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Search for "biotechnology" in Full Text gives 183 result(s) in Beilstein Journal of Organic Chemistry.

4-(1-Methylamino)ethylidene-1,5-disubstituted pyrrolidine-2,3-diones: synthesis, anti-inflammatory effect and in silico approaches

  • Nguyen Tran Nguyen,
  • Vo Viet Dai,
  • Luc Van Meervelt,
  • Do Thi Thao and
  • Nguyen Minh Thong

Beilstein J. Org. Chem. 2025, 21, 817–829, doi:10.3762/bjoc.21.65

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  • Nguyen Tran Nguyen Vo Viet Dai Luc Van Meervelt Do Thi Thao Nguyen Minh Thong The University of Danang-University of Science and Education, Danang 550000, Vietnam Biomolecular Architecture, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium Institute of Biotechnology
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Published 24 Apr 2025

Origami with small molecules: exploiting the C–F bond as a conformational tool

  • Patrick Ryan,
  • Ramsha Iftikhar and
  • Luke Hunter

Beilstein J. Org. Chem. 2025, 21, 680–716, doi:10.3762/bjoc.21.54

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  • recognition processes. Therefore, methods for controlling the conformations of sugars are likely to have diverse and valuable applications in biotechnology and medicine. The structure of a sugar molecule offers several potential locations where fluorine can be introduced. Typical patterns include the
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Published 02 Apr 2025

Photocatalyzed elaboration of antibody-based bioconjugates

  • Marine Le Stum,
  • Eugénie Romero and
  • Gary A. Molander

Beilstein J. Org. Chem. 2025, 21, 616–629, doi:10.3762/bjoc.21.49

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  • tremendous promise within the domains of biotechnology and biomedical research [57][58]. To date, such entities have most often been formulated from the expression of fusion proteins, although more recently post-translational protein–protein conjugation has been recognized as a means to access such
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Published 18 Mar 2025

Antibiofilm and cytotoxic metabolites from the entomopathogenic fungus Samsoniella aurantia

  • Rita Toshe,
  • Syeda J. Khalid,
  • Blondelle Matio Kemkuignou,
  • Esteban Charria-Girón,
  • Paul Eckhardt,
  • Birthe Sandargo,
  • Kunlapat Nuchthien,
  • J. Jennifer Luangsa-ard,
  • Till Opatz,
  • Hedda Schrey,
  • Sherif S. Ebada and
  • Marc Stadler

Beilstein J. Org. Chem. 2025, 21, 327–339, doi:10.3762/bjoc.21.23

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  • Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 113 Thailand Science Park, Phahonyothin Rd., Khlong Nueng, Khlong Luang, Pathum Thani 12120, Thailand Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
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Published 11 Feb 2025

Interaction of a pyrene derivative with cationic [60]fullerene in phospholipid membranes and its effects on photodynamic actions

  • Hayato Takagi,
  • Çetin Çelik,
  • Ryosuke Fukuda,
  • Qi Guo,
  • Tomohiro Higashino,
  • Hiroshi Imahori,
  • Yoko Yamakoshi and
  • Tatsuya Murakami

Beilstein J. Org. Chem. 2024, 20, 2732–2738, doi:10.3762/bjoc.20.231

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  • Hayato Takagi Cetin Celik Ryosuke Fukuda Qi Guo Tomohiro Higashino Hiroshi Imahori Yoko Yamakoshi Tatsuya Murakami Department of Biotechnology and Pharmaceutical Engineering, Graduate School of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu City, Toyama 939-0398, Japan
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Published 30 Oct 2024

Cell-free protein synthesis with technical additives – expanding the parameter space of in vitro gene expression

  • Tabea Bartsch,
  • Stephan Lütz and
  • Katrin Rosenthal

Beilstein J. Org. Chem. 2024, 20, 2242–2253, doi:10.3762/bjoc.20.192

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  • were taken from the databases Chemistry WebBook by the National Institute of Standards and Technology (NIST) (https://webbook.nist.gov/) at 1 bar and 25 °C, PubChem by the National Center for Biotechnology and Information (https://pubchem.ncbi.nlm.nih.gov/), and GESTIS-Stoffdatenbank by Institut für
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Published 04 Sep 2024

Finding the most potent compounds using active learning on molecular pairs

  • Zachary Fralish and
  • Daniel Reker

Beilstein J. Org. Chem. 2024, 20, 2152–2162, doi:10.3762/bjoc.20.185

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  • Science & Engineering Graduate (NDSEG) Fellowship Program. This research was supported by the Duke Science & Technology Initiative and by the NIH NIGMS grant R35GM151255. Conflict of Interest D.R. acts as a consultant to the pharmaceutical and biotechnology industry, as a mentor for Start2, and on the
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Published 27 Aug 2024

Computational toolbox for the analysis of protein–glycan interactions

  • Ferran Nieto-Fabregat,
  • Maria Pia Lenza,
  • Angela Marseglia,
  • Cristina Di Carluccio,
  • Antonio Molinaro,
  • Alba Silipo and
  • Roberta Marchetti

Beilstein J. Org. Chem. 2024, 20, 2084–2107, doi:10.3762/bjoc.20.180

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Published 22 Aug 2024

Allostreptopyrroles A–E, β-alkylpyrrole derivatives from an actinomycete Allostreptomyces sp. RD068384

  • Marwa Elsbaey,
  • Naoya Oku,
  • Mohamed S. A. Abdel-Mottaleb and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2024, 20, 1981–1987, doi:10.3762/bjoc.20.174

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  • Marwa Elsbaey Naoya Oku Mohamed S. A. Abdel-Mottaleb Yasuhiro Igarashi Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398
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Published 13 Aug 2024

Synthesis of cyclic β-1,6-oligosaccharides from glucosamine monomers by electrochemical polyglycosylation

  • Md Azadur Rahman,
  • Hirofumi Endo,
  • Takashi Yamamoto,
  • Shoma Okushiba,
  • Norihiko Sasaki and
  • Toshiki Nokami

Beilstein J. Org. Chem. 2024, 20, 1421–1427, doi:10.3762/bjoc.20.124

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  • Md Azadur Rahman Hirofumi Endo Takashi Yamamoto Shoma Okushiba Norihiko Sasaki Toshiki Nokami Department of Chemistry and Biotechnology, Tottori University, 4-101 Koyamacho-minami, Tottori city, 680-8552 Tottori, Japan Center for Research on Green Sustainable Chemistry, Faculty of Engineering
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Published 26 Jun 2024

Monitoring carbohydrate 3D structure quality with the Privateer database

  • Jordan S. Dialpuri,
  • Haroldas Bagdonas,
  • Lucy C. Schofield,
  • Phuong Thao Pham,
  • Lou Holland and
  • Jon Agirre

Beilstein J. Org. Chem. 2024, 20, 931–939, doi:10.3762/bjoc.20.83

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  • late Willy von der Lieth, pioneers of carbohydrate structure validation, whose research informed some of the methods showcased in the Privateer database. Funding Jordan Dialpuri is funded by the Biotechnology and Biological Sciences Research Council (BBSRC; grant No. BB/T0072221). Haroldas Bagdonas is
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Published 24 Apr 2024

Activity assays of NnlA homologs suggest the natural product N-nitroglycine is degraded by diverse bacteria

  • Kara A. Strickland,
  • Brenda Martinez Rodriguez,
  • Ashley A. Holland,
  • Shelby Wagner,
  • Michelle Luna-Alva,
  • David E. Graham and
  • Jonathan D. Caranto

Beilstein J. Org. Chem. 2024, 20, 830–840, doi:10.3762/bjoc.20.75

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  • products. Experimental General reagents and protocols Isopropyl β-ᴅ-1-thiogalactopyranoside (IPTG) and 5-aminolevulinic acid (5-ALA) were purchased from Gold Biotechnology. NNG was purchased from AAblocks. 2-NAE was purchased from Toronto Research Chemicals. General buffers and media components were
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Published 17 Apr 2024

Introduction of a human- and keyboard-friendly N-glycan nomenclature

  • Friedrich Altmann,
  • Johannes Helm,
  • Martin Pabst and
  • Johannes Stadlmann

Beilstein J. Org. Chem. 2024, 20, 607–620, doi:10.3762/bjoc.20.53

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  • Friedrich Altmann Johannes Helm Martin Pabst Johannes Stadlmann Department of Chemistry, BOKU University, Vienna, Austria Department of Biotechnology, Delft University of Technology, Delft, The Netherlands 10.3762/bjoc.20.53 Abstract In the beginning was the word. But there were no words for N
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Published 15 Mar 2024

A myo-inositol dehydrogenase involved in aminocyclitol biosynthesis of hygromycin A

  • Michael O. Akintubosun and
  • Melanie A. Higgins

Beilstein J. Org. Chem. 2024, 20, 589–596, doi:10.3762/bjoc.20.51

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  • buffers (Tris-HCl, HEPES, CHES and CAPS) from pH 7.5 to 11. Different inositol substrates, including myo-inositol, scyllo-inositol, muco-inositol, epi-inositol, ᴅ-chiro-inositol, ʟ-chiro-inositol, and ᴅ-glucose were tested. Inositol substrates were purchased from TCI Chemicals or Santa Cruz Biotechnology
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Published 14 Mar 2024

Pseudallenes A and B, new sulfur-containing ovalicin sesquiterpenoid derivatives with antimicrobial activity from the deep-sea cold seep sediment-derived fungus Pseudallescheria boydii CS-793

  • Zhen Ying,
  • Xiao-Ming Li,
  • Sui-Qun Yang,
  • Hong-Lei Li,
  • Xin Li,
  • Bin-Gui Wang and
  • Ling-Hong Meng

Beilstein J. Org. Chem. 2024, 20, 470–478, doi:10.3762/bjoc.20.42

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  • Chinese Academy of Sciences, Yuquan Road 19A, Beijing 100049, China Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Wenhai Road 1, Qingdao 266237, China 10.3762/bjoc.20.42 Abstract Pseudallenes A and B (1 and 2), the new and rare examples of
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Published 28 Feb 2024

Identification of the p-coumaric acid biosynthetic gene cluster in Kutzneria albida: insights into the diazotization-dependent deamination pathway

  • Seiji Kawai,
  • Akito Yamada,
  • Yohei Katsuyama and
  • Yasuo Ohnishi

Beilstein J. Org. Chem. 2024, 20, 1–11, doi:10.3762/bjoc.20.1

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  • Seiji Kawai Akito Yamada Yohei Katsuyama Yasuo Ohnishi Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan Collaborative Research Institute for Innovative Microbiology, The University of Tokyo
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Published 02 Jan 2024

Studying specificity in protein–glycosaminoglycan recognition with umbrella sampling

  • Mateusz Marcisz,
  • Sebastian Anila,
  • Margrethe Gaardløs,
  • Martin Zacharias and
  • Sergey A. Samsonov

Beilstein J. Org. Chem. 2023, 19, 1933–1946, doi:10.3762/bjoc.19.144

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  • Mateusz Marcisz Sebastian Anila Margrethe Gaardlos Martin Zacharias Sergey A. Samsonov Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland Physics Department, Technical University
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Published 19 Dec 2023

Synthetic approach to 2-alkyl-4-quinolones and 2-alkyl-4-quinolone-3-carboxamides based on common β-keto amide precursors

  • Yordanka Mollova-Sapundzhieva,
  • Plamen Angelov,
  • Danail Georgiev and
  • Pavel Yanev

Beilstein J. Org. Chem. 2023, 19, 1804–1810, doi:10.3762/bjoc.19.132

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  • experimental details and analytical data. Supporting Information File 26: Processed NMR spectra. Acknowledgements We are grateful to Prof. Tsanko Gechev and the Center of Plant Systems Biology and Biotechnology, Plovdiv, for providing access to their Waters Acquity - Synapt XS UPLC - mass spectrometry system
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Published 23 Nov 2023

Synthesis of imidazo[1,2-a]pyridine-containing peptidomimetics by tandem of Groebke–Blackburn–Bienaymé and Ugi reactions

  • Oleksandr V. Kolomiiets,
  • Alexander V. Tsygankov,
  • Maryna N. Kornet,
  • Aleksander A. Brazhko,
  • Vladimir I. Musatov and
  • Valentyn A. Chebanov

Beilstein J. Org. Chem. 2023, 19, 727–735, doi:10.3762/bjoc.19.53

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  • , 61072, Kharkiv, Ukraine Faculty of Chemistry, V. N. Karazin Kharkiv National University, Svobody sq., 4, 61022, Kharkiv, Ukraine National Technical University "Kharkiv Polytechnic Institute", Kyrpychova st., 2, Kharkiv, 61002, Ukraine Laboratory of Biotechnology of Physiologically Active Substances
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Published 26 May 2023

Phenanthridine–pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme

  • Josipa Matić,
  • Tana Tandarić,
  • Marijana Radić Stojković,
  • Filip Šupljika,
  • Zrinka Karačić,
  • Ana Tomašić Paić,
  • Lucija Horvat,
  • Robert Vianello and
  • Lidija-Marija Tumir

Beilstein J. Org. Chem. 2023, 19, 550–565, doi:10.3762/bjoc.19.40

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  • Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Croatia Laboratory for Protein Biochemistry and Molecular Modelling, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia Laboratory for Molecular Plant Biology and
  • Biotechnology, Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia 10.3762/bjoc.19.40 Abstract Two novel conjugate molecules were designed: pyrene and phenanthridine-amino acid units with a different linker length between the aromatic fragments. Molecular
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Published 26 Apr 2023

Continuous flow synthesis of 6-monoamino-6-monodeoxy-β-cyclodextrin

  • János Máté Orosz,
  • Dóra Ujj,
  • Petr Kasal,
  • Gábor Benkovics and
  • Erika Bálint

Beilstein J. Org. Chem. 2023, 19, 294–302, doi:10.3762/bjoc.19.25

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  • Janos Mate Orosz Dora Ujj Petr Kasal Gabor Benkovics Erika Balint Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111 Budapest, Hungary Department of Organic Chemistry, Faculty
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Published 09 Mar 2023

Nostochopcerol, a new antibacterial monoacylglycerol from the edible cyanobacterium Nostochopsis lobatus

  • Naoya Oku,
  • Saki Hayashi,
  • Yuji Yamaguchi,
  • Hiroyuki Takenaka and
  • Yasuhiro Igarashi

Beilstein J. Org. Chem. 2023, 19, 133–138, doi:10.3762/bjoc.19.13

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  • Naoya Oku Saki Hayashi Yuji Yamaguchi Hiroyuki Takenaka Yasuhiro Igarashi Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939-0398, Japan MAC Gifu Research Institute, MicroAlgae Corporation, 4-15 Akebono, Gifu 500-8148
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Published 09 Feb 2023

Synthesis of C6-modified mannose 1-phosphates and evaluation of derived sugar nucleotides against GDP-mannose dehydrogenase

  • Sanaz Ahmadipour,
  • Alice J. C. Wahart,
  • Jonathan P. Dolan,
  • Laura Beswick,
  • Chris S. Hawes,
  • Robert A. Field and
  • Gavin J. Miller

Beilstein J. Org. Chem. 2022, 18, 1379–1384, doi:10.3762/bjoc.18.142

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  • Sanaz Ahmadipour Alice J. C. Wahart Jonathan P. Dolan Laura Beswick Chris S. Hawes Robert A. Field Gavin J. Miller Department of Chemistry & Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK Lennard-Jones Laboratory, School of Chemical
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Published 30 Sep 2022

Computational model predicts protein binding sites of a luminescent ligand equipped with guanidiniocarbonyl-pyrrole groups

  • Neda Rafieiolhosseini,
  • Matthias Killa,
  • Thorben Neumann,
  • Niklas Tötsch,
  • Jean-Noël Grad,
  • Alexander Höing,
  • Thies Dirksmeyer,
  • Jochen Niemeyer,
  • Christian Ottmann,
  • Shirley K. Knauer,
  • Michael Giese,
  • Jens Voskuhl and
  • Daniel Hoffmann

Beilstein J. Org. Chem. 2022, 18, 1322–1331, doi:10.3762/bjoc.18.137

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  • Neda Rafieiolhosseini Matthias Killa Thorben Neumann Niklas Totsch Jean-Noel Grad Alexander Hoing Thies Dirksmeyer Jochen Niemeyer Christian Ottmann Shirley K. Knauer Michael Giese Jens Voskuhl Daniel Hoffmann Bioinformatics and Computational Biophysics, Center for Medical Biotechnology (ZMB
  • Department of Molecular Biology II, Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstraße 5, 45141 Essen, Germany Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, PO Box 513
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Published 23 Sep 2022

Ferrocenoyl-adenines: substituent effects on regioselective acylation

  • Mateja Toma,
  • Gabrijel Zubčić,
  • Jasmina Lapić,
  • Senka Djaković,
  • Davor Šakić and
  • Valerije Vrček

Beilstein J. Org. Chem. 2022, 18, 1270–1277, doi:10.3762/bjoc.18.133

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  • Mateja Toma Gabrijel Zubcic Jasmina Lapic Senka Djakovic Davor Sakic Valerije Vrcek Faculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia 10.3762
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Published 19 Sep 2022
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