Search results

Search for "organic" in Full Text gives 2924 result(s) in Beilstein Journal of Organic Chemistry. Showing first 200.

Selective monoformylation of naphthalene-fused propellanes for methylene-alternating copolymers

  • Kenichi Kato,
  • Tatsuki Hiroi,
  • Seina Okada,
  • Shunsuke Ohtani and
  • Tomoki Ogoshi

Beilstein J. Org. Chem. 2025, 21, 1183–1191, doi:10.3762/bjoc.21.95

Graphical Abstract
  • , Kanazawa, 920-1192, Japan 10.3762/bjoc.21.95 Abstract Development of three-dimensional (3D) building blocks is a key to change tight molecular assemblies of rigid π-conjugated planes into organic functional materials endowed with molecular-size cavities. To increase the diversity of available 3D building
  • go beyond common organic functional materials composed of rigid π-conjugated planes and flexible peripheral substituents. Because larger π-conjugated planes mostly display low solubility and dense packing due to the π–π stacking and CH–π interactions, surrounding alkyl and other flexible moieties are
  • storage and transport [27][28][29]. Further progress in such unique organic materials largely depends on the exploitation of 3D π-building blocks. However, the variety of building blocks are limited to a few families such as tetraphenylmethane and triptycene [30][31][32][33][34][35][36][37][38][39
PDF
Album
Supp Info
Full Research Paper
Published 18 Jun 2025

Enhancing chemical synthesis planning: automated quantum mechanics-based regioselectivity prediction for C–H activation with directing groups

  • Julius Seumer,
  • Nicolai Ree and
  • Jan H. Jensen

Beilstein J. Org. Chem. 2025, 21, 1171–1182, doi:10.3762/bjoc.21.94

Graphical Abstract
  • Julius Seumer Nicolai Ree Jan H. Jensen Department of Chemistry, University of Copenhagen, Copenhagen, Denmark 10.3762/bjoc.21.94 Abstract The mild and selective functionalization of carbon–hydrogen (C–H) bonds remains a pivotal challenge in organic synthesis, crucial for developing complex
  • molecular architectures in pharmaceuticals, polymers, and agrochemicals. Despite advancements in directing group (DG) methodologies and computational approaches, predicting accurate regioselectivity in C–H activation poses significant difficulties due to the diversity and complexity of organic compounds
  • carbon–hydrogen (C–H) bonds represent a fundamental challenge in modern organic chemistry, particularly because of the inherent stability and prevalence of these bonds in organic molecules. These bonds, which typically exhibit bond energies ranging from 90 to 110 kcal·mol−1, constitute the majority of
PDF
Album
Supp Info
Full Research Paper
Published 16 Jun 2025

Synthetic approach to borrelidin fragments: focus on key intermediates

  • Yudhi Dwi Kurniawan,
  • Zetryana Puteri Tachrim,
  • Teni Ernawati,
  • Faris Hermawan,
  • Ima Nurasiyah and
  • Muhammad Alfin Sulmantara

Beilstein J. Org. Chem. 2025, 21, 1135–1160, doi:10.3762/bjoc.21.91

Graphical Abstract
  • complex structure, remains an attractive target for synthetic organic chemists worldwide. Several comprehensive reviews on borrelidin have been published, with a strong focus on its synthesis. The first notable comparison of total synthesis methods was conducted by Ōmura in 2005 [48], highlighting four
PDF
Album
Review
Published 12 Jun 2025

Gold extraction at the molecular level using α- and β-cyclodextrins

  • Susana Santos Braga

Beilstein J. Org. Chem. 2025, 21, 1116–1125, doi:10.3762/bjoc.21.89

Graphical Abstract
  • organic compounds, with the driving forces leading to inclusion being van der Waals and hydrophobic interactions for apolar guests, and/or hydrogen bonding when the guest features H-bond accepting groups that interact with the hydroxy groups of the cyclodextrins. Interactions with metal ions/complexes and
  • coordination with inorganic and organometallic complexes involves hydrophobic interactions and van der Waals forces (mainly with the organic parts of these guests). Several forces are at play in the formation of supramolecular assemblies with gold in the form of haloaurate ions, as detailed in the forthcoming
  • tridimensional γ-CD metal-organic frameworks (CD-MOFs) [38][39] using a variety of salts instead of the traditional KOH employed to link them together. In his experiments, he used a different cyclodextrin, α-CD, in the place of the traditionally employed one, γ-CD. α-CD molecules did not, however, form the
PDF
Album
Review
Published 06 Jun 2025

A versatile route towards 6-arylpipecolic acids

  • Erich Gebel,
  • Cornelia Göcke,
  • Carolin Gruner and
  • Norbert Sewald

Beilstein J. Org. Chem. 2025, 21, 1104–1115, doi:10.3762/bjoc.21.88

Graphical Abstract
  • Erich Gebel Cornelia Gocke Carolin Gruner Norbert Sewald Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Universitätsstraße 25, D-33615 Bielefeld, Germany 10.3762/bjoc.21.88 Abstract Pipecolic acid is known as a non-proteinogenic amino acid with a secondary amine
PDF
Album
Supp Info
Full Research Paper
Published 04 Jun 2025

Supramolecular assembly of hypervalent iodine macrocycles and alkali metals

  • Krishna Pandey,
  • Lucas X. Orton,
  • Grayson Venus,
  • Waseem A. Hussain,
  • Toby Woods,
  • Lichang Wang and
  • Kyle N. Plunkett

Beilstein J. Org. Chem. 2025, 21, 1095–1103, doi:10.3762/bjoc.21.87

Graphical Abstract
  • demonstrates several atoms (e.g., Cl, I, S, P etc.) that exhibit hypervalent properties. Among these atoms, iodine has gained significant attention, particularly in the form of hypervalent iodine reagents. In organic chemistry, these reagents are valued for their distinct reactivities, safe handling, high
PDF
Album
Supp Info
Full Research Paper
Published 30 May 2025

Salen–scandium(III) complex-catalyzed asymmetric (3 + 2) annulation of aziridines and aldehydes

  • Linqiang Wang and
  • Jiaxi Xu

Beilstein J. Org. Chem. 2025, 21, 1087–1094, doi:10.3762/bjoc.21.86

Graphical Abstract
  • Linqiang Wang Jiaxi Xu State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, People’s Republic of China 10.3762/bjoc.21.86 Abstract Oxazolidine is one of the crucial structural
  • [5] and the FDA-approved antibiotic linezolid [6] (Figure 1). Both chiral oxazolidines [7][8] and oxazolidinones [9][10] have been utilized as chiral auxiliary groups in many asymmetric organic transformations. Oxazolidine derivatives have been prepared mainly from condensation of vicinal amino
PDF
Album
Supp Info
Full Research Paper
Published 28 May 2025

Recent advances in synthetic approaches for bioactive cinnamic acid derivatives

  • Betty A. Kustiana,
  • Galuh Widiyarti and
  • Teni Ernawati

Beilstein J. Org. Chem. 2025, 21, 1031–1086, doi:10.3762/bjoc.21.85

Graphical Abstract
  • applications in organic reactions. Similarly, Kunishima and co-workers (2021) utilized (N,N’-dialkyl)triazinedione-4-(dimethylamino)pyridine (ATD-DMAP) for the amidation of cinnamic acid (7) to generate the corresponding amide 10 in excellent yield (Scheme 5B) [37]. Mechanistically, the carboxyl group attacks
  • multimetal-organic framework (M-MOF, M= Cu, Ni) which successfully catalyzed the one-pot cyclopropenone hydration/Chan–Lam coupling reaction of 309 and boronic acid 341 to give the corresponding ester 310 in good yield via the formation of acid 342 (Scheme 76B). Cyclopropenone was also subjected to non-metal
PDF
Album
Review
Published 28 May 2025

Biobased carbon dots as photoreductants – an investigation by using triarylsulfonium salts

  • Valentina Benazzi,
  • Arianna Bini,
  • Ilaria Bertuol,
  • Mariangela Novello,
  • Federica Baldi,
  • Matteo Hoch,
  • Alvise Perosa and
  • Stefano Protti

Beilstein J. Org. Chem. 2025, 21, 1024–1030, doi:10.3762/bjoc.21.84

Graphical Abstract
  • different organic sources as photoreductants. Such carbon nanomaterials were synthesized by two different approaches, either hydrothermal or pyrolytic, from citric acid and glucose as the starting organic substrates. On the other hand, carbon dots deriving from fishery waste (bass scales) and fruit
  • approach, CDs arise from the decomposition of large carbogenic structures (including graphite, graphite sheets and carbon nanotubes), whereas in the bottom-up approach such materials are obtained by carbonization of small organic molecules and biowastes (carbohydrates, polymers, bioorganic compounds
  • photooxidant or photoreductant in the presence of a suitable electron donor or acceptor [18], and these properties have been exploited in procedures for the formation of both C–C and C–heteroatom bonds [18][19]. Our research groups recently focused on the application of CDs in light-mediated organic synthesis
PDF
Album
Supp Info
Full Research Paper
Published 26 May 2025

Recent total synthesis of natural products leveraging a strategy of enamide cyclization

  • Chun-Yu Mi,
  • Jia-Yuan Zhai and
  • Xiao-Ming Zhang

Beilstein J. Org. Chem. 2025, 21, 999–1009, doi:10.3762/bjoc.21.81

Graphical Abstract
  • well-established that it is featured in nearly every organic chemistry textbook. However, despite their versatility, enamines themselves are not easily handling compounds in experimental settings. Their sensitivity to hydrolysis complicates their isolation and identification, and following the
  • followed by deprotection completed the total synthesis, giving rise to (−)-cephalocyclidin A in 10 steps from known compounds. Conclusion In summary, the perception of enamides as stable chemical entities with limited utilities in organic synthesis has evolved, and these compounds are now widely used in
PDF
Album
Review
Published 22 May 2025

On the photoluminescence in triarylmethyl-centered mono-, di-, and multiradicals

  • Daniel Straub,
  • Markus Gross,
  • Mona E. Arnold,
  • Julia Zolg and
  • Alexander J. C. Kuehne

Beilstein J. Org. Chem. 2025, 21, 964–998, doi:10.3762/bjoc.21.80

Graphical Abstract
  • Daniel Straub Markus Gross Mona E. Arnold Julia Zolg Alexander J. C. Kuehne OC III - Institute of Organic and Macromolecular Chemistry, Ulm University, Albert-Einstein-Allee 11, 89081 Ulm, Germany Center for Integrated Quantum Science and Technology, Ulm University, Albert-Einstein-Allee 11, 89081
  • Ulm, Germany 10.3762/bjoc.21.80 Abstract Organic radicals with light-emitting properties and exceptional stability offer exciting opportunities to address spin-statistical limitations in organic electronics and advance quantum technologies. These radicals, acting as small molecular magnets, exhibit
  • overcoming scalability challenges in quantum technologies. Despite their potential, achieving high luminescence quantum yields has largely been limited to donor-functionalized monoradicals, and a detailed understanding of the luminescent behavior of open-shell organic molecules remains elusive. This review
PDF
Album
Supp Info
Review
Published 21 May 2025

Studies on the syntheses of β-carboline alkaloids brevicarine and brevicolline

  • Benedek Batizi,
  • Patrik Pollák,
  • András Dancsó,
  • Péter Keglevich,
  • Gyula Simig,
  • Balázs Volk and
  • Mátyás Milen

Beilstein J. Org. Chem. 2025, 21, 955–963, doi:10.3762/bjoc.21.79

Graphical Abstract
  • Benedek Batizi Patrik Pollak Andras Dancso Peter Keglevich Gyula Simig Balazs Volk Matyas Milen Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary Egis
  • Pharmaceuticals Plc., Directorate of Drug Substance Development, P. O. Box 100, Keresztúri út 30-38, H-1475 Budapest, Hungary Department of Organic Chemistry, Faculty of Pharmacy, Semmelweis University, Hőgyes Endre utca 7, H-1092 Budapest, Hungary Center for Pharmacology and Drug Research & Development
PDF
Album
Supp Info
Full Research Paper
Published 20 May 2025

Study of tribenzo[b,d,f]azepine as donor in D–A photocatalysts

  • Katy Medrano-Uribe,
  • Jorge Humbrías-Martín and
  • Luca Dell’Amico

Beilstein J. Org. Chem. 2025, 21, 935–944, doi:10.3762/bjoc.21.76

Graphical Abstract
  • demonstrate that these simple D–A structures exhibit promising photocatalytic properties, comparable to those of more complex D–A–D systems. Keywords: donor–acceptor system; photocatalyst design; photoredox catalysis; organic photocatalyst; Introduction In recent years, photocatalysis has emerged as a
  • powerful tool for the construction and functionalization of organic molecules and materials. Thus, the scientific community has focused on the design and study of new organic molecules that can be used as photocatalysts, replacing generally more expensive metal-based complexes [1][2][3]. Furthermore, there
  • is a particular interest in the obtainment of organic molecules with well-balanced redox potentials in the excited state that can act as bimodal photocatalysts, facilitating their use in oxidative and reductive quenching cycles. In this sense, it is crucial to understand the molecule's structure
PDF
Album
Supp Info
Full Research Paper
Published 14 May 2025

A convergent synthetic approach to the tetracyclic core framework of khayanolide-type limonoids

  • Zhiyang Zhang,
  • Jialei Hu,
  • Hanfeng Ding,
  • Li Zhang and
  • Peirong Rao

Beilstein J. Org. Chem. 2025, 21, 926–934, doi:10.3762/bjoc.21.75

Graphical Abstract
  • synthesis of azadiradione (1). Following this, Ley and his team successfully synthesized azadirachtin (2) in 2007, a limonoid extensively utilized in organic agriculture [11]. In recent years, remarkable progress has been made on the total syntheses of various limonoids, with notable contributions from
PDF
Album
Supp Info
Full Research Paper
Published 12 May 2025

Recent advances in controllable/divergent synthesis

  • Jilei Cao,
  • Leiyang Bai and
  • Xuefeng Jiang

Beilstein J. Org. Chem. 2025, 21, 890–914, doi:10.3762/bjoc.21.73

Graphical Abstract
  • , 3663 North Zhongshan Road, Shanghai 200062, PR China School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, PR China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road
  • , Shanghai 200032, PR China 10.3762/bjoc.21.73 Abstract The development of streamlined methodologies for the expeditious assembly of structurally diverse organic architectures represents a paramount objective in contemporary synthetic chemistry, with far-reaching implications across pharmaceutical
  • development, advanced materials innovation, and fundamental molecular science research. In recent years, controllable/divergent synthetic strategies for organic functional molecules using common starting materials have garnered significant attention due to their high efficiency. This review categorizes recent
PDF
Album
Review
Published 07 May 2025

Dicarboxylate recognition based on ultracycle hosts through cooperative hydrogen bonding and anion–π interactions

  • Wen-Hui Mi,
  • Teng-Yu Huang,
  • Xu-Dong Wang,
  • Yu-Fei Ao,
  • Qi-Qiang Wang and
  • De-Xian Wang

Beilstein J. Org. Chem. 2025, 21, 884–889, doi:10.3762/bjoc.21.72

Graphical Abstract
  • Sciences, Beijing 100049, China 10.3762/bjoc.21.72 Abstract The efficient binding of dicarboxylates represents an important yet challenging issue in supramolecular chemistry. In this study, we designed functional ultracycles as hosts to accommodate large organic dicarboxylate anions. These ultracycles
PDF
Album
Supp Info
Letter
Published 06 May 2025

Cu–Bpin-mediated dimerization of 4,4-dichloro-2-butenoic acid derivatives enables the synthesis of densely functionalized cyclopropanes

  • Patricia Gómez-Roibás,
  • Andrea Chaves-Pouso and
  • Martín Fañanás-Mastral

Beilstein J. Org. Chem. 2025, 21, 877–883, doi:10.3762/bjoc.21.71

Graphical Abstract
  • aliphatic gem-dichloride, we explored the feasibility of a base-mediated formation of chlorocyclopropanes (Table 2). Evaluation of bases such as metal tert-butoxides, phosphates, acetates, and organic amines resulted in either low conversion or decomposition of 2 (see Supporting Information File 1 for
PDF
Album
Supp Info
Letter
Published 05 May 2025

Data accessibility in the chemical sciences: an analysis of recent practice in organic chemistry journals

  • Sally Bloodworth,
  • Cerys Willoughby and
  • Simon J. Coles

Beilstein J. Org. Chem. 2025, 21, 864–876, doi:10.3762/bjoc.21.70

Graphical Abstract
  • chemical sciences, and the ‘FAIR Guiding Principles for scientific data management and stewardship’ provide a measurable set of guidelines that can be used to ensure the accessibility of reusable data. We investigate the data practice of researchers publishing in specialist organic chemistry journals, by
  • data guidance. We suggest first steps that researchers can take to move towards a positive culture of data sharing in organic chemistry. Routine actions that we encourage as standard practice include deposition of raw and metadata to open repositories, and inclusion of machine-readable structure
  • identifiers for all reported compounds. Keywords: data availability; FAIR principles; journal guidelines; NMR data; organic chemistry; Introduction Fundamental to science is the ability of researchers to build upon the findings of others. Scientific data are no longer perceived as simply an output of
PDF
Album
Supp Info
Full Research Paper
Published 02 May 2025

Light-enabled intramolecular [2 + 2] cycloaddition via photoactivation of simple alkenylboronic esters

  • Lewis McGhie,
  • Hannah M. Kortman,
  • Jenna Rumpf,
  • Peter H. Seeberger and
  • John J. Molloy

Beilstein J. Org. Chem. 2025, 21, 854–863, doi:10.3762/bjoc.21.69

Graphical Abstract
  • , Germany 10.3762/bjoc.21.69 Abstract The photoactivation of organic molecules via energy transfer (EnT) catalysis is often limited to conjugated systems that have low-energy triplet excited states, with simple alkenes remaining an intractable challenge. The ability to address this limitation, using high
  • activate organic molecules has had a profound impact on contemporary synthesis, enabling the practitioner to strategically construct molecules that are higher in energy from simple feedstock commodities [1][2][3][4][5]. Indeed, the unique ability to access high energy intermediates leveraging light, has
  • facilitated landmark organic transformations, such as the venerable Paternò–Büchi [6][7][8], Norrish–Yang [9][10][11], and enone–alkene cycloadditions [12][13][14], that proceed via the generation of a singlet or triplet diradical through the activation of an unsaturated bond [2][14]. While these seminal
PDF
Album
Supp Info
Letter
Published 30 Apr 2025

Unraveling cooperative interactions between complexed ions in dual-host strategy for cesium salt separation

  • Zhihua Liu,
  • Ya-Zhi Chen,
  • Ji Wang,
  • Qingling Nie,
  • Wei Zhao and
  • Biao Wu

Beilstein J. Org. Chem. 2025, 21, 845–853, doi:10.3762/bjoc.21.68

Graphical Abstract
  • the dual-host strategy were aimed at separating alkali metal halide salts from aqueous solutions into organic phases, including KCl, CsCl, and CsNO3 [23][24][25][26][27][28][29]. In these studies, 18-crown-6 was commonly utilized, and various anion receptors were selected to achieve tailored anion
  • that a tripodal hexaurea receptor L (Figure 1b) could selectively and reversibly extract sulfate and phosphate anions from water into organic phase (under pH control) [30][31][32][33]. Single crystal structures of the receptor–K2SO4 complex in the presence of 18-crown-6 clearly displayed ion-dipole
PDF
Album
Supp Info
Full Research Paper
Published 29 Apr 2025

Chitosan-supported CuI-catalyzed cascade reaction of 2-halobenzoic acids and amidines for the synthesis of quinazolinones

  • Xuhong Zhao,
  • Weishuang Li,
  • Mengli Yang,
  • Bojie Li,
  • Yaoyao Zhang,
  • Lizhen Huang and
  • Lei Zhu

Beilstein J. Org. Chem. 2025, 21, 839–844, doi:10.3762/bjoc.21.67

Graphical Abstract
  • efficient, reusable heterogeneous catalyst for this cascade reaction, achieving good to excellent yields without any loss of activity even after ten cycles of simple filtration-based recovery [12]. Moreover, a copper catalyst has been shown to function effectively in both organic and aqueous media [13][14
  • quinazolinones, and the wide application of the chitosan-supported copper catalyst in various organic transformations [19][20][21], the use of chitosan-supported copper for quinazolinone synthesis has not been reported. As part of our ongoing research interest in chitosan and chitosan-supported copper catalysts
  • in organic transformations [22][23][24], we intended to investigate the use of chitosan-supported copper as a catalyst for the synthesis of quinazolinones from 2-halobenzoic acids and amidines under mild reaction conditions (Scheme 1c). Results and Discussion The initial reactions commenced with 2
PDF
Album
Supp Info
Full Research Paper
Published 28 Apr 2025

Substituent effects in N-acetylated phenylazopyrazole photoswitches

  • Radek Tovtik,
  • Dennis Marzin,
  • Pia Weigel,
  • Stefano Crespi and
  • Nadja A. Simeth

Beilstein J. Org. Chem. 2025, 21, 830–838, doi:10.3762/bjoc.21.66

Graphical Abstract
  • Radek Tovtik Dennis Marzin Pia Weigel Stefano Crespi Nadja A. Simeth Institute of Organic and Biomolecular Chemistry, Georg-August-University, Tammannstraße 2, 37077 Goettingen, Germany Department of Chemistry, Ångström laboratory, Uppsala University, Box 523, 751 20 Uppsala, Sweden Cluster of
  • discovered that simple acylation of the pyrazole moiety leads to increased quantum yields of isomerization, long Z-isomer life-times, good spectral separation, and high photostability. Keywords: azobenzenes; azopyrazoles; photochromism; photoswitches; substituent effects; Introduction Organic photoswitches
PDF
Album
Supp Info
Full Research Paper
Published 25 Apr 2025

4-(1-Methylamino)ethylidene-1,5-disubstituted pyrrolidine-2,3-diones: synthesis, anti-inflammatory effect and in silico approaches

  • Nguyen Tran Nguyen,
  • Vo Viet Dai,
  • Luc Van Meervelt,
  • Do Thi Thao and
  • Nguyen Minh Thong

Beilstein J. Org. Chem. 2025, 21, 817–829, doi:10.3762/bjoc.21.65

Graphical Abstract
  • organic cation transporter 2 (OCT2) was examined, with OCT2 playing a pivotal role in the renal elimination of both xenobiotics and endogenous compounds. The predicted results suggest that none of the studied compounds act as OCT2 substrates. Toxicity was assessed using the Ames test, a widely accepted
PDF
Album
Supp Info
Full Research Paper
Published 24 Apr 2025

Regioselective formal hydrocyanation of allenes: synthesis of β,γ-unsaturated nitriles with α-all-carbon quaternary centers

  • Seeun Lim,
  • Teresa Kim and
  • Yunmi Lee

Beilstein J. Org. Chem. 2025, 21, 800–806, doi:10.3762/bjoc.21.63

Graphical Abstract
  • are important intermediates in organic syntheses because of the versatility of the cyano group, which can be readily transformed into a wide range of functional groups, including amides, carboxylic acids, amines, aldehydes, ketones, and N-heterocycles [6][7][8]. However, the synthesis of all-carbon
  • with diverse functional groups [12][13][14]. Consequently, the development of selective and predictable strategies for the introduction of cyano groups into quaternary carbon frameworks has become necessary in organic synthesis. The transition-metal-catalyzed hydrocyanation of carbon–carbon double
PDF
Album
Supp Info
Full Research Paper
Published 17 Apr 2025

Carbon-rich materials: from polyaromatic molecules to fullerenes and other carbon allotropes

  • Hiroko Yamada and
  • Yoko Yamakoshi

Beilstein J. Org. Chem. 2025, 21, 798–799, doi:10.3762/bjoc.21.62

Graphical Abstract
  • on carbon-rich materials. We highly appreciate that so many of our colleagues and friends – researchers with a variety of backgrounds working on these special molecules – agreed to contribute to this project. The authors hail from diverse research areas, including synthetic organic chemistry, surface
PDF
Editorial
Published 17 Apr 2025
Other Beilstein-Institut Open Science Activities