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Search for "radical" in Full Text gives 827 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Solvent-dependent chemoselective synthesis of different isoquinolinones mediated by the hypervalent iodine(III) reagent PISA

  • Ze-Nan Hu,
  • Yan-Hui Wang,
  • Jia-Bing Wu,
  • Ze Chen,
  • Dou Hong and
  • Chi Zhang

Beilstein J. Org. Chem. 2024, 20, 1914–1921, doi:10.3762/bjoc.20.167

Graphical Abstract
  • radical clock experiment was carried out with 1d under the optimal reaction conditions, resulting in the formation of 2d in 54% yield, and no cyclopropyl ring opening products were observed. This result suggested that no radical intermediates were generated during the reaction (Scheme 5). According to the
  • HFIP (3.0 mL) at room temperature. Isolated yield is stated. aThe yield of 2k was 56%. bThe yield of 2m was 24%. cThe yield of 2n was 11%. Control experiment to test for radical intermediates. Proposed mechanism for the reaction between 1a and PISA in anhydrous acetonitrile. Two other resonance
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Published 07 Aug 2024

Novel oxidative routes to N-arylpyridoindazolium salts

  • Oleg A. Levitskiy,
  • Yuri K. Grishin and
  • Tatiana V. Magdesieva

Beilstein J. Org. Chem. 2024, 20, 1906–1913, doi:10.3762/bjoc.20.166

Graphical Abstract
  • oxidation of both N-centers was demonstrated in [19]. The wide variety of the subsequent reaction channels for the radical cations formed under chemical or electrochemical oxidation of diarylamines, as well as availability of variously substituted diarylamines make them perspective starting compounds for
  • amount (5%) of the N,N’-diaryldihydrophenazine radical cation that is the byproduct corresponding to the intermolecular oxidative C–N coupling of the diarylamine A1 was detected in the reaction mixture. This emphasizes that the both processes are of the same nature and proceed through the same
  • intermediate (i.e., the diarylamines’ radical cation) and indicates the dominance of the intramolecular cyclization over the intermolecular C–N coupling process. Oxidation of diarylamines in the presence of an excess of trifluoroacetic acid gave no targeted pyridoindazolium salts, whereas the amount of
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Published 07 Aug 2024

Electrochemical radical cation aza-Wacker cyclizations

  • Sota Adachi and
  • Yohei Okada

Beilstein J. Org. Chem. 2024, 20, 1900–1905, doi:10.3762/bjoc.20.165

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  • Sota Adachi Yohei Okada Department of Applied Biological Science, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo 183-8509, Japan 10.3762/bjoc.20.165 Abstract Electrochemical or photochemical single-electron oxidation of bench-stable substrates can generate radical
  • cations that offer unique reactivities as intermediates in various bond-formation processes. Such intermediates can potentially take part in both radical and ionic bond formation; however, the mechanisms involved are complicated and not fully understood. Herein, we report electrochemical radical cation
  • aza-Wacker cyclizations under acidic conditions, which are expected to proceed via radical cations generated by single-electron oxidation of alkenes. Keywords: alkene; aza-Wacker cyclization; electrochemistry; radical cation; sulfonamide; Introduction Activating bench-stable substrates is the first
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Published 05 Aug 2024

Synthesis of polycyclic aromatic quinones by continuous flow electrochemical oxidation: anodic methoxylation of polycyclic aromatic phenols (PAPs)

  • Hiwot M. Tiruye,
  • Solon Economopoulos and
  • Kåre B. Jørgensen

Beilstein J. Org. Chem. 2024, 20, 1746–1757, doi:10.3762/bjoc.20.153

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  • radical (potassium nitrosodisulfonate) [13] or catalytic systems like methyltrioxorhenium(VII) (MeReO3) [14] and 2-iodobenzenesulfonic acids (IBS)/Oxone® [15] led to either p-quinones or o-quinones, depending on the substituents in the para-position to the hydroxy group. Recently, hypervalent iodine
  • dimers, which indicates a radical intermediate [36]. Swenton and co-workers [37] established evidence for the phenoxonium ion (Scheme 1), and were further able to divert the reaction into forming ortho-oxidation due to steric hindrance (Scheme 2). Cyclic voltammetry studies of the oxidation of 2-naphthol
  • chrysenols nor phenanthrols, suggesting a chemically irreversible reaction of the radical cation intermediate with the ensuing product no longer being electrochemically active within the potential window of the CV scans. However, a reduction peak was observed for compound 1b (see Figure S2 in Supporting
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Published 24 Jul 2024

Syntheses and medicinal chemistry of spiro heterocyclic steroids

  • Laura L. Romero-Hernández,
  • Ana Isabel Ahuja-Casarín,
  • Penélope Merino-Montiel,
  • Sara Montiel-Smith,
  • José Luis Vega-Báez and
  • Jesús Sandoval-Ramírez

Beilstein J. Org. Chem. 2024, 20, 1713–1745, doi:10.3762/bjoc.20.152

Graphical Abstract
  • yields (82–85%) (Scheme 28). The authors proposed a free radical mechanism facilitated by hydrogen peroxide, generating a primary radical at the terminal nitrogen atom -CO-HN• which then adds to the carbon atom of the imino group. The reaction mechanism was substantiated by theoretical calculations
  • . According to the mechanism, the heterocyclic ring closes by the attack of the bulky radical -CO-HN• over the α steroidal side to circumvent the 1,3-diaxial interaction with the methyl group at C-10. Spiro-1,3,4-oxadiazoline steroid Shamsuzzaman et al. achieved the synthesis of 5’-acetamido-3’-acetyl-(3R
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Published 24 Jul 2024

Chemo-enzymatic total synthesis: current approaches toward the integration of chemical and enzymatic transformations

  • Ryo Tanifuji and
  • Hiroki Oguri

Beilstein J. Org. Chem. 2024, 20, 1693–1712, doi:10.3762/bjoc.20.151

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  • toward developing a chemo-enzymatic synthetic process. Presumably, the reactive iron(IV)-oxo species in dioxygenase BscD abstracts an allylic hydrogen at C1 and generates intermediate A. Subsequent α-face-selective hydroxylation of the resulting allylic radical at the C3 position would yield brassicicene
  • ]. The P450 enzyme BscF is responsible for regioselective abstraction of a hydrogen at C12 and subsequent diastereoselective hydroxylation of the radical intermediate B to produce brassicicene B (10). Meanwhile, further single-electron oxidation of the intermediate B would trigger a Wagner–Meerwein-type
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Published 23 Jul 2024

Ring opening of photogenerated azetidinols as a strategy for the synthesis of aminodioxolanes

  • Henning Maag,
  • Daniel J. Lemcke and
  • Johannes M. Wahl

Beilstein J. Org. Chem. 2024, 20, 1671–1676, doi:10.3762/bjoc.20.148

Graphical Abstract
  • the 54% and 63% yield, respectively (Table 1, entries 3 and 4). We observed an increase in Norrish II fragmentation in these cases. The observed diastereoselectivity was poor, supporting the radical character of the ring-closing event. A similar trend was observed when studying the methanesulfonyl (Ms
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Published 19 Jul 2024

Methyltransferases from RiPP pathways: shaping the landscape of natural product chemistry

  • Maria-Paula Schröder,
  • Isabel P.-M. Pfeiffer and
  • Silja Mordhorst

Beilstein J. Org. Chem. 2024, 20, 1652–1670, doi:10.3762/bjoc.20.147

Graphical Abstract
  • (Mg2+-dependent, metal-independent, cobalamin-dependent), common structural folds (class I–V, with class I being the largest group, characterised by the Rossmann fold) [58], or catalytic mechanism (SN2 mechanism, radical mechanism, Figure 3) [59]. This review categorises RiPP MTs based on the acceptor
  • atom, describing O-, N-, C-, and S-MTs; halide MTs have not (yet) been identified in RiPP pathways. The enzymes described below are either conventional SAM-dependent MTs or radical SAM (rSAM) MTs; rSAM MTs are one subfamily of the large rSAM enzyme superfamily, which encompasses enzymes catalysing a
  • involved in RiPP maturation, all C-MTs described in the following section are classified as rSAM C-MTs. Radical SAM C-methyltransferases Radical SAM enzymes typically contain a conserved CxxxCxxC motif. The cysteine residues of this motif coordinate a [4Fe-4S] cluster. rSAM MTs can be classified based on
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Published 18 Jul 2024

Benzylic C(sp3)–H fluorination

  • Alexander P. Atkins,
  • Alice C. Dean and
  • Alastair J. J. Lennox

Beilstein J. Org. Chem. 2024, 20, 1527–1547, doi:10.3762/bjoc.20.137

Graphical Abstract
  • radicals and ions imparted through delocalisation with the adjacent π-system [13][14][15]. In general, the more stabilised the benzylic radical, the weaker the C(sp3)–H bond, as demonstrated when considering the BDEs of a series of phenyl-substituted methanes (Figure 1B). The changes in BDE correlate with
  • mechanistic strategies, namely, electrophilic, radical and nucleophilic approaches, and highlighted when emerging technologies, such as photo- and electrochemistry effect the desired transformation [22][27]. Review Electrophilic benzylic C(sp3)–H fluorination Base mediated Electrophilic fluorinating reagents
  • excess NFSI, the heterobenzyl fluoride is obtained. In the case of product 3, the authors suggested that the absence of radical clock rearrangement products supported a polar mechanism. Conveniently, when both benzylic and heterobenzylic C–H bonds were present in a substrate, the reaction was selective
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Published 10 Jul 2024

Tetrabutylammonium iodide-catalyzed oxidative α-azidation of β-ketocarbonyl compounds using sodium azide

  • Christopher Mairhofer,
  • David Naderer and
  • Mario Waser

Beilstein J. Org. Chem. 2024, 20, 1510–1517, doi:10.3762/bjoc.20.135

Graphical Abstract
  • insights we also carried out our standard reaction (Table 1, entry 14) in the presence of well-established radical traps like TEMPO, di-tert-butylhydroxytoluene (BHT), or 1,1-diphenylethene (DPE). In neither case any influence on the yield was observed, thus ruling out a mechanism involving radical species
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Published 05 Jul 2024

Electrophotochemical metal-catalyzed synthesis of alkylnitriles from simple aliphatic carboxylic acids

  • Yukang Wang,
  • Yan Yao and
  • Niankai Fu

Beilstein J. Org. Chem. 2024, 20, 1497–1503, doi:10.3762/bjoc.20.133

Graphical Abstract
  • synthesis; electrophotocatalysis; radical decarboxylation; Introduction Alkylnitriles and their derivatives are widely found in pharmaceuticals and biologically active compounds [1][2][3]. In addition, within the field of synthetic organic chemistry, nitriles are synthetically useful handles that can be
  • different types of aliphatic acids including primary ones could be successfully employed (Figure 1B, reaction 1). The groups of Waser [23] and Gonzalez-Gomez [24] reported the direct conversion of aliphatic acids to the corresponding alkylnitriles by merging photoredox catalysis and radical cyanation
  • have provided innovative strategies, substrates in all of these reaction systems are generally limited to benzylic, α-amino-, and α-oxy aliphatic acids, presumably due to the necessity of stabilized radical intermediates for the following radical cyanation step. We and others have recently demonstrated
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Published 03 Jul 2024

Synthesis of 4-functionalized pyrazoles via oxidative thio- or selenocyanation mediated by PhICl2 and NH4SCN/KSeCN

  • Jialiang Wu,
  • Haofeng Shi,
  • Xuemin Li,
  • Jiaxin He,
  • Chen Zhang,
  • Fengxia Sun and
  • Yunfei Du

Beilstein J. Org. Chem. 2024, 20, 1453–1461, doi:10.3762/bjoc.20.128

Graphical Abstract
  • ][44][45]. However, the electrophilic thiocyanation of biologically important pyrazoles has been less explored [46][47][48]. Among them, the majority of the reported methods proceed through a radical pathway, with the SCN radical generated by the reaction of the thiocyanate source with a corresponding
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Published 28 Jun 2024

Synthesis of cyclic β-1,6-oligosaccharides from glucosamine monomers by electrochemical polyglycosylation

  • Md Azadur Rahman,
  • Hirofumi Endo,
  • Takashi Yamamoto,
  • Shoma Okushiba,
  • Norihiko Sasaki and
  • Toshiki Nokami

Beilstein J. Org. Chem. 2024, 20, 1421–1427, doi:10.3762/bjoc.20.124

Graphical Abstract
  • product of monomer 6. The proposed mechanism is shown in Scheme 2. Anodic oxidation of thioglycoside 6 generated radical cation 11, which was converted to glycosyl triflate 12. 1,6-Anhydrosugar 7 was produced via 4C1-to-1C4 conformational change of the pyran ring to generate cation intermediate 13
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Published 26 Jun 2024

Generation of alkyl and acyl radicals by visible-light photoredox catalysis: direct activation of C–O bonds in organic transformations

  • Mithu Roy,
  • Bitan Sardar,
  • Itu Mallick and
  • Dipankar Srimani

Beilstein J. Org. Chem. 2024, 20, 1348–1375, doi:10.3762/bjoc.20.119

Graphical Abstract
  • photocatalysts, transition-metal photoredox catalysts, and metallaphotocatalysts to produce acyl and alkyl radicals driven by visible light. Keywords: acyl radical; alkyl radical; sustainable catalysis; visible light; Introduction The growing awareness of the necessity for sustainable developments has been
  • heightened by the current energy crisis and the adverse impacts of industrialization. The development of green and energy-efficient methods in organic chemistry that use renewable sources of starting materials is considered highly sustainable [1][2][3]. Radical reactions have profound applications in organic
  • synthesis [4][5][6][7][8][9]. In the context of sustainable catalysis, visible-light-mediated chemistry is becoming a prominent viable option for radical transformations in the synthesis of biologically useful compounds due to the energy efficiency and environmental friendliness [10][11]. Recently, the
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Published 14 Jun 2024

Transition-metal-catalyst-free electroreductive alkene hydroarylation with aryl halides under visible-light irradiation

  • Kosuke Yamamoto,
  • Kazuhisa Arita,
  • Masami Kuriyama and
  • Osamu Onomura

Beilstein J. Org. Chem. 2024, 20, 1327–1333, doi:10.3762/bjoc.20.116

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  • Kosuke Yamamoto Kazuhisa Arita Masami Kuriyama Osamu Onomura Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan 10.3762/bjoc.20.116 Abstract The radical hydroarylation of alkenes is an efficient strategy for accessing linear alkylarenes with
  • that a reductive radical-polar crossover pathway is likely to be involved in this transformation. Keywords: aryl halides; C–C bond formation; electroreduction; radicals; visible light; Introduction Alkene hydroarylation is an attractive method for the construction of alkylarenes, which serve as
  • a hydride donor [5][6][7][8]. On the other hand, aryl radical-involved hydroarylation would be a promising alternative for the synthesis of alkylarenes with high anti-Markovnikov selectivity [9][10]. Aryl halides have received increased attention as ideal radical precursors because of their
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Published 10 Jun 2024

Phenotellurazine redox catalysts: elements of design for radical cross-dehydrogenative coupling reactions

  • Alina Paffen,
  • Christopher Cremer and
  • Frederic W. Patureau

Beilstein J. Org. Chem. 2024, 20, 1292–1297, doi:10.3762/bjoc.20.112

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Published 04 Jun 2024

Mechanistic investigations of polyaza[7]helicene in photoredox and energy transfer catalysis

  • Johannes Rocker,
  • Till J. B. Zähringer,
  • Matthias Schmitz,
  • Till Opatz and
  • Christoph Kerzig

Beilstein J. Org. Chem. 2024, 20, 1236–1245, doi:10.3762/bjoc.20.106

Graphical Abstract
  • catalyst in the sulfonylation/arylation of styrenes and as a triplet sensitizer in energy transfer catalysis. The singlet lifetime is sufficiently long to exploit the exceptional excited state reduction potential for the activation of 4-cyanopyridine. Photoinduced electron transfer generating the radical
  • 0.34, is essentially non-reactive under our conditions. Cyanopyridine- and sulfinate-derived radicals are produced in equal concentrations in the catalytic cycle, suggesting that radical coupling is indeed the final reaction step to give the stable sulfonylation/arylation product. The triplet of Aza-H
  • potentials of Aza-H and the substrates and initial steady-state fluorescence quenching experiments (Scheme 1, left), but detailed mechanistic insights and direct evidence of the transient radical ions could not be obtained yet [45]. Figure 1A illustrates the absorption and emission spectra of Aza-H in MeCN
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Published 28 May 2024

Competing electrophilic substitution and oxidative polymerization of arylamines with selenium dioxide

  • Vishnu Selladurai and
  • Selvakumar Karuthapandi

Beilstein J. Org. Chem. 2024, 20, 1221–1235, doi:10.3762/bjoc.20.105

Graphical Abstract
  • similar mechanism may be assumed for the formation of the other oxamides 9 and 13. Mechanism for the formation of 2,5-bis((2-methoxyphenyl)amino)cyclohexa-2,5-diene-1,4-dione (10) Generally, formation of polyaniline occurs through a radical mechanism. Such a radical mechanism is relevant for the formation
  • of quinones having exceptional radical-stabilizing abilities. The best example in nature is the radical pathway in the catechol oxidation process [56][57][58]. The structure of o-anisidine resembles catechol as it has two adjacent electron-donating functions (NH2 and OMe). For o-anisidine, the amine
  • radical resulting from reaction of o-anisidine with SeO2 is stabilized by resonance (Scheme 7). It combines with the hydroxyl radical and undergoes subsequent oxidation to give 2-methoxycyclohexa-2,5-diene-1,4-dione. This iminoquinone upon hydrolysis gives 2-methoxycyclohexa-2,5-diene-1,4-dione, and the
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Published 27 May 2024

Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis

  • Jinmin Gao,
  • Liyuan Li,
  • Shijie Shen,
  • Guomin Ai,
  • Bin Wang,
  • Fang Guo,
  • Tongjian Yang,
  • Hui Han,
  • Zhengren Xu,
  • Guohui Pan and
  • Keqiang Fan

Beilstein J. Org. Chem. 2024, 20, 1198–1206, doi:10.3762/bjoc.20.102

Graphical Abstract
  • -dependent reactions of AlpJ-family oxygenases. Furthermore, the AlpJ- and JadG-catalyzed reactions of CR1 could be quenched by superoxide dismutase, supporting a catalytic mechanism wherein the substrate CR1 reductively activates molecular oxygen, generating a substrate radical and the superoxide anion O2
  • bond cleavage, ring opening, and rearrangement reactions, yielding the respective products. Furthermore, the reactions of 8 catalyzed by JadG and AlpJ could be quenched by superoxide dismutase (SOD), supporting a catalytic mechanism involving the generation of a substrate radical and the superoxide
  • substrates to activate molecular oxygen, leading to the generation of a substrate radical and the superoxide anion O2•− [29][33][37]. The well-established superoxide trapping agent superoxide dismutase (SOD) has demonstrated significant inhibition of the NMO-catalyzed monooxygenation reaction [29]. To probe
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Published 23 May 2024

Two-fold addition reaction of silylene to C60: structural and electronic properties of a bis-adduct

  • Masahiro Kako,
  • Masato Kai,
  • Masanori Yasui,
  • Michio Yamada,
  • Yutaka Maeda and
  • Takeshi Akasaka

Beilstein J. Org. Chem. 2024, 20, 1179–1188, doi:10.3762/bjoc.20.100

Graphical Abstract
  • perpendicularly. Unfortunately, the matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry of 3 afforded no molecular ion peak expected for adducts derived from Dip2Si and C60 while a base peak at m/z 720 due to C60 was observed probably because of the low stability of radical
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Published 22 May 2024

Manganese-catalyzed C–C and C–N bond formation with alcohols via borrowing hydrogen or hydrogen auto-transfer

  • Mohd Farhan Ansari,
  • Atul Kumar Maurya,
  • Abhishek Kumar and
  • Saravanakumar Elangovan

Beilstein J. Org. Chem. 2024, 20, 1111–1166, doi:10.3762/bjoc.20.98

Graphical Abstract
  • control studies with Hg and TEMPO indicated that the reactions were homogeneous and did not proceed through a radical pathway. Synthesis of heterocycles via C–C and C–N bond formation In 2016, Beller and co-workers reported an intramolecular cyclization using 2-(2-aminophenyl)ethanol for the synthesis of
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Published 21 May 2024

Light on the sustainable preparation of aryl-cored dibromides

  • Fabrizio Roncaglia,
  • Alberto Ughetti,
  • Nicola Porcelli,
  • Biagio Anderlini,
  • Andrea Severini and
  • Luca Rigamonti

Beilstein J. Org. Chem. 2024, 20, 1076–1087, doi:10.3762/bjoc.20.95

Graphical Abstract
  • considering the most atom-economical options, namely chlorine and bromine, the latter typically exhibits some advantages over the former. These include: (i) better regioselectivity in radical processes, attributed to the lower bond enthalpy of H–Br (88 kcal/mol) compared to H–Cl (103 kcal/mol) [17], (ii
  • functionalisation on the aromatic ring when used in the dark [20]. A classic example is the bromination of toluene with molecular bromine. When the system is exposed to light (right side of Figure 1), a radical mechanism is initiated by Br• coming from Br2 homolysis. Propagation involves the reversible abstraction
  • of a benzylic hydrogen atom from the substrate by Br•, to give HBr and a structure-stabilised carbon-centred radical, which may react with Br2 to give the brominated product, thus regenerating Br• that is able to sustain the chain process. In the absence of light (left side of Figure 1), the reaction
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Published 14 May 2024

Auxiliary strategy for the general and practical synthesis of diaryliodonium(III) salts with diverse organocarboxylate counterions

  • Naoki Miyamoto,
  • Daichi Koseki,
  • Kohei Sumida,
  • Elghareeb E. Elboray,
  • Naoko Takenaga,
  • Ravi Kumar and
  • Toshifumi Dohi

Beilstein J. Org. Chem. 2024, 20, 1020–1028, doi:10.3762/bjoc.20.90

Graphical Abstract
  • photoinitiated radical polymerizations [7][8]. Consequently, there exists a growing interest in the development of more convenient synthetic routes for these compounds, facilitating the creation of structurally novel diaryliodonium(III) salts. The counterions of diaryliodonium(III) salts play a crucial role in
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Published 03 May 2024

Spin and charge interactions between nanographene host and ferrocene

  • Akira Suzuki,
  • Yuya Miyake,
  • Ryoga Shibata and
  • Kazuyuki Takai

Beilstein J. Org. Chem. 2024, 20, 1011–1019, doi:10.3762/bjoc.20.89

Graphical Abstract
  • part in the arbitrarily shaped edges results in the emergence of radical π-electron states called “edge states”, which are spatially localized at the edge site. The edge states appear at the Dirac point at which two linear conduction (anti-bonding) π*- and valence (bonding) π-bands touch each other in
  • the electronic energy bands of graphene. Since the Fermi level is located at the Dirac point for neutral nanographene, edge states are half-filled like singly occupied molecular orbitals (SOMO) of radical states. Namely, nanographene sheets become magnetic and chemically active due to the edge states
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Published 02 May 2024

Carbonylative synthesis and functionalization of indoles

  • Alex De Salvo,
  • Raffaella Mancuso and
  • Xiao-Feng Wu

Beilstein J. Org. Chem. 2024, 20, 973–1000, doi:10.3762/bjoc.20.87

Graphical Abstract
  • interesting method toward indole-3-yl aryl ketones was reported by Zhang et al. Considering the ability of the aryldiazonium salts to act as aryl radical source, in presence of the suitable metal catalyst or taking advantage of photocatalysis, they decided to perform a direct carbonylation of indoles with
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Published 30 Apr 2024
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