1a. This is the morphology of the

A few-layer graphene/chlorin e6 hybrid nanomaterial and its application in photodynamic therapy against Candida albicans

• Selene Acosta,
• Carlos Moreno-Aguilar,
• Dania Hernández-Sánchez,
• Beatriz Morales-Cruzado,
• Erick Sarmiento-Gomez,
• Carla Bittencourt,
• Luis Octavio Sánchez-Vargas and
• Mildred Quintana

Beilstein J. Nanotechnol. 2020, 11, 1054–1061, doi:10.3762/bjnano.11.90

• Discussion The liquid phase exfoliation of graphite was first carried out in toxic, non-biocompatible solvents due to the match in the surface energy of graphene and the solvents [33]. However, the interest in using graphene for biological applications has led to the development of new synthetic techniques

• , such as the exfoliation of graphene assisted by molecules that display amphiphilic properties [34][35]. These molecules are intercalated between the graphene sheets, conferring stability and solubility in media in which graphene by itself is not soluble. In 2016, Hernández et al. [36] reported the

• synthesis of FLG by the exfoliation of graphite in water and phosphate buffer saline (PBS) using Ce6 as the stabilizing molecule. The π–π stacking interactions between FLG and Ce6 allows the stabilization of FLG in biocompatible media. Following this methodology, a FLG-Ce6 hybrid nanomaterial was prepared

Microwave-induced electric discharges on metal particles for the synthesis of inorganic nanomaterials under solvent-free conditions

• Vijay Tripathi,
• Harit Kumar,
• Anubhav Agarwal and
• Leela S. Panchakarla

Beilstein J. Nanotechnol. 2020, 11, 1019–1025, doi:10.3762/bjnano.11.86

• . However, the choice of graphite or g-C3N4 has shown little to no difference in the synthesis of nanoparticles. We have also studied exfoliation of graphite and graphite oxide (GO) under microwave irradiation in the presence of Zn metal. We have observed exfoliation of graphite into few-layered graphene

• . We have also seen a partial rolling of graphene sheets into nanoscrolls (Figure 5a,b). The formation of ultrasmall nanoparticles of ZnO along with graphene was detected (see Figure S8 in Supporting Information File 1). In the case of GO exfoliation, we have observed the formation of nanosheets of

• Cu. (a, b) TEM images of few-layered graphene partially rolled into nanoscrolls synthesized by irradiating graphite with microwaves in the presence of Zn metal for 30 s. (c) TEM image of graphite oxide after exfoliation trough microwave irradiation in the presence of Zn metal for 30 s and (d) the

Measurement of electrostatic tip–sample interactions by time-domain Kelvin probe force microscopy

• Christian Ritz,
• Tino Wagner and
• Andreas Stemmer

Beilstein J. Nanotechnol. 2020, 11, 911–921, doi:10.3762/bjnano.11.76

• exfoliation from bulk graphite [32][33] and deposited on a piece of Si/SiO2. Measurements were carried out using an Asylum Research Cypher AFM connected to a Zurich Instruments HF2 lock-in amplifier. Figure 3 shows the results of the open-loop controller. During the FM-AFM measurement the tip voltage was

Light–matter interactions in two-dimensional layered WSe₂ for gauging evolution of phonon dynamics

• Avra S. Bandyopadhyay,
• Chandan Biswas and
• Anupama B. Kaul

Beilstein J. Nanotechnol. 2020, 11, 782–797, doi:10.3762/bjnano.11.63

• , ML and bulk samples, were mechanically exfoliated on top of SiO2/Si substrates (SiO2 thickness = 270 nm) using the scotch tape method [1][30][31]. The mechanical exfoliation process used in this study is similar to the one reported in our earlier work [30]. Prior to the exfoliation procedure, the

• sapphire substrate is used compared to SiO2/Si substrates [24]. As the SiO2/Si susbstrate and the preparation method (mechanical exfoliation) remained the same for 1L and bulk WSe2 used in our study, this may be the reason why the intensity of the Raman mode remained unchanged even in bulk WSe2. Moreover

Hexagonal boron nitride: a review of the emerging material platform for single-photon sources and the spin–photon interface

• Stefania Castelletto,
• Faraz A. Inam,
• Shin-ichiro Sato and
• Alberto Boretti

Beilstein J. Nanotechnol. 2020, 11, 740–769, doi:10.3762/bjnano.11.61

Exfoliation in a low boiling point solvent and electrochemical applications of MoO₃

• Matangi Sricharan,
• Bikesh Gupta,
• Sreejesh Moolayadukkam and
• H. S. S. Ramakrishna Matte

Beilstein J. Nanotechnol. 2020, 11, 662–670, doi:10.3762/bjnano.11.52

• in areas such as energy storage devices, electronic devices and catalysis. To efficiently utilize the properties of MoO3 arising from its two-dimensional nature exfoliation is necessary. In this work, the exfoliation of MoO3 is carried out in 2-butanone for the first time. The achieved concentration

• of the dispersion is about 0.57 mg·mL−1 with a yield of 5.7%, which are the highest values reported to date. These high values of concentration and yield can be attributed to a favorable matching of energies involved in exfoliation and stabilization of MoO3 nanosheets in 2-butanone. Interestingly

• mV·s−1. Keywords: 2-butanone; liquid-phase exfoliation; low-boiling point solvent; molybdenum trioxide (MoO3); supercapacitors; Introduction The advent of graphene has opened a new area of research in the field of two-dimensional materials [1]. The extraordinary properties of graphene have led

Electrochemically derived functionalized graphene for bulk production of hydrogen peroxide

• Munaiah Yeddala,
• Pallavi Thakur,
• Anugraha A and
• Tharangattu N. Narayanan

Beilstein J. Nanotechnol. 2020, 11, 432–442, doi:10.3762/bjnano.11.34

• the role of C=O groups in graphene towards sustainable peroxide formation. We demonstrate a versatile single-step electrochemical exfoliation of graphite to graphene with a controllable degree of oxygen functionalities and thickness, leading to the formation of large quantities of functionalized

• of our previous works, different halogenated graphene materials were developed via a single-step electrochemical exfoliation (EE) method [42]. It was found that such a method can produce graphene with varying degrees of oxygen functionalities [43]. Here we explore the possibility of functional groups

• to control graphene toward the electrochemical production of H2O2 in alkaline medium, and the amount of peroxide generated is quantified using a spectroscopic technique. A large amount of H2O2 is found to be formed via such simple modification of the exfoliation parameters, and the details are

DFT calculations of the structure and stability of copper clusters on MoS₂

• Cara-Lena Nies and
• Michael Nolan

Beilstein J. Nanotechnol. 2020, 11, 391–406, doi:10.3762/bjnano.11.30

• character of Cu nanoclusters is preserved. Keywords: copper (Cu); density functional theory (DFT); 2D materials; molybdenum disulfide (MoS2); thin film nucleation; Introduction Since the successful exfoliation of monolayers of graphene by Novoselov et al., 2D materials have gained a large interest in a

• exfoliation. However, the scalability of CVD and ALD processes makes 2D materials grown via these methods more realistic for a wider range of applications [4]. Transition metal dichalcogenides (TMDs) are of particular interest as they exhibit a large variety of properties. TMDs such as MoS2 are intrinsic