Computational toolbox for the analysis of protein–glycan interactions

• Ferran Nieto-Fabregat,
• Maria Pia Lenza,
• Angela Marseglia,
• Cristina Di Carluccio,
• Antonio Molinaro,
• Alba Silipo and
• Roberta Marchetti

Beilstein J. Org. Chem. 2024, 20, 2084–2107, doi:10.3762/bjoc.20.180

Multicomponent syntheses of pyrazoles via (3 + 2)-cyclocondensation and (3 + 2)-cycloaddition key steps

• Ignaz Betcke,
• Alissa C. Götzinger,
• Maryna M. Kornet and
• Thomas J. J. Müller

Beilstein J. Org. Chem. 2024, 20, 2024–2077, doi:10.3762/bjoc.20.178

Understanding X-ray-induced isomerisation in photoswitchable surfactant assemblies

• Beatrice E. Jones,
• Camille Blayo,
• Jake L. Greenfield,
• Matthew J. Fuchter,
• Nathan Cowieson and
• Rachel C. Evans

Beilstein J. Org. Chem. 2024, 20, 2005–2015, doi:10.3762/bjoc.20.176

• pattern to that of the native, E isomer (Figure 2). Changes occur immediately, after 1 s of X-ray exposure, and saturate after ca. 5 s. The changes are comparable to those observed on Z–E isomerisation induced using blue (460 nm) light or heating to 55 °C but occur at a much faster rate (Figure S2

• the micelle shape of this isomer. The fast rate of the morphology change, in comparison to using blue light or heating to 55 °C, shows rapid rates of Z–E isomerisation from X-ray-induced catalysis, which may be due to the presence of multiple different catalysing species and therefore isomerisation

• that Z–E isomerisation cannot be easily induced using gentle heating or visible light, as shown by the stability of the UV–vis absorbance spectra and SAXS patterns under these conditions (Figures S1 and S3, Supporting Information File 1). In contrast, irradiation with X-rays leads to significant

Harnessing the versatility of hydrazones through electrosynthetic oxidative transformations

• Aurélie Claraz

Beilstein J. Org. Chem. 2024, 20, 1988–2004, doi:10.3762/bjoc.20.175

• prepared prior to the electrolysis through the condensation of 2-hydrazinopyridine 13 and various aromatic, aliphatic and α,β-unsaturated aldehydes 14. The electrooxidative transformation was performed under constant current at 7 mA in a mixture of acetonitrile and water under heating. From a mechanistic

Negishi-coupling-enabled synthesis of α-heteroaryl-α-amino acid building blocks for DNA-encoded chemical library applications

• Matteo Gasparetto,
• Balázs Fődi and
• Gellért Sipos

Beilstein J. Org. Chem. 2024, 20, 1922–1932, doi:10.3762/bjoc.20.168

• )acetate at the bottom of the vial after a few hours of storage in the fridge. The solid can be easily re-dissolved by gentle heating, and without affecting the product concentration and integrity. After a brief screening, Pd(dba)2 and X-Phos (in a 1:2 ratio) were selected as the catalyst system for the

• screening and rapid optimization [46][47]. Homogenous heating and mixing in flow reactors can lead to higher reaction rates and yields. In terms of photochemistry, continuous flow setups provide enhanced light irradiation as well [48][49]. These advantages make flow chemistry a powerful tool for chemical

Access to 2-oxoazetidine-3-carboxylic acid derivatives via thermal microwave-assisted Wolff rearrangement of 3-diazotetramic acids in the presence of nucleophiles

• Ivan Lyutin,
• Vasilisa Krivovicheva,
• Grigory Kantin and
• Dmitry Dar’in

Beilstein J. Org. Chem. 2024, 20, 1894–1899, doi:10.3762/bjoc.20.164

• tested in a previous study [3]. The reaction requires rather severe heating under microwave irradiation (200 °C, chlorobenzene, sealed vial), ensuring complete conversion of the diazo compound in a rather short time. Initial experiments using p-anisidine as a nucleophile showed that the target β-lactam

• derivative 3a could be obtained in high yield (83%) after simple chromatographic separation of the reaction mixture (Scheme 2). When the synthesis was carried out using conventional heating in 1,2-dichlorobenzene (200 °C, 1 h), product 3a was obtained in slightly lower yield (75%), so further experiments

The Groebke–Blackburn–Bienaymé reaction in its maturity: innovation and improvements since its 21st birthday (2019–2023)

• Cristina Martini,
• Muhammad Idham Darussalam Mardjan and
• Andrea Basso

Beilstein J. Org. Chem. 2024, 20, 1839–1879, doi:10.3762/bjoc.20.162

• earth (RE) triflates before the report by Longo et al. [5], who found La and Gd performing better than Eu and Yb, and similarly to Sc in a model reaction between 2-aminopyridine (1), benzaldehyde (2) and tert-butyl isocyanide to give 3 under microwave (MW) heating. However, when methyl isocyanoacetate

• temperature and then, upon addition of the boronic acid, heating at 60 °C (Scheme 9). Similar efficiencies were observed with a wide range of boronic acids (10 examples, 49–87% yield). The biohybrid was suitable also for gram-scale synthesis and for storage at room temperature under inert atmosphere, showing

• (OTf)3 (5 mol %) as acidic catalyst, and a non-microwave instant heating reactor, performing the reaction at 60 °C and obtaining 25 in 78% yield. Moving forward to investigate the scope of the reaction with different 2-aminoamidines and isocyanides, they obtained 18 different products with isolated

A facile three-component route to powerful 5-aryldeazaalloxazine photocatalysts

• Ivana Weisheitelová,
• Radek Cibulka,
• Marek Sikorski and
• Tetiana Pavlovska

Beilstein J. Org. Chem. 2024, 20, 1831–1838, doi:10.3762/bjoc.20.161

• heating conditions (CH). Syntheses were performed in DMSO, DMSO/AlCl3, DMF/AlCl3 and AcOH/H2SO4 at 110 °C (Table 1, entries 5, 6, 9, and 12). Under these conditions, the reaction time was significantly reduced to 1 hour from the usual 15 hours, however, the yields stayed in the range of 30%, and the

• reaction mixtures contained a large number of impurities. In summary, standard heating conditions exhibited distinct advantages over MW, and the reaction performance in DMSO was the most effective. Moreover, DMSO is considered an environmentally friendly solvent (for detailed information on reaction

• derivatives, 2i–l and 2m–p, respectively, was accompanied by several complications, and the isolation of the products required precipitation with 2-propanol in several cases. The heating time was prolonged to two days for 8-methoxy derivatives 2m–p, nevertheless giving moderate yields. For 7-methoxy

Ugi bisamides based on pyrrolyl-β-chlorovinylaldehyde and their unusual transformations

• Alexander V. Tsygankov,
• Vladyslav O. Vereshchak,
• Tetiana O. Savluk,
• Serhiy M. Desenko,
• Valeriia V. Ananieva,
• Oleksandr V. Buravov,
• Yana I. Sakhno,
• Svitlana V. Shishkina and
• Valentyn A. Chebanov

Beilstein J. Org. Chem. 2024, 20, 1773–1784, doi:10.3762/bjoc.20.156

• conventional thermal heating, amide 10a was isolated, albeit in a lower yield and accompanied with tar formation. In addition to the 1H, 13C NMR spectra and mass spectrometry data, the structure of compound 10d was established by X-ray diffraction analysis (Figure 3). It was also found that the substituents at

• for two days and then heating the reaction mixture in a closed vessel at 80 °C for 3 hours (Scheme 5). This procedure led to the formation and isolation of the products 10d and 12e with yields which are similar to the tandem reaction. Using the example of bisamide 8c, it was found that changing the

• corresponding amide 10. The expected fact that the amides 10 could not be formed from the ketobisamides 12 (Table 3) was also confirmed; stirring the latter in MeCN or EtOH in the presence of HCl at room temperature or under heating did not lead to formation, not even to the appearance of traces of the amide

Synthesis and characterization of 1,2,3,4-naphthalene and anthracene diimides

• Adam D. Bass,
• Daniela Castellanos,
• Xavier A. Calicdan and
• Dennis D. Cao

Beilstein J. Org. Chem. 2024, 20, 1767–1772, doi:10.3762/bjoc.20.155

• . Heating 5 with hexylamine or aniline in refluxing acetic acid successfully led to the formation of the targeted aromatic diimides bearing either N-hexyl (7-Hex) or N-phenyl (7-Ph) substitutions in good yields. The same strategy was employed to create the imide-capped anthracenes 8-Hex and 8-Ph

Syntheses and medicinal chemistry of spiro heterocyclic steroids

• Laura L. Romero-Hernández,
• Ana Isabel Ahuja-Casarín,
• Penélope Merino-Montiel,
• Sara Montiel-Smith,
• José Luis Vega-Báez and
• Jesús Sandoval-Ramírez

Beilstein J. Org. Chem. 2024, 20, 1713–1745, doi:10.3762/bjoc.20.152

• 140a,b (α/β 35:65), which were successfully separated. The following aminolysis of the isolated compounds was achieved by microwave heating using 3 equivalents of butylamine in ethanol at 180 °C. Finally, formation of morpholinones 142 and 143 was accomplished by N-acylation of the corresponding amino

Oxidation of benzylic alcohols to carbonyls using N-heterocyclic stabilized λ³-iodanes

• Thomas J. Kuczmera,
• Pim Puylaert and
• Boris J. Nachtsheim

Beilstein J. Org. Chem. 2024, 20, 1677–1683, doi:10.3762/bjoc.20.149

• exchanged with the hydroxy group of the NHI [21]. No such ion was measured in the mixture before heating. This ion therefore indicates an I–Cl bond in the activated iodane. Starting from I-OH, in a potential path a) formation of hypochlorous acid is suggested, which consequently oxidizes the alcohol through

Supramolecular assemblies of amphiphilic donor–acceptor Stenhouse adducts as macroscopic soft scaffolds

• Ka-Lung Hung,
• Leong-Hung Cheung,
• Yikun Ren,
• Ming-Hin Chau,
• Yan-Yi Lam,
• Takashi Kajitani and
• Franco King-Chi Leung

Beilstein J. Org. Chem. 2024, 20, 1590–1603, doi:10.3762/bjoc.20.142

• heating. Flash column chromatography was performed using Macherey-Nagel silica gel 60 (230–400 mesh). Deuterated solvents were purchased from Cambridge Isotope Laboratories. UV–vis spectroscopy UV–vis measurements were performed on an Agilent Cary 60 UV–vis spectrophotometer with a quartz cuvette of 1 cm

Benzylic C(sp³)–H fluorination

• Alexander P. Atkins,
• Alice C. Dean and
• Alastair J. J. Lennox

Beilstein J. Org. Chem. 2024, 20, 1527–1547, doi:10.3762/bjoc.20.137

• authors proposed that under heating K2S2O8 decomposed to SO4•− which could then abstract the benzylic hydrogen to generate the benzylic radical. Fluorine-atom-transfer with Selectfluor then afforded the benzyl fluoride. Other fluorinating reagents such as NFSI or DAST did not perform as well. By varying

• /H2O and heating, the decarboxylation pathway could be enabled to afford primary benzyl fluorides. In the same year, Barham and co-workers also showed that the radical dication TEDA2+• was capable of HAT on unactivated C(sp3)–H, enabling fluorination at these positions [63]. This work utilised para

Photoswitchable glycoligands targeting Pseudomonas aeruginosa LecA

• Yu Fan,
• Ahmed El Rhaz,
• Stéphane Maisonneuve,
• Emilie Gillon,
• Maha Fatthalla,
• Franck Le Bideau,
• Guillaume Laurent,
• Samir Messaoudi,
• Anne Imberty and
• Juan Xie

Beilstein J. Org. Chem. 2024, 20, 1486–1496, doi:10.3762/bjoc.20.132

• with 10% H2SO4 in EtOH and heating about 30 s at 400–600 °C. Column chromatography purification was performed on CombiFlash® Rf+ and RediSep® RF or RF Gold normal phase silica columns (with UV detection at 254 and 350 nm for all azobenzene derivatives), or by flash column chromatography employing

Synthesis of substituted triazole–pyrazole hybrids using triazenylpyrazole precursors

• Simone Gräßle,
• Laura Holzhauer,
• Nicolai Wippert,
• Olaf Fuhr,
• Martin Nieger,
• Nicole Jung and
• Stefan Bräse

Beilstein J. Org. Chem. 2024, 20, 1396–1404, doi:10.3762/bjoc.20.121

• from triazenylpyrazoles. Initial experiments with TFA and trimethylsilyl azide at 0–25 °C in DCM failed for 4-substituted pyrazoles; the formation of the target products was only observed when 5-methylpyrazoles such as 15b were used. Therefore, a modified procedure was applied, heating the triazenes to

Generation of alkyl and acyl radicals by visible-light photoredox catalysis: direct activation of C–O bonds in organic transformations

• Mithu Roy,
• Bitan Sardar,
• Itu Mallick and
• Dipankar Srimani

Beilstein J. Org. Chem. 2024, 20, 1348–1375, doi:10.3762/bjoc.20.119

• reduction of xanthates. Under blue-light irradiation, xanthates were reacted with B2cat2 (19) in dimethylacetamide (DMAc), providing the borylated product in decent yield. The methodology was metal-free and did not require conventional heating. Nevertheless, the borylation process was limited to secondary

Rhodium-catalyzed homo-coupling reaction of aryl Grignard reagents and its application for the synthesis of an integrin inhibitor

• Kazuyuki Sato,
• Satoki Teranishi,
• Atsushi Sakaue,
• Yukiko Karuo,
• Atsushi Tarui,
• Kentaro Kawai,
• Hiroyuki Takeda,
• Tatsuo Kinashi and
• Masaaki Omote

Beilstein J. Org. Chem. 2024, 20, 1341–1347, doi:10.3762/bjoc.20.118

• , since the preparation of Grignard reagents derived from haloarenes with Mg in situ requires heating for a long time, we decided to use heating conditions for the one-pot homo-coupling reaction. Most homo-coupling products were obtained in this reaction, although the product yield decreased when using

Sustainable tandem acylation/Diels–Alder reaction toward versatile tricyclic epoxyisoindole-7-carboxylic acids in renewable green solvents

• Ayhan Yıldırım

Beilstein J. Org. Chem. 2024, 20, 1308–1319, doi:10.3762/bjoc.20.114

• conventional Diels–Alder reactions [95][118][119][120][121][122][123][124]. On the other hand, the initially exo carboxylic acid substituent in the oxanorbornene ring is converted to its endo isomer by epimerization upon heating the cycloadduct in a mixture of pyridine–glacial acetic acid (1:1). In the process

Synthesis of indano[60]fullerene thioketone and its application in organic solar cells

• Yong-Chang Zhai,
• Shimon Oiwa,
• Shinobu Aoyagi,
• Shohei Ohno,
• Tsubasa Mikie,
• Jun-Zhuo Wang,
• Hirofumi Amada,
• Koki Yamanaka,
• Kazuhira Miwa,
• Naoyuki Imai,
• Takeshi Igarashi,
• Itaru Osaka and
• Yutaka Matsuo

Beilstein J. Org. Chem. 2024, 20, 1270–1277, doi:10.3762/bjoc.20.109

• -term stability and a remarkable PCE of 22.11%, surpassing that of the commonly used C60 (20.45%). This improved performance can be attributed to the evaporated amorphous film, which prevents the transformation of the film into a crystalline state during the heating and aging of the devices

Competing electrophilic substitution and oxidative polymerization of arylamines with selenium dioxide

• Vishnu Selladurai and
• Selvakumar Karuthapandi

Beilstein J. Org. Chem. 2024, 20, 1221–1235, doi:10.3762/bjoc.20.105

• SeO2. For a methyl anthranilate solution, no color change was observed immediately upon addition of SeO2 as well as after 5 min of heating. The color of aniline and o-anisidine solutions became very intense after 5 min of heating. After 5 min of heating, the color intensity followed the following order

Structure–property relationships in dicyanopyrazinoquinoxalines and their hydrogen-bonding-capable dihydropyrazinoquinoxalinedione derivatives

• Tural N. Akhmedov,
• Ajeet Kumar,
• Daken J. Starkenburg,
• Kyle J. Chesney,
• Khalil A. Abboud,
• Novruz G. Akhmedov,
• Jiangeng Xue and
• Ronald K. Castellano

Beilstein J. Org. Chem. 2024, 20, 1037–1052, doi:10.3762/bjoc.20.92

• level, and no imaginary frequencies were found. Molecular orbital plots were made using GaussView v. 5.0.898 from the Gaussian output files. Thermogravimetric analysis Thermal gravimetric analysis (TGA) was performed on a TA Instruments TGA Q5000-0121 V3.8 Build 256 at a heating rate of 10 °C/min using

Auxiliary strategy for the general and practical synthesis of diaryliodonium(III) salts with diverse organocarboxylate counterions

• Naoki Miyamoto,
• Daichi Koseki,
• Kohei Sumida,
• Elghareeb E. Elboray,
• Naoko Takenaga,
• Ravi Kumar and
• Toshifumi Dohi

Beilstein J. Org. Chem. 2024, 20, 1020–1028, doi:10.3762/bjoc.20.90

• compared to trifluoroacetic acid, TfOH, HBF4, and p-TsOH, present a wider substrate scope, including acid-sensitive groups, in the preparation of diaryliodonium(III) salts. While the counterion exchange of diaryliodonium(III) chloride with silver acetate was reported [20], this method required heating

Spin and charge interactions between nanographene host and ferrocene

• Akira Suzuki,
• Yuya Miyake,
• Ryoga Shibata and
• Kazuyuki Takai

Beilstein J. Org. Chem. 2024, 20, 1011–1019, doi:10.3762/bjoc.20.89

• surface of ACFs, which were removed by heating the FeCp2-treated ACFs at 150 °C for 3 hours without FeCp2 vapor. XPS spectra were recorded using a PHI-5600 (ULVAC-PHI) with an Al Kα X-ray source (1486.7 eV) for samples mounted on an indium film. Raman spectroscopy measurements were performed by LabRAM HR

Carbonylative synthesis and functionalization of indoles

• Alex De Salvo,
• Raffaella Mancuso and
• Xiao-Feng Wu

Beilstein J. Org. Chem. 2024, 20, 973–1000, doi:10.3762/bjoc.20.87

• generated by heating 1 equiv of Mo(CO)6 at 100 °C in DMF in a sealed glass chamber (chamber 1). Afterwards, the gas passes into another sealed glass chamber (chamber 2) containing the substrate, Pd(OAc)2 (5 mol %), tm-phen (10 mol %) and DMF at the same temperature (Scheme 19). Ragaini and co-workers, in