Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines

• Eric Buchy,
• Branko Vukosavljevic,
• Maike Windbergs,
• Dunja Sobot,
• Camille Dejean,
• Simona Mura,
• Patrick Couvreur and
• Didier Desmaële

Beilstein J. Org. Chem. 2016, 12, 1127–1135, doi:10.3762/bjoc.12.109

• : deuterium labelling; nanomedicine; Raman spectroscopy; Shapiro reaction; squalene; Introduction Application of nanotechnology to medicine holds promises to profoundly impact healthcare especially to treat severe diseases such as cancer, intracellular infections, neurodegenerative diseases, etc. Indeed, the

The role of alkyl substituents in deazaadenine-based diarylethene photoswitches

• Christopher Sarter,
• Michael Heimes and
• Andres Jäschke

Beilstein J. Org. Chem. 2016, 12, 1103–1110, doi:10.3762/bjoc.12.106

• information storage, they found many applications in materials sciences, nanotechnology, and biomimetic chemistry [31][32][33][34][35][36][37][38][39][40][41][42]. Their most typical architecture is shown in Figure 1A: two heteroaromatic, most often five-membered heterocyclic rings are connected via a

Syntheses of dibenzo[d,d']benzo[2,1-b:3,4-b']difuran derivatives and their application to organic field-effect transistors

• Minh Anh Truong and
• Koji Nakano

Beilstein J. Org. Chem. 2016, 12, 805–812, doi:10.3762/bjoc.12.79

• this work (XRD) was conducted in Nagoya University, supported by the Nanotechnology Platform Program (Molecule and Material Synthesis) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. We are grateful to Prof. Shusaku Nagano at Nagoya University for XRD analysis of

Hydroquinone–pyrrole dyads with varied linkers

• Hao Huang,
• Christoffer Karlsson,
• Maria Strømme,
• Martin Sjödin and
• Adolf Gogoll

Beilstein J. Org. Chem. 2016, 12, 89–96, doi:10.3762/bjoc.12.10

• Hao Huang Christoffer Karlsson Maria Stromme Martin Sjodin Adolf Gogoll Nanotechnology and Functional Materials, Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, Box 534, SE-751 21 Uppsala, Sweden Department of Chemistry - BMC, Biomedical Centre, Uppsala University

Synthesis and photophysical characteristics of polyfluorene polyrotaxanes

• Aurica Farcas,
• Giulia Tregnago,
• Ana-Maria Resmerita,
• Pierre-Henri Aubert and
• Franco Cacialli

Beilstein J. Org. Chem. 2015, 11, 2677–2688, doi:10.3762/bjoc.11.288

• Aurica Farcas Giulia Tregnago Ana-Maria Resmerita Pierre-Henri Aubert Franco Cacialli Supramolecular Chemistry Group, ‘‘Petru Poni’’ Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley, 700487-Iasi, Romania London Centre for Nanotechnology and Department of Physics and Astronomy

Size-controlled and redox-responsive supramolecular nanoparticles

• Raquel Mejia-Ariza,
• Gavin A. Kronig and
• Jurriaan Huskens

Beilstein J. Org. Chem. 2015, 11, 2388–2399, doi:10.3762/bjoc.11.260

• Raquel Mejia-Ariza Gavin A. Kronig Jurriaan Huskens Molecular NanoFabrication group, MESA+ Institute for Nanotechnology University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands 10.3762/bjoc.11.260 Abstract Control over the assembly and disassembly of nanoparticles is pivotal for

Co-solvation effect on the binding mode of the α-mangostin/β-cyclodextrin inclusion complex

• Chompoonut Rungnim,
• Sarunya Phunpee,
• Manaschai Kunaseth,
• Supawadee Namuangruk,
• Kanin Rungsardthong,
• Thanyada Rungrotmongkol and
• Uracha Ruktanonchai

Beilstein J. Org. Chem. 2015, 11, 2306–2317, doi:10.3762/bjoc.11.251

• Chompoonut Rungnim Sarunya Phunpee Manaschai Kunaseth Supawadee Namuangruk Kanin Rungsardthong Thanyada Rungrotmongkol Uracha Ruktanonchai National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani 12120, Thailand Faculty of Pharmacy Thammasat

• -CD), in six inclusion complexes. MM-PBSA binding free energies (kcal/mol) and their energy components for α-MGS/β-CD complexes at different EtOH concentrations. Supporting Information Supporting Information File 484: Additional data. Acknowledgements The authors thank the National Nanotechnology

Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo

• Alireza Shakoori,
• John B. Bremner,
• Mohammed K. Abdel-Hamid,
• Anthony C. Willis,
• Rachada Haritakun and
• Paul A. Keller

Beilstein J. Org. Chem. 2015, 11, 481–492, doi:10.3762/bjoc.11.54

• probably being mediated, at least in some cases, through microtubule destabilisation and inhibition of tubulin polymerisation [20][21][22]. Conclusion The search for diversity in new heterocyclic chemical space is increasingly important in areas such as medicinal chemistry and nanotechnology, where novel

Formulation development, stability and anticancer efficacy of core-shell cyclodextrin nanocapsules for oral chemotherapy with camptothecin

• Hale Ünal,
• Naile Öztürk and
• Erem Bilensoy

Beilstein J. Org. Chem. 2015, 11, 204–212, doi:10.3762/bjoc.11.22

• Hale Unal Naile Ozturk Erem Bilensoy Division of Nanotechnology and Nanomedicine, Graduate School of Science and Engineering, Hacettepe University, Beytepe, Ankara, 06800, Turkey Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Sıhhıye, Ankara, 06100, Turkey

Binding mode and free energy prediction of fisetin/β-cyclodextrin inclusion complexes

• Bodee Nutho,
• Wasinee Khuntawee,
• Chompoonut Rungnim,
• Piamsook Pongsawasdi,
• Peter Wolschann,
• Alfred Karpfen,
• Nawee Kungwan and
• Thanyada Rungrotmongkol

Beilstein J. Org. Chem. 2014, 10, 2789–2799, doi:10.3762/bjoc.10.296

• , Chulalongkorn University, Bangkok, 10330, Thailand National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Thanon Phahonyothin Tambon Khlong Nueng, Amphoe Khlong Luang, Pathum Thani 12120, Thailand Department of Pharmaceutical Technology

A versatile δ-aminolevulinic acid (ΑLA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry

• Chrysie Aggelidou,
• Theodossis A. Theodossiou,
• Antonio Ricardo Gonçalves,
• Mariza Lampropoulou and
• Konstantina Yannakopoulou

Beilstein J. Org. Chem. 2014, 10, 2414–2420, doi:10.3762/bjoc.10.251

• Chrysie Aggelidou Theodossis A. Theodossiou Antonio Ricardo Goncalves Mariza Lampropoulou Konstantina Yannakopoulou Institute of Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, National Center for Scientific Research “Demokritos”, Patriarchou Gregoriou & Neapoleos

Multivalent glycosystems for nanoscience

• Thisbe K. Lindhorst

Beilstein J. Org. Chem. 2014, 10, 2345–2347, doi:10.3762/bjoc.10.244

• nanotechnology”. As a result, 27 excellent publications are presented in this fine collection. I would like to sincerely congratulate all contributors for their research and results. We can be proud of what has been achieved. We should be inspired by what has been suggested. And we have definitely been

The chemoenzymatic synthesis of clofarabine and related 2′-deoxyfluoroarabinosyl nucleosides: the electronic and stereochemical factors determining substrate recognition by E. coli nucleoside phosphorylases

• Ilja V. Fateev,
• Konstantin V. Antonov,
• Irina D. Konstantinova,
• Tatyana I. Muravyova,
• Frank Seela,
• Roman S. Esipov,
• Anatoly I. Miroshnikov and
• Igor A. Mikhailopulo

Beilstein J. Org. Chem. 2014, 10, 1657–1669, doi:10.3762/bjoc.10.173

• , Russia Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Heisenbergstraße 11, D-48149 Münster, Germany Institute of Bioorganic Chemistry, National Academy of Sciences, Acad. Kuprevicha 5/2, 220141 Minsk, Belarus 10.3762/bjoc.10.173 Abstract Two approaches to the

A promising cellulose-based polyzwitterion with pH-sensitive charges

• Thomas Elschner and
• Thomas Heinze

Beilstein J. Org. Chem. 2014, 10, 1549–1556, doi:10.3762/bjoc.10.159

• example proteins, nucleotides, and polysaccharides like alginates. Synthetic ionic polymers are widely used in the field of water treatment [2], protein separation, desalination, binding of metal ions, in the oil industry [3] and nanotechnology [4]. In general, these polymers may be divided into water

Bis(β-lactosyl)-[60]fullerene as novel class of glycolipids useful for the detection and the decontamination of biological toxins of the Ricinus communis family

• Hirofumi Dohi,
• Takeru Kanazawa,
• Akihiro Saito,
• Keita Sato,
• Hirotaka Uzawa,
• Yasuo Seto and
• Yoshihiro Nishida

Beilstein J. Org. Chem. 2014, 10, 1504–1512, doi:10.3762/bjoc.10.155

• detection of the biological toxin. Glyco-nanotechnology for locking the deadly toxin at the bottom In an assumed situation of bioterrorism, the total time required for the identification and the decontamination is one of the key factors for minimizing possible damages from contaminated biological toxins

Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs

• Fabrizio Chiodo,
• Marco Marradi,
• Javier Calvo,
• Eloisa Yuste and
• Soledad Penadés

Beilstein J. Org. Chem. 2014, 10, 1339–1346, doi:10.3762/bjoc.10.136

• therapeutic approach for the treatment of HIV infection is based on the highly active antiretroviral therapy (HAART), a cocktail of antiretroviral drugs. Notwithstanding HAART has shown different drawbacks like toxic side effects and the emergence of viral multidrug resistance. Nanotechnology offers new tools

• systems (DDSs) with high efficacy and therapeutic selectivity [8] to overcome the drawbacks of HAART. Nanotechnology allows the construction of novel systems that could bring changes in this scenario. Over the last years, different nano-constructions have been designed as prophylactic agents against HIV

A new building block for DNA network formation by self-assembly and polymerase chain reaction

• Holger Bußkamp,
• Sascha Keller,
• Marta Robotta,
• Malte Drescher and
• Andreas Marx

Beilstein J. Org. Chem. 2014, 10, 1037–1046, doi:10.3762/bjoc.10.104

• hydrogels. Keywords: AFM; branched DNA; DNA; DNA polymerase; nanotechnology; nucleic acids; PCR; self-assembly; Introduction DNA has found applications in the field of nanotechnology due to its inherent properties. The simplicity and predictability of DNA secondary structure are of outstanding potential

• for the design of self-assembled architectures [1][2][3]. Inspired by naturally existing self-assembled DNA architectures known as Holliday junctions, Seeman envisioned the approach to organize DNA with branched DNA (bDNA) and thereby initiated the field of structural DNA nanotechnology [4]. Since

Staudinger ligation towards cyclodextrin dimers in aqueous/organic media. Synthesis, conformations and guest-encapsulation ability

• Malamatenia D. Manouilidou,
• Yannis G. Lazarou,
• Irene M. Mavridis and
• Konstantina Yannakopoulou

Beilstein J. Org. Chem. 2014, 10, 774–783, doi:10.3762/bjoc.10.73

• Malamatenia D. Manouilidou Yannis G. Lazarou Irene M. Mavridis Konstantina Yannakopoulou Institute of Advanced Materials, Physicochemical Processes, Nanotechnology & Microsystems, National Center for Scientific Research “Demokritos”, Terma Patriarchou Gregoriou & Neapoleos, Aghia Paraskevi Attikis

Tuning the interactions between electron spins in fullerene-based triad systems

• Maria A. Lebedeva,
• Thomas W. Chamberlain,
• E. Stephen Davies,
• Bradley E. Thomas,
• Martin Schröder and
• Andrei N. Khlobystov

Beilstein J. Org. Chem. 2014, 10, 332–343, doi:10.3762/bjoc.10.31

• Maria A. Lebedeva Thomas W. Chamberlain E. Stephen Davies Bradley E. Thomas Martin Schroder Andrei N. Khlobystov School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK Nottingham Nanoscience & Nanotechnology Centre, University of Nottingham, University Park, Nottingham, NG7 2RD, UK

Gallium-containing polymer brush film as efficient supported Lewis acid catalyst in a glass microreactor

• Rajesh Munirathinam,
• Roberto Ricciardi,
• Richard J. M. Egberink,
• Jurriaan Huskens,
• Michael Holtkamp,
• Herbert Wormeester,
• Uwe Karst and
• Willem Verboom

Beilstein J. Org. Chem. 2013, 9, 1698–1704, doi:10.3762/bjoc.9.194

• Rajesh Munirathinam Roberto Ricciardi Richard J. M. Egberink Jurriaan Huskens Michael Holtkamp Herbert Wormeester Uwe Karst Willem Verboom Laboratory of Molecular Nanofabrication, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands University

• of Münster, Institute of Inorganic and Analytical Chemistry, Corrensstr. 28/30, 48149 Münster, Germany, Laboratory of Physics of Interfaces and Nanomaterials, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands 10.3762/bjoc.9.194 Abstract

Synthesis, photophysical and electrochemical characterization of terpyridine-functionalized dendritic oligothiophenes and their Ru(II) complexes

• Amaresh Mishra,
• Elena Mena-Osteritz and
• Peter Bäuerle

Beilstein J. Org. Chem. 2013, 9, 866–876, doi:10.3762/bjoc.9.100

• has found applications in opto-electronic devices and nanotechnology [11][12][13]. The stability of these transition-metal complexes is generally attributed to the σ-donor/π-acceptor character of the dative metal–nitrogen bond. These Ru(II) complexes possess various important photophysical features

Cyclodextrin-based nanosponges as drug carriers

• Francesco Trotta,
• Marco Zanetti and
• Roberta Cavalli

Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235

• ; cross-linked polymers; cyclodextrin; drug delivery; nanosponges; Review Recent advances in nanotechnology demonstrate the increased attention that is now being paid to the supramolecular assembly of simple components for therapeutic and diagnostic purposes. The design of new biomaterials based on

• effective nanotechnology for the treatment of both androgen-sensitive and castrate-refractory prostate cancer in cell-line experiments [42]. Nanosponges can be used to store and prolong the release of volatile molecules, such as essential oils, following their encapsulation. Linalool, a liquid component of

Beilstein Journal of Organic Chemistry: Open Access comes of age in Organic Chemistry

• Peter H. Seeberger

Beilstein J. Org. Chem. 2012, 8, 1284–1286, doi:10.3762/bjoc.8.145

• the scientific content and quality themselves. Of particular note are the lab videos that are made to correspond to a paper published in the Beilstein Journal of Organic Chemistry or in the Beilstein Journal of Nanotechnology. This combination allows scientists to use a visual medium to go further in

Liquid-crystalline nanoparticles: Hybrid design and mesophase structures

• Gareth L. Nealon,
• Romain Greget,
• Cristina Dominguez,
• Zsuzsanna T. Nagy,
• Daniel Guillon,
• Jean-Louis Gallani and
• Bertrand Donnio

Beilstein J. Org. Chem. 2012, 8, 349–370, doi:10.3762/bjoc.8.39

• ; Introduction The term "nanotechnology" has gone far beyond the realms of universities and research laboratories and is understood by scientist and layman alike to be synonymous with "high-tech" and "futuristic", promising to bring about tremendous advances in our quality of life. By utilising a "bottom-up

• molecular machines and devices, with dimensions on the order of atoms and molecules, capable of performing specific predetermined tasks [2]. At the core of this nanotechnology revolution lies the nanoparticle (NP), the most common of which being metallic particles (including alloys and oxides) with at least

• morphology (size, shape and roughness) and can be manipulated by coating with suitable structure-directing agents. Amongst the techniques used to assemble NPs, self-assembly methods show immense promise towards achieving the ambitious results expected from the field of nanotechnology research [23]. Liquid

Highly efficient cyclosarin degradation mediated by a β-cyclodextrin derivative containing an oxime-derived substituent

• Michael Zengerle,
• Florian Brandhuber,
• Christian Schneider,
• Franz Worek,
• Georg Reiter and
• Stefan Kubik

Beilstein J. Org. Chem. 2011, 7, 1543–1554, doi:10.3762/bjoc.7.182

• binding properties, and their relatively straightforward chemical modification have made cyclodextrins indispensable tools in applications such as sensing [2], nanotechnology [3][4], polymer chemistry [5][6][7][8], medicinal chemistry [9][10], food chemistry [11], and others. Importantly, the scope of